Motif ID: GTF2I.p2

Z-value: 2.780


Transcription factors associated with GTF2I.p2:

Gene SymbolEntrez IDGene Name
GTF2I 2969 general transcription factor II, i

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
GTF2Ihg19_v1_chr7_+_74072038_740720510.585.3e-04Click!


Activity profile for motif GTF2I.p2.

activity profile for motif GTF2I.p2


Sorted Z-values histogram for motif GTF2I.p2

Sorted Z-values for motif GTF2I.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of GTF2I.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_+_144899330 11.452 NM_001144003
NM_001144004
NM_001144005
NM_032539
 SLITRK2



SLIT and NTRK-like family, member 2



chr19_-_51071279 9.196 NM_001080457
 LRRC4B
leucine rich repeat containing 4B
chr19_-_49149252 8.829 NM_001217
 CA11
carbonic anhydrase XI
chr2_+_79740059 7.499 NM_001164883
NM_004389
 CTNNA2

catenin (cadherin-associated protein), alpha 2

chr19_-_51487070 7.176 NM_139277
NM_001207053
NM_001243126
NM_005046
 KLK7



kallikrein-related peptidase 7



chr17_+_37783202 6.978 PPP1R1B
protein phosphatase 1, regulatory (inhibitor) subunit 1B
chr19_-_47975074 6.773 SLC8A2
solute carrier family 8 (sodium/calcium exchanger), member 2
chr17_-_7120917 6.601 NM_001128827
 DLG4
discs, large homolog 4 (Drosophila)
chr20_+_43374487 6.461 NM_022358
 KCNK15
potassium channel, subfamily K, member 15
chr17_+_37783176 6.459 NM_032192
 PPP1R1B
protein phosphatase 1, regulatory (inhibitor) subunit 1B
chr4_-_5889992 6.031 CRMP1
collapsin response mediator protein 1
chr6_+_1390068 6.027 NM_001452
 FOXF2
forkhead box F2
chr16_-_65155881 5.989 NM_001797
 CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
chr14_-_24047993 5.925 NM_001146028
NM_032452
 JPH4

junctophilin 4

chr4_-_16900028 5.816 LDB2
LIM domain binding 2
chr20_-_55841090 5.564 BMP7
bone morphogenetic protein 7
chr15_-_37392358 5.420 NM_170674
NM_170675
NM_170676
NM_170677
 MEIS2



Meis homeobox 2



chr11_-_62688732 5.370 CHRM1
cholinergic receptor, muscarinic 1
chr4_-_5890142 5.313 CRMP1
collapsin response mediator protein 1
chr1_+_203444882 5.279 NM_002725
NM_201348
 PRELP

proline/arginine-rich end leucine-rich repeat protein


Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 130 entries
Enrichment   P-value GO Accession GO Term
11.89 2.90e-04 GO:0050807 regulation of synapse organization
11.40 1.43e-02 GO:0007214 gamma-aminobutyric acid signaling pathway
10.80 2.04e-02 GO:0051963 regulation of synaptogenesis
10.13 1.18e-03 GO:0050803 regulation of synapse structure and activity
9.77 1.62e-03 GO:0021954 central nervous system neuron development
9.43 2.17e-03 GO:0071804 cellular potassium ion transport
9.43 2.17e-03 GO:0071805 potassium ion transmembrane transport
6.84 2.93e-02 GO:0051899 membrane depolarization
5.78 1.59e-03 GO:0048565 digestive tract development
5.26 3.05e-02 GO:0042472 inner ear morphogenesis
5.13 5.88e-03 GO:0055123 digestive system development
4.97 1.59e-07 GO:0030900 forebrain development
4.95 1.07e-06 GO:0006813 potassium ion transport
4.94 3.58e-03 GO:0021537 telencephalon development
4.89 4.07e-03 GO:0048839 inner ear development
4.78 5.22e-03 GO:0030324 lung development
4.68 1.05e-07 GO:0045664 regulation of neuron differentiation
4.63 7.50e-03 GO:0030323 respiratory tube development
4.62 1.43e-03 GO:0060541 respiratory system development
4.61 1.83e-02 GO:0030326 embryonic limb morphogenesis

Gene overrepresentation in compartment category:

Showing 1 to 20 of 35 entries
Enrichment   P-value GO Accession GO Term
6.47 2.08e-02 GO:0042734 presynaptic membrane
5.88 5.47e-04 GO:0030426 growth cone
5.70 7.50e-04 GO:0030427 site of polarized growth
5.70 5.95e-03 GO:0034707 chloride channel complex
5.50 5.36e-05 GO:0008076 voltage-gated potassium channel complex
5.50 5.36e-05 GO:0034705 potassium channel complex
5.31 1.44e-08 GO:0045211 postsynaptic membrane
5.07 6.13e-07 GO:0034703 cation channel complex
4.95 3.07e-03 GO:0033267 axon part
4.93 1.24e-10 GO:0034702 ion channel complex
4.28 2.53e-06 GO:0030424 axon
4.18 1.77e-06 GO:0030425 dendrite
3.97 6.80e-13 GO:0045202 synapse
3.92 5.49e-09 GO:0044456 synapse part
3.80 3.69e-02 GO:0019717 synaptosome
3.77 5.26e-03 GO:0031225 anchored to membrane
3.48 3.18e-09 GO:0043005 neuron projection
3.22 5.32e-07 GO:0031012 extracellular matrix
3.22 1.01e-02 GO:0043025 neuronal cell body
3.13 1.43e-02 GO:0044297 cell body

Gene overrepresentation in function category:

Showing 1 to 20 of 33 entries
Enrichment   P-value GO Accession GO Term
25.64 3.34e-02 GO:0004157 dihydropyrimidinase activity
22.79 3.56e-03 GO:0008503 benzodiazepine receptor activity
12.60 2.26e-04 GO:0004890 GABA-A receptor activity
12.43 3.93e-05 GO:0016917 GABA receptor activity
9.50 4.52e-02 GO:0005234 extracellular-glutamate-gated ion channel activity
8.55 4.22e-03 GO:0008066 glutamate receptor activity
7.60 3.68e-02 GO:0019905 syntaxin binding
6.17 5.06e-05 GO:0005230 extracellular ligand-gated ion channel activity
5.97 6.54e-04 GO:0004714 transmembrane receptor protein tyrosine kinase activity
5.70 3.61e-08 GO:0005267 potassium channel activity
5.30 5.63e-08 GO:0022843 voltage-gated cation channel activity
5.23 5.51e-05 GO:0005249 voltage-gated potassium channel activity
5.13 1.19e-03 GO:0005201 extracellular matrix structural constituent
4.92 8.54e-06 GO:0015276 ligand-gated ion channel activity
4.92 8.54e-06 GO:0022834 ligand-gated channel activity
4.66 6.34e-14 GO:0022836 gated channel activity
4.64 8.00e-03 GO:0019199 transmembrane receptor protein kinase activity
4.39 4.41e-07 GO:0005244 voltage-gated ion channel activity
4.39 4.41e-07 GO:0022832 voltage-gated channel activity
4.28 7.00e-10 GO:0005261 cation channel activity