Motif ID: HIC1.p2

Z-value: 2.445


Transcription factors associated with HIC1.p2:

Gene SymbolEntrez IDGene Name
HIC1 3090 hypermethylated in cancer 1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HIC1hg19_v1_chr17_+_1958354_19584420.029.0e-01Click!


Activity profile for motif HIC1.p2.

activity profile for motif HIC1.p2


Sorted Z-values histogram for motif HIC1.p2

Sorted Z-values for motif HIC1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HIC1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_+_92920592 8.393 NR2F1
NR2F2
nuclear receptor subfamily 2, group F, member 1
nuclear receptor subfamily 2, group F, member 2
chr19_+_708766 7.699 NM_001040134
NM_002579
PALM

paralemmin

chr9_-_112083005 7.364 NM_018424
NM_019114
EPB41L4B

erythrocyte membrane protein band 4.1 like 4B

chr4_+_2061238 6.872 NM_178557
NAT8L
N-acetyltransferase 8-like (GCN5-related, putative)
chr12_-_132905781 6.702 NM_001122636
GALNT9
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 9 (GalNAc-T9)
chr17_-_31386 6.675 NM_003585
DOC2B
double C2-like domains, beta
chr1_+_18434236 6.481 NM_032880
IGSF21
immunoglobin superfamily, member 21
chr12_+_121078421 6.085 NM_001033677
CABP1
calcium binding protein 1
chr11_+_101980736 6.069 NM_001130145
NM_001195044
NM_006106
YAP1


Yes-associated protein 1


chr18_-_70210762 6.005 CBLN2
cerebellin 2 precursor
chr15_-_29862926 5.628 NM_015307
FAM189A1
family with sequence similarity 189, member A1
chr7_-_108096693 5.008 NM_001193582
NM_001193583
NM_001193584
NM_005010
NRCAM



neuronal cell adhesion molecule



chr10_+_102107001 5.004 SCD
stearoyl-CoA desaturase (delta-9-desaturase)
chr10_+_102106771 4.992 NM_005063
SCD
stearoyl-CoA desaturase (delta-9-desaturase)
chr9_+_132934685 4.752 NM_014286
NCS1
neuronal calcium sensor 1
chr11_-_61348290 4.710 NM_001252065
NM_004200
SYT7

synaptotagmin VII

chr2_-_27718098 4.439 NM_022823
FNDC4
fibronectin type III domain containing 4
chr17_-_31242 4.405


chr6_+_56819706 4.358 NM_152731
BEND6
BEN domain containing 6
chr15_+_41851153 4.242 NM_006293
TYRO3
TYRO3 protein tyrosine kinase
chr17_-_6459746 4.199 NM_001165966
NM_031220
PITPNM3

PITPNM family member 3

chr1_+_210406194 4.098 NM_019605
SERTAD4
SERTA domain containing 4
chr2_-_224903933 4.079 NM_001136528
NM_006216
SERPINE2

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2

chr2_-_27718059 4.052 FNDC4
fibronectin type III domain containing 4
chr5_-_171881355 4.050 SH3PXD2B
SH3 and PX domains 2B
chr1_+_205538164 4.045 MFSD4
major facilitator superfamily domain containing 4
chr10_+_102106958 4.036 SCD
stearoyl-CoA desaturase (delta-9-desaturase)
chr7_+_45614179 3.918 ADCY1
adenylate cyclase 1 (brain)
chr14_+_33408458 3.889 NM_001164749
NM_001165893
NM_022123
NM_173159
NPAS3



neuronal PAS domain protein 3



chr14_+_105331581 3.883 NM_001112726
NM_015005
KIAA0284

KIAA0284

chr1_-_62785067 3.841 NM_181712
KANK4
KN motif and ankyrin repeat domains 4
chr13_-_110959441 3.835 NM_001845
COL4A1
collagen, type IV, alpha 1
chr11_+_369723 3.793 NM_178537
B4GALNT4
beta-1,4-N-acetyl-galactosaminyl transferase 4
chr11_-_106888829 3.777 NM_000855
GUCY1A2
guanylate cyclase 1, soluble, alpha 2
chr8_+_65493610 3.746 BHLHE22
basic helix-loop-helix family, member e22
chr6_+_56819923 3.742 BEND6
BEN domain containing 6
chr22_+_39853316 3.669 NM_002409
MGAT3
mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
chr9_+_130965668 3.663 DNM1
dynamin 1
chr6_-_166721870 3.661 NM_175922
PRR18
proline rich 18
chr19_-_460995 3.649 NM_012435
SHC2
SHC (Src homology 2 domain containing) transforming protein 2
chr22_+_48885255 3.623 NM_001082967
FAM19A5
family with sequence similarity 19 (chemokine (C-C motif)-like), member A5
chr13_+_98795710 3.609 FARP1
FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
chr13_+_110959592 3.602 NM_001846
COL4A2
collagen, type IV, alpha 2
chr1_+_205538111 3.571 NM_181644
MFSD4
major facilitator superfamily domain containing 4
chr9_+_130965608 3.562 NM_001005336
NM_004408
DNM1

dynamin 1

chr1_+_19970674 3.505 NM_005380
NBL1
neuroblastoma, suppression of tumorigenicity 1
chr5_-_11903964 3.478 NM_001332
CTNND2
catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)
chr1_-_95392449 3.466 CNN3
calponin 3, acidic
chr13_-_102068705 3.465 NM_052867
NALCN
sodium leak channel, non-selective
chr19_-_47922339 3.447 MEIS3
Meis homeobox 3
chr19_-_47922738 3.415 NM_001009813
NM_020160
MEIS3

Meis homeobox 3

chr6_+_147829784 3.386 NM_001030060
SAMD5
sterile alpha motif domain containing 5
chr9_+_130965666 3.375 DNM1
dynamin 1
chr1_-_62784971 3.366 KANK4
KN motif and ankyrin repeat domains 4
chr15_-_51386815 3.362 TNFAIP8L3
tumor necrosis factor, alpha-induced protein 8-like 3
chr1_+_161228516 3.301 NM_001102566
PCP4L1
Purkinje cell protein 4 like 1
chr10_-_123357503 3.244 NM_000141
NM_001144917
NM_001144918
NM_001144919
NM_022970
FGFR2




fibroblast growth factor receptor 2




chr20_-_62462568 3.236 ZBTB46
zinc finger and BTB domain containing 46
chr9_+_87283453 3.228 NM_001018064
NM_006180
NTRK2

neurotrophic tyrosine kinase, receptor, type 2

chr7_-_150038689 3.188 NM_002889
RARRES2
retinoic acid receptor responder (tazarotene induced) 2
chr11_-_110583120 3.179 NM_020809
ARHGAP20
Rho GTPase activating protein 20
chr1_-_31381436 3.172 NM_014654
SDC3
syndecan 3
chr11_-_12030882 3.149 NM_013253
DKK3
dickkopf 3 homolog (Xenopus laevis)
chr5_-_11904127 3.107 CTNND2
catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)
chr16_+_222845 3.104 NM_000517
HBA1
HBA2
hemoglobin, alpha 1
hemoglobin, alpha 2
chr5_+_176237435 3.103 NM_133369
UNC5A
unc-5 homolog A (C. elegans)
chr15_-_23115243 3.071 LOC283683
uncharacterized LOC283683
chr3_+_39851028 3.071 NM_015460
MYRIP
myosin VIIA and Rab interacting protein
chr11_-_12030838 3.054 DKK3
dickkopf 3 homolog (Xenopus laevis)
chr4_+_150999412 3.030 NM_001040260
NM_001040261
DCLK2

doublecortin-like kinase 2

chr12_+_70759974 3.028 NM_014505
KCNMB4
potassium large conductance calcium-activated channel, subfamily M, beta member 4
chr6_+_1390068 3.023 NM_001452
FOXF2
forkhead box F2
chr16_+_87636492 3.022 NM_020655
JPH3
junctophilin 3
chr2_-_224903324 2.989 NM_001136530
SERPINE2
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
chr7_-_122526410 2.987 CADPS2
Ca++-dependent secretion activator 2
chr7_-_98467483 2.981 TMEM130
transmembrane protein 130
chr20_-_54580011 2.961 NM_080617
CBLN4
cerebellin 4 precursor
chr11_+_1411089 2.940 NM_003957
BRSK2
BR serine/threonine kinase 2
chr9_+_17578952 2.937 NM_003026
SH3GL2
SH3-domain GRB2-like 2
chr7_+_31092067 2.932 NM_001118
NM_001199635
NM_001199636
NM_001199637
ADCYAP1R1



adenylate cyclase activating polypeptide 1 (pituitary) receptor type I



chr8_+_98881277 2.921 NM_002380
NM_030583
MATN2

matrilin 2

chr1_-_85930610 2.915 DDAH1
dimethylarginine dimethylaminohydrolase 1
chr19_-_47922468 2.907 MEIS3
Meis homeobox 3
chr15_+_101420032 2.887 ALDH1A3
aldehyde dehydrogenase 1 family, member A3
chr9_-_101470836 2.877 NM_005458
GABBR2
gamma-aminobutyric acid (GABA) B receptor, 2
chrX_+_2746810 2.862 NM_001079855
NM_001184702
NM_001184703
NM_001184704
NM_003918
GYG2




glycogenin 2




chr9_-_112083196 2.860 EPB41L4B
erythrocyte membrane protein band 4.1 like 4B
chr4_+_95679075 2.854 NM_001203
BMPR1B
bone morphogenetic protein receptor, type IB
chr19_+_3224700 2.838 NM_021938
NM_001172673
CELF5

CUGBP, Elav-like family member 5

chr8_+_27491460 2.812 NM_016240
NM_182826
SCARA3

scavenger receptor class A, member 3

chr16_+_4421774 2.810 NM_138440
VASN
vasorin
chr13_+_98795468 2.809 FARP1
FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
chr6_+_44238479 2.804 NM_001137560
TMEM151B
transmembrane protein 151B
chr8_+_104152876 2.784 NM_001024372
NM_024812
BAALC

brain and acute leukemia, cytoplasmic

chr2_-_70995113 2.744 NM_001185055
NM_001617
NM_017482
NM_017488
ADD2



adducin 2 (beta)



chr11_-_82444889 2.738 NM_175885
FAM181B
family with sequence similarity 181, member B
chr1_-_85930733 2.685 NM_012137
DDAH1
dimethylarginine dimethylaminohydrolase 1
chr2_+_11052062 2.680 NM_002236
KCNF1
potassium voltage-gated channel, subfamily F, member 1
chr7_-_132261268 2.680 NM_001105543
NM_020911
PLXNA4

plexin A4

chr13_-_40177304 2.664 LHFP
lipoma HMGIC fusion partner
chr19_-_19006868 2.663 NM_021267
NM_198207
NM_001492
CERS1

GDF1
ceramide synthase 1

growth differentiation factor 1
chr2_-_102003859 2.655 CREG2
cellular repressor of E1A-stimulated genes 2
chr4_-_5894695 2.654 NM_001014809
CRMP1
collapsin response mediator protein 1
chr10_-_15413054 2.645 NM_001010924
FAM171A1
family with sequence similarity 171, member A1
chr11_+_61520000 2.644 NM_001127392
C11orf9
chromosome 11 open reading frame 9
chr11_-_12030622 2.632 NM_015881
DKK3
dickkopf 3 homolog (Xenopus laevis)
chr9_-_72287097 2.622 NM_001163
APBA1
amyloid beta (A4) precursor protein-binding, family A, member 1
chr22_+_39853534 2.617 MGAT3
mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
chr10_-_118501981 2.594 NM_025015
HSPA12A
heat shock 70kDa protein 12A
chr12_-_130388211 2.588 NM_133448
TMEM132D
transmembrane protein 132D
chr7_+_45614081 2.579 NM_021116
ADCY1
adenylate cyclase 1 (brain)
chr11_-_12030757 2.578 DKK3
dickkopf 3 homolog (Xenopus laevis)
chr19_-_1237840 2.577 NM_152769
C19orf26
chromosome 19 open reading frame 26
chr7_+_73082157 2.568 NM_001077621
VPS37D
vacuolar protein sorting 37 homolog D (S. cerevisiae)
chr5_-_171881421 2.568 NM_001017995
SH3PXD2B
SH3 and PX domains 2B
chr19_+_7660698 2.560 NM_001080429
NM_020902
CAMSAP3

calmodulin regulated spectrin-associated protein family, member 3

chr19_-_47922391 2.542 MEIS3
Meis homeobox 3
chr1_-_71513259 2.505 NM_001126044
NM_198714
NM_198715
NM_198716
NM_198717
NM_198718
NM_198719
PTGER3






prostaglandin E receptor 3 (subtype EP3)






chr1_-_20812271 2.492 CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr14_+_100111446 2.482 NM_001127258
NM_032425
HHIPL1

HHIP-like 1

chr15_+_96873845 2.481 NM_021005
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr6_-_131384387 2.475 NM_001135554
NM_001135555
NM_001199388
NM_001431
EPB41L2



erythrocyte membrane protein band 4.1-like 2



chr9_+_137979513 2.473 OLFM1
olfactomedin 1
chr11_-_12030539 2.433 DKK3
dickkopf 3 homolog (Xenopus laevis)
chr2_-_233792825 2.429 NM_001114090
NGEF
neuronal guanine nucleotide exchange factor
chr5_+_76506705 2.405 NM_001029851
NM_001029852
NM_001029853
NM_001029854
NM_003719
PDE8B




phosphodiesterase 8B




chr11_-_9113092 2.403 NM_001170690
NM_020974
SCUBE2

signal peptide, CUB domain, EGF-like 2

chr9_-_13279562 2.401 MPDZ
multiple PDZ domain protein
chr15_+_68871285 2.398 NM_006091
CORO2B
coronin, actin binding protein, 2B
chr3_-_145968819 2.371 PLSCR4
phospholipid scramblase 4
chr22_+_33197678 2.363 TIMP3
TIMP metallopeptidase inhibitor 3
chr2_+_242498118 2.362 NM_032515
BOK
BCL2-related ovarian killer
chr4_-_5889992 2.360 CRMP1
collapsin response mediator protein 1
chr19_+_15218141 2.344 NM_033025
SYDE1
synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
chr2_-_10220321 2.338 NM_001037160
CYS1
cystin 1
chr9_+_103235634 2.335 TMEFF1
transmembrane protein with EGF-like and two follistatin-like domains 1
chr12_+_128751947 2.333 NM_001136103
TMEM132C
transmembrane protein 132C
chr11_-_130298305 2.317 ADAMTS8
ADAM metallopeptidase with thrombospondin type 1 motif, 8
chr10_+_116853118 2.314 NM_207303
ATRNL1
attractin-like 1
chrX_+_152240726 2.305 NM_001170944
NM_001242319
NM_032882
PNMA6C
PNMA6D
PNMA6A
paraneoplastic antigen like 6C
paraneoplastic antigen like 6D
paraneoplastic antigen like 6A
chr2_-_241759627 2.282 NM_001244008
NM_004321
KIF1A

kinesin family member 1A

chr12_+_117176085 2.259 NM_001109903
NM_032814
RNFT2

ring finger protein, transmembrane 2

chr2_-_1748240 2.232 PXDN
peroxidasin homolog (Drosophila)
chr6_-_84419018 2.231 SNAP91
synaptosomal-associated protein, 91kDa homolog (mouse)
chr11_+_66059364 2.230 NM_153266
TMEM151A
transmembrane protein 151A
chr11_-_790103 2.230 NM_016564
CEND1
cell cycle exit and neuronal differentiation 1
chr16_+_84002099 2.224 NM_019065
NECAB2
N-terminal EF-hand calcium binding protein 2
chrX_-_43741500 2.222 MAOB
monoamine oxidase B
chr16_+_87636574 2.220 JPH3
junctophilin 3
chr6_-_131384321 2.215 EPB41L2
erythrocyte membrane protein band 4.1-like 2
chr2_+_173600634 2.195 RAPGEF4
Rap guanine nucleotide exchange factor (GEF) 4
chr12_-_120806893 2.190 NM_002442
MSI1
musashi homolog 1 (Drosophila)
chr17_+_79008945 2.180 NM_001144888
NM_006340
NM_017450
NM_017451
BAIAP2



BAI1-associated protein 2



chr19_+_589849 2.165 NM_001194
HCN2
hyperpolarization activated cyclic nucleotide-gated potassium channel 2
chr2_-_102003923 2.149 NM_153836
CREG2
cellular repressor of E1A-stimulated genes 2
chr4_-_6474009 2.148 PPP2R2C
protein phosphatase 2, regulatory subunit B, gamma
chr19_-_11373117 2.141 NM_020812
DOCK6
dedicator of cytokinesis 6
chr2_-_99552677 2.137 NM_207362
C2orf55
chromosome 2 open reading frame 55
chr3_-_145968958 2.137 NM_001128306
NM_001177304
NM_020353
PLSCR4


phospholipid scramblase 4


chr14_-_77737549 2.136 NM_021257
NGB
neuroglobin
chr1_-_20812727 2.127 NM_018584
CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr17_-_80056104 2.117 NM_004104
FASN
fatty acid synthase
chr16_+_226678 2.110 NM_000558
HBA1
HBA2
hemoglobin, alpha 1
hemoglobin, alpha 2
chr7_-_122526781 2.110 NM_001009571
NM_001167940
NM_017954
CADPS2


Ca++-dependent secretion activator 2


chrX_-_128788913 2.109 NM_017413
APLN
apelin
chr17_+_7554711 2.104 ATP1B2
ATPase, Na+/K+ transporting, beta 2 polypeptide
chr22_+_33197744 2.101 TIMP3
TIMP metallopeptidase inhibitor 3
chr22_+_51113069 2.093 NM_001080420
SHANK3
SH3 and multiple ankyrin repeat domains 3
chr19_-_5340700 2.085 NM_002850
NM_130853
NM_130854
NM_130855
PTPRS



protein tyrosine phosphatase, receptor type, S



chr14_+_67999915 2.084 NM_020715
PLEKHH1
pleckstrin homology domain containing, family H (with MyTH4 domain) member 1
chr15_+_101420004 2.071 NM_000693
ALDH1A3
aldehyde dehydrogenase 1 family, member A3
chr6_-_69344918 2.067


chr6_+_159590428 2.061 NM_032532
FNDC1
fibronectin type III domain containing 1
chr20_-_4229519 2.054 NM_000678
ADRA1D
adrenergic, alpha-1D-, receptor
chr4_+_3768295 2.054 NM_000683
ADRA2C
adrenergic, alpha-2C-, receptor
chr3_+_11034436 2.051 SLC6A1
solute carrier family 6 (neurotransmitter transporter, GABA), member 1
chr6_-_150185161 2.050 LRP11
low density lipoprotein receptor-related protein 11
chr4_+_1795004 2.046 NM_000142
NM_001163213
NM_022965
FGFR3


fibroblast growth factor receptor 3


chr13_-_27334777 2.046 NM_005288
GPR12
G protein-coupled receptor 12
chr5_+_38845962 2.042 NM_003999
OSMR
oncostatin M receptor
chr19_-_11591439 2.031 NM_001420
NM_032281
ELAVL3

ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)

chr8_-_143858436 2.030 NM_177476
NM_177477
LYNX1

Ly6/neurotoxin 1

chr1_+_14925177 2.029 NM_015209
NM_201628
KAZN

kazrin, periplakin interacting protein

chr18_-_21242592 2.028 NM_173505
ANKRD29
ankyrin repeat domain 29
chr7_-_98467615 2.022 TMEM130
transmembrane protein 130
chr10_-_108924287 2.020 NM_001013031
NM_001206569
NM_001206570
NM_001206571
NM_001206572
NM_052918
SORCS1





sortilin-related VPS10 domain containing receptor 1





chr19_-_51071279 2.019 NM_001080457
LRRC4B
leucine rich repeat containing 4B
chr16_-_80837878 2.019 NM_152342
CDYL2
chromodomain protein, Y-like 2
chr12_+_26111951 2.014 NM_001164748
NM_007211
RASSF8

Ras association (RalGDS/AF-6) domain family (N-terminal) member 8

chr17_-_78009453 2.011 NM_019020
TBC1D16
TBC1 domain family, member 16
chr18_+_12407894 2.008 NM_001142405
NM_006553
SLMO1

slowmo homolog 1 (Drosophila)

chr1_-_11714396 2.004 FBXO2
F-box protein 2
chr10_+_122216465 1.991 NM_001030059
PPAPDC1A
phosphatidic acid phosphatase type 2 domain containing 1A
chr14_-_58618807 1.990 NM_001001872
C14orf37
chromosome 14 open reading frame 37
chr16_+_18995255 1.974 NM_024847
TMC7
transmembrane channel-like 7
chr2_+_173600595 1.953 RAPGEF4
Rap guanine nucleotide exchange factor (GEF) 4
chr19_-_39523132 1.948 NM_178820
FBXO27
F-box protein 27
chr14_-_77607958 1.939 ZDHHC22
zinc finger, DHHC-type containing 22
chr16_+_58497628 1.924 NDRG4
NDRG family member 4
chr8_-_143859177 1.924 LYNX1
Ly6/neurotoxin 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
2.45 6.47e-12 GO:0007399 nervous system development
3.03 7.73e-12 GO:0048699 generation of neurons
2.95 9.64e-12 GO:0022008 neurogenesis
3.19 1.13e-10 GO:0030182 neuron differentiation
3.63 5.46e-09 GO:0048812 neuron projection morphogenesis
3.60 1.36e-08 GO:0048667 cell morphogenesis involved in neuron differentiation
3.21 1.50e-08 GO:0048666 neuron development
2.65 1.75e-08 GO:0048468 cell development
3.63 1.98e-08 GO:0007409 axonogenesis
3.38 2.83e-08 GO:0031175 neuron projection development
3.25 1.53e-07 GO:0000904 cell morphogenesis involved in differentiation
3.23 1.86e-07 GO:0048858 cell projection morphogenesis
3.21 2.40e-07 GO:0032990 cell part morphogenesis
2.76 4.67e-06 GO:0030030 cell projection organization
2.81 6.89e-06 GO:0000902 cell morphogenesis
1.69 7.36e-06 GO:0048731 system development
1.84 1.37e-05 GO:0030154 cell differentiation
1.63 1.83e-05 GO:0048856 anatomical structure development
2.66 2.99e-05 GO:0032989 cellular component morphogenesis
1.98 4.26e-05 GO:0009653 anatomical structure morphogenesis
1.79 5.03e-05 GO:0048869 cellular developmental process
17.63 7.08e-05 GO:0060441 epithelial tube branching involved in lung morphogenesis
3.32 8.14e-05 GO:0007411 axon guidance
1.53 8.64e-05 GO:0023052 signaling
1.55 1.48e-04 GO:0007275 multicellular organismal development
13.22 7.60e-04 GO:0060425 lung morphogenesis
2.62 1.13e-03 GO:0007417 central nervous system development
2.14 2.64e-03 GO:0040011 locomotion
1.46 3.12e-03 GO:0032502 developmental process
2.65 4.57e-03 GO:0007268 synaptic transmission
1.76 4.85e-03 GO:0023051 regulation of signaling
2.53 5.23e-03 GO:0019226 transmission of nerve impulse
2.53 5.23e-03 GO:0035637 multicellular organismal signaling
3.07 9.01e-03 GO:0051960 regulation of nervous system development
2.15 9.91e-03 GO:0007267 cell-cell signaling
3.12 1.91e-02 GO:0050767 regulation of neurogenesis
1.91 3.09e-02 GO:0007154 cell communication
1.32 4.03e-02 GO:0032501 multicellular organismal process
1.43 4.12e-02 GO:0007165 signal transduction
2.60 4.70e-02 GO:0007420 brain development

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
1.42 1.04e-11 GO:0016020 membrane
3.75 5.15e-10 GO:0043005 neuron projection
3.70 7.65e-10 GO:0045202 synapse
1.44 2.39e-09 GO:0044425 membrane part
1.84 2.16e-07 GO:0044459 plasma membrane part
1.54 3.17e-07 GO:0005886 plasma membrane
1.53 4.96e-07 GO:0071944 cell periphery
3.54 2.81e-06 GO:0044456 synapse part
2.67 3.75e-06 GO:0030054 cell junction
4.22 2.63e-05 GO:0043025 neuronal cell body
1.38 3.91e-05 GO:0031224 intrinsic to membrane
4.10 4.17e-05 GO:0044297 cell body
2.22 4.20e-05 GO:0042995 cell projection
4.08 4.56e-05 GO:0030424 axon
1.37 1.20e-04 GO:0016021 integral to membrane
3.82 1.27e-04 GO:0030425 dendrite
1.86 7.40e-04 GO:0031226 intrinsic to plasma membrane
1.86 8.67e-04 GO:0005887 integral to plasma membrane
2.62 2.56e-03 GO:0031012 extracellular matrix
4.12 1.49e-02 GO:0019898 extrinsic to membrane
4.31 4.71e-02 GO:0014069 postsynaptic density

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
2.64 3.51e-04 GO:0030695 GTPase regulator activity
2.57 6.15e-04 GO:0060589 nucleoside-triphosphatase regulator activity
3.57 7.82e-03 GO:0005085 guanyl-nucleotide exchange factor activity
1.87 1.97e-02 GO:0030234 enzyme regulator activity
11.11 2.15e-02 GO:0030552 cAMP binding
28.34 2.55e-02 GO:0004157 dihydropyrimidinase activity
28.34 2.55e-02 GO:0070097 delta-catenin binding
2.65 2.77e-02 GO:0005083 small GTPase regulator activity