Motif ID: HIC1.p2

Z-value: 2.445


Transcription factors associated with HIC1.p2:

Gene SymbolEntrez IDGene Name
HIC1 3090 hypermethylated in cancer 1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HIC1hg19_v1_chr17_+_1958354_19584420.029.0e-01Click!


Activity profile for motif HIC1.p2.

activity profile for motif HIC1.p2


Sorted Z-values histogram for motif HIC1.p2

Sorted Z-values for motif HIC1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HIC1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_92920592 8.393 NR2F1
NR2F2
nuclear receptor subfamily 2, group F, member 1
nuclear receptor subfamily 2, group F, member 2
chr19_+_708766 7.699 NM_001040134
NM_002579
 PALM

paralemmin

chr9_-_112083005 7.364 NM_018424
NM_019114
 EPB41L4B

erythrocyte membrane protein band 4.1 like 4B

chr4_+_2061238 6.872 NM_178557
 NAT8L
N-acetyltransferase 8-like (GCN5-related, putative)
chr12_-_132905781 6.702 NM_001122636
 GALNT9
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 9 (GalNAc-T9)
chr17_-_31386 6.675 NM_003585
 DOC2B
double C2-like domains, beta
chr1_+_18434236 6.481 NM_032880
 IGSF21
immunoglobin superfamily, member 21
chr12_+_121078421 6.085 NM_001033677
 CABP1
calcium binding protein 1
chr11_+_101980736 6.069 NM_001130145
NM_001195044
NM_006106
 YAP1


Yes-associated protein 1


chr18_-_70210762 6.005 CBLN2
cerebellin 2 precursor
chr15_-_29862926 5.628 NM_015307
 FAM189A1
family with sequence similarity 189, member A1
chr7_-_108096693 5.008 NM_001193582
NM_001193583
NM_001193584
NM_005010
 NRCAM



neuronal cell adhesion molecule



chr10_+_102107001 5.004 SCD
stearoyl-CoA desaturase (delta-9-desaturase)
chr10_+_102106771 4.992 NM_005063
 SCD
stearoyl-CoA desaturase (delta-9-desaturase)
chr9_+_132934685 4.752 NM_014286
 NCS1
neuronal calcium sensor 1
chr11_-_61348290 4.710 NM_001252065
NM_004200
 SYT7

synaptotagmin VII

chr2_-_27718098 4.439 NM_022823
 FNDC4
fibronectin type III domain containing 4
chr17_-_31242 4.405


chr6_+_56819706 4.358 NM_152731
 BEND6
BEN domain containing 6
chr15_+_41851153 4.242 NM_006293
 TYRO3
TYRO3 protein tyrosine kinase

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 40 entries
Enrichment   P-value GO Accession GO Term
17.63 7.08e-05 GO:0060441 epithelial tube branching involved in lung morphogenesis
13.22 7.60e-04 GO:0060425 lung morphogenesis
3.63 5.46e-09 GO:0048812 neuron projection morphogenesis
3.63 1.98e-08 GO:0007409 axonogenesis
3.60 1.36e-08 GO:0048667 cell morphogenesis involved in neuron differentiation
3.38 2.83e-08 GO:0031175 neuron projection development
3.32 8.14e-05 GO:0007411 axon guidance
3.25 1.53e-07 GO:0000904 cell morphogenesis involved in differentiation
3.23 1.86e-07 GO:0048858 cell projection morphogenesis
3.21 1.50e-08 GO:0048666 neuron development
3.21 2.40e-07 GO:0032990 cell part morphogenesis
3.19 1.13e-10 GO:0030182 neuron differentiation
3.12 1.91e-02 GO:0050767 regulation of neurogenesis
3.07 9.01e-03 GO:0051960 regulation of nervous system development
3.03 7.73e-12 GO:0048699 generation of neurons
2.95 9.64e-12 GO:0022008 neurogenesis
2.81 6.89e-06 GO:0000902 cell morphogenesis
2.76 4.67e-06 GO:0030030 cell projection organization
2.66 2.99e-05 GO:0032989 cellular component morphogenesis
2.65 1.75e-08 GO:0048468 cell development

Gene overrepresentation in compartment category:

Showing 1 to 20 of 21 entries
Enrichment   P-value GO Accession GO Term
4.31 4.71e-02 GO:0014069 postsynaptic density
4.22 2.63e-05 GO:0043025 neuronal cell body
4.12 1.49e-02 GO:0019898 extrinsic to membrane
4.10 4.17e-05 GO:0044297 cell body
4.08 4.56e-05 GO:0030424 axon
3.82 1.27e-04 GO:0030425 dendrite
3.75 5.15e-10 GO:0043005 neuron projection
3.70 7.65e-10 GO:0045202 synapse
3.54 2.81e-06 GO:0044456 synapse part
2.67 3.75e-06 GO:0030054 cell junction
2.62 2.56e-03 GO:0031012 extracellular matrix
2.22 4.20e-05 GO:0042995 cell projection
1.86 7.40e-04 GO:0031226 intrinsic to plasma membrane
1.86 8.67e-04 GO:0005887 integral to plasma membrane
1.84 2.16e-07 GO:0044459 plasma membrane part
1.54 3.17e-07 GO:0005886 plasma membrane
1.53 4.96e-07 GO:0071944 cell periphery
1.44 2.39e-09 GO:0044425 membrane part
1.42 1.04e-11 GO:0016020 membrane
1.38 3.91e-05 GO:0031224 intrinsic to membrane

Gene overrepresentation in function category:

Showing 1 to 8 of 8 entries
Enrichment   P-value GO Accession GO Term
28.34 2.55e-02 GO:0004157 dihydropyrimidinase activity
28.34 2.55e-02 GO:0070097 delta-catenin binding
11.11 2.15e-02 GO:0030552 cAMP binding
3.57 7.82e-03 GO:0005085 guanyl-nucleotide exchange factor activity
2.65 2.77e-02 GO:0005083 small GTPase regulator activity
2.64 3.51e-04 GO:0030695 GTPase regulator activity
2.57 6.15e-04 GO:0060589 nucleoside-triphosphatase regulator activity
1.87 1.97e-02 GO:0030234 enzyme regulator activity