Motif ID: GUAGUGU

Z-value: 1.780


Mature miRNA associated with seed GUAGUGU:

NamemiRBase Accession
hsa-miR-142-3p MIMAT0000434



Activity profile for motif GUAGUGU.

activity profile for motif GUAGUGU


Sorted Z-values histogram for motif GUAGUGU

Sorted Z-values for motif GUAGUGU



Network of associatons between targets according to the STRING database.



First level regulatory network of GUAGUGU

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_-_101631965 7.125 NM_180991
 SLCO4C1
solute carrier organic anion transporter family, member 4C1
chr7_+_50344255 6.474 NM_001220765
NM_001220766
NM_001220767
NM_001220768
NM_001220769
NM_001220770
NM_001220771
NM_001220772
NM_001220773
NM_001220774
NM_001220775
NM_001220776
NM_006060
 IKZF1












IKAROS family zinc finger 1 (Ikaros)












chrX_+_49832214 5.509 NM_000084
 CLCN5
chloride channel 5
chr4_-_40631846 5.334 NM_001098634
 RBM47
RNA binding motif protein 47
chr6_-_91006580 5.275 NM_001170794
 BACH2
BTB and CNC homology 1, basic leucine zipper transcription factor 2
chr6_-_91006460 5.246 NM_021813
 BACH2
BTB and CNC homology 1, basic leucine zipper transcription factor 2
chr21_-_44846927 4.679 NM_173354
 SIK1
salt-inducible kinase 1
chr5_+_49962771 4.672 NM_001178056
NM_024615
 PARP8

poly (ADP-ribose) polymerase family, member 8

chr20_+_57766074 4.606 NM_178457
 ZNF831
zinc finger protein 831
chr21_+_30671736 4.595 NM_206866
 BACH1
BTB and CNC homology 1, basic leucine zipper transcription factor 1
chr2_-_145277879 4.436 NM_001171653
NM_014795
 ZEB2

zinc finger E-box binding homeobox 2

chr14_-_35344852 4.339 NM_013448
NM_182648
 BAZ1A

bromodomain adjacent to zinc finger domain, 1A

chrX_+_9432980 4.334 NM_005647
 TBL1X
transducin (beta)-like 1X-linked
chr20_-_52199635 4.289 NM_006526
 ZNF217
zinc finger protein 217
chr1_-_92951593 4.236 NM_001127216
 GFI1
growth factor independent 1 transcription repressor
chr1_-_92952429 4.164 NM_005263
 GFI1
growth factor independent 1 transcription repressor
chr12_+_57916607 4.096 NM_052897
 MBD6
methyl-CpG binding domain protein 6
chr5_-_39074494 3.908 NM_152756
 RICTOR
RPTOR independent companion of MTOR, complex 2
chr1_-_29450406 3.768 NM_001003682
 TMEM200B
transmembrane protein 200B
chrX_+_49687212 3.756 NM_001127898
NM_001127899
 CLCN5

chloride channel 5


Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 50 entries
Enrichment   P-value GO Accession GO Term
33.36 4.27e-03 GO:0043401 steroid hormone mediated signaling pathway
19.55 4.40e-03 GO:0009755 hormone-mediated signaling pathway
13.17 5.20e-03 GO:0034339 regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor
6.68 2.35e-02 GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter
6.16 1.40e-02 GO:0032582 negative regulation of gene-specific transcription
4.82 1.12e-03 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
4.47 1.40e-02 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
4.39 2.81e-04 GO:0045892 negative regulation of transcription, DNA-dependent
4.30 3.74e-04 GO:0051253 negative regulation of RNA metabolic process
4.14 2.96e-04 GO:0010629 negative regulation of gene expression
4.09 1.58e-02 GO:0032583 regulation of gene-specific transcription
3.85 1.72e-03 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
3.80 2.04e-03 GO:0051172 negative regulation of nitrogen compound metabolic process
3.78 2.24e-03 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
3.61 4.09e-03 GO:0010558 negative regulation of macromolecule biosynthetic process
3.57 9.24e-03 GO:0045893 positive regulation of transcription, DNA-dependent
3.54 1.42e-03 GO:0010557 positive regulation of macromolecule biosynthetic process
3.53 5.45e-03 GO:0051254 positive regulation of RNA metabolic process
3.50 6.21e-03 GO:0010628 positive regulation of gene expression
3.47 7.06e-03 GO:0031327 negative regulation of cellular biosynthetic process

Gene overrepresentation in compartment category:

Showing 1 to 13 of 13 entries
Enrichment   P-value GO Accession GO Term
125.10 9.38e-03 GO:0005642 annulate lamellae
8.26 1.32e-02 GO:0016585 chromatin remodeling complex
2.96 1.52e-02 GO:0044451 nucleoplasm part
2.25 4.20e-02 GO:0005654 nucleoplasm
1.72 1.09e-05 GO:0005634 nucleus
1.43 1.20e-04 GO:0043231 intracellular membrane-bounded organelle
1.43 1.28e-04 GO:0043227 membrane-bounded organelle
1.35 6.66e-04 GO:0043229 intracellular organelle
1.35 7.37e-04 GO:0043226 organelle
1.31 1.15e-05 GO:0005622 intracellular
1.29 3.83e-04 GO:0044424 intracellular part
1.13 4.40e-03 GO:0044464 cell part
1.13 4.43e-03 GO:0005623 cell

Gene overrepresentation in function category:

Showing 1 to 19 of 19 entries
Enrichment   P-value GO Accession GO Term
37.53 9.37e-03 GO:0046965 retinoid X receptor binding
31.28 1.70e-02 GO:0042974 retinoic acid receptor binding
14.72 5.08e-04 GO:0003707 steroid hormone receptor activity
13.91 7.15e-04 GO:0004879 ligand-dependent nuclear receptor activity
5.81 4.22e-03 GO:0010843 promoter binding
5.69 8.04e-05 GO:0008134 transcription factor binding
5.58 5.80e-03 GO:0000975 regulatory region DNA binding
5.58 5.80e-03 GO:0001067 regulatory region nucleic acid binding
5.58 5.80e-03 GO:0044212 transcription regulatory region DNA binding
3.70 1.39e-04 GO:0043565 sequence-specific DNA binding
3.16 7.80e-05 GO:0030528 transcription regulator activity
2.84 2.39e-03 GO:0001071 nucleic acid binding transcription factor activity
2.84 2.39e-03 GO:0003700 sequence-specific DNA binding transcription factor activity
2.25 1.02e-04 GO:0003677 DNA binding
2.16 2.29e-03 GO:0008270 zinc ion binding
1.99 8.92e-05 GO:0003676 nucleic acid binding
1.90 2.99e-02 GO:0046914 transition metal ion binding
1.40 1.97e-02 GO:0005515 protein binding
1.23 5.96e-03 GO:0005488 binding