Motif ID: GUAACAG

Z-value: 1.149


Mature miRNA associated with seed GUAACAG:

NamemiRBase Accession
hsa-miR-194 MIMAT0000460



Activity profile for motif GUAACAG.

activity profile for motif GUAACAG


Sorted Z-values histogram for motif GUAACAG

Sorted Z-values for motif GUAACAG



Network of associatons between targets according to the STRING database.



First level regulatory network of GUAACAG

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_-_36105005 3.223 NM_000458
NM_001165923
HNF1B

HNF1 homeobox B

chr6_+_133562488 3.137 NM_004100
NM_172103
NM_172105
EYA4


eyes absent homolog 4 (Drosophila)


chr11_+_12695851 3.094 NM_021961
TEAD1
TEA domain family member 1 (SV40 transcriptional enhancer factor)
chr3_-_126076057 2.870 NM_014079
KLF15
Kruppel-like factor 15
chr8_+_55370494 2.641 NM_022454
SOX17
SRY (sex determining region Y)-box 17
chr15_+_96875793 2.512 NM_001145156
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr15_+_96873845 2.496 NM_021005
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr15_+_96869156 2.326 NM_001145155
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr1_-_178840079 2.260 NM_004673
ANGPTL1
angiopoietin-like 1
chr11_-_17410205 2.235 NM_000525
KCNJ11
potassium inwardly-rectifying channel, subfamily J, member 11
chr11_-_17410863 2.217 NM_001166290
KCNJ11
potassium inwardly-rectifying channel, subfamily J, member 11
chr1_+_82266081 2.216 NM_012302
LPHN2
latrophilin 2
chr14_-_38064440 2.200 NM_004496
FOXA1
forkhead box A1
chr11_-_16424391 2.087 NM_001145819
NM_017508
SOX6

SRY (sex determining region Y)-box 6

chr15_+_96876568 1.999 NM_001145157
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr11_-_16497917 1.924 NM_033326
SOX6
SRY (sex determining region Y)-box 6
chr19_-_46272496 1.896 NM_175875
SIX5
SIX homeobox 5
chr16_-_73092533 1.859 NM_001164766
ZFHX3
zinc finger homeobox 3
chr11_-_16430425 1.828 NM_001145811
SOX6
SRY (sex determining region Y)-box 6
chr1_-_225840660 1.819 NM_001008493
NM_018212
ENAH

enabled homolog (Drosophila)

chrX_+_70443055 1.813 NM_000166
GJB1
gap junction protein, beta 1, 32kDa
chrX_-_71933709 1.807 NM_001122670
NM_001172436
NM_002637
PHKA1


phosphorylase kinase, alpha 1 (muscle)


chr11_+_69924407 1.772 NM_018043
ANO1
anoctamin 1, calcium activated chloride channel
chr20_-_43977023 1.765 NM_002999
SDC4
syndecan 4
chr4_-_23891608 1.740 NM_013261
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr14_+_85996454 1.717 NM_013231
FLRT2
fibronectin leucine rich transmembrane protein 2
chrX_+_49687212 1.690 NM_001127898
NM_001127899
CLCN5

chloride channel 5

chr13_-_107187312 1.652 NM_004093
EFNB2
ephrin-B2
chr2_-_208634051 1.611 NM_003468
FZD5
frizzled family receptor 5
chrX_+_38420690 1.607 NM_004615
TSPAN7
tetraspanin 7
chr1_-_214724974 1.529 NM_005401
PTPN14
protein tyrosine phosphatase, non-receptor type 14
chr9_+_72658496 1.488 NM_153267
MAMDC2
MAM domain containing 2
chr1_-_156051788 1.473 NM_001093725
MEX3A
mex-3 homolog A (C. elegans)
chr3_+_38495778 1.446 NM_001106
ACVR2B
activin A receptor, type IIB
chr12_+_27677044 1.431 NM_001198915
NM_001198916
NM_003622
NM_177444
PPFIBP1



PTPRF interacting protein, binding protein 1 (liprin beta 1)



chr2_+_85198176 1.411 NM_020122
KCMF1
potassium channel modulatory factor 1
chr9_-_4300028 1.386 NM_001042413
GLIS3
GLIS family zinc finger 3
chr2_-_190445521 1.385 NM_014585
SLC40A1
solute carrier family 40 (iron-regulated transporter), member 1
chr3_-_149688638 1.381 NM_002628
NM_053024
PFN2

profilin 2

chr8_+_77593506 1.370 NM_024721
ZFHX4
zinc finger homeobox 4
chr3_+_69915374 1.353 NM_198177
MITF
microphthalmia-associated transcription factor
chr8_+_102504661 1.332 NM_024915
GRHL2
grainyhead-like 2 (Drosophila)
chr3_+_69788562 1.327 NM_198159
MITF
microphthalmia-associated transcription factor
chr9_-_8733893 1.311 NM_001040712
NM_001171025
NM_130391
NM_130392
NM_130393
PTPRD




protein tyrosine phosphatase, receptor type, D




chr15_-_56035176 1.280 NM_173814
PRTG
protogenin
chr6_+_19837599 1.255 NM_001546
ID4
inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
chr16_-_73082169 1.250 NM_006885
ZFHX3
zinc finger homeobox 3
chr16_-_58768132 1.230 NM_002080
GOT2
glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2)
chr1_-_93646245 1.216 NM_001167830
NM_016040
TMED5

transmembrane emp24 protein transport domain containing 5

chr12_-_76425375 1.214 NM_007350
PHLDA1
pleckstrin homology-like domain, family A, member 1
chrX_+_49832214 1.177 NM_000084
CLCN5
chloride channel 5
chr2_-_213403280 1.155 NM_001042599
NM_005235
ERBB4

v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)

chr5_-_139726173 1.139 NM_001945
HBEGF
heparin-binding EGF-like growth factor
chr16_-_51185150 1.130 NM_002968
SALL1
sal-like 1 (Drosophila)
chrX_+_38660653 1.097 NM_001098790
NM_001098791
MID1IP1

MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish))

chr7_-_100493481 1.092 NM_000665
NM_015831
ACHE

acetylcholinesterase

chr8_+_42752019 1.056 NM_032410
HOOK3
hook homolog 3 (Drosophila)
chr16_-_51184507 1.051 NM_001127892
SALL1
sal-like 1 (Drosophila)
chr18_+_55102777 1.042 NM_004852
ONECUT2
one cut homeobox 2
chr4_+_95679075 1.038 NM_001203
BMPR1B
bone morphogenetic protein receptor, type IB
chr3_+_69812620 1.026 NM_001184967
MITF
microphthalmia-associated transcription factor
chr3_+_39851028 1.024 NM_015460
MYRIP
myosin VIIA and Rab interacting protein
chr14_+_55034329 1.015 NM_001161576
NM_015589
SAMD4A

sterile alpha motif domain containing 4A

chr5_-_58571916 1.014 NM_001197220
PDE4D
phosphodiesterase 4D, cAMP-specific
chr3_-_113465101 1.011 NM_025146
NAA50
N(alpha)-acetyltransferase 50, NatE catalytic subunit
chr1_-_52456292 1.009 NM_002867
RAB3B
RAB3B, member RAS oncogene family
chr4_+_119809978 0.992 NM_001128933
NM_001128934
NM_133477
SYNPO2


synaptopodin 2


chr9_-_4152182 0.980 NM_152629
GLIS3
GLIS family zinc finger 3
chr9_-_10612722 0.966 NM_002839
PTPRD
protein tyrosine phosphatase, receptor type, D
chr1_-_153958688 0.958 NM_002870
RAB13
RAB13, member RAS oncogene family
chr14_+_39734475 0.952 NM_203354
CTAGE5
CTAGE family, member 5
chr3_+_69812961 0.950 NM_006722
MITF
microphthalmia-associated transcription factor
chr5_-_115910406 0.944 NM_020796
SEMA6A
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
chr11_-_64901995 0.942 NM_032431
NM_172230
SYVN1

synovial apoptosis inhibitor 1, synoviolin

chr1_+_184356128 0.938 NM_030806
C1orf21
chromosome 1 open reading frame 21
chr8_+_15397595 0.931 NM_006765
NM_178234
TUSC3

tumor suppressor candidate 3

chr12_+_72666462 0.925 NM_013381
TRHDE
thyrotropin-releasing hormone degrading enzyme
chr4_+_87856152 0.923 NM_001166693
AFF1
AF4/FMR2 family, member 1
chr5_-_59064437 0.922 NM_001197218
PDE4D
phosphodiesterase 4D, cAMP-specific
chr19_-_40791291 0.920 NM_001243027
NM_001243028
NM_001626
AKT2


v-akt murine thymoma viral oncogene homolog 2


chr18_+_6834431 0.896 NM_001010000
ARHGAP28
Rho GTPase activating protein 28
chr4_+_41614911 0.891 NM_001112719
NM_001112720
LIMCH1

LIM and calponin homology domains 1

chr13_-_41240607 0.889 NM_002015
FOXO1
forkhead box O1
chr4_+_41362750 0.887 NM_001112717
NM_001112718
NM_014988
LIMCH1


LIM and calponin homology domains 1


chr5_-_37835928 0.877 NM_001190468
NM_001190469
GDNF

glial cell derived neurotrophic factor

chr11_-_70935807 0.855 NM_012309
SHANK2
SH3 and multiple ankyrin repeat domains 2
chrX_-_31526414 0.851 NM_004014
DMD
dystrophin
chr15_-_37393364 0.825 NM_001220482
NM_002399
MEIS2

Meis homeobox 2

chr3_-_98620452 0.824 NM_080927
DCBLD2
discoidin, CUB and LCCL domain containing 2
chr5_-_58652671 0.817 NM_001197219
PDE4D
phosphodiesterase 4D, cAMP-specific
chr11_-_70507911 0.816 NM_133266
SHANK2
SH3 and multiple ankyrin repeat domains 2
chr5_-_59189620 0.798 NM_001104631
PDE4D
phosphodiesterase 4D, cAMP-specific
chr15_-_30114536 0.791 NM_003257
NM_175610
TJP1

tight junction protein 1 (zona occludens 1)

chrX_-_32173585 0.787 NM_004013
NM_004020
NM_004021
NM_004022
NM_004023
DMD




dystrophin




chrX_-_32430370 0.783 NM_004011
NM_004012
DMD

dystrophin

chr7_+_114055048 0.775 NM_001172766
NM_014491
NM_148898
NM_148900
FOXP2



forkhead box P2



chr4_-_83483099 0.775 NM_001080506
TMEM150C
transmembrane protein 150C
chr1_+_27248212 0.770 NM_006600
NUDC
nuclear distribution gene C homolog (A. nidulans)
chr3_+_36421944 0.759 NM_003149
STAC
SH3 and cysteine rich domain
chrX_-_31284946 0.752 NM_004015
NM_004016
NM_004017
NM_004018
NM_004019
DMD




dystrophin




chr12_-_88974094 0.751 NM_000899
NM_003994
KITLG

KIT ligand

chr10_+_124768401 0.748 NM_001609
ACADSB
acyl-CoA dehydrogenase, short/branched chain
chr5_-_37835592 0.737 NM_199231
GDNF
glial cell derived neurotrophic factor
chr11_-_86666211 0.732 NM_012193
FZD4
frizzled family receptor 4
chr5_-_37839781 0.728 NM_000514
GDNF
glial cell derived neurotrophic factor
chrX_+_70435048 0.725 NM_001097642
GJB1
gap junction protein, beta 1, 32kDa
chr1_+_52608045 0.719 NM_004799
NM_007323
NM_007324
ZFYVE9


zinc finger, FYVE domain containing 9


chr20_+_36661849 0.713 NM_021215
RPRD1B
regulation of nuclear pre-mRNA domain containing 1B
chr3_-_64211111 0.707 NM_198859
PRICKLE2
prickle homolog 2 (Drosophila)
chrX_-_33357725 0.699 NM_000109
DMD
dystrophin
chr4_+_1795004 0.697 NM_000142
NM_001163213
NM_022965
FGFR3


fibroblast growth factor receptor 3


chr3_+_180630054 0.690 NM_001013438
NM_001013439
NM_005087
FXR1


fragile X mental retardation, autosomal homolog 1


chr12_+_93771607 0.684 NM_019094
NM_199040
NUDT4

NUDT4P1
nudix (nucleoside diphosphate linked moiety X)-type motif 4

nudix (nucleoside diphosphate linked moiety X)-type motif 4 pseudogene 1
chr5_-_58334936 0.677 NM_001197221
NM_001197222
PDE4D

phosphodiesterase 4D, cAMP-specific

chrX_+_152907892 0.672 NM_001395
DUSP9
dual specificity phosphatase 9
chr12_-_31743822 0.670 NM_144973
DENND5B
DENN/MADD domain containing 5B
chr17_+_38465422 0.670 NM_000964
RARA
retinoic acid receptor, alpha
chr6_+_107811272 0.667 NM_018013
SOBP
sine oculis binding protein homolog (Drosophila)
chr9_-_74979829 0.660 NM_001102420
NM_001102421
NM_006007
ZFAND5


zinc finger, AN1-type domain 5


chrX_-_33229428 0.657 NM_004006
DMD
dystrophin
chr17_+_38498270 0.656 NM_001024809
RARA
retinoic acid receptor, alpha
chr17_+_35294771 0.653 NM_005568
LHX1
LIM homeobox 1
chr21_-_16437125 0.645 NM_003489
NRIP1
nuclear receptor interacting protein 1
chr16_-_12009804 0.638 NM_001130006
NM_002094
GSPT1

G1 to S phase transition 1

chr7_-_94285477 0.623 NM_001099400
NM_001099401
NM_003919
SGCE


sarcoglycan, epsilon


chr5_-_141704575 0.622 NM_001127496
NM_030964
SPRY4

sprouty homolog 4 (Drosophila)

chr4_+_87928083 0.608 NM_005935
AFF1
AF4/FMR2 family, member 1
chr12_-_23737507 0.600 NM_178010
SOX5
SRY (sex determining region Y)-box 5
chr17_-_8534008 0.598 NM_005964
MYH10
myosin, heavy chain 10, non-muscle
chr3_-_122233781 0.594 NM_002264
KPNA1
karyopherin alpha 1 (importin alpha 5)
chr12_-_102872329 0.577 NM_001111284
IGF1
insulin-like growth factor 1 (somatomedin C)
chr5_+_177019196 0.575 NM_017510
TMED9
transmembrane emp24 protein transport domain containing 9
chr3_+_69985750 0.562 NM_000248
NM_001184968
NM_198158
NM_198178
MITF



microphthalmia-associated transcription factor



chrX_-_33146543 0.560 NM_004010
NM_004009
DMD

dystrophin

chr2_-_174828775 0.550 NM_001017371
SP3
Sp3 transcription factor
chr5_-_41510627 0.548 NM_001005473
PLCXD3
phosphatidylinositol-specific phospholipase C, X domain containing 3
chr6_+_43445255 0.523 NM_001146016
NM_001146018
NM_001146019
NM_001146020
NM_080604
TJAP1




tight junction associated protein 1 (peripheral)




chr11_+_22689653 0.521 NM_177553
GAS2
growth arrest-specific 2
chr10_-_13390189 0.520 NM_001195602
NM_001195604
NM_012247
SEPHS1


selenophosphate synthetase 1


chr9_+_35161950 0.516 NM_006377
UNC13B
unc-13 homolog B (C. elegans)
chr2_-_158732341 0.507 NM_001111067
ACVR1
activin A receptor, type I
chr3_+_148709140 0.502 NM_001184720
NM_001184721
NM_004130
GYG1


glycogenin 1


chr14_-_100070442 0.501 NM_001144995
CCDC85C
coiled-coil domain containing 85C
chr12_-_24715349 0.499 NM_152989
SOX5
SRY (sex determining region Y)-box 5
chr15_-_37392358 0.492 NM_170674
NM_170675
NM_170676
NM_170677
MEIS2



Meis homeobox 2



chr2_-_158731622 0.486 NM_001105
ACVR1
activin A receptor, type I
chr12_+_65218351 0.484 NM_015279
TBC1D30
TBC1 domain family, member 30
chr10_-_33623771 0.482 NM_001024628
NM_001024629
NM_001244972
NM_001244973
NM_003873
NRP1




neuropilin 1




chr5_-_59783885 0.480 NM_001165899
PDE4D
phosphodiesterase 4D, cAMP-specific
chr4_-_74904329 0.479 NM_002090
CXCL3
chemokine (C-X-C motif) ligand 3
chr7_-_139876718 0.474 NM_030647
JHDM1D
jumonji C domain containing histone demethylase 1 homolog D (S. cerevisiae)
chr10_+_31608097 0.470 NM_001174093
NM_001174095
NM_001174096
NM_030751
ZEB1



zinc finger E-box binding homeobox 1



chrX_-_135338640 0.466 NM_001173516
MAP7D3
MAP7 domain containing 3
chr8_-_33370552 0.458 NM_025115
NM_001102401
TTI2

TELO2 interacting protein 2

chr13_-_45992474 0.455 NM_001010875
SLC25A30
solute carrier family 25, member 30
chr4_+_184020343 0.449 NM_024949
WWC2
WW and C2 domain containing 2
chr3_+_147127151 0.440 NM_003412
ZIC1
Zic family member 1
chr12_+_107349539 0.435 NM_152261
C12orf23
chromosome 12 open reading frame 23
chr1_+_112938799 0.432 NM_018704
CTTNBP2NL
CTTNBP2 N-terminal like
chr6_-_83903632 0.413 NM_001199917
PGM3
phosphoglucomutase 3
chr8_-_38326351 0.413 NM_001174063
NM_001174064
NM_015850
NM_023105
NM_023106
NM_023110
FGFR1





fibroblast growth factor receptor 1





chr5_-_76934508 0.412 NM_032109
OTP
orthopedia homeobox
chr3_+_197476423 0.410 NM_001011537
FYTTD1
forty-two-three domain containing 1
chr16_+_47495166 0.408 NM_000293
NM_001031835
PHKB

phosphorylase kinase, beta

chr16_-_12010518 0.396 NM_001130007
GSPT1
G1 to S phase transition 1
chr17_-_33390676 0.394 NM_001017368
RFFL
ring finger and FYVE-like domain containing 1
chr11_+_22696318 0.393 NM_005256
GAS2
growth arrest-specific 2
chr12_-_54020081 0.392 NM_001130060
NM_001206682
NM_006856
ATF7


activating transcription factor 7


chr22_+_41253055 0.387 NM_001204827
NM_022098
XPNPEP3

X-prolyl aminopeptidase (aminopeptidase P) 3, putative

chr11_+_107461807 0.385 NM_001130037
NM_018712
ELMOD1

ELMO/CED-12 domain containing 1

chr3_+_197476623 0.383 NM_032288
FYTTD1
forty-two-three domain containing 1
chr11_-_115375065 0.381 NM_001098517
NM_014333
CADM1

cell adhesion molecule 1

chr17_-_1359410 0.381 NM_005206
NM_016823
CRK

v-crk sarcoma virus CT10 oncogene homolog (avian)

chr17_+_38474472 0.380 NM_001145301
NM_001145302
RARA

retinoic acid receptor, alpha

chr10_+_114709963 0.379 NM_001146274
NM_001146283
NM_001146284
NM_001146285
NM_001146286
NM_001198525
NM_001198526
NM_001198527
NM_001198528
NM_001198529
NM_001198530
NM_001198531
NM_030756
TCF7L2












transcription factor 7-like 2 (T-cell specific, HMG-box)












chr3_+_32280154 0.372 NM_178868
CMTM8
CKLF-like MARVEL transmembrane domain containing 8
chr20_-_25604583 0.366 NM_152667
NANP
N-acetylneuraminic acid phosphatase
chr19_+_41903693 0.365 NM_000709
NM_001164783
BCKDHA

branched chain keto acid dehydrogenase E1, alpha polypeptide

chr8_-_97172943 0.364 NM_001001557
GDF6
growth differentiation factor 6
chr8_-_38325241 0.363 NM_001174065
NM_001174066
NM_001174067
FGFR1


fibroblast growth factor receptor 1


chr5_-_88119604 0.361 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr8_+_58906968 0.361 NM_147189
FAM110B
family with sequence similarity 110, member B
chr17_+_66508098 0.349 NM_212471
PRKAR1A
protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)
chr14_+_77564570 0.342 NM_033426
KIAA1737
KIAA1737
chr20_-_524335 0.342 NM_001895
NM_177559
NM_177560
CSNK2A1


casein kinase 2, alpha 1 polypeptide


chr3_-_196242190 0.341 NM_001077657
C3orf43
chromosome 3 open reading frame 43
chr12_+_123868608 0.334 NM_020382
SETD8
SET domain containing (lysine methyltransferase) 8
chr20_-_60640842 0.327 NM_003185
TAF4
TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa
chr7_+_138916230 0.325 NM_173569
UBN2
ubinuclein 2
chr16_+_69599868 0.322 NM_001113178
NM_006599
NM_138713
NM_138714
NM_173214
NM_173215
NFAT5





nuclear factor of activated T-cells 5, tonicity-responsive





chr10_+_31610063 0.321 NM_001128128
NM_001174094
ZEB1

zinc finger E-box binding homeobox 1

chrX_+_119737743 0.320 NM_014060
MCTS1
malignant T cell amplified sequence 1
chrX_+_38663072 0.318 NM_021242
MID1IP1
MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish))
chr7_-_152133071 0.317 NM_170606
MLL3
myeloid/lymphoid or mixed-lineage leukemia 3
chr3_-_118864881 0.313 NM_152538
IGSF11
immunoglobulin superfamily, member 11
chr11_+_22688156 0.312 NM_001143830
GAS2
growth arrest-specific 2
chr12_-_24102563 0.311 NM_006940
SOX5
SRY (sex determining region Y)-box 5
chr2_-_122406994 0.309 NM_001142273
NM_001142274
NM_001207051
NM_015282
CLASP1



cytoplasmic linker associated protein 1



chr11_-_59436488 0.304 NM_152716
PATL1
protein associated with topoisomerase II homolog 1 (yeast)
chr11_+_111473099 0.297 NM_015191
SIK2
salt-inducible kinase 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
3.58 8.10e-05 GO:0048513 organ development
14.88 1.86e-04 GO:0045165 cell fate commitment
2.50 1.99e-04 GO:0032502 developmental process
2.68 3.52e-04 GO:0048856 anatomical structure development
2.88 3.61e-04 GO:0048518 positive regulation of biological process
2.55 4.83e-04 GO:0007275 multicellular organismal development
2.91 1.14e-03 GO:0048522 positive regulation of cellular process
4.80 2.27e-03 GO:0031328 positive regulation of cellular biosynthetic process
4.72 2.70e-03 GO:0009891 positive regulation of biosynthetic process
2.62 3.40e-03 GO:0048731 system development
4.95 4.52e-03 GO:0010557 positive regulation of macromolecule biosynthetic process
301.57 5.06e-03 GO:0060677 ureteric bud elongation
5.38 5.94e-03 GO:0045893 positive regulation of transcription, DNA-dependent
8.17 9.98e-03 GO:0035295 tube development
4.13 1.05e-02 GO:0006357 regulation of transcription from RNA polymerase II promoter
5.02 1.09e-02 GO:0051254 positive regulation of RNA metabolic process
4.97 1.19e-02 GO:0010628 positive regulation of gene expression
1.74 1.28e-02 GO:0050794 regulation of cellular process
2.66 1.59e-02 GO:2000112 regulation of cellular macromolecule biosynthetic process
2.53 1.83e-02 GO:0031326 regulation of cellular biosynthetic process
2.51 2.15e-02 GO:0009889 regulation of biosynthetic process
2.59 2.30e-02 GO:0010556 regulation of macromolecule biosynthetic process
5.03 2.91e-02 GO:0009887 organ morphogenesis
4.43 3.17e-02 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
5.62 3.61e-02 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
5.62 3.61e-02 GO:0072358 cardiovascular system development
5.62 3.61e-02 GO:0072359 circulatory system development
3.17 3.67e-02 GO:0009653 anatomical structure morphogenesis
4.30 4.08e-02 GO:0051173 positive regulation of nitrogen compound metabolic process
2.17 4.42e-02 GO:0031323 regulation of cellular metabolic process
2.67 4.52e-02 GO:0048523 negative regulation of cellular process
2.22 4.96e-02 GO:0060255 regulation of macromolecule metabolic process
10.56 4.97e-02 GO:0060562 epithelial tube morphogenesis
6.34 4.99e-02 GO:0007420 brain development

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
5.46 2.07e-02 GO:0045202 synapse
1.90 4.23e-02 GO:0005886 plasma membrane
2.38 4.82e-02 GO:0044459 plasma membrane part

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
4.56 1.15e-04 GO:0001071 nucleic acid binding transcription factor activity
4.56 1.15e-04 GO:0003700 sequence-specific DNA binding transcription factor activity
4.14 8.79e-04 GO:0030528 transcription regulator activity
16.23 1.26e-03 GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
6.87 6.03e-03 GO:0016563 transcription activator activity
14.38 1.58e-02 GO:0003705 sequence-specific enhancer binding RNA polymerase II transcription factor activity
86.18 2.11e-02 GO:0000982 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity
86.18 2.11e-02 GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
1.31 2.59e-02 GO:0005488 binding
12.08 3.09e-02 GO:0005057 receptor signaling protein activity
7.79 4.11e-02 GO:0010843 promoter binding
7.48 4.94e-02 GO:0000975 regulatory region DNA binding
7.48 4.94e-02 GO:0001067 regulatory region nucleic acid binding
7.48 4.94e-02 GO:0044212 transcription regulatory region DNA binding