Motif ID: HNF1A.p2

Z-value: 10.540


Transcription factors associated with HNF1A.p2:

Gene SymbolEntrez IDGene Name
HNF1A 6927 HNF1 homeobox A

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HNF1Ahg19_v1_chr12_+_121416548_1214165690.834.8e-09Click!


Activity profile for motif HNF1A.p2.

activity profile for motif HNF1A.p2


Sorted Z-values histogram for motif HNF1A.p2

Sorted Z-values for motif HNF1A.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HNF1A.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_72649734 161.545 NM_000583
 GC
group-specific component (vitamin D binding protein)
chr1_-_159684274 158.324 NM_000567
 CRP
C-reactive protein, pentraxin-related
chr4_+_74347461 145.745 NM_001133
 AFM
afamin
chr4_-_155511838 131.965 NM_000508
NM_021871
 FGA

fibrinogen alpha chain

chr4_+_155484131 129.741 NM_001184741
NM_005141
 FGB

fibrinogen beta chain

chr17_-_64225496 119.840 NM_000042
 APOH
apolipoprotein H (beta-2-glycoprotein I)
chr4_+_74269971 115.688 NM_000477
 ALB
albumin
chr1_+_159557615 106.774 NM_001639
 APCS
amyloid P component, serum
chr17_+_41052813 95.277 NM_000151
 G6PC
glucose-6-phosphatase, catalytic subunit
chr2_+_234668914 93.719 NM_000463
 UGT1A1
UDP glucuronosyltransferase 1 family, polypeptide A1
chr5_-_147211141 91.777 SPINK1
serine peptidase inhibitor, Kazal type 1
chr2_+_234601511 89.928 NM_001072
 UGT1A6
UDP glucuronosyltransferase 1 family, polypeptide A6
chr19_-_36303766 89.070 PRODH2
proline dehydrogenase (oxidase) 2
chrX_-_105282714 88.849 NM_000354
 SERPINA7
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr5_-_147211235 88.367 NM_003122
 SPINK1
serine peptidase inhibitor, Kazal type 1
chr8_-_17752847 88.288 NM_147203
NM_201553
NM_004467
NM_201552
 FGL1



fibrinogen-like 1



chr14_-_94854910 86.867 SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr6_+_161123224 86.262 NM_000301
NM_001168338
 PLG

plasminogen

chr14_-_94789641 82.717 NM_001756
 SERPINA6
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
chr14_-_94855120 81.964 NM_000295
 SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 67 entries
Enrichment   P-value GO Accession GO Term
73.11 2.40e-03 GO:0034392 negative regulation of smooth muscle cell apoptosis
54.83 9.51e-03 GO:0015712 hexose phosphate transport
54.83 9.51e-03 GO:0015760 glucose-6-phosphate transport
43.87 2.35e-02 GO:0051552 flavone metabolic process
36.56 4.66e-02 GO:0034391 regulation of smooth muscle cell apoptosis
33.23 1.88e-04 GO:0046415 urate metabolic process
32.49 3.87e-03 GO:0009812 flavonoid metabolic process
32.49 3.87e-03 GO:0051918 negative regulation of fibrinolysis
30.46 3.18e-04 GO:0051917 regulation of fibrinolysis
26.59 9.91e-03 GO:0009698 phenylpropanoid metabolic process
22.85 1.68e-03 GO:0015721 bile acid and bile salt transport
22.50 2.10e-02 GO:0030194 positive regulation of blood coagulation
21.33 2.19e-05 GO:0017144 drug metabolic process
20.89 2.91e-02 GO:0042730 fibrinolysis
19.50 3.93e-02 GO:0050820 positive regulation of coagulation
18.28 7.16e-05 GO:0030195 negative regulation of blood coagulation
17.65 9.33e-05 GO:0050819 negative regulation of coagulation
15.00 4.37e-05 GO:0030193 regulation of blood coagulation
14.27 6.63e-05 GO:0006721 terpenoid metabolic process
13.93 8.09e-05 GO:0050818 regulation of coagulation

Gene overrepresentation in compartment category:

Showing 1 to 20 of 27 entries
Enrichment   P-value GO Accession GO Term
31.33 1.35e-02 GO:0005577 fibrinogen complex
31.33 1.35e-02 GO:0046581 intercellular canaliculus
15.13 3.55e-04 GO:0031526 brush border membrane
12.66 4.99e-06 GO:0031983 vesicle lumen
12.45 3.40e-05 GO:0031093 platelet alpha granule lumen
12.19 4.04e-05 GO:0034774 secretory granule lumen
12.19 4.65e-02 GO:0034364 high-density lipoprotein particle
11.70 5.61e-05 GO:0060205 cytoplasmic membrane-bounded vesicle lumen
11.38 3.77e-04 GO:0005903 brush border
10.26 1.59e-04 GO:0031091 platelet alpha granule
8.27 2.55e-10 GO:0016324 apical plasma membrane
7.28 2.03e-10 GO:0045177 apical part of cell
5.94 8.48e-08 GO:0005792 microsome
5.74 1.50e-07 GO:0042598 vesicular fraction
3.25 1.87e-07 GO:0005624 membrane fraction
3.24 3.69e-07 GO:0005615 extracellular space
3.15 4.27e-07 GO:0005626 insoluble fraction
3.12 2.67e-05 GO:0005789 endoplasmic reticulum membrane
3.05 4.25e-05 GO:0042175 nuclear membrane-endoplasmic reticulum network
2.88 8.06e-05 GO:0044432 endoplasmic reticulum part

Gene overrepresentation in function category:

Showing 1 to 20 of 35 entries
Enrichment   P-value GO Accession GO Term
41.78 3.31e-04 GO:0005436 sodium:phosphate symporter activity
33.95 3.67e-15 GO:0015020 glucuronosyltransferase activity
29.25 7.90e-06 GO:0008514 organic anion transmembrane transporter activity
26.59 2.99e-03 GO:0001972 retinoic acid binding
22.50 6.33e-03 GO:0015114 phosphate transmembrane transporter activity
14.15 9.68e-04 GO:0015296 anion:cation symporter activity
13.00 4.30e-05 GO:0015103 inorganic anion transmembrane transporter activity
10.45 2.49e-04 GO:0033293 monocarboxylic acid binding
9.97 8.00e-03 GO:0043498 cell surface binding
9.88 4.00e-02 GO:0005504 fatty acid binding
8.68 2.26e-07 GO:0008194 UDP-glycosyltransferase activity
8.50 7.63e-05 GO:0015294 solute:cation symporter activity
7.86 1.60e-04 GO:0015081 sodium ion transmembrane transporter activity
6.75 6.33e-05 GO:0015293 symporter activity
6.73 7.12e-03 GO:0004867 serine-type endopeptidase inhibitor activity
6.47 3.26e-05 GO:0008509 anion transmembrane transporter activity
6.31 5.06e-07 GO:0015291 secondary active transmembrane transporter activity
5.97 2.40e-04 GO:0046873 metal ion transmembrane transporter activity
5.95 2.98e-05 GO:0016758 transferase activity, transferring hexosyl groups
5.63 2.57e-02 GO:0005342 organic acid transmembrane transporter activity