Motif ID: HNF4A_NR2F1,2.p2

Z-value: 4.517


Transcription factors associated with HNF4A_NR2F1,2.p2:

Gene SymbolEntrez IDGene Name
HNF4A 3172 hepatocyte nuclear factor 4, alpha
NR2F1 7025 nuclear receptor subfamily 2, group F, member 1
NR2F2 7026 nuclear receptor subfamily 2, group F, member 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HNF4Ahg19_v1_chr20_+_42984088_429840990.904.5e-12Click!
NR2F2hg19_v1_chr15_+_96876568_96876568-0.125.0e-01Click!
NR2F1hg19_v1_chr5_+_92918924_92919042-0.067.6e-01Click!


Activity profile for motif HNF4A_NR2F1,2.p2.

activity profile for motif HNF4A_NR2F1,2.p2


Sorted Z-values histogram for motif HNF4A_NR2F1,2.p2

Sorted Z-values for motif HNF4A_NR2F1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HNF4A_NR2F1,2.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_+_4153593 26.167 NM_032607
 CREB3L3
cAMP responsive element binding protein 3-like 3
chr10_+_96698409 23.530 NM_000771
 CYP2C9
cytochrome P450, family 2, subfamily C, polypeptide 9
chr3_+_186383770 22.171 NM_000412
 HRG
histidine-rich glycoprotein
chr17_+_27370155 22.155 PIPOX
pipecolic acid oxidase
chr1_+_16068916 22.083 NM_001013641
 TMEM82
transmembrane protein 82
chr3_-_42917191 21.035 CYP8B1
cytochrome P450, family 8, subfamily B, polypeptide 1
chrX_+_138612894 20.264 NM_000133
 F9
coagulation factor IX
chr12_-_57351381 20.012 NM_003708
 RDH16
retinol dehydrogenase 16 (all-trans)
chr1_-_173886464 19.728 NM_000488
 SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr3_-_194072004 19.203 NM_001080513
 CPN2
carboxypeptidase N, polypeptide 2
chr3_+_52812438 18.730 NM_001166434
 ITIH1
inter-alpha-trypsin inhibitor heavy chain 1
chr1_-_173886401 18.457 SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr16_+_56685810 17.782 NM_005947
 MT1B
metallothionein 1B
chr4_+_22694547 17.119 NM_001128432
NM_020973
 GBA3

glucosidase, beta, acid 3 (cytosolic)

chr14_-_94855120 17.079 NM_000295
 SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr10_+_96522457 16.296 NM_000769
 CYP2C19
cytochrome P450, family 2, subfamily C, polypeptide 19
chr15_+_85427891 16.280 NM_004213
NM_201651
 SLC28A1

solute carrier family 28 (sodium-coupled nucleoside transporter), member 1

chr6_+_131148544 16.177 NM_001195597
 LOC100507203
uncharacterized LOC100507203
chr17_-_34329083 15.665 NM_032965
 CCL15
chemokine (C-C motif) ligand 15
chr11_-_6462129 15.065 NM_000613
 HPX
hemopexin

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 116 entries
Enrichment   P-value GO Accession GO Term
22.22 2.27e-07 GO:0042737 drug catabolic process
22.22 1.57e-02 GO:0010901 regulation of very-low-density lipoprotein particle remodeling
20.83 1.10e-04 GO:0042738 exogenous drug catabolic process
19.84 2.30e-03 GO:0010873 positive regulation of cholesterol esterification
18.52 4.59e-02 GO:0010898 positive regulation of triglyceride catabolic process
18.52 4.59e-02 GO:0016098 monoterpenoid metabolic process
18.52 4.59e-02 GO:0034384 high-density lipoprotein particle clearance
16.67 7.76e-04 GO:0090208 positive regulation of triglyceride metabolic process
15.43 1.30e-02 GO:0010872 regulation of cholesterol esterification
15.43 1.30e-02 GO:0033700 phospholipid efflux
13.89 3.21e-03 GO:0034377 plasma lipoprotein particle assembly
13.89 3.21e-03 GO:0065005 protein-lipid complex assembly
13.89 2.52e-02 GO:0070989 oxidative demethylation
12.82 5.78e-03 GO:0090207 regulation of triglyceride metabolic process
12.15 1.29e-03 GO:0050996 positive regulation of lipid catabolic process
11.57 8.48e-06 GO:0017144 drug metabolic process
11.36 6.25e-05 GO:0034367 macromolecular complex remodeling
11.36 6.25e-05 GO:0034368 protein-lipid complex remodeling
11.36 6.25e-05 GO:0034369 plasma lipoprotein particle remodeling
11.11 4.60e-04 GO:0006699 bile acid biosynthetic process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 36 entries
Enrichment   P-value GO Accession GO Term
13.89 3.89e-04 GO:0042627 chylomicron
13.89 2.45e-02 GO:0034366 spherical high-density lipoprotein particle
12.50 2.73e-06 GO:0034361 very-low-density lipoprotein particle
12.50 2.73e-06 GO:0034385 triglyceride-rich lipoprotein particle
10.42 1.87e-05 GO:0034364 high-density lipoprotein particle
7.94 6.71e-05 GO:0032994 protein-lipid complex
7.94 6.71e-05 GO:0034358 plasma lipoprotein particle
4.81 2.12e-02 GO:0031983 vesicle lumen
4.63 2.52e-13 GO:0005792 microsome
4.59 1.44e-13 GO:0042598 vesicular fraction
4.49 1.14e-04 GO:0005788 endoplasmic reticulum lumen
3.93 2.93e-03 GO:0005777 peroxisome
3.93 2.93e-03 GO:0042579 microbody
3.89 1.45e-09 GO:0005759 mitochondrial matrix
2.89 3.16e-05 GO:0005743 mitochondrial inner membrane
2.74 6.99e-05 GO:0019866 organelle inner membrane
2.69 1.59e-11 GO:0044432 endoplasmic reticulum part
2.58 5.30e-11 GO:0005624 membrane fraction
2.53 8.65e-11 GO:0005626 insoluble fraction
2.53 1.98e-08 GO:0044429 mitochondrial part

Gene overrepresentation in function category:

Showing 1 to 20 of 54 entries
Enrichment   P-value GO Accession GO Term
22.22 4.09e-03 GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity
19.84 5.98e-04 GO:0031210 phosphatidylcholine binding
16.67 2.01e-04 GO:0016725 oxidoreductase activity, acting on CH or CH2 groups
13.89 6.55e-03 GO:0050997 quaternary ammonium group binding
12.73 1.03e-07 GO:0070330 aromatase activity
11.75 2.98e-07 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
10.42 6.38e-03 GO:0003995 acyl-CoA dehydrogenase activity
8.84 4.13e-03 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen
8.03 2.00e-06 GO:0019825 oxygen binding
7.94 3.70e-02 GO:0004364 glutathione transferase activity
7.78 1.06e-02 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors
7.51 2.55e-04 GO:0005504 fatty acid binding
7.27 4.62e-08 GO:0050660 flavin adenine dinucleotide binding
6.95 4.03e-06 GO:0033293 monocarboxylic acid binding
6.95 1.95e-03 GO:0050661 NADP binding
6.95 2.37e-02 GO:0015020 glucuronosyltransferase activity
6.60 2.27e-08 GO:0004497 monooxygenase activity
6.50 3.36e-04 GO:0051287 NAD binding
6.41 1.23e-04 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors
6.05 3.11e-16 GO:0050662 coenzyme binding