Motif ID: GUGCAAA

Z-value: 1.139


Mature miRNA associated with seed GUGCAAA:

NamemiRBase Accession
hsa-miR-19a MIMAT0000073
hsa-miR-19b MIMAT0000074



Activity profile for motif GUGCAAA.

activity profile for motif GUGCAAA


Sorted Z-values histogram for motif GUGCAAA

Sorted Z-values for motif GUGCAAA



Network of associatons between targets according to the STRING database.



First level regulatory network of GUGCAAA

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_-_152147520 4.217 NM_001009555
NM_001128923
SH3D19

SH3 domain containing 19

chr4_-_152096655 4.192 NM_001128924
SH3D19
SH3 domain containing 19
chr13_-_107187312 3.873 NM_004093
EFNB2
ephrin-B2
chr2_-_1748285 3.861 NM_012293
PXDN
peroxidasin homolog (Drosophila)
chr11_+_43963809 3.724 NM_001145033
C11orf96
chromosome 11 open reading frame 96
chr10_-_30348433 3.678 NM_020848
KIAA1462
KIAA1462
chr1_+_82266081 3.667 NM_012302
LPHN2
latrophilin 2
chr8_+_40010986 3.519 NM_020130
C8orf4
chromosome 8 open reading frame 4
chr9_-_14398981 3.463 NM_001190738
NFIB
nuclear factor I/B
chr7_+_128470462 3.441 NM_001127487
NM_001458
FLNC

filamin C, gamma

chr13_-_78549663 3.403 NM_000115
EDNRB
endothelin receptor type B
chr2_+_121103670 3.342 NM_002193
INHBB
inhibin, beta B
chr11_+_69924407 3.326 NM_018043
ANO1
anoctamin 1, calcium activated chloride channel
chr6_+_168841829 3.315 NM_001166412
NM_022138
SMOC2

SPARC related modular calcium binding 2

chr15_+_99645152 3.267 NM_015286
NM_145728
SYNM

synemin, intermediate filament protein

chr4_+_41614911 3.235 NM_001112719
NM_001112720
LIMCH1

LIM and calponin homology domains 1

chr4_+_41362750 3.226 NM_001112717
NM_001112718
NM_014988
LIMCH1


LIM and calponin homology domains 1


chr10_+_115803805 3.195 NM_000684
ADRB1
adrenergic, beta-1-, receptor
chr6_+_121756744 3.181 NM_000165
GJA1
gap junction protein, alpha 1, 43kDa
chr9_-_14314036 3.043 NM_001190737
NM_005596
NFIB

nuclear factor I/B

chr1_+_57110745 2.978 NM_006252
PRKAA2
protein kinase, AMP-activated, alpha 2 catalytic subunit
chr10_+_112404104 2.935 NM_001134363
RBM20
RNA binding motif protein 20
chr11_+_69455837 2.898 NM_053056
CCND1
cyclin D1
chr3_-_169381417 2.882 NM_001205194
NM_004991
MECOM

MDS1 and EVI1 complex locus

chr6_-_132272311 2.871 NM_001901
CTGF
connective tissue growth factor
chr1_-_95007139 2.851 NM_001178096
NM_001993
F3

coagulation factor III (thromboplastin, tissue factor)

chr3_+_61547179 2.829 NM_002841
PTPRG
protein tyrosine phosphatase, receptor type, G
chr7_+_134576150 2.818 NM_033139
NM_033140
CALD1

caldesmon 1

chr1_-_214724974 2.770 NM_005401
PTPN14
protein tyrosine phosphatase, non-receptor type 14
chr3_-_168864066 2.752 NM_001105077
NM_001163999
NM_005241
MECOM


MDS1 and EVI1 complex locus


chr13_-_78493902 2.737 NM_001201397
EDNRB
endothelin receptor type B
chr8_-_12990731 2.617 NM_006094
DLC1
deleted in liver cancer 1
chr3_+_153839136 2.583 NM_001251963
NM_015595
ARHGEF26

Rho guanine nucleotide exchange factor (GEF) 26

chr22_-_36424397 2.575 NM_001082578
NM_001082579
RBFOX2

RNA binding protein, fox-1 homolog (C. elegans) 2

chr18_-_30050394 2.466 NM_001242409
NM_022751
FAM59A

family with sequence similarity 59, member A

chr6_+_1390068 2.391 NM_001452
FOXF2
forkhead box F2
chr1_-_201438150 2.390 NM_012396
PHLDA3
pleckstrin homology-like domain, family A, member 3
chr15_+_84322809 2.371 NM_207517
ADAMTSL3
ADAMTS-like 3
chr8_-_12973752 2.363 NM_001164271
DLC1
deleted in liver cancer 1
chr1_-_46598250 2.357 NM_003629
NM_001114172
PIK3R3

phosphoinositide-3-kinase, regulatory subunit 3 (gamma)

chr11_+_8060179 2.347 NM_003320
TUB
tubby homolog (mouse)
chrX_-_34675366 2.327 NM_031442
TMEM47
transmembrane protein 47
chr3_-_98620452 2.316 NM_080927
DCBLD2
discoidin, CUB and LCCL domain containing 2
chr7_+_134464161 2.301 NM_004342
NM_033138
NM_033157
CALD1


caldesmon 1


chr3_-_168864325 2.292 NM_001105078
MECOM
MDS1 and EVI1 complex locus
chr3_-_184870727 2.278 NM_001025266
C3orf70
chromosome 3 open reading frame 70
chr3_+_29322802 2.256 NM_001003792
NM_001003793
NM_001177711
NM_001177712
NM_014483
RBMS3




RNA binding motif, single stranded interacting protein 3




chr22_-_36236421 2.246 NM_001031695
NM_001082576
NM_001082577
NM_014309
RBFOX2



RNA binding protein, fox-1 homolog (C. elegans) 2



chr12_+_2162388 2.236 NM_000719
NM_001129827
NM_001129829
NM_001129830
NM_001129831
NM_001129832
NM_001129833
NM_001129834
NM_001129835
NM_001129836
NM_001129837
NM_001129838
NM_001129839
NM_001129840
NM_001129841
NM_001129842
NM_001129843
NM_001129844
NM_001129846
NM_001167623
NM_001167624
NM_001167625
NM_199460
CACNA1C






















calcium channel, voltage-dependent, L type, alpha 1C subunit






















chr8_+_106331146 2.225 NM_012082
ZFPM2
zinc finger protein, multitype 2
chr2_+_189156395 2.221 NM_001252668
NM_001252669
NM_016315
GULP1


GULP, engulfment adaptor PTB domain containing 1


chr8_-_17658385 2.207 NM_001001924
NM_001001925
MTUS1

microtubule associated tumor suppressor 1

chr3_-_168865521 2.191 NM_001164000
MECOM
MDS1 and EVI1 complex locus
chr10_+_23983674 2.149 NM_001098500
KIAA1217
KIAA1217
chr1_-_117210301 2.123 NM_001007237
NM_001542
IGSF3

immunoglobulin superfamily, member 3

chr12_-_102872329 2.123 NM_001111284
IGF1
insulin-like growth factor 1 (somatomedin C)
chr8_-_81787015 2.087 NM_001033723
ZNF704
zinc finger protein 704
chrX_-_10588458 2.077 NM_000381
NM_033289
MID1

midline 1 (Opitz/BBB syndrome)

chrX_-_10544852 2.051 NM_001193277
MID1
midline 1 (Opitz/BBB syndrome)
chr11_+_27015627 2.037 NM_203371
FIBIN
fin bud initiation factor homolog (zebrafish)
chr10_+_24497719 2.035 NM_001098501
NM_019590
KIAA1217

KIAA1217

chr7_+_20370724 2.002 NM_002214
ITGB8
integrin, beta 8
chr14_+_55034329 1.984 NM_001161576
NM_015589
SAMD4A

sterile alpha motif domain containing 4A

chr2_+_102770401 1.973 NM_000877
IL1R1
interleukin 1 receptor, type I
chr14_-_89020888 1.967 NM_007039
PTPN21
protein tyrosine phosphatase, non-receptor type 21
chr1_-_27339326 1.949 NM_052943
FAM46B
family with sequence similarity 46, member B
chr9_-_140196702 1.924 NM_001004354
NRARP
NOTCH-regulated ankyrin repeat protein
chrX_+_152954965 1.910 NM_001142806
SLC6A8
solute carrier family 6 (neurotransmitter transporter, creatine), member 8
chr9_-_34589679 1.869 NM_001842
NM_147164
CNTFR

ciliary neurotrophic factor receptor

chrX_-_10645726 1.864 NM_001098624
MID1
midline 1 (Opitz/BBB syndrome)
chr3_-_64211111 1.844 NM_198859
PRICKLE2
prickle homolog 2 (Drosophila)
chr5_+_38445577 1.832 NM_182801
EGFLAM
EGF-like, fibronectin type III and laminin G domains
chr2_-_20424627 1.788 NM_002997
SDC1
syndecan 1
chr19_-_4559713 1.785 NM_032108
SEMA6B
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
chr8_-_124553448 1.780 NM_001242463
NM_058229
FBXO32

F-box protein 32

chr8_-_17555158 1.766 NM_020749
MTUS1
microtubule associated tumor suppressor 1
chr5_+_38403633 1.754 NM_182798
EGFLAM
EGF-like, fibronectin type III and laminin G domains
chr8_+_75736771 1.753 NM_015886
PI15
peptidase inhibitor 15
chr6_-_116381765 1.753 NM_002031
FRK
fyn-related kinase
chr1_-_94147201 1.745 NM_003567
BCAR3
breast cancer anti-estrogen resistance 3
chr12_-_102874373 1.737 NM_000618
NM_001111283
NM_001111285
IGF1


insulin-like growth factor 1 (somatomedin C)


chr8_-_17580024 1.724 NM_001166393
MTUS1
microtubule associated tumor suppressor 1
chr13_-_78492906 1.686 NM_001122659
NM_003991
EDNRB

endothelin receptor type B

chr8_-_17579729 1.680 NM_001001931
MTUS1
microtubule associated tumor suppressor 1
chr1_-_153958688 1.677 NM_002870
RAB13
RAB13, member RAS oncogene family
chrX_+_152953751 1.674 NM_001142805
NM_005629
SLC6A8

solute carrier family 6 (neurotransmitter transporter, creatine), member 8

chr16_+_3070310 1.664 NM_016639
TNFRSF12A
tumor necrosis factor receptor superfamily, member 12A
chr16_+_21169911 1.663 NM_020422
TMEM159
transmembrane protein 159
chr14_+_37667116 1.655 NM_001195296
NM_001195297
NM_138731
MIPOL1


mirror-image polydactyly 1


chr18_-_56296188 1.654 NM_052947
ALPK2
alpha-kinase 2
chr3_+_174577069 1.653 NM_207015
NAALADL2
N-acetylated alpha-linked acidic dipeptidase-like 2
chr6_+_118228688 1.653 NM_001029858
SLC35F1
solute carrier family 35, member F1
chr17_+_1959512 1.652 NM_001098202
HIC1
hypermethylated in cancer 1
chr4_+_38869346 1.645 NM_138389
FAM114A1
family with sequence similarity 114, member A1
chr7_-_27183225 1.644 NM_019102
HOXA5
homeobox A5
chr5_+_172068188 1.642 NM_001142651
NEURL1B
neuralized homolog 1B (Drosophila)
chr17_+_1958354 1.639 NM_006497
HIC1
hypermethylated in cancer 1
chr14_-_61190458 1.628 NM_017420
SIX4
SIX homeobox 4
chr5_+_38258510 1.623 NM_001205301
NM_152403
EGFLAM

EGF-like, fibronectin type III and laminin G domains

chr5_-_134369841 1.618 NM_002653
PITX1
paired-like homeodomain 1
chr5_+_71403040 1.614 NM_005909
MAP1B
microtubule-associated protein 1B
chr1_+_160085519 1.580 NM_000702
ATP1A2
ATPase, Na+/K+ transporting, alpha 2 polypeptide
chr1_+_42846427 1.569 NM_173642
RIMKLA
ribosomal modification protein rimK-like family member A
chr2_-_86564632 1.568 NM_001164731
NM_001164732
NM_022912
REEP1


receptor accessory protein 1


chr11_+_8102691 1.538 NM_177972
TUB
tubby homolog (mouse)
chr15_+_62939509 1.530 NM_015059
TLN2
talin 2
chr11_-_12030882 1.525 NM_013253
DKK3
dickkopf 3 homolog (Xenopus laevis)
chrX_-_114468604 1.516 NM_001243963
NM_020871
LRCH2

leucine-rich repeats and calponin homology (CH) domain containing 2

chr7_-_79082870 1.516 NM_012301
MAGI2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr20_-_56286540 1.493 NM_199171
PMEPA1
prostate transmembrane protein, androgen induced 1
chr12_+_12938540 1.478 NM_030817
APOLD1
apolipoprotein L domain containing 1
chr18_-_812268 1.462 NM_005433
YES1
v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1
chr2_+_177053306 1.458 NM_024501
HOXD1
homeobox D1
chr8_-_13372183 1.443 NM_024767
NM_182643
DLC1

deleted in liver cancer 1

chr6_-_167040700 1.431 NM_021135
RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr8_-_124544376 1.420 NM_148177
FBXO32
F-box protein 32
chr17_+_19140674 1.416 NM_001102664
NM_014964
NM_148921
EPN2


epsin 2


chr3_-_185826748 1.411 NM_004454
ETV5
ets variant 5
chr11_-_12030622 1.407 NM_015881
DKK3
dickkopf 3 homolog (Xenopus laevis)
chr11_-_118023534 1.401 NM_001142348
NM_174934
SCN4B

sodium channel, voltage-gated, type IV, beta

chr11_-_12030128 1.395 NM_001018057
DKK3
dickkopf 3 homolog (Xenopus laevis)
chr10_-_79686279 1.394 NM_004747
DLG5
discs, large homolog 5 (Drosophila)
chr3_-_87040246 1.393 NM_016206
VGLL3
vestigial like 3 (Drosophila)
chr13_-_38172862 1.383 NM_001135934
NM_001135935
NM_001135936
NM_006475
POSTN



periostin, osteoblast specific factor



chr22_+_40390935 1.383 NM_138435
FAM83F
family with sequence similarity 83, member F
chr2_-_20425166 1.382 NM_001006946
SDC1
syndecan 1
chr5_-_136834887 1.382 NM_004598
SPOCK1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
chrX_-_17879355 1.380 NM_001172732
NM_001172739
NM_001172743
NM_021785
RAI2



retinoic acid induced 2



chr11_-_46722115 1.369 NM_004308
ARHGAP1
Rho GTPase activating protein 1
chr5_-_1882764 1.355 NM_016358
IRX4
iroquois homeobox 4
chr7_-_14029641 1.353 NM_001163147
NM_004956
ETV1

ets variant 1

chr1_+_61542928 1.350 NM_001145511
NFIA
nuclear factor I/A
chr7_-_14030864 1.350 NM_001163149
ETV1
ets variant 1
chr17_+_53342320 1.349 NM_002126
HLF
hepatic leukemia factor
chr7_-_50800018 1.347 NM_001001549
NM_005311
GRB10

growth factor receptor-bound protein 10

chrX_+_105066531 1.345 NM_198465
NRK
Nik related kinase
chr7_-_50772997 1.342 NM_001001550
GRB10
growth factor receptor-bound protein 10
chr10_+_28966419 1.341 NM_012342
BAMBI
BMP and activin membrane-bound inhibitor homolog (Xenopus laevis)
chr6_-_167275657 1.340 NM_001006932
RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr1_+_44444848 1.338 NM_003780
B4GALT2
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
chr20_-_56284945 1.326 NM_020182
PMEPA1
prostate transmembrane protein, androgen induced 1
chr7_-_50861114 1.313 NM_001001555
GRB10
growth factor receptor-bound protein 10
chr20_-_56285576 1.297 NM_199169
NM_199170
PMEPA1

prostate transmembrane protein, androgen induced 1

chr8_-_93107442 1.291 NM_001198629
NM_001198630
NM_001198632
NM_175635
RUNX1T1



runt-related transcription factor 1; translocated to, 1 (cyclin D-related)



chr4_-_52904424 1.270 NM_000232
SGCB
sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
chrX_-_10851808 1.269 NM_033290
MID1
midline 1 (Opitz/BBB syndrome)
chr20_-_36793646 1.253 NM_004613
NM_198951
TGM2

transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)

chr14_+_55221505 1.251 NM_001161577
SAMD4A
sterile alpha motif domain containing 4A
chr12_+_12878718 1.248 NM_001130415
APOLD1
apolipoprotein L domain containing 1
chr3_+_187871473 1.226 NM_001167672
LPP
LIM domain containing preferred translocation partner in lipoma
chr10_+_6186758 1.221 NM_001145443
PFKFB3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
chr11_-_118016134 1.218 NM_001142349
SCN4B
sodium channel, voltage-gated, type IV, beta
chr2_+_173940505 1.211 NM_016653
NM_133646
ZAK

sterile alpha motif and leucine zipper containing kinase AZK

chr2_+_203241044 1.208 NM_001204
BMPR2
bone morphogenetic protein receptor, type II (serine/threonine kinase)
chr8_-_93107881 1.208 NM_001198625
NM_001198626
NM_001198627
NM_001198631
NM_001198634
NM_001198679
RUNX1T1





runt-related transcription factor 1; translocated to, 1 (cyclin D-related)





chr7_-_45960738 1.202 NM_000598
NM_001013398
IGFBP3

insulin-like growth factor binding protein 3

chr3_-_69062744 1.198 NM_173654
C3orf64
chromosome 3 open reading frame 64
chr7_+_29846112 1.198 NM_001080529
WIPF3
WAS/WASL interacting protein family, member 3
chr7_-_14031049 1.191 NM_001163148
ETV1
ets variant 1
chr4_-_120549115 1.179 NM_033437
PDE5A
phosphodiesterase 5A, cGMP-specific
chr2_-_86565205 1.168 NM_001164730
REEP1
receptor accessory protein 1
chr7_-_14025826 1.167 NM_001163150
NM_001163151
NM_001163152
ETV1


ets variant 1


chr3_+_187943192 1.161 NM_001167671
LPP
LIM domain containing preferred translocation partner in lipoma
chr8_+_70378858 1.158 NM_001128204
NM_015170
SULF1

sulfatase 1

chr20_+_36531498 1.144 NM_080607
VSTM2L
V-set and transmembrane domain containing 2 like
chr17_-_7387513 1.129 NM_020899
ZBTB4
zinc finger and BTB domain containing 4
chr9_-_16870719 1.128 NM_017637
BNC2
basonuclin 2
chr4_-_120548329 1.120 NM_033430
PDE5A
phosphodiesterase 5A, cGMP-specific
chr16_+_4382224 1.119 NM_032575
GLIS2
GLIS family zinc finger 2
chr8_+_70405027 1.119 NM_001128205
NM_001128206
SULF1

sulfatase 1

chr7_+_114055048 1.112 NM_001172766
NM_014491
NM_148898
NM_148900
FOXP2



forkhead box P2



chr18_-_22932109 1.112 NM_015461
ZNF521
zinc finger protein 521
chr4_+_75858205 1.108 NM_015393
PARM1
prostate androgen-regulated mucin-like protein 1
chr7_+_45614081 1.107 NM_021116
ADCY1
adenylate cyclase 1 (brain)
chr1_+_44445548 1.101 NM_030587
B4GALT2
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
chr1_+_183605207 1.085 NM_015149
RGL1
ral guanine nucleotide dissociation stimulator-like 1
chr5_-_158526698 1.077 NM_024007
EBF1
early B-cell factor 1
chr22_-_30642683 1.063 NM_002309
LIF
leukemia inhibitory factor (cholinergic differentiation factor)
chr7_-_11871735 1.061 NM_015204
THSD7A
thrombospondin, type I, domain containing 7A
chr1_+_44446176 1.054 NM_001005417
B4GALT2
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
chr2_+_46524448 1.054 NM_001430
EPAS1
endothelial PAS domain protein 1
chr1_-_227505796 1.052 NM_003607
NM_014826
CDC42BPA

CDC42 binding protein kinase alpha (DMPK-like)

chr3_+_42695175 1.051 NM_145166
ZBTB47
zinc finger and BTB domain containing 47
chr4_+_81952118 1.041 NM_001201
BMP3
bone morphogenetic protein 3
chr6_-_88854989 1.036 NM_033181
CNR1
cannabinoid receptor 1 (brain)
chr18_-_65183922 1.017 NM_032160
DSEL
dermatan sulfate epimerase-like
chr2_+_69240137 1.012 NM_018153
NM_032208
NM_053034
ANTXR1


anthrax toxin receptor 1


chr9_-_34590137 1.002 NM_001207011
CNTFR
ciliary neurotrophic factor receptor
chr7_-_27205148 0.996 NM_152739
HOXA9
homeobox A9
chr2_+_109745996 0.987 NM_001099289
SH3RF3
SH3 domain containing ring finger 3
chr8_-_93115453 0.976 NM_001198633
NM_175634
RUNX1T1

runt-related transcription factor 1; translocated to, 1 (cyclin D-related)

chr2_-_213403280 0.970 NM_001042599
NM_005235
ERBB4

v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)

chr15_+_39873276 0.967 NM_003246
THBS1
thrombospondin 1
chr2_+_101436491 0.959 NM_002518
NPAS2
neuronal PAS domain protein 2
chr8_+_104310660 0.958 NM_001164615
FZD6
frizzled family receptor 6
chr8_+_104311058 0.948 NM_001164616
NM_003506
FZD6

frizzled family receptor 6

chr2_-_128421965 0.943 NM_017980
LIMS2
LIM and senescent cell antigen-like domains 2
chr2_+_173686314 0.940 NM_001100397
RAPGEF4
Rap guanine nucleotide exchange factor (GEF) 4
chr8_-_93029864 0.925 NM_175636
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr1_+_201708940 0.922 NM_001167738
NAV1
neuron navigator 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
2.22 2.37e-07 GO:0032502 developmental process
2.10 6.22e-05 GO:0007275 multicellular organismal development
2.53 1.18e-04 GO:0030154 cell differentiation
2.46 2.31e-04 GO:0048869 cellular developmental process
1.60 2.37e-04 GO:0050794 regulation of cellular process
2.18 2.74e-04 GO:0048731 system development
1.54 5.83e-04 GO:0050789 regulation of biological process
2.06 7.08e-04 GO:0048856 anatomical structure development
1.47 4.93e-03 GO:0065007 biological regulation
29.33 6.80e-03 GO:0045445 myoblast differentiation
1.65 7.08e-03 GO:0032501 multicellular organismal process
8.33 1.65e-02 GO:0060541 respiratory system development
2.06 1.96e-02 GO:0048522 positive regulation of cellular process
2.07 2.49e-02 GO:0048519 negative regulation of biological process
2.13 2.64e-02 GO:0048523 negative regulation of cellular process
19.55 3.70e-02 GO:0048286 lung alveolus development
3.12 4.11e-02 GO:2000026 regulation of multicellular organismal development
2.37 4.53e-02 GO:0009653 anatomical structure morphogenesis

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
1.79 4.71e-04 GO:0005886 plasma membrane
1.76 7.33e-04 GO:0071944 cell periphery
2.01 1.05e-02 GO:0044459 plasma membrane part
3.27 1.08e-02 GO:0030054 cell junction
65.97 3.62e-02 GO:0016942 insulin-like growth factor binding protein complex

Nothing significant found in function category.