Motif ID: HLF.p2

Z-value: 2.470


Transcription factors associated with HLF.p2:

Gene SymbolEntrez IDGene Name
HLF 3131 hepatic leukemia factor

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HLFhg19_v1_chr17_+_53342320_53342344-0.067.4e-01Click!


Activity profile for motif HLF.p2.

activity profile for motif HLF.p2


Sorted Z-values histogram for motif HLF.p2

Sorted Z-values for motif HLF.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HLF.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_-_39364562 26.894 NM_001737
 C9
complement component 9
chr9_+_117085302 22.587 NM_000607
 ORM1
orosomucoid 1
chr3_+_186435097 20.122 NM_000893
NM_001102416
NM_001166451
 KNG1


kininogen 1


chr9_+_117092068 20.062 NM_000608
 ORM2
orosomucoid 2
chr19_-_41356193 17.665 NM_000762
 CYP2A6
cytochrome P450, family 2, subfamily A, polypeptide 6
chr4_+_155484131 17.196 NM_001184741
NM_005141
 FGB

fibrinogen beta chain

chr16_+_72088507 16.280 NM_001126102
NM_005143
 HP

haptoglobin

chr16_+_72097124 14.262 NM_020995
 HPR
haptoglobin-related protein
chr3_+_186383770 14.186 NM_000412
 HRG
histidine-rich glycoprotein
chr6_+_131894343 14.143 NM_000045
NM_001244438
 ARG1

arginase, liver

chr19_+_41594367 13.097 NM_000766
 CYP2A13
cytochrome P450, family 2, subfamily A, polypeptide 13
chr10_-_52645430 13.019 NM_001198818
NM_001198819
NM_001198820
NM_014576
NM_138932
NM_138933
 A1CF





APOBEC1 complementation factor





chr14_-_70263871 12.094 NM_003049
 SLC10A1
solute carrier family 10 (sodium/bile acid cotransporter family), member 1
chr19_+_35773409 11.380 NM_021175
 HAMP
hepcidin antimicrobial peptide
chr2_-_88427535 10.831 NM_001443
 FABP1
fatty acid binding protein 1, liver
chr11_-_116663106 10.729 NM_001166598
NM_052968
 APOA5

apolipoprotein A-V

chr1_+_196857143 10.340 NM_001201550
NM_001201551
NM_006684
 CFHR4


complement factor H-related 4


chr11_+_63057371 10.107 NM_001039752
 SLC22A10
solute carrier family 22, member 10
chr3_+_186330844 10.094 NM_001622
 AHSG
alpha-2-HS-glycoprotein
chr11_-_6462129 9.919 NM_000613
 HPX
hemopexin

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 66 entries
Enrichment   P-value GO Accession GO Term
40.21 3.61e-02 GO:0010873 positive regulation of cholesterol esterification
37.53 2.21e-03 GO:0006107 oxaloacetate metabolic process
29.32 4.53e-04 GO:0015721 bile acid and bile salt transport
28.87 7.33e-03 GO:0006957 complement activation, alternative pathway
22.08 2.36e-02 GO:0031640 killing of cells of other organism
21.66 2.26e-04 GO:0071825 protein-lipid complex subunit organization
21.66 2.26e-04 GO:0071827 plasma lipoprotein particle organization
21.33 2.59e-03 GO:0034367 macromolecular complex remodeling
21.33 2.59e-03 GO:0034368 protein-lipid complex remodeling
21.33 2.59e-03 GO:0034369 plasma lipoprotein particle remodeling
19.55 4.11e-03 GO:0045923 positive regulation of fatty acid metabolic process
17.88 1.05e-05 GO:0006956 complement activation
17.75 9.40e-05 GO:0006953 acute-phase response
16.92 3.23e-08 GO:0072376 protein activation cascade
16.09 1.47e-03 GO:0097006 regulation of plasma lipoprotein particle levels
15.14 1.55e-02 GO:0006958 complement activation, classical pathway
14.08 3.33e-03 GO:0006094 gluconeogenesis
13.90 8.32e-05 GO:0002526 acute inflammatory response
13.41 2.86e-02 GO:0002455 humoral immune response mediated by circulating immunoglobulin
12.95 1.48e-04 GO:0019217 regulation of fatty acid metabolic process

Gene overrepresentation in compartment category:

Showing 1 to 13 of 13 entries
Enrichment   P-value GO Accession GO Term
31.28 8.56e-04 GO:0042627 chylomicron
23.46 2.25e-05 GO:0034364 high-density lipoprotein particle
21.45 3.74e-07 GO:0032994 protein-lipid complex
21.45 3.74e-07 GO:0034358 plasma lipoprotein particle
18.77 7.84e-03 GO:0034361 very-low-density lipoprotein particle
18.77 7.84e-03 GO:0034385 triglyceride-rich lipoprotein particle
10.83 2.66e-03 GO:0031983 vesicle lumen
9.99 2.04e-02 GO:0031093 platelet alpha granule lumen
9.78 2.26e-02 GO:0034774 secretory granule lumen
9.39 2.75e-02 GO:0060205 cytoplasmic membrane-bounded vesicle lumen
4.16 3.03e-10 GO:0005615 extracellular space
3.30 7.23e-08 GO:0044421 extracellular region part
2.66 7.19e-10 GO:0005576 extracellular region

Gene overrepresentation in function category:

Showing 1 to 18 of 18 entries
Enrichment   P-value GO Accession GO Term
93.82 2.30e-02 GO:0008389 coumarin 7-hydroxylase activity
93.82 2.30e-02 GO:0010698 acetyltransferase activator activity
40.21 8.16e-03 GO:0031210 phosphatidylcholine binding
35.19 1.30e-02 GO:0016832 aldehyde-lyase activity
28.15 2.73e-02 GO:0050997 quaternary ammonium group binding
10.67 2.00e-02 GO:0016830 carbon-carbon lyase activity
8.46 5.68e-05 GO:0008201 heparin binding
7.04 4.16e-02 GO:0004497 monooxygenase activity
7.03 9.42e-05 GO:0005539 glycosaminoglycan binding
6.50 2.06e-04 GO:0001871 pattern binding
6.50 2.06e-04 GO:0030247 polysaccharide binding
5.24 1.65e-03 GO:0005543 phospholipid binding
5.22 3.04e-02 GO:0004252 serine-type endopeptidase activity
5.15 3.34e-02 GO:0004866 endopeptidase inhibitor activity
4.94 4.41e-02 GO:0061135 endopeptidase regulator activity
4.88 4.82e-02 GO:0030414 peptidase inhibitor activity
3.60 7.06e-03 GO:0030246 carbohydrate binding
3.16 2.93e-02 GO:0008289 lipid binding