Motif ID: GTF2A1,2.p2

Z-value: 1.760


Transcription factors associated with GTF2A1,2.p2:

Gene SymbolEntrez IDGene Name
GTF2A1 2957 general transcription factor IIA, 1, 19/37kDa
GTF2A2 2958 general transcription factor IIA, 2, 12kDa

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
GTF2A2hg19_v1_chr15_-_59949536_59949765-0.105.8e-01Click!
GTF2A1hg19_v1_chr14_-_81687574_81687574-0.058.0e-01Click!


Activity profile for motif GTF2A1,2.p2.

activity profile for motif GTF2A1,2.p2


Sorted Z-values histogram for motif GTF2A1,2.p2

Sorted Z-values for motif GTF2A1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of GTF2A1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_+_99956630 5.121 NM_001142462
NM_053001
OSR2

odd-skipped related 2 (Drosophila)

chr12_+_53491417 3.863 NM_002178
IGFBP6
insulin-like growth factor binding protein 6
chr2_+_27301434 3.842 NM_007046
EMILIN1
elastin microfibril interfacer 1
chr16_+_55515468 3.787 NM_001127891
MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
chr1_+_22138757 3.769 NM_001013693
LDLRAD2
low density lipoprotein receptor class A domain containing 2
chr2_+_168043792 3.741 NM_001199144
NM_001199145
XIRP2

xin actin-binding repeat containing 2

chr15_-_76005095 3.569 CSPG4
chondroitin sulfate proteoglycan 4
chr12_+_53491448 3.421 IGFBP6
insulin-like growth factor binding protein 6
chr15_-_62457481 3.404 NM_001007595
C2CD4B
C2 calcium-dependent domain containing 4B
chr17_-_48278987 3.374 NM_000088
COL1A1
collagen, type I, alpha 1
chr11_-_62457001 3.327 LRRN4CL
LRRN4 C-terminal like
chr12_+_109577201 3.306 NM_001093
ACACB
acetyl-CoA carboxylase beta
chr21_-_43735462 3.277 TFF3
trefoil factor 3 (intestinal)
chr17_-_48278874 3.249 COL1A1
collagen, type I, alpha 1
chr11_+_130318457 3.235 NM_139055
ADAMTS15
ADAM metallopeptidase with thrombospondin type 1 motif, 15
chr17_+_41006094 3.234 AOC3
amine oxidase, copper containing 3 (vascular adhesion protein 1)
chr12_-_7245006 3.218 NM_001733
C1R
complement component 1, r subcomponent
chr15_-_76005179 3.125 NM_001897
CSPG4
chondroitin sulfate proteoglycan 4
chrX_-_15402469 3.119 NM_004469
FIGF
c-fos induced growth factor (vascular endothelial growth factor D)
chr17_+_45286713 3.087 NM_002476
MYL4
myosin, light chain 4, alkali; atrial, embryonic
chr12_-_7245048 3.084 C1R
complement component 1, r subcomponent
chr1_-_20306908 3.039 NM_000300
NM_001161727
NM_001161728
PLA2G2A


phospholipase A2, group IIA (platelets, synovial fluid)


chr7_+_127881330 2.826 NM_000230
LEP
leptin
chr11_-_62457370 2.822 NM_203422
LRRN4CL
LRRN4 C-terminal like
chr1_-_153581415 2.822 S100A16
S100 calcium binding protein A16
chr2_+_176994421 2.816 NM_001199747
NM_001199746
NM_019558
HOXD8


homeobox D8


chr1_+_159173802 2.813 NM_002036
DARC
Duffy blood group, chemokine receptor
chr2_+_27301693 2.736 EMILIN1
elastin microfibril interfacer 1
chr19_+_840970 2.725 NM_002777
PRTN3
proteinase 3
chr10_-_45474210 2.679 NM_007021
C10orf10
chromosome 10 open reading frame 10
chr21_-_43735705 2.618 NM_003226
TFF3
trefoil factor 3 (intestinal)
chr20_-_44455932 2.614 NM_003279
TNNC2
troponin C type 2 (fast)
chr12_-_22089627 2.611 NM_005691
NM_020297
ABCC9

ATP-binding cassette, sub-family C (CFTR/MRP), member 9

chr2_+_74120132 2.539 ACTG2
actin, gamma 2, smooth muscle, enteric
chr11_-_119217365 2.504 NM_015645
NM_031433
C1QTNF5
MFRP
C1q and tumor necrosis factor related protein 5
membrane frizzled-related protein
chr19_+_6739697 2.498 NM_004240
TRIP10
thyroid hormone receptor interactor 10
chr1_+_86046434 2.427 NM_001554
CYR61
cysteine-rich, angiogenic inducer, 61
chr17_-_34328607 2.301 CCL14-CCL15
CCL14-CCL15 readthrough
chr12_-_15038724 2.280 NM_000900
NM_001190839
MGP

matrix Gla protein

chr8_+_40010986 2.258 NM_020130
C8orf4
chromosome 8 open reading frame 4
chr7_+_20686965 2.179 NM_001163942
NM_001163993
NM_178559
ABCB5


ATP-binding cassette, sub-family B (MDR/TAP), member 5


chr1_+_47264669 2.166 NM_000779
NM_001099772
CYP4B1

cytochrome P450, family 4, subfamily B, polypeptide 1

chr19_+_41725098 2.163 NM_001699
NM_021913
AXL

AXL receptor tyrosine kinase

chr6_-_105584220 2.154 NM_147147
BVES
blood vessel epicardial substance
chr2_+_74120092 2.146 NM_001199893
NM_001615
ACTG2

actin, gamma 2, smooth muscle, enteric

chr19_+_41725277 2.137 AXL
AXL receptor tyrosine kinase
chr17_-_46651809 2.137 NM_002146
HOXB3
homeobox B3
chr16_-_49860917 2.125 NM_015069
ZNF423
zinc finger protein 423
chr1_+_203444882 2.095 NM_002725
NM_201348
PRELP

proline/arginine-rich end leucine-rich repeat protein

chr2_+_205410465 2.077 NM_057177
NM_152526
NM_205863
PARD3B


par-3 partitioning defective 3 homolog B (C. elegans)


chr1_-_20306093 2.077 NM_001161729
PLA2G2A
phospholipase A2, group IIA (platelets, synovial fluid)
chr11_-_2018568 2.063 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr11_-_2018446 2.006 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr11_+_7506599 1.997 NM_198474
OLFML1
olfactomedin-like 1
chr2_-_211168315 1.995 NM_079422
MYL1
myosin, light chain 1, alkali; skeletal, fast
chr11_-_111782447 1.979 NM_001885
CRYAB
crystallin, alpha B
chr3_+_29322802 1.977 NM_001003792
NM_001003793
NM_001177711
NM_001177712
NM_014483
RBMS3




RNA binding motif, single stranded interacting protein 3




chr15_-_74659926 1.970 NM_000781
CYP11A1
cytochrome P450, family 11, subfamily A, polypeptide 1
chr11_-_2018334 1.957 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr1_-_165414499 1.950 NM_006917
RXRG
retinoid X receptor, gamma
chr22_-_24640850 1.919 NM_001099781
NM_001099782
NM_004121
GGT5


gamma-glutamyltransferase 5


chr19_+_41725259 1.911 AXL
AXL receptor tyrosine kinase
chr5_+_38403633 1.910 NM_182798
EGFLAM
EGF-like, fibronectin type III and laminin G domains
chr20_+_20033157 1.907 NM_015585
C20orf26
chromosome 20 open reading frame 26
chr2_+_177028804 1.907 NM_006898
HOXD3
homeobox D3
chr2_-_198540583 1.896 NM_144629
RFTN2
raftlin family member 2
chr1_+_156084579 1.896 LMNA
lamin A/C
chr5_+_40909617 1.881 C7
complement component 7
chrX_-_55057408 1.867 NM_000032
NM_001037967
NM_001037968
ALAS2


aminolevulinate, delta-, synthase 2


chr5_+_15500288 1.864 NM_012304
FBXL7
F-box and leucine-rich repeat protein 7
chr20_+_31870940 1.856 NM_033197
BPIFB1
BPI fold containing family B, member 1
chr8_+_75736771 1.854 NM_015886
PI15
peptidase inhibitor 15
chr16_+_22825806 1.853 NM_006043
HS3ST2
heparan sulfate (glucosamine) 3-O-sulfotransferase 2
chr7_-_41742666 1.847 NM_002192
INHBA
inhibin, beta A
chr17_+_4854383 1.829 NM_001193503
NM_001976
NM_053013
ENO3


enolase 3 (beta, muscle)


chr4_+_24797084 1.813 NM_003102
SOD3
superoxide dismutase 3, extracellular
chr5_+_150027837 1.799 SYNPO
synaptopodin
chr11_-_73720281 1.778 NM_003356
NM_022803
UCP3

uncoupling protein 3 (mitochondrial, proton carrier)

chr13_-_38172862 1.772 NM_001135934
NM_001135935
NM_001135936
NM_006475
POSTN



periostin, osteoblast specific factor



chr4_+_24797203 1.755 SOD3
superoxide dismutase 3, extracellular
chr2_-_218808705 1.752 NM_022648
TNS1
tensin 1
chr19_-_45826131 1.738 CKM
creatine kinase, muscle
chr2_-_96781887 1.731 NM_000682
ADRA2B
adrenergic, alpha-2B-, receptor
chr19_+_41725131 1.726 AXL
AXL receptor tyrosine kinase
chr19_+_41725135 1.723 AXL
AXL receptor tyrosine kinase
chr17_+_1665233 1.721 NM_002615
SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr20_+_36149606 1.703 NM_005386
NM_181689
NNAT

neuronatin

chr17_+_77030471 1.674 NM_198593
C1QTNF1
C1q and tumor necrosis factor related protein 1
chr1_-_57045214 1.661 PPAP2B
phosphatidic acid phosphatase type 2B
chr17_+_1665342 1.660 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr21_-_28217692 1.659 NM_006988
ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr17_-_1389013 1.652 NM_001080950
MYO1C
myosin IC
chr19_-_45826232 1.651 NM_001824
CKM
creatine kinase, muscle
chr9_+_72658496 1.637 NM_153267
MAMDC2
MAM domain containing 2
chr7_-_75443026 1.621 NM_002991
CCL24
chemokine (C-C motif) ligand 24
chr1_-_57044980 1.616 PPAP2B
phosphatidic acid phosphatase type 2B
chr22_+_22758538 1.614


chr1_-_57045129 1.606 PPAP2B
phosphatidic acid phosphatase type 2B
chr12_-_102874373 1.604 NM_000618
NM_001111283
NM_001111285
IGF1


insulin-like growth factor 1 (somatomedin C)


chr4_+_41614911 1.604 NM_001112719
NM_001112720
LIMCH1

LIM and calponin homology domains 1

chr1_+_110993748 1.603 NM_032414
PROK1
prokineticin 1
chr22_+_31487315 1.594 SMTN
smoothelin
chr1_-_57045235 1.573 NM_003713
PPAP2B
phosphatidic acid phosphatase type 2B
chr1_+_156084565 1.566 LMNA
lamin A/C
chr12_-_102872329 1.563 NM_001111284
IGF1
insulin-like growth factor 1 (somatomedin C)
chr21_+_42540092 1.562 BACE2
beta-site APP-cleaving enzyme 2
chr10_-_5541401 1.557 NM_017422
CALML5
calmodulin-like 5
chr19_+_859673 1.553 CFD
complement factor D (adipsin)
chr20_-_13971256 1.550 NM_025229
SEL1L2
sel-1 suppressor of lin-12-like 2 (C. elegans)
chr11_-_2019070 1.545 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr21_+_42540054 1.541 BACE2
beta-site APP-cleaving enzyme 2
chr19_+_859658 1.540 NM_001928
CFD
complement factor D (adipsin)
chr9_+_2621740 1.537 NM_001018056
NM_003383
VLDLR

very low density lipoprotein receptor

chr1_+_156084541 1.536 LMNA
lamin A/C
chr22_+_33196801 1.535 NM_000362
TIMP3
TIMP metallopeptidase inhibitor 3
chr5_+_150020201 1.521 NM_001109974
NM_007286
SYNPO

synaptopodin

chr3_-_99594915 1.509 NM_014890
FILIP1L
filamin A interacting protein 1-like
chr8_+_19796581 1.508 NM_000237
LPL
lipoprotein lipase
chr7_+_100770378 1.480 NM_000602
NM_001165413
SERPINE1

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

chr5_+_140566655 1.479 NM_019119
PCDHB9
protocadherin beta 9
chr9_+_2622134 1.478 VLDLR
very low density lipoprotein receptor
chr19_+_840963 1.475 PRTN3
proteinase 3
chr6_-_105584542 1.470 NM_007073
BVES
blood vessel epicardial substance
chr17_-_66951381 1.464 NM_007168
ABCA8
ATP-binding cassette, sub-family A (ABC1), member 8
chr17_+_48133357 1.464 ITGA3
integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
chr11_-_5531152 1.460 NM_017481
UBQLN3
ubiquilin 3
chr1_-_168105620 1.458 NM_153832
GPR161
G protein-coupled receptor 161
chr2_+_95537177 1.457 NM_144705
TEKT4
tektin 4
chr6_-_85472312 1.452 TBX18
T-box 18
chr2_-_110873533 1.427 MALL
mal, T-cell differentiation protein-like
chr13_-_110959441 1.424 NM_001845
COL4A1
collagen, type IV, alpha 1
chr5_+_40909487 1.424 C7
complement component 7
chr16_+_215972 1.423 NM_001003938
HBM
hemoglobin, mu
chr11_-_64825992 1.423 NM_005468
NAALADL1
N-acetylated alpha-linked acidic dipeptidase-like 1
chr3_-_149375584 1.416 NM_001168280
NM_015472
WWTR1

WW domain containing transcription regulator 1

chr9_+_124043719 1.414 GSN
gelsolin
chr3_-_78666943 1.414 ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr5_+_40909558 1.414 NM_000587
C7
complement component 7
chr22_+_22676814 1.411


chr9_+_72658735 1.399 MAMDC2
MAM domain containing 2
chrX_+_99899162 1.397 NM_014467
SRPX2
sushi-repeat containing protein, X-linked 2
chr15_+_74466024 1.389 NM_005545
ISLR
immunoglobulin superfamily containing leucine-rich repeat
chr12_+_54378929 1.389 NM_017409
HOXC10
homeobox C10
chr16_+_811049 1.383 NM_013404
MSLN
mesothelin
chr21_+_19617145 1.381 NM_024944
CHODL
chondrolectin
chr8_+_19796730 1.379 LPL
lipoprotein lipase
chr1_+_53527822 1.378 NM_001199081
PODN
podocan
chr1_+_156084458 1.377 NM_005572
NM_170707
NM_170708
LMNA


lamin A/C


chr1_+_159141376 1.372 NM_021189
NM_001127173
CADM3

cell adhesion molecule 3

chr4_+_41614933 1.371 LIMCH1
LIM and calponin homology domains 1
chr20_-_3662635 1.357 NM_025220
NM_153202
ADAM33

ADAM metallopeptidase domain 33

chr12_-_8088629 1.355 NM_006931
SLC2A3
solute carrier family 2 (facilitated glucose transporter), member 3
chr19_-_55660557 1.352 NM_001126132
NM_001126133
NM_003283
TNNT1


troponin T type 1 (skeletal, slow)


chr13_+_111154013 1.345 COL4A2
collagen, type IV, alpha 2
chr2_+_205410556 1.340 PARD3B
par-3 partitioning defective 3 homolog B (C. elegans)
chrX_+_99899388 1.332 SRPX2
sushi-repeat containing protein, X-linked 2
chr12_-_56106061 1.331 NM_001144997
ITGA7
integrin, alpha 7
chr17_+_61554420 1.311 NM_000789
ACE
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
chr19_-_42947050 1.302 NM_198477
CXCL17
chemokine (C-X-C motif) ligand 17
chr17_+_48133331 1.279 NM_002204
NM_005501
ITGA3

integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)

chr6_-_123957941 1.274 NM_001251987
NM_006073
TRDN

triadin

chr7_-_99698916 1.272 MCM7
minichromosome maintenance complex component 7
chr9_+_136243226 1.267 NM_153710
C9orf96
chromosome 9 open reading frame 96
chr8_+_144295067 1.265 NM_178172
GPIHBP1
glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1
chr16_+_31539202 1.264 NM_016633
AHSP
alpha hemoglobin stabilizing protein
chr13_-_40177200 1.263 LHFP
lipoma HMGIC fusion partner
chr16_+_22825481 1.262 HS3ST2
heparan sulfate (glucosamine) 3-O-sulfotransferase 2
chr7_+_116395440 1.257


chr5_-_134369571 1.256 PITX1
paired-like homeodomain 1
chr1_+_53527723 1.255 NM_001199080
NM_001199082
NM_153703
PODN


podocan


chr12_+_13349601 1.250 NM_001423
EMP1
epithelial membrane protein 1
chr1_-_27339326 1.248 NM_052943
FAM46B
family with sequence similarity 46, member B
chr10_+_88426538 1.246 LDB3
LIM domain binding 3
chr12_+_130647002 1.246 NM_007197
FZD10
frizzled family receptor 10
chr2_+_56411123 1.245 NM_001080433
CCDC85A
coiled-coil domain containing 85A
chr3_-_48130283 1.239 MAP4
microtubule-associated protein 4
chr17_+_37821598 1.239 NM_003673
TCAP
titin-cap (telethonin)
chr11_-_33744272 1.237 NM_001127223
NM_001127225
NM_001127226
CD59


CD59 molecule, complement regulatory protein


chr7_+_6793739 1.228 NM_173565
NM_001099697
RSPH10B
RSPH10B2
radial spoke head 10 homolog B (Chlamydomonas)
radial spoke head 10 homolog B2 (Chlamydomonas)
chr18_-_22931970 1.214 ZNF521
zinc finger protein 521
chr6_-_112575880 1.204 LAMA4
laminin, alpha 4
chr1_+_203444955 1.199 PRELP
proline/arginine-rich end leucine-rich repeat protein
chr6_-_29527477 1.199 UBD
ubiquitin D
chr8_+_37553269 1.194 NM_025069
ZNF703
zinc finger protein 703
chr3_+_42700837 1.192 ZBTB47
zinc finger and BTB domain containing 47
chr9_+_2622099 1.190 VLDLR
very low density lipoprotein receptor
chr4_-_76957139 1.189 NM_005409
CXCL11
chemokine (C-X-C motif) ligand 11
chr18_-_53303129 1.175 NM_001243226
TCF4
transcription factor 4
chr21_+_47546427 1.171 COL6A2
collagen, type VI, alpha 2
chr14_-_107122358 1.167


chr1_-_169703178 1.166 NM_000450
SELE
selectin E
chr22_+_23029175 1.162 IGLV3-25
immunoglobulin lambda variable 3-25
chr18_-_22932109 1.161 NM_015461
ZNF521
zinc finger protein 521
chrX_-_139866582 1.159 NM_004065
CDR1
cerebellar degeneration-related protein 1, 34kDa
chrX_-_15333726 1.141 NM_001201583
NM_080873
ASB11

ankyrin repeat and SOCS box containing 11

chr1_+_171060017 1.137 NM_001002294
NM_006894
FMO3

flavin containing monooxygenase 3

chr14_+_105953531 1.137 CRIP1
cysteine-rich protein 1 (intestinal)
chr1_+_84768333 1.134 NM_001134664
SAMD13
sterile alpha motif domain containing 13
chr21_-_28217272 1.131 ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr3_+_140396865 1.131 NM_152616
TRIM42
tripartite motif containing 42

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
2.35 2.00e-09 GO:0048856 anatomical structure development
2.17 3.28e-09 GO:0032502 developmental process
2.42 7.27e-09 GO:0048731 system development
2.22 1.15e-08 GO:0007275 multicellular organismal development
1.78 1.68e-06 GO:0032501 multicellular organismal process
2.68 4.49e-05 GO:0009653 anatomical structure morphogenesis
5.73 4.76e-05 GO:0001944 vasculature development
5.73 4.76e-05 GO:0040012 regulation of locomotion
5.76 1.27e-04 GO:0001568 blood vessel development
4.28 1.83e-04 GO:0072358 cardiovascular system development
4.28 1.83e-04 GO:0072359 circulatory system development
4.26 4.35e-04 GO:0051094 positive regulation of developmental process
2.30 5.55e-04 GO:0048513 organ development
5.50 6.06e-04 GO:0030334 regulation of cell migration
4.14 6.49e-04 GO:0048646 anatomical structure formation involved in morphogenesis
5.44 6.97e-04 GO:2000145 regulation of cell motility
2.18 1.06e-03 GO:0048869 cellular developmental process
3.00 1.14e-03 GO:0050793 regulation of developmental process
2.19 1.42e-03 GO:0030154 cell differentiation
3.04 1.58e-03 GO:0009888 tissue development
6.12 1.59e-03 GO:0007517 muscle organ development
6.83 1.78e-03 GO:0040017 positive regulation of locomotion
4.95 1.98e-03 GO:0051270 regulation of cellular component movement
6.52 2.68e-03 GO:0001525 angiogenesis
5.52 4.31e-03 GO:0048514 blood vessel morphogenesis
4.52 5.42e-03 GO:0001501 skeletal system development
5.96 6.06e-03 GO:0003012 muscle system process
3.03 8.29e-03 GO:2000026 regulation of multicellular organismal development
6.36 1.04e-02 GO:0030335 positive regulation of cell migration
6.36 1.04e-02 GO:2000147 positive regulation of cell motility
51.18 1.51e-02 GO:0020027 hemoglobin metabolic process
2.65 1.51e-02 GO:0009605 response to external stimulus
5.95 1.78e-02 GO:0051272 positive regulation of cellular component movement
4.32 1.96e-02 GO:0022603 regulation of anatomical structure morphogenesis
5.84 2.07e-02 GO:0006936 muscle contraction
13.84 2.37e-02 GO:0006941 striated muscle contraction
13.84 2.37e-02 GO:0030049 muscle filament sliding
13.84 2.37e-02 GO:0033275 actin-myosin filament sliding
13.47 2.70e-02 GO:0070252 actin-mediated cell contraction
2.85 3.21e-02 GO:0007155 cell adhesion
2.85 3.21e-02 GO:0022610 biological adhesion
2.95 3.26e-02 GO:0009790 embryo development
7.55 3.33e-02 GO:0045765 regulation of angiogenesis
4.35 4.00e-02 GO:0061061 muscle structure development
3.99 4.17e-02 GO:0045597 positive regulation of cell differentiation
2.31 4.30e-02 GO:0051239 regulation of multicellular organismal process

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
3.92 6.03e-11 GO:0044421 extracellular region part
2.80 2.46e-10 GO:0005576 extracellular region
6.24 9.56e-10 GO:0031012 extracellular matrix
5.69 1.11e-06 GO:0005578 proteinaceous extracellular matrix
3.30 3.38e-05 GO:0005615 extracellular space
6.35 1.69e-02 GO:0044420 extracellular matrix part

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
10.24 1.47e-04 GO:0005201 extracellular matrix structural constituent
2.85 2.18e-02 GO:0005198 structural molecule activity