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• Mean activities

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• Activity deltas table
• Regulatory interactions
• Motifs sorted by significance (text)
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Motif ID: HNF4A_NR2F1,2.p2

Z-value: 4.517

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr19_+_4153593	26.167	NM_032607	CREB3L3	cAMP responsive element binding protein 3-like 3
chr10_+_96698409	23.530	NM_000771	CYP2C9	cytochrome P450, family 2, subfamily C, polypeptide 9
chr3_+_186383770	22.171	NM_000412	HRG	histidine-rich glycoprotein
chr17_+_27370155	22.155		PIPOX	pipecolic acid oxidase
chr1_+_16068916	22.083	NM_001013641	TMEM82	transmembrane protein 82
chr3_-_42917191	21.035		CYP8B1	cytochrome P450, family 8, subfamily B, polypeptide 1
chrX_+_138612894	20.264	NM_000133	F9	coagulation factor IX
chr12_-_57351381	20.012	NM_003708	RDH16	retinol dehydrogenase 16 (all-trans)
chr1_-_173886464	19.728	NM_000488	SERPINC1	serpin peptidase inhibitor, clade C (antithrombin), member 1
chr3_-_194072004	19.203	NM_001080513	CPN2	carboxypeptidase N, polypeptide 2
chr3_+_52812438	18.730	NM_001166434	ITIH1	inter-alpha-trypsin inhibitor heavy chain 1
chr1_-_173886401	18.457		SERPINC1	serpin peptidase inhibitor, clade C (antithrombin), member 1
chr16_+_56685810	17.782	NM_005947	MT1B	metallothionein 1B
chr4_+_22694547	17.119	NM_001128432 NM_020973	GBA3	glucosidase, beta, acid 3 (cytosolic)
chr14_-_94855120	17.079	NM_000295	SERPINA1	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr10_+_96522457	16.296	NM_000769	CYP2C19	cytochrome P450, family 2, subfamily C, polypeptide 19
chr15_+_85427891	16.280	NM_004213 NM_201651	SLC28A1	solute carrier family 28 (sodium-coupled nucleoside transporter), member 1
chr6_+_131148544	16.177	NM_001195597	LOC100507203	uncharacterized LOC100507203
chr17_-_34329083	15.665	NM_032965	CCL15	chemokine (C-C motif) ligand 15
chr11_-_6462129	15.065	NM_000613	HPX	hemopexin
chr1_-_161193190	14.975		APOA2	apolipoprotein A-II
chr19_-_15590203	14.252	NM_052890	PGLYRP2	peptidoglycan recognition protein 2
chr3_+_46539484	14.143	NM_031440	RTP3	receptor (chemosensory) transporter protein 3
chr11_-_116693907	13.664	NM_000482	APOA4	apolipoprotein A-IV
chr6_+_31913763	13.319		CFB	complement factor B
chrX_+_106143393	13.206	NM_001171092	CLDN2	claudin 2
chr10_+_102732285	13.194	NM_001203244 NM_017893	SEMA4G	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
chr17_-_26697224	12.794		VTN	vitronectin
chr11_-_116663106	12.783	NM_001166598 NM_052968	APOA5	apolipoprotein A-V
chr2_-_238499317	12.779		RAB17	RAB17, member RAS oncogene family
chr6_+_31913852	12.424		CFB	complement factor B
chr10_-_96829074	12.221	NM_000770 NM_001198853 NM_001198854 NM_001198855	CYP2C8	cytochrome P450, family 2, subfamily C, polypeptide 8
chr1_+_196857143	12.084	NM_001201550 NM_001201551 NM_006684	CFHR4	complement factor H-related 4
chr11_+_46740736	11.906	NM_000506	F2	coagulation factor II (thrombin)
chr11_+_46740769	11.854		F2	coagulation factor II (thrombin)
chr17_+_4675175	11.846	NM_003963	TM4SF5	transmembrane 4 L six family member 5
chr17_+_27369917	11.772	NM_016518	PIPOX	pipecolic acid oxidase
chr17_+_41052813	11.553	NM_000151	G6PC	glucose-6-phosphatase, catalytic subunit
chr1_-_161193375	11.508	NM_001643	APOA2	apolipoprotein A-II
chr2_-_238499713	11.436	NM_022449	RAB17	RAB17, member RAS oncogene family
chr1_-_230849847	11.231		AGT	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr1_-_230849863	11.160		AGT	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr5_-_39364562	11.127	NM_001737	C9	complement component 9
chrX_+_106171328	11.086		CLDN2	claudin 2
chr17_+_72439187	11.080		GPRC5C	G protein-coupled receptor, family C, group 5, member C
chr2_-_241831385	11.050	NM_024861	C2orf54	chromosome 2 open reading frame 54
chr3_-_42917632	11.048	NM_004391	CYP8B1	cytochrome P450, family 8, subfamily B, polypeptide 1
chr10_+_96443250	11.029	NM_000772 NM_001128925	CYP2C18	cytochrome P450, family 2, subfamily C, polypeptide 18
chr19_-_4540078	10.838		LRG1	leucine-rich alpha-2-glycoprotein 1
chr2_-_21266893	10.833		APOB	apolipoprotein B (including Ag(x) antigen)
chr12_+_109273856	10.736	NM_001917	DAO	D-amino-acid oxidase
chr1_-_155271186	10.622	NM_000298	PKLR	pyruvate kinase, liver and RBC
chr22_-_42526792	10.587		CYP2D6	cytochrome P450, family 2, subfamily D, polypeptide 6
chr20_-_61992516	10.564	NM_000744	CHRNA4	cholinergic receptor, nicotinic, alpha 4
chr20_+_56136136	10.344	NM_002591	PCK1	phosphoenolpyruvate carboxykinase 1 (soluble)
chr6_+_31623668	10.336	NM_019101	APOM	apolipoprotein M
chr22_-_42526877	10.335	NM_000106 NM_001025161	CYP2D6	cytochrome P450, family 2, subfamily D, polypeptide 6
chr4_-_72671236	10.269	NM_001204306	GC	group-specific component (vitamin D binding protein)
chr19_+_45445494	10.173	NM_001646	APOC4-APOC2 APOC4	APOC4-APOC2 readthrough apolipoprotein C-IV
chr1_-_120311466	10.168	NM_001166107 NM_005518	HMGCS2	3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
chr17_+_7533452	9.951	NM_001040 NM_001146279 NM_001146280 NM_001146281	SHBG	sex hormone-binding globulin
chr16_+_21245015	9.876	NM_145865	ANKS4B	ankyrin repeat and sterile alpha motif domain containing 4B
chr4_-_88243994	9.841	NM_001136230 NM_178135	HSD17B13	hydroxysteroid (17-beta) dehydrogenase 13
chr6_+_31623688	9.837		APOM	apolipoprotein M
chr1_-_169555710	9.827	NM_000130	F5	coagulation factor V (proaccelerin, labile factor)
chr1_-_169555624	9.826		F5	coagulation factor V (proaccelerin, labile factor)
chr19_-_59023323	9.810	NM_012254	SLC27A5	solute carrier family 27 (fatty acid transporter), member 5
chr2_-_21225640	9.698		APOB	apolipoprotein B (including Ag(x) antigen)
chr17_+_7531275	9.646		SHBG	sex hormone-binding globulin
chr19_+_5823817	9.616	NM_004558	NRTN	neurturin
chr2_-_88427535	9.518	NM_001443	FABP1	fatty acid binding protein 1, liver
chr7_+_137761177	9.466	NM_001190906 NM_001190907 NM_005989	AKR1D1	aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)
chr16_+_56666533	9.431	NM_176870	MT1M	metallothionein 1M
chr10_-_74714479	9.293	NM_032562	PLA2G12B	phospholipase A2, group XIIB
chr11_-_116708334	9.246	NM_000039	APOA1	apolipoprotein A-I
chr17_-_7082654	9.140	NM_001197216 NM_001671	ASGR1	asialoglycoprotein receptor 1
chr14_-_24777064	9.119
chr19_+_41497182	9.091	NM_000767	CYP2B6	cytochrome P450, family 2, subfamily B, polypeptide 6
chr19_-_51017124	9.085	NM_001114598	ASPDH	aspartate dehydrogenase domain containing
chr14_-_24777160	8.983		CIDEB	cell death-inducing DFFA-like effector b
chr14_-_94854910	8.878		SERPINA1	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr19_-_16045669	8.617	NM_001128932 NM_021187	CYP4F11	cytochrome P450, family 4, subfamily F, polypeptide 11
chr3_-_120400957	8.579		HGD	homogentisate 1,2-dioxygenase
chr9_-_104147261	8.548	NM_001701	BAAT	bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)
chr1_-_230850335	8.536	NM_000029	AGT	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr14_-_24777153	8.457		CIDEB	cell death-inducing DFFA-like effector b
chr2_+_211421322	8.438	NM_001875	CPS1	carbamoyl-phosphate synthase 1, mitochondrial
chr6_+_31982538	8.414	NM_001242823 NM_001252204 NM_007293 NM_001002029	LOC100293534 C4A C4B	complement C4-B-like complement component 4A (Rodgers blood group) complement component 4B (Chido blood group)
chr22_+_24891114	8.412	NM_016327	UPB1	ureidopropionase, beta
chr8_-_17743062	8.409		FGL1	fibrinogen-like 1
chr19_+_41594367	8.375	NM_000766	CYP2A13	cytochrome P450, family 2, subfamily A, polypeptide 13
chr3_+_186435097	8.347	NM_000893 NM_001102416 NM_001166451	KNG1	kininogen 1
chr12_-_21757752	8.218	NM_021957	GYS2	glycogen synthase 2 (liver)
chr4_+_69962191	8.200	NM_001074	UGT2B7	UDP glucuronosyltransferase 2 family, polypeptide B7
chr14_-_24777184	8.160		CIDEB	cell death-inducing DFFA-like effector b
chr6_+_31913708	8.053	NM_001710	CFB	complement factor B
chr6_+_31913920	8.020		CFB	complement factor B
chr13_+_113760101	7.957	NM_000131 NM_019616	F7	coagulation factor VII (serum prothrombin conversion accelerator)
chr2_+_27719702	7.942	NM_001486	GCKR	glucokinase (hexokinase 4) regulator
chr1_-_177939049	7.941	NM_033127	SEC16B	SEC16 homolog B (S. cerevisiae)
chr14_-_65409445	7.861	NM_002083	GPX2	glutathione peroxidase 2 (gastrointestinal)
chr19_-_39303520	7.812		LGALS4	lectin, galactoside-binding, soluble, 4
chr17_+_1646290	7.804	NM_001165920	SERPINF2	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
chr19_-_7968426	7.764
chr10_+_74653338	7.764	NM_152635	OIT3	oncoprotein induced transcript 3
chr12_-_122296619	7.751	NM_002150	HPD	4-hydroxyphenylpyruvate dioxygenase
chr10_-_129691202	7.714	NM_152311	CLRN3	clarin 3
chr22_+_25003610	7.645	NM_001032365	GGT1	gamma-glutamyltransferase 1
chr2_+_211458078	7.577	NM_001122634	CPS1	carbamoyl-phosphate synthase 1, mitochondrial
chr2_+_234601511	7.553	NM_001072	UGT1A6	UDP glucuronosyltransferase 1 family, polypeptide A6
chr17_+_19437140	7.522	NM_018242	SLC47A1	solute carrier family 47, member 1
chr1_-_151345156	7.515	NM_003944	SELENBP1	selenium binding protein 1
chr12_-_322612	7.501	NM_003044 NM_001122847	SLC6A12	solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12
chr10_-_74714563	7.420		PLA2G12B	phospholipase A2, group XIIB
chr11_+_46740759	7.409		F2	coagulation factor II (thrombin)
chr17_-_26697293	7.387		VTN	vitronectin
chr4_+_100495972	7.342		MTTP	microsomal triglyceride transfer protein
chr2_+_10091791	7.312	NM_198182	GRHL1	grainyhead-like 1 (Drosophila)
chr19_+_41497284	7.233		CYP2B6	cytochrome P450, family 2, subfamily B, polypeptide 6
chr11_+_63137260	7.228	NM_080866	SLC22A9	solute carrier family 22 (organic anion transporter), member 9
chr10_-_129691047	7.141
chr1_+_196946666	7.137	NM_030787	CFHR5	complement factor H-related 5
chrX_+_106163605	7.114	NM_020384	CLDN2	claudin 2
chr6_+_43266008	7.111		SLC22A7	solute carrier family 22 (organic anion transporter), member 7
chr13_+_113777112	7.040	NM_000504	F10	coagulation factor X
chr12_-_56756526	6.970	NM_001638	APOF	apolipoprotein F
chr1_+_171060017	6.861	NM_001002294 NM_006894	FMO3	flavin containing monooxygenase 3
chr12_+_100897137	6.835	NM_001206992 NM_001206993	NR1H4	nuclear receptor subfamily 1, group H, member 4
chr17_-_26697310	6.831		VTN	vitronectin
chr17_+_7533403	6.783		SHBG	sex hormone-binding globulin
chrX_-_105282714	6.780	NM_000354	SERPINA7	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr3_+_186330711	6.737		AHSG	alpha-2-HS-glycoprotein
chr20_-_7921068	6.730	NM_017545	HAO1	hydroxyacid oxidase (glycolate oxidase) 1
chr11_+_2924504	6.724		SLC22A18	solute carrier family 22, member 18
chr12_+_57828457	6.674	NM_005538	INHBC	inhibin, beta C
chr1_-_11107150	6.650		MASP2	mannan-binding lectin serine peptidase 2
chr6_+_31895401	6.614		C2	complement component 2
chr17_-_36105005	6.581	NM_000458 NM_001165923	HNF1B	HNF1 homeobox B
chr16_-_16317290	6.540	NM_001079528 NM_001171	ABCC6	ATP-binding cassette, sub-family C (CFTR/MRP), member 6
chr17_-_26697358	6.506	NM_000638	VTN	vitronectin
chr17_-_7018049	6.474	NM_001181 NM_001201352 NM_080912 NM_080913	ASGR2	asialoglycoprotein receptor 2
chr19_-_36304200	6.462	NM_021232	PRODH2	proline dehydrogenase (oxidase) 2
chr10_+_115310589	6.429	NM_001177660	HABP2	hyaluronan binding protein 2
chr2_+_219283809	6.376	NM_007127	VIL1	villin 1
chr17_+_1646143	6.367		SERPINF2	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
chr3_+_108855560	6.364		FLJ22763	uncharacterized LOC401081
chr1_-_155270738	6.330	NM_181871	PKLR	pyruvate kinase, liver and RBC
chr17_-_34328530	6.321		CCL14-CCL15 CCL15	CCL14-CCL15 readthrough chemokine (C-C motif) ligand 15
chr19_-_4540035	6.293	NM_052972	LRG1	leucine-rich alpha-2-glycoprotein 1
chr17_+_1646129	6.284	NM_000934 NM_001165921	SERPINF2	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
chr12_+_16500528	6.258	NM_020300 NM_145791	MGST1	microsomal glutathione S-transferase 1
chr1_-_230849936	6.160		AGT	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr22_-_30901597	6.148	NM_001161368 NM_174977	SEC14L4	SEC14-like 4 (S. cerevisiae)
chr4_-_175443791	6.115	NM_000860 NM_001145816	HPGD	hydroxyprostaglandin dehydrogenase 15-(NAD)
chr10_+_101542554	6.008		ABCC2	ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr7_-_15601574	5.967	NM_001004320	AGMO	alkylglycerol monooxygenase
chr11_-_62996998	5.962	NM_199352	SLC22A25	solute carrier family 22, member 25
chr3_-_50340979	5.941	NM_007312 NM_033159 NM_153282 NM_153283 NM_153285	HYAL1	hyaluronoglucosaminidase 1
chr2_+_219646448	5.888	NM_000784	CYP27A1	cytochrome P450, family 27, subfamily A, polypeptide 1
chr5_-_42811959	5.841	NM_001085486 NM_001093726 NM_005410	SEPP1	selenoprotein P, plasma, 1
chr7_-_100240334	5.816		TFR2	transferrin receptor 2
chr1_-_24127157	5.745	NM_001008216	GALE	UDP-galactose-4-epimerase
chr11_-_61348290	5.710	NM_001252065 NM_004200	SYT7	synaptotagmin VII
chr1_+_196788860	5.695	NM_002113	CFHR1	complement factor H-related 1
chr11_+_74870824	5.690	NM_001145211	SLCO2B1	solute carrier organic anion transporter family, member 2B1
chr7_-_99277518	5.654	NM_000777 NM_001190484	CYP3A5	cytochrome P450, family 3, subfamily A, polypeptide 5
chr1_-_24126891	5.642	NM_000403	GALE	UDP-galactose-4-epimerase
chr10_+_101542460	5.637	NM_000392	ABCC2	ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr12_+_113860146	5.613	NM_138432	SDSL	serine dehydratase-like
chr1_-_177939347	5.612		SEC16B	SEC16 homolog B (S. cerevisiae)
chr17_+_4692226	5.553	NM_001014985	GLTPD2	glycolipid transfer protein domain containing 2
chr17_-_7017971	5.492		ASGR2	asialoglycoprotein receptor 2
chr12_-_7125727	5.473	NM_005768	LPCAT3	lysophosphatidylcholine acyltransferase 3
chr16_-_87970107	5.431	NM_001739	CA5A	carbonic anhydrase VA, mitochondrial
chr6_+_31949800	5.420	NM_001242823 NM_001252204 NM_007293 NM_001002029	LOC100293534 C4A C4B	complement C4-B-like complement component 4A (Rodgers blood group) complement component 4B (Chido blood group)
chr2_+_158958381	5.402	NM_173355	UPP2	uridine phosphorylase 2
chr1_-_15911461	5.383	NM_024758	AGMAT	agmatine ureohydrolase (agmatinase)
chr4_-_175443601	5.370		HPGD	hydroxyprostaglandin dehydrogenase 15-(NAD)
chr9_+_74764266	5.368	NM_001242505 NM_001242506 NM_004293	GDA	guanine deaminase
chr5_-_41213513	5.354	NM_000065	C6	complement component 6
chr2_+_120125141	5.353	NM_001079863	DBI	diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
chr3_-_58522873	5.347	NM_003500	ACOX2	acyl-CoA oxidase 2, branched chain
chr10_-_50970321	5.331	NM_001143996 NM_001143997 NM_018245	OGDHL	oxoglutarate dehydrogenase-like
chr1_+_145727712	5.321		PDZK1	PDZ domain containing 1
chr17_-_36104874	5.313		HNF1B	HNF1 homeobox B
chr6_+_30130982	5.288	NM_033229	TRIM15	tripartite motif containing 15
chr19_+_6464259	5.284	NM_139161 NM_174881	CRB3	crumbs homolog 3 (Drosophila)
chr19_+_45116921	5.275	NM_001205280	IGSF23	immunoglobulin superfamily, member 23
chr1_+_145727665	5.264	NM_001201325 NM_001201326 NM_002614	PDZK1	PDZ domain containing 1
chr12_+_56075418	5.242		METTL7B	methyltransferase like 7B
chr17_-_34308455	5.235	NM_004590	CCL16	chemokine (C-C motif) ligand 16
chr2_-_165477818	5.211		GRB14	growth factor receptor-bound protein 14
chr2_-_31637598	5.173	NM_000379	XDH	xanthine dehydrogenase
chrX_+_38211735	5.169	NM_000531	OTC	ornithine carbamoyltransferase
chr12_+_56075329	5.129	NM_152637	METTL7B	methyltransferase like 7B
chr2_-_21266809	5.107		APOB	apolipoprotein B (including Ag(x) antigen)
chr2_-_169887832	5.094	NM_003742	ABCB11	ATP-binding cassette, sub-family B (MDR/TAP), member 11
chr10_+_135160843	5.081	NM_001145201 NM_145202	PRAP1	proline-rich acidic protein 1
chr17_-_34328607	5.072		CCL14-CCL15	CCL14-CCL15 readthrough
chrX_-_128977291	5.041	NM_001008222	ZDHHC9	zinc finger, DHHC-type containing 9

Gene overrepresentation in process category:

Enrichment	P-value	GO Accession	GO Term
3.81	1.27e-24	GO:0006082	organic acid metabolic process
2.55	2.32e-24	GO:0044281	small molecule metabolic process
3.36	1.05e-23	GO:0055114	oxidation-reduction process
3.73	2.56e-23	GO:0042180	cellular ketone metabolic process
3.72	1.17e-22	GO:0019752	carboxylic acid metabolic process
3.72	1.17e-22	GO:0043436	oxoacid metabolic process
2.87	2.62e-16	GO:0006629	lipid metabolic process
6.68	1.26e-14	GO:0006805	xenobiotic metabolic process
6.68	1.26e-14	GO:0071466	cellular response to xenobiotic stimulus
6.63	1.60e-14	GO:0009410	response to xenobiotic stimulus
3.52	1.17e-13	GO:0009308	amine metabolic process
4.25	3.48e-13	GO:0032787	monocarboxylic acid metabolic process
4.82	1.24e-12	GO:0008202	steroid metabolic process
1.40	8.22e-12	GO:0008152	metabolic process
5.81	7.07e-11	GO:0016054	organic acid catabolic process
5.81	7.07e-11	GO:0046395	carboxylic acid catabolic process
3.48	9.58e-11	GO:0044106	cellular amine metabolic process
3.69	5.29e-10	GO:0006520	cellular amino acid metabolic process
1.83	3.66e-09	GO:0042221	response to chemical stimulus
3.04	5.32e-09	GO:0044283	small molecule biosynthetic process
3.12	1.02e-08	GO:0006066	alcohol metabolic process
2.92	1.43e-08	GO:0044282	small molecule catabolic process
2.64	4.55e-08	GO:0044255	cellular lipid metabolic process
7.74	5.85e-08	GO:0072376	protein activation cascade
6.11	1.23e-07	GO:0009310	amine catabolic process
6.28	2.18e-07	GO:0009063	cellular amino acid catabolic process
22.22	2.27e-07	GO:0042737	drug catabolic process
3.93	6.17e-07	GO:0016053	organic acid biosynthetic process
3.93	6.17e-07	GO:0046394	carboxylic acid biosynthetic process
2.82	7.84e-06	GO:0071702	organic substance transport
11.57	8.48e-06	GO:0017144	drug metabolic process
3.62	1.53e-05	GO:0006631	fatty acid metabolic process
7.94	3.54e-05	GO:0006956	complement activation
3.47	3.84e-05	GO:0051186	cofactor metabolic process
11.36	6.25e-05	GO:0034367	macromolecular complex remodeling
11.36	6.25e-05	GO:0034368	protein-lipid complex remodeling
11.36	6.25e-05	GO:0034369	plasma lipoprotein particle remodeling
3.49	6.37e-05	GO:0005996	monosaccharide metabolic process
1.83	8.69e-05	GO:0009056	catabolic process
20.83	1.10e-04	GO:0042738	exogenous drug catabolic process
6.45	1.39e-04	GO:0045834	positive regulation of lipid metabolic process
3.61	2.11e-04	GO:0019318	hexose metabolic process
3.59	2.34e-04	GO:0006725	cellular aromatic compound metabolic process
4.16	2.88e-04	GO:0051346	negative regulation of hydrolase activity
2.72	2.96e-04	GO:0008610	lipid biosynthetic process
4.83	3.33e-04	GO:0010466	negative regulation of peptidase activity
9.62	3.45e-04	GO:0071825	protein-lipid complex subunit organization
9.62	3.45e-04	GO:0071827	plasma lipoprotein particle organization
11.11	4.60e-04	GO:0006699	bile acid biosynthetic process
2.26	4.81e-04	GO:0005975	carbohydrate metabolic process
7.94	5.54e-04	GO:0002455	humoral immune response mediated by circulating immunoglobulin
16.67	7.76e-04	GO:0090208	positive regulation of triglyceride metabolic process
4.54	8.19e-04	GO:0006694	steroid biosynthetic process
1.29	8.42e-04	GO:0044237	cellular metabolic process
3.88	8.63e-04	GO:0006006	glucose metabolic process
1.29	8.72e-04	GO:0044238	primary metabolic process
4.03	9.70e-04	GO:0016052	carbohydrate catabolic process
7.51	9.84e-04	GO:0008206	bile acid metabolic process
5.47	1.08e-03	GO:0055088	lipid homeostasis
3.40	1.16e-03	GO:0052547	regulation of peptidase activity
1.48	1.19e-03	GO:0006810	transport
12.15	1.29e-03	GO:0050996	positive regulation of lipid catabolic process
8.33	1.39e-03	GO:0050994	regulation of lipid catabolic process
3.47	1.44e-03	GO:0006732	coenzyme metabolic process
5.75	1.68e-03	GO:0019217	regulation of fatty acid metabolic process
8.07	1.89e-03	GO:0006958	complement activation, classical pathway
19.84	2.30e-03	GO:0010873	positive regulation of cholesterol esterification
3.37	2.34e-03	GO:0052548	regulation of endopeptidase activity
9.26	2.36e-03	GO:0042304	regulation of fatty acid biosynthetic process
2.13	2.72e-03	GO:0046483	heterocycle metabolic process
1.46	2.81e-03	GO:0051234	establishment of localization
5.47	2.97e-03	GO:0010951	negative regulation of endopeptidase activity
1.99	3.08e-03	GO:0055085	transmembrane transport
13.89	3.21e-03	GO:0034377	plasma lipoprotein particle assembly
13.89	3.21e-03	GO:0065005	protein-lipid complex assembly
3.68	3.85e-03	GO:0019216	regulation of lipid metabolic process
5.29	4.26e-03	GO:0046890	regulation of lipid biosynthetic process
4.21	4.97e-03	GO:0044275	cellular carbohydrate catabolic process
12.82	5.78e-03	GO:0090207	regulation of triglyceride metabolic process
7.14	5.82e-03	GO:0097006	regulation of plasma lipoprotein particle levels
8.23	6.47e-03	GO:0019439	aromatic compound catabolic process
5.56	6.84e-03	GO:0016064	immunoglobulin mediated immune response
5.46	8.23e-03	GO:0019724	B cell mediated immunity
1.87	8.56e-03	GO:0070887	cellular response to chemical stimulus
7.94	8.78e-03	GO:0046889	positive regulation of lipid biosynthetic process
4.52	1.04e-02	GO:0006959	humoral immune response
5.91	1.05e-02	GO:0019218	regulation of steroid metabolic process
3.43	1.07e-02	GO:0006869	lipid transport
9.26	1.12e-02	GO:0009081	branched chain family amino acid metabolic process
4.18	1.15e-02	GO:0008203	cholesterol metabolic process
1.76	1.21e-02	GO:0044248	cellular catabolic process
2.66	1.27e-02	GO:0042493	response to drug
5.79	1.29e-02	GO:0061041	regulation of wound healing
15.43	1.30e-02	GO:0010872	regulation of cholesterol esterification
15.43	1.30e-02	GO:0033700	phospholipid efflux
3.22	1.49e-02	GO:0010038	response to metal ion
6.41	1.54e-02	GO:0030193	regulation of blood coagulation
5.67	1.57e-02	GO:0019319	hexose biosynthetic process
22.22	1.57e-02	GO:0010901	regulation of very-low-density lipoprotein particle remodeling
1.38	1.58e-02	GO:0051179	localization
5.09	1.66e-02	GO:0046364	monosaccharide biosynthetic process
4.25	2.07e-02	GO:0046164	alcohol catabolic process
13.89	2.52e-02	GO:0070989	oxidative demethylation
3.89	2.72e-02	GO:0016125	sterol metabolic process
5.95	2.93e-02	GO:0050818	regulation of coagulation
2.24	2.95e-02	GO:0044262	cellular carbohydrate metabolic process
8.10	3.03e-02	GO:0045923	positive regulation of fatty acid metabolic process
4.39	3.23e-02	GO:0046165	alcohol biosynthetic process
3.45	3.26e-02	GO:0006790	sulfur compound metabolic process
3.15	3.53e-02	GO:0010876	lipid localization
9.80	3.68e-02	GO:0043691	reverse cholesterol transport
1.50	3.79e-02	GO:0065008	regulation of biological quality
18.52	4.59e-02	GO:0010898	positive regulation of triglyceride catabolic process
18.52	4.59e-02	GO:0016098	monoterpenoid metabolic process
18.52	4.59e-02	GO:0034384	high-density lipoprotein particle clearance
2.29	4.80e-02	GO:0006091	generation of precursor metabolites and energy

Gene overrepresentation in compartment category:

Enrichment	P-value	GO Accession	GO Term
4.59	1.44e-13	GO:0042598	vesicular fraction
4.63	2.52e-13	GO:0005792	microsome
1.44	1.11e-11	GO:0044444	cytoplasmic part
2.69	1.59e-11	GO:0044432	endoplasmic reticulum part
2.58	5.30e-11	GO:0005624	membrane fraction
2.31	7.21e-11	GO:0000267	cell fraction
2.53	8.65e-11	GO:0005626	insoluble fraction
3.89	1.45e-09	GO:0005759	mitochondrial matrix
2.21	3.42e-09	GO:0005783	endoplasmic reticulum
2.53	1.98e-08	GO:0044429	mitochondrial part
2.01	3.21e-08	GO:0005739	mitochondrion
2.41	3.93e-07	GO:0005789	endoplasmic reticulum membrane
1.26	4.13e-07	GO:0005737	cytoplasm
2.36	9.07e-07	GO:0042175	nuclear membrane-endoplasmic reticulum network
1.69	1.01e-06	GO:0031090	organelle membrane
12.50	2.73e-06	GO:0034361	very-low-density lipoprotein particle
12.50	2.73e-06	GO:0034385	triglyceride-rich lipoprotein particle
2.16	7.22e-06	GO:0005615	extracellular space
10.42	1.87e-05	GO:0034364	high-density lipoprotein particle
1.63	2.83e-05	GO:0005576	extracellular region
2.89	3.16e-05	GO:0005743	mitochondrial inner membrane
2.46	5.78e-05	GO:0005740	mitochondrial envelope
7.94	6.71e-05	GO:0032994	protein-lipid complex
7.94	6.71e-05	GO:0034358	plasma lipoprotein particle
2.74	6.99e-05	GO:0019866	organelle inner membrane
4.49	1.14e-04	GO:0005788	endoplasmic reticulum lumen
13.89	3.89e-04	GO:0042627	chylomicron
1.66	4.34e-04	GO:0012505	endomembrane system
1.81	9.86e-04	GO:0044421	extracellular region part
2.31	1.03e-03	GO:0031966	mitochondrial membrane
1.96	1.80e-03	GO:0031975	envelope
1.96	2.45e-03	GO:0031967	organelle envelope
3.93	2.93e-03	GO:0005777	peroxisome
3.93	2.93e-03	GO:0042579	microbody
4.81	2.12e-02	GO:0031983	vesicle lumen
13.89	2.45e-02	GO:0034366	spherical high-density lipoprotein particle

Gene overrepresentation in function category:

Enrichment	P-value	GO Accession	GO Term
3.70	1.46e-24	GO:0016491	oxidoreductase activity
5.63	1.55e-20	GO:0048037	cofactor binding
6.05	3.11e-16	GO:0050662	coenzyme binding
5.23	6.17e-12	GO:0009055	electron carrier activity
1.49	9.53e-12	GO:0003824	catalytic activity
6.60	2.27e-08	GO:0004497	monooxygenase activity
7.27	4.62e-08	GO:0050660	flavin adenine dinucleotide binding
12.73	1.03e-07	GO:0070330	aromatase activity
11.75	2.98e-07	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
3.76	9.16e-07	GO:0005506	iron ion binding
8.03	2.00e-06	GO:0019825	oxygen binding
4.46	2.05e-06	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
2.73	3.54e-06	GO:0042803	protein homodimerization activity
6.95	4.03e-06	GO:0033293	monocarboxylic acid binding
4.10	1.01e-05	GO:0031406	carboxylic acid binding
2.60	3.02e-05	GO:0008289	lipid binding
6.41	1.23e-04	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors
5.83	1.30e-04	GO:0005319	lipid transporter activity
3.81	1.55e-04	GO:0004866	endopeptidase inhibitor activity
16.67	2.01e-04	GO:0016725	oxidoreductase activity, acting on CH or CH2 groups
4.07	2.23e-04	GO:0020037	heme binding
5.56	2.32e-04	GO:0005496	steroid binding
7.51	2.55e-04	GO:0005504	fatty acid binding
2.16	2.84e-04	GO:0046983	protein dimerization activity
3.66	3.00e-04	GO:0061135	endopeptidase regulator activity
6.50	3.36e-04	GO:0051287	NAD binding
2.86	3.38e-04	GO:0004857	enzyme inhibitor activity
3.61	3.70e-04	GO:0030414	peptidase inhibitor activity
3.32	4.41e-04	GO:0061134	peptidase regulator activity
3.82	5.75e-04	GO:0046906	tetrapyrrole binding
19.84	5.98e-04	GO:0031210	phosphatidylcholine binding
3.78	1.31e-03	GO:0019842	vitamin binding
1.99	1.37e-03	GO:0042802	identical protein binding
6.95	1.95e-03	GO:0050661	NADP binding
3.83	2.13e-03	GO:0016614	oxidoreductase activity, acting on CH-OH group of donors
4.01	2.42e-03	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
1.71	3.98e-03	GO:0005215	transporter activity
22.22	4.09e-03	GO:0060228	phosphatidylcholine-sterol O-acyltransferase activator activity
8.84	4.13e-03	GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen
10.42	6.38e-03	GO:0003995	acyl-CoA dehydrogenase activity
13.89	6.55e-03	GO:0050997	quaternary ammonium group binding
5.34	7.11e-03	GO:0030170	pyridoxal phosphate binding
5.34	7.11e-03	GO:0070279	vitamin B6 binding
3.28	8.99e-03	GO:0004252	serine-type endopeptidase activity
7.78	1.06e-02	GO:0016645	oxidoreductase activity, acting on the CH-NH group of donors
3.21	1.18e-02	GO:0005539	glycosaminoglycan binding
2.94	2.26e-02	GO:0017171	serine hydrolase activity
3.50	2.34e-02	GO:0008201	heparin binding
6.95	2.37e-02	GO:0015020	glucuronosyltransferase activity
2.97	3.23e-02	GO:0001871	pattern binding
2.97	3.23e-02	GO:0030247	polysaccharide binding
7.94	3.70e-02	GO:0004364	glutathione transferase activity
4.90	3.88e-02	GO:0003707	steroid hormone receptor activity
4.81	4.55e-02	GO:0005507	copper ion binding