Motif ID: HMGA1,2.p2

Z-value: 1.506


Transcription factors associated with HMGA1,2.p2:

Gene SymbolEntrez IDGene Name
HMGA1 3159 high mobility group AT-hook 1
HMGA2 8091 high mobility group AT-hook 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HMGA2hg19_v1_chr12_+_66218568_662186460.354.8e-02Click!
HMGA1hg19_v1_chr6_+_34204647_34204654-0.183.3e-01Click!


Activity profile for motif HMGA1,2.p2.

activity profile for motif HMGA1,2.p2


Sorted Z-values histogram for motif HMGA1,2.p2

Sorted Z-values for motif HMGA1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HMGA1,2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_153175918 6.189 NM_001010857
 LELP1
late cornified envelope-like proline-rich 1
chr4_-_88450243 5.350 SPARCL1
SPARC-like 1 (hevin)
chrX_+_83116153 5.272 NM_021118
 CYLC1
cylicin, basic protein of sperm head cytoskeleton 1
chr13_-_46679143 5.029 NM_001872
NM_016413
 CPB2

carboxypeptidase B2 (plasma)

chr18_-_24722757 4.594 NM_001243848
 CHST9
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9
chr4_-_69817478 4.465 NM_024743
 UGT2A3
UDP glucuronosyltransferase 2 family, polypeptide A3
chr4_+_74270832 4.459 ALB
albumin
chr11_-_102401430 4.156 NM_002423
 MMP7
matrix metallopeptidase 7 (matrilysin, uterine)
chr5_+_40909558 3.961 NM_000587
 C7
complement component 7
chrX_-_114252132 3.748 NM_000640
 IL13RA2
interleukin 13 receptor, alpha 2
chr4_+_88896801 3.722 NM_000582
NM_001040058
NM_001040060
NM_001251829
NM_001251830
 SPP1




secreted phosphoprotein 1




chr4_+_88896838 3.708 SPP1
secreted phosphoprotein 1
chr13_+_52436116 3.678 NM_031290
 CCDC70
coiled-coil domain containing 70
chr5_-_41261539 3.643 NM_001115131
 C6
complement component 6
chr2_-_21231406 3.629 APOB
apolipoprotein B (including Ag(x) antigen)
chr2_+_234590583 3.626 NM_019077
 UGT1A7
UDP glucuronosyltransferase 1 family, polypeptide A7
chr4_+_69681709 3.499 NM_001075
NM_001144767
 UGT2B10

UDP glucuronosyltransferase 2 family, polypeptide B10

chr4_+_100495972 3.473 MTTP
microsomal triglyceride transfer protein
chr3_-_165555252 3.455 NM_000055
 BCHE
butyrylcholinesterase
chr1_-_169703178 3.442 NM_000450
 SELE
selectin E

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 14 of 14 entries
Enrichment   P-value GO Accession GO Term
25.03 6.45e-05 GO:0015721 bile acid and bile salt transport
20.54 2.81e-02 GO:0006957 complement activation, alternative pathway
12.92 4.93e-03 GO:0006958 complement activation, classical pathway
12.04 1.17e-06 GO:0072376 protein activation cascade
11.45 1.03e-02 GO:0002455 humoral immune response mediated by circulating immunoglobulin
11.13 2.28e-03 GO:0006956 complement activation
10.83 1.45e-02 GO:0008206 bile acid metabolic process
4.58 8.59e-04 GO:0008202 steroid metabolic process
3.86 1.69e-03 GO:0032787 monocarboxylic acid metabolic process
2.56 1.84e-02 GO:0019752 carboxylic acid metabolic process
2.56 1.84e-02 GO:0043436 oxoacid metabolic process
2.50 2.63e-02 GO:0042180 cellular ketone metabolic process
2.50 2.70e-02 GO:0006082 organic acid metabolic process
2.41 3.69e-03 GO:0006629 lipid metabolic process

Gene overrepresentation in compartment category:

Showing 1 to 6 of 6 entries
Enrichment   P-value GO Accession GO Term
38.15 2.48e-04 GO:0005579 membrane attack complex
28.61 1.69e-02 GO:0005577 fibrinogen complex
5.92 2.60e-02 GO:0014069 postsynaptic density
3.32 1.26e-08 GO:0005615 extracellular space
2.83 1.35e-07 GO:0044421 extracellular region part
2.31 2.69e-09 GO:0005576 extracellular region

Gene overrepresentation in function category:

Showing 1 to 8 of 8 entries
Enrichment   P-value GO Accession GO Term
66.75 1.13e-05 GO:0047023 androsterone dehydrogenase activity
50.06 3.06e-03 GO:0047115 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
40.05 7.57e-03 GO:0032052 bile acid binding
13.91 5.51e-03 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
11.92 1.21e-02 GO:0015020 glucuronosyltransferase activity
11.92 1.21e-02 GO:0016229 steroid dehydrogenase activity
7.54 8.35e-03 GO:0005319 lipid transporter activity
4.48 1.79e-02 GO:0031406 carboxylic acid binding