Motif ID: HAND1,2.p2

Z-value: 2.119


Transcription factors associated with HAND1,2.p2:

Gene SymbolEntrez IDGene Name
HAND1 9421 heart and neural crest derivatives expressed 1
HAND2 9464 heart and neural crest derivatives expressed 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HAND1hg19_v1_chr5_-_153857820_153857825-0.202.7e-01Click!
HAND2hg19_v1_chr4_-_174450343_1744504390.048.3e-01Click!


Activity profile for motif HAND1,2.p2.

activity profile for motif HAND1,2.p2


Sorted Z-values histogram for motif HAND1,2.p2

Sorted Z-values for motif HAND1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HAND1,2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_-_107179043 7.068 IGHA1
immunoglobulin heavy constant alpha 1
chr2_+_204732509 6.443 NM_001037631
NM_005214
 CTLA4

cytotoxic T-lymphocyte-associated protein 4

chr10_+_102123420 5.981


chr6_+_134210264 5.459 TCF21
transcription factor 21
chr22_+_22723972 5.326


chr1_+_26644458 5.303 CD52
CD52 molecule
chr14_-_107078578 5.235


chr6_+_134210247 5.101 NM_198392
NM_003206
 TCF21

transcription factor 21

chr22_+_23063107 4.924 IGLJ3
immunoglobulin lambda joining 3
chr22_+_23213671 4.708 IGLV4-3
immunoglobulin lambda variable 4-3
chr1_+_26644380 4.468 NM_001803
 CD52
CD52 molecule
chr2_+_228678556 4.288 NM_001130046
NM_004591
 CCL20

chemokine (C-C motif) ligand 20

chr14_-_107170076 4.255 IGHV1-69
IGHG1
immunoglobulin heavy variable 1-69
immunoglobulin heavy constant gamma 1 (G1m marker)
chr14_-_106774311 3.795 IGHA1
immunoglobulin heavy constant alpha 1
chr12_+_49716970 3.730 NM_001100620
NM_005480
 TROAP

trophinin associated protein (tastin)

chr7_+_76139744 3.720 NM_030570
NM_182684
 UPK3B

uroplakin 3B

chr11_+_67171400 3.671 NM_198517
 TBC1D10C
TBC1 domain family, member 10C
chr12_-_91505541 3.575 NM_002345
 LUM
lumican
chr14_-_106208537 3.522


chr14_-_106321626 3.506



Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 20 entries
Enrichment   P-value GO Accession GO Term
55.19 9.70e-03 GO:0020027 hemoglobin metabolic process
18.93 4.45e-04 GO:0002455 humoral immune response mediated by circulating immunoglobulin
17.81 5.45e-03 GO:0006958 complement activation, classical pathway
13.15 2.52e-02 GO:0006956 complement activation
12.05 6.84e-03 GO:0016064 immunoglobulin mediated immune response
11.83 7.61e-03 GO:0019724 B cell mediated immunity
11.20 2.00e-03 GO:0002449 lymphocyte mediated immunity
11.04 4.29e-04 GO:0006959 humoral immune response
10.45 3.21e-03 GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
10.17 3.84e-03 GO:0002250 adaptive immune response
8.89 9.45e-03 GO:0002443 leukocyte mediated immunity
7.00 3.96e-03 GO:0002252 immune effector process
5.09 7.87e-03 GO:0009617 response to bacterium
4.29 7.24e-04 GO:0050776 regulation of immune response
4.08 6.25e-03 GO:0051707 response to other organism
3.90 7.48e-06 GO:0006955 immune response
3.60 1.33e-02 GO:0009607 response to biotic stimulus
3.38 1.76e-07 GO:0002376 immune system process
3.33 3.00e-03 GO:0002682 regulation of immune system process
3.29 5.92e-04 GO:0006952 defense response

Gene overrepresentation in compartment category:

Showing 1 to 4 of 4 entries
Enrichment   P-value GO Accession GO Term
30.11 1.35e-02 GO:0005583 fibrillar collagen
3.41 2.98e-05 GO:0005615 extracellular space
3.19 1.05e-13 GO:0005576 extracellular region
2.86 2.31e-04 GO:0044421 extracellular region part

Gene overrepresentation in function category:

Showing 1 to 3 of 3 entries
Enrichment   P-value GO Accession GO Term
110.38 1.18e-02 GO:0004912 interleukin-3 receptor activity
110.38 1.18e-02 GO:0019978 interleukin-3 binding
27.60 2.68e-10 GO:0003823 antigen binding