Motif ID: HAND1,2.p2

Z-value: 2.119


Transcription factors associated with HAND1,2.p2:

Gene SymbolEntrez IDGene Name
HAND1 9421 heart and neural crest derivatives expressed 1
HAND2 9464 heart and neural crest derivatives expressed 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HAND1hg19_v1_chr5_-_153857820_153857825-0.202.7e-01Click!
HAND2hg19_v1_chr4_-_174450343_1744504390.048.3e-01Click!


Activity profile for motif HAND1,2.p2.

activity profile for motif HAND1,2.p2


Sorted Z-values histogram for motif HAND1,2.p2

Sorted Z-values for motif HAND1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HAND1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr14_-_107179043 7.068 IGHA1
immunoglobulin heavy constant alpha 1
chr2_+_204732509 6.443 NM_001037631
NM_005214
CTLA4

cytotoxic T-lymphocyte-associated protein 4

chr10_+_102123420 5.981


chr6_+_134210264 5.459 TCF21
transcription factor 21
chr22_+_22723972 5.326


chr1_+_26644458 5.303 CD52
CD52 molecule
chr14_-_107078578 5.235


chr6_+_134210247 5.101 NM_198392
NM_003206
TCF21

transcription factor 21

chr22_+_23063107 4.924 IGLJ3
immunoglobulin lambda joining 3
chr22_+_23213671 4.708 IGLV4-3
immunoglobulin lambda variable 4-3
chr1_+_26644380 4.468 NM_001803
CD52
CD52 molecule
chr2_+_228678556 4.288 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr14_-_107170076 4.255 IGHV1-69
IGHG1
immunoglobulin heavy variable 1-69
immunoglobulin heavy constant gamma 1 (G1m marker)
chr14_-_106774311 3.795 IGHA1
immunoglobulin heavy constant alpha 1
chr12_+_49716970 3.730 NM_001100620
NM_005480
TROAP

trophinin associated protein (tastin)

chr7_+_76139744 3.720 NM_030570
NM_182684
UPK3B

uroplakin 3B

chr11_+_67171400 3.671 NM_198517
TBC1D10C
TBC1 domain family, member 10C
chr12_-_91505541 3.575 NM_002345
LUM
lumican
chr14_-_106208537 3.522


chr14_-_106321626 3.506


chrX_+_128913881 3.422 NM_018990
SASH3
SAM and SH3 domain containing 3
chr7_-_84751246 3.419 NM_152754
SEMA3D
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D
chr14_-_106791054 3.352 IGHV4-31
IGHV3-30
IGHA1
IGHD
IGHG1
IGHG2
IGHG3
IGHM
SCFV
immunoglobulin heavy variable 4-31
immunoglobulin heavy variable 3-30
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant delta
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 2 (G2m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
immunoglobulin heavy constant mu
single-chain Fv fragment
chr7_-_20256942 3.302 NM_182762
MACC1
metastasis associated in colon cancer 1
chr16_-_31146992 3.285 PRSS8
protease, serine, 8
chr20_-_1165116 3.258 NM_018354
TMEM74B
transmembrane protein 74B
chr12_+_49688908 3.220 NM_006262
PRPH
peripherin
chr11_+_60869929 3.160 NM_014207
CD5
CD5 molecule
chrX_+_128913897 3.146 SASH3
SAM and SH3 domain containing 3
chr16_+_57728711 3.107 NM_032269
CCDC135
coiled-coil domain containing 135
chr11_+_67171379 3.101 TBC1D10C
TBC1 domain family, member 10C
chr9_-_100700422 3.086 NM_197978
HEMGN
hemogen
chr17_-_39092714 3.084 KRT23
keratin 23 (histone deacetylase inducible)
chr5_+_34656482 3.045 RAI14
retinoic acid induced 14
chr14_-_106471439 3.026 IGHA1
IGHG1
IGHM
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant mu
chr7_-_81399286 2.984 NM_000601
NM_001010931
NM_001010932
NM_001010933
NM_001010934
HGF




hepatocyte growth factor (hepapoietin A; scatter factor)




chr19_-_7796977 2.905 NM_001244856
NM_198492
CLEC4G

C-type lectin domain family 4, member G

chr12_-_53600999 2.887 NM_000889
ITGB7
integrin, beta 7
chr14_-_106518424 2.887 IGH@
IGHA1
IGHG1
IGHG2
IGHM
immunoglobulin heavy locus
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 2 (G2m marker)
immunoglobulin heavy constant mu
chr19_-_17958773 2.884 JAK3
Janus kinase 3
chr1_+_28261503 2.880 NM_001009568
NM_014474
SMPDL3B

sphingomyelin phosphodiesterase, acid-like 3B

chr14_-_107013474 2.816 IGHA1
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr5_-_121814781 2.760


chr2_-_27718059 2.688 FNDC4
fibronectin type III domain containing 4
chr14_-_106746056 2.647


chr20_-_29978285 2.646 NM_153289
NM_153323
NM_173460
DEFB119


defensin, beta 119


chr19_+_45452427 2.627 APOC2
apolipoprotein C-II
chr8_-_86290333 2.627 NM_001128829
NM_001128830
NM_001128831
NM_001738
CA1



carbonic anhydrase I



chr11_-_119999516 2.606 TRIM29
tripartite motif containing 29
chr17_-_72619794 2.565 NM_181449
CD300E
CD300e molecule
chr14_-_65409445 2.507 NM_002083
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr2_-_89513056 2.494 IGKC
immunoglobulin kappa constant
chr12_+_41086189 2.404 NM_001843
NM_175038
CNTN1

contactin 1

chr16_-_28608367 2.389 NM_001054
SULT1A2
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
chr2_-_27718098 2.384 NM_022823
FNDC4
fibronectin type III domain containing 4
chr1_-_160681552 2.377 NM_001778
CD48
CD48 molecule
chr17_-_48278987 2.369 NM_000088
COL1A1
collagen, type I, alpha 1
chr6_+_6588933 2.307 NM_004271
LY86
lymphocyte antigen 86
chr9_+_72658496 2.300 NM_153267
MAMDC2
MAM domain containing 2
chr6_+_36973409 2.250 NM_173558
FGD2
FYVE, RhoGEF and PH domain containing 2
chr19_+_5914192 2.242 NM_004058
NM_080590
CAPS

calcyphosine

chr19_+_55999859 2.240 NM_001144950
NM_001195267
SSC5D

scavenger receptor cysteine rich domain containing (5 domains)

chr19_+_36393381 2.228 NM_001007469
NM_014266
HCST

hematopoietic cell signal transducer

chrX_-_55057408 2.158 NM_000032
NM_001037967
NM_001037968
ALAS2


aminolevulinate, delta-, synthase 2


chr11_+_71903172 2.156 NM_016729
FOLR1
folate receptor 1 (adult)
chr16_+_57438678 2.141 NM_002987
CCL17
chemokine (C-C motif) ligand 17
chr3_-_167098070 2.140 NM_001199202
NM_001199201
NM_024687
ZBBX


zinc finger, B-box domain containing


chr17_-_48278874 2.128 COL1A1
collagen, type I, alpha 1
chr20_+_31870940 2.118 NM_033197
BPIFB1
BPI fold containing family B, member 1
chr14_-_106586333 2.056 IGHV4-31
immunoglobulin heavy variable 4-31
chr14_-_106405633 2.037 IGHM
immunoglobulin heavy constant mu
chr1_-_157746863 2.035 NM_030764
FCRL2
Fc receptor-like 2
chr14_+_75988765 2.031 NM_006399
BATF
basic leucine zipper transcription factor, ATF-like
chr5_+_148786439 2.031 MIR143HG
MIR143 host gene (non-protein coding)
chr17_-_56358266 1.977 NM_000250
MPO
myeloperoxidase
chr18_+_61254533 1.950 NM_012397
SERPINB13
serpin peptidase inhibitor, clade B (ovalbumin), member 13
chr19_+_11649578 1.938 NM_001299
CNN1
calponin 1, basic, smooth muscle
chr7_+_100199881 1.924 NM_002593
PCOLCE
procollagen C-endopeptidase enhancer
chr17_+_32582295 1.907 NM_002982
CCL2
chemokine (C-C motif) ligand 2
chr3_+_108015392 1.874 HHLA2
HERV-H LTR-associating 2
chr14_-_107170400 1.866 IGHV4-31
IGHV1-69
IGHA1
IGHG1
IGHG3
IGHM
immunoglobulin heavy variable 4-31
immunoglobulin heavy variable 1-69
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
immunoglobulin heavy constant mu
chr8_+_134203281 1.861 NM_001204869
NM_001204870
NM_003882
NM_080838
WISP1



WNT1 inducible signaling pathway protein 1



chr5_-_64858931 1.856 NM_022145
CENPK
centromere protein K
chr12_-_23737507 1.832 NM_178010
SOX5
SRY (sex determining region Y)-box 5
chr22_+_45072936 1.808 PRR5
proline rich 5 (renal)
chr14_+_75988838 1.800 BATF
basic leucine zipper transcription factor, ATF-like
chr11_+_118215058 1.765 NM_000073
CD3G
CD3g molecule, gamma (CD3-TCR complex)
chr2_+_3642421 1.753 NM_024027
NM_199235
COLEC11

collectin sub-family member 11

chr18_+_21572736 1.749 NM_153211
TTC39C
tetratricopeptide repeat domain 39C
chr19_-_8642309 1.740 NM_012335
MYO1F
myosin IF
chr1_+_150245182 1.720 NM_024579
C1orf54
chromosome 1 open reading frame 54
chr12_-_7245006 1.706 NM_001733
C1R
complement component 1, r subcomponent
chr15_-_43513024 1.699 EPB42
erythrocyte membrane protein band 4.2
chr2_+_113875469 1.694 NM_000577
NM_173841
NM_173843
IL1RN


interleukin 1 receptor antagonist


chr12_-_7245048 1.690 C1R
complement component 1, r subcomponent
chr19_-_10213332 1.678 NM_031917
ANGPTL6
angiopoietin-like 6
chr2_-_133427624 1.653 LYPD1
LY6/PLAUR domain containing 1
chr17_-_38074842 1.615 NM_001042471
NM_001165958
NM_001165959
GSDMB


gasdermin B


chr9_+_72658735 1.607 MAMDC2
MAM domain containing 2
chr10_-_104211244 1.596 NM_024886
C10orf95
chromosome 10 open reading frame 95
chr2_+_231860838 1.591 NM_139073
SPATA3
spermatogenesis associated 3
chr6_-_30652434 1.588 PPP1R18
protein phosphatase 1, regulatory subunit 18
chr19_-_54804172 1.578 NM_001172654
NM_006865
LILRA3

LILRA6
leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3

leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
chrX_-_48328601 1.565 NM_033518
SLC38A5
solute carrier family 38, member 5
chr14_-_106494166 1.561 IGHV4-31
IGHA1
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant alpha 1
chr17_+_45908992 1.552 NM_033413
LRRC46
leucine rich repeat containing 46
chr20_+_29956420 1.551 NM_054112
DEFB118
defensin, beta 118
chr3_+_51895644 1.549 NM_203424
IQCF2
IQ motif containing F2
chr14_-_106237675 1.545 IGHM
immunoglobulin heavy constant mu
chr22_+_37309618 1.535 NM_000395
CSF2RB
colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
chr20_+_123230 1.535 NM_030931
DEFB126
defensin, beta 126
chrX_-_48328564 1.530 SLC38A5
solute carrier family 38, member 5
chr16_-_31147062 1.514 NM_002773
PRSS8
protease, serine, 8
chr17_+_37784750 1.513 NM_001242464
NM_181505
PPP1R1B

protein phosphatase 1, regulatory (inhibitor) subunit 1B

chr19_-_51893791 1.508 NM_001193623
LOC147646
uncharacterized LOC147646
chr10_-_73848530 1.493 NM_001244950
SPOCK2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chr7_-_116963328 1.474 NM_003391
WNT2
wingless-type MMTV integration site family member 2
chr10_-_90712510 1.470 NM_001613
ACTA2
actin, alpha 2, smooth muscle, aorta
chr17_+_40913233 1.468 RAMP2
receptor (G protein-coupled) activity modifying protein 2
chr12_-_9913415 1.468 NM_001781
CD69
CD69 molecule
chr11_+_111411419 1.468 LAYN
layilin
chr17_-_43025027 1.464 NM_001080443
KIF18B
kinesin family member 18B
chr13_-_46742678 1.458 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr14_-_107066061 1.451 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr19_-_54604070 1.439 NM_130771
NM_133168
NM_133169
NM_206818
OSCAR



osteoclast associated, immunoglobulin-like receptor



chr1_-_89738477 1.437 NM_001134486
NM_052942
GBP5

guanylate binding protein 5

chr1_+_26485510 1.432 NM_024869
FAM110D
family with sequence similarity 110, member D
chr20_-_1306512 1.425 NM_001199784
SDCBP2
syndecan binding protein (syntenin) 2
chr11_+_71927818 1.422 NM_000803
NM_001113534
NM_001113535
NM_001113536
FOLR2



folate receptor 2 (fetal)



chr1_+_171217632 1.418 NM_002021
FMO1
flavin containing monooxygenase 1
chr16_+_56995761 1.414 NM_000078
CETP
cholesteryl ester transfer protein, plasma
chrX_+_36065052 1.411 NM_173695
CXorf59
chromosome X open reading frame 59
chr1_+_156030965 1.407 NM_020387
RAB25
RAB25, member RAS oncogene family
chr5_+_34687663 1.404 NM_001145523
RAI14
retinoic acid induced 14
chr11_-_5537815 1.402 NM_145053
UBQLNL
ubiquilin-like
chr12_-_49259549 1.402 NM_014470
RND1
Rho family GTPase 1
chr19_+_35606731 1.398 NM_001136007
NM_001136008
NM_001136009
NM_001136010
NM_001136011
NM_001136012
NM_005971
NM_021910
FXYD3







FXYD domain containing ion transport regulator 3







chr12_-_53601051 1.390 ITGB7
integrin, beta 7
chr11_+_111411232 1.389 NM_178834
LAYN
layilin
chr11_+_369723 1.388 NM_178537
B4GALNT4
beta-1,4-N-acetyl-galactosaminyl transferase 4
chr20_-_42355566 1.380 NM_001008901
NM_176791
GTSF1L

gametocyte specific factor 1-like

chr8_+_11351509 1.366 NM_001715
BLK
B lymphoid tyrosine kinase
chr11_-_5271035 1.360 NM_000559
HBG1
hemoglobin, gamma A
chr4_-_174320616 1.357 NM_007281
SCRG1
stimulator of chondrogenesis 1
chr1_-_160832466 1.354 NM_001166663
NM_001166664
NM_016382
CD244


CD244 molecule, natural killer cell receptor 2B4


chr3_-_123339423 1.353 NM_053031
NM_053032
MYLK

myosin light chain kinase

chr3_+_112051914 1.351 NM_001004196
NM_005944
CD200

CD200 molecule

chr14_-_106092256 1.317 IGHG4
immunoglobulin heavy constant gamma 4 (G4m marker)
chr1_-_157670280 1.315 NM_052939
FCRL3
Fc receptor-like 3
chr14_-_106111114 1.313 IGHG2
immunoglobulin heavy constant gamma 2 (G2m marker)
chr8_-_38008332 1.303 NM_000349
STAR
steroidogenic acute regulatory protein
chr22_+_51176623 1.303 NM_001097
ACR
acrosin
chr22_+_22712091 1.295 IGLV1-44
IGL@
immunoglobulin lambda variable 1-44
immunoglobulin lambda locus
chr1_+_207262211 1.292 NM_001017365
NM_001017366
C4BPB

complement component 4 binding protein, beta

chr5_-_138725544 1.292 NM_016459
MZB1
marginal zone B and B1 cell-specific protein
chr17_-_56358161 1.288 MPO
myeloperoxidase
chr11_-_117800067 1.288 NM_001077263
NM_001206789
NM_001206790
NM_001244995
TMPRSS13



transmembrane protease, serine 13



chr14_+_62462540 1.275 NM_031914
SYT16
synaptotagmin XVI
chr1_+_22979681 1.273 NM_000491
C1QB
complement component 1, q subcomponent, B chain
chr17_-_56358118 1.267 MPO
myeloperoxidase
chr17_-_34195745 1.265 NM_152781
C17orf66
chromosome 17 open reading frame 66
chr2_+_97202463 1.263 NM_212481
ARID5A
AT rich interactive domain 5A (MRF1-like)
chr12_+_6875468 1.256 NM_002824
PTMS
parathymosin
chr20_+_44330654 1.233 NM_172005
WFDC13
WAP four-disulfide core domain 13
chr4_+_36283243 1.230 NM_001136536
DTHD1
death domain containing 1
chr7_-_2883649 1.228 NM_007353
GNA12
guanine nucleotide binding protein (G protein) alpha 12
chr20_-_56285576 1.227 NM_199169
NM_199170
PMEPA1

prostate transmembrane protein, androgen induced 1

chr13_+_114462148 1.226 NM_182614
FAM70B
family with sequence similarity 70, member B
chr17_-_8770976 1.206 NM_001010855
PIK3R6
phosphoinositide-3-kinase, regulatory subunit 6
chr1_+_207262583 1.202 NM_000716
NM_001017364
NM_001017367
C4BPB


complement component 4 binding protein, beta


chr2_-_167343477 1.201 NM_002976
SCN7A
sodium channel, voltage-gated, type VII, alpha
chr1_-_167883243 1.200 NM_001167749
NM_018417
ADCY10

adenylate cyclase 10 (soluble)

chr21_+_34602304 1.194 IFNAR2
interferon (alpha, beta and omega) receptor 2
chr12_+_27485767 1.193 NM_001248002
NM_001248003
NM_001248004
NM_001248005
NM_020183
ARNTL2




aryl hydrocarbon receptor nuclear translocator-like 2




chr2_+_189839132 1.181 COL3A1
collagen, type III, alpha 1
chr6_-_41715078 1.181 NM_001166424
NM_002630
PGC

progastricsin (pepsinogen C)

chr14_+_21359542 1.180 NM_002935
RNASE3
ribonuclease, RNase A family, 3
chr7_-_75419063 1.176 NM_006072
CCL26
chemokine (C-C motif) ligand 26
chr17_-_42345434 1.176 NM_000342
SLC4A1
solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)
chr19_+_55587220 1.163 NM_133180
EPS8L1
EPS8-like 1
chr12_+_6875574 1.161 PTMS
parathymosin
chr14_-_107113943 1.161 IGHA1
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr21_+_34602273 1.155 IFNAR2
interferon (alpha, beta and omega) receptor 2
chr19_+_35820069 1.155 NM_001185099
NM_001185100
NM_001185101
NM_001771
CD22



CD22 molecule



chr9_-_132515290 1.153 NM_004878
PTGES
prostaglandin E synthase
chr14_-_106209380 1.145 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr16_-_10788729 1.142 NM_144674
TEKT5
tektin 5
chr14_+_96722546 1.140 NM_000710
BDKRB1
bradykinin receptor B1
chr5_+_147258273 1.137 NM_054023
SCGB3A2
secretoglobin, family 3A, member 2
chr2_+_219246751 1.130 NM_000578
SLC11A1
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
chr3_+_112052020 1.124 CD200
CD200 molecule
chr4_-_40631846 1.112 NM_001098634
RBM47
RNA binding motif protein 47
chr8_-_27850368 1.103 NM_173833
SCARA5
scavenger receptor class A, member 5 (putative)
chr19_+_51226593 1.103 NM_002975
CLEC11A
C-type lectin domain family 11, member A
chr11_+_45943171 1.097 NM_152312
GYLTL1B
glycosyltransferase-like 1B
chr17_-_34266359 1.094 NM_020426
LYZL6
lysozyme-like 6
chr5_+_40909558 1.092 NM_000587
C7
complement component 7
chr22_+_45072687 1.090 NM_001017530
NM_001198721
NM_015366
PRR5


proline rich 5 (renal)


chr11_-_133715368 1.090 NM_174927
SPATA19
spermatogenesis associated 19
chr1_+_161676761 1.087 NM_001184866
NM_001184867
NM_001184870
NM_001184871
NM_001184872
NM_001184873
NM_032738
FCRLA






Fc receptor-like A







Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
3.38 1.76e-07 GO:0002376 immune system process
3.90 7.48e-06 GO:0006955 immune response
11.04 4.29e-04 GO:0006959 humoral immune response
18.93 4.45e-04 GO:0002455 humoral immune response mediated by circulating immunoglobulin
3.29 5.92e-04 GO:0006952 defense response
4.29 7.24e-04 GO:0050776 regulation of immune response
11.20 2.00e-03 GO:0002449 lymphocyte mediated immunity
3.33 3.00e-03 GO:0002682 regulation of immune system process
10.45 3.21e-03 GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
10.17 3.84e-03 GO:0002250 adaptive immune response
7.00 3.96e-03 GO:0002252 immune effector process
17.81 5.45e-03 GO:0006958 complement activation, classical pathway
4.08 6.25e-03 GO:0051707 response to other organism
12.05 6.84e-03 GO:0016064 immunoglobulin mediated immune response
11.83 7.61e-03 GO:0019724 B cell mediated immunity
5.09 7.87e-03 GO:0009617 response to bacterium
8.89 9.45e-03 GO:0002443 leukocyte mediated immunity
55.19 9.70e-03 GO:0020027 hemoglobin metabolic process
3.60 1.33e-02 GO:0009607 response to biotic stimulus
13.15 2.52e-02 GO:0006956 complement activation

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
3.19 1.05e-13 GO:0005576 extracellular region
3.41 2.98e-05 GO:0005615 extracellular space
2.86 2.31e-04 GO:0044421 extracellular region part
30.11 1.35e-02 GO:0005583 fibrillar collagen

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
27.60 2.68e-10 GO:0003823 antigen binding
110.38 1.18e-02 GO:0004912 interleukin-3 receptor activity
110.38 1.18e-02 GO:0019978 interleukin-3 binding