Motif ID: GTF2A1,2.p2

Z-value: 1.760


Transcription factors associated with GTF2A1,2.p2:

Gene SymbolEntrez IDGene Name
GTF2A1 2957 general transcription factor IIA, 1, 19/37kDa
GTF2A2 2958 general transcription factor IIA, 2, 12kDa

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
GTF2A2hg19_v1_chr15_-_59949536_59949765-0.105.8e-01Click!
GTF2A1hg19_v1_chr14_-_81687574_81687574-0.058.0e-01Click!


Activity profile for motif GTF2A1,2.p2.

activity profile for motif GTF2A1,2.p2


Sorted Z-values histogram for motif GTF2A1,2.p2

Sorted Z-values for motif GTF2A1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of GTF2A1,2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_+_99956630 5.121 NM_001142462
NM_053001
 OSR2

odd-skipped related 2 (Drosophila)

chr12_+_53491417 3.863 NM_002178
 IGFBP6
insulin-like growth factor binding protein 6
chr2_+_27301434 3.842 NM_007046
 EMILIN1
elastin microfibril interfacer 1
chr16_+_55515468 3.787 NM_001127891
 MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
chr1_+_22138757 3.769 NM_001013693
 LDLRAD2
low density lipoprotein receptor class A domain containing 2
chr2_+_168043792 3.741 NM_001199144
NM_001199145
 XIRP2

xin actin-binding repeat containing 2

chr15_-_76005095 3.569 CSPG4
chondroitin sulfate proteoglycan 4
chr12_+_53491448 3.421 IGFBP6
insulin-like growth factor binding protein 6
chr15_-_62457481 3.404 NM_001007595
 C2CD4B
C2 calcium-dependent domain containing 4B
chr17_-_48278987 3.374 NM_000088
 COL1A1
collagen, type I, alpha 1
chr11_-_62457001 3.327 LRRN4CL
LRRN4 C-terminal like
chr12_+_109577201 3.306 NM_001093
 ACACB
acetyl-CoA carboxylase beta
chr21_-_43735462 3.277 TFF3
trefoil factor 3 (intestinal)
chr17_-_48278874 3.249 COL1A1
collagen, type I, alpha 1
chr11_+_130318457 3.235 NM_139055
 ADAMTS15
ADAM metallopeptidase with thrombospondin type 1 motif, 15
chr17_+_41006094 3.234 AOC3
amine oxidase, copper containing 3 (vascular adhesion protein 1)
chr12_-_7245006 3.218 NM_001733
 C1R
complement component 1, r subcomponent
chr15_-_76005179 3.125 NM_001897
 CSPG4
chondroitin sulfate proteoglycan 4
chrX_-_15402469 3.119 NM_004469
 FIGF
c-fos induced growth factor (vascular endothelial growth factor D)
chr17_+_45286713 3.087 NM_002476
 MYL4
myosin, light chain 4, alkali; atrial, embryonic

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 46 entries
Enrichment   P-value GO Accession GO Term
51.18 1.51e-02 GO:0020027 hemoglobin metabolic process
13.84 2.37e-02 GO:0006941 striated muscle contraction
13.84 2.37e-02 GO:0030049 muscle filament sliding
13.84 2.37e-02 GO:0033275 actin-myosin filament sliding
13.47 2.70e-02 GO:0070252 actin-mediated cell contraction
7.55 3.33e-02 GO:0045765 regulation of angiogenesis
6.83 1.78e-03 GO:0040017 positive regulation of locomotion
6.52 2.68e-03 GO:0001525 angiogenesis
6.36 1.04e-02 GO:0030335 positive regulation of cell migration
6.36 1.04e-02 GO:2000147 positive regulation of cell motility
6.12 1.59e-03 GO:0007517 muscle organ development
5.96 6.06e-03 GO:0003012 muscle system process
5.95 1.78e-02 GO:0051272 positive regulation of cellular component movement
5.84 2.07e-02 GO:0006936 muscle contraction
5.76 1.27e-04 GO:0001568 blood vessel development
5.73 4.76e-05 GO:0001944 vasculature development
5.73 4.76e-05 GO:0040012 regulation of locomotion
5.52 4.31e-03 GO:0048514 blood vessel morphogenesis
5.50 6.06e-04 GO:0030334 regulation of cell migration
5.44 6.97e-04 GO:2000145 regulation of cell motility

Gene overrepresentation in compartment category:

Showing 1 to 6 of 6 entries
Enrichment   P-value GO Accession GO Term
6.35 1.69e-02 GO:0044420 extracellular matrix part
6.24 9.56e-10 GO:0031012 extracellular matrix
5.69 1.11e-06 GO:0005578 proteinaceous extracellular matrix
3.92 6.03e-11 GO:0044421 extracellular region part
3.30 3.38e-05 GO:0005615 extracellular space
2.80 2.46e-10 GO:0005576 extracellular region

Gene overrepresentation in function category:

Showing 1 to 2 of 2 entries
Enrichment   P-value GO Accession GO Term
10.24 1.47e-04 GO:0005201 extracellular matrix structural constituent
2.85 2.18e-02 GO:0005198 structural molecule activity