Motif ID: HOX{A4,D4}.p2

Z-value: 1.182


Transcription factors associated with HOX{A4,D4}.p2:

Gene SymbolEntrez IDGene Name
HOXA4 3201 homeobox A4
HOXD4 3233 homeobox D4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HOXD4hg19_v1_chr2_+_177016112_177016314-0.681.8e-05Click!
HOXA4hg19_v1_chr7_-_27170351_27170398-0.522.1e-03Click!


Activity profile for motif HOX{A4,D4}.p2.

activity profile for motif HOX{A4,D4}.p2


Sorted Z-values histogram for motif HOX{A4,D4}.p2

Sorted Z-values for motif HOX{A4,D4}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HOX{A4,D4}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_74269971 6.714 NM_000477
 ALB
albumin
chr8_-_17743062 4.404 FGL1
fibrinogen-like 1
chr10_+_11047339 4.360 CELF2
CUGBP, Elav-like family member 2
chr11_-_6462129 3.682 NM_000613
 HPX
hemopexin
chr4_-_72649734 3.671 NM_000583
 GC
group-specific component (vitamin D binding protein)
chr10_+_11047253 3.323 NM_001025077
 CELF2
CUGBP, Elav-like family member 2
chr10_-_92681025 3.269 NM_014391
 ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr9_-_104145800 2.917 NM_001127610
 BAAT
bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)
chr4_-_65275000 2.908 NM_001010874
 TECRL
trans-2,3-enoyl-CoA reductase-like
chr10_+_11047274 2.813 CELF2
CUGBP, Elav-like family member 2
chr4_-_44653657 2.785 NM_182592
 YIPF7
Yip1 domain family, member 7
chrX_-_131573638 2.719 NM_018388
NM_133486
 MBNL3

muscleblind-like 3 (Drosophila)

chr17_-_64225496 2.607 NM_000042
 APOH
apolipoprotein H (beta-2-glycoprotein I)
chr17_-_10421858 2.539 NM_005963
 MYH1
myosin, heavy chain 1, skeletal muscle, adult
chrX_-_19688991 2.497 NM_001184960
 SH3KBP1
SH3-domain kinase binding protein 1
chr1_+_167298280 2.382 NM_001198783
 POU2F1
POU class 2 homeobox 1
chr3_+_121312169 2.371 NM_016298
 FBXO40
F-box protein 40
chr11_-_16424391 2.341 NM_001145819
NM_017508
 SOX6

SRY (sex determining region Y)-box 6

chr22_+_21128378 2.327 NM_000185
 SERPIND1
serpin peptidase inhibitor, clade D (heparin cofactor), member 1
chr17_-_10452939 2.315 NM_001100112
NM_017534
 MYH2

myosin, heavy chain 2, skeletal muscle, adult


Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 39 entries
Enrichment   P-value GO Accession GO Term
174.10 2.23e-02 GO:0001897 cytolysis by symbiont of host cells
174.10 2.23e-02 GO:0001907 killing by symbiont of host cells
174.10 2.23e-02 GO:0019836 hemolysis by symbiont of host erythrocytes
174.10 2.23e-02 GO:0044004 disruption by symbiont of host cells
174.10 2.23e-02 GO:0044179 hemolysis in other organism
174.10 2.23e-02 GO:0051715 cytolysis in other organism
174.10 2.23e-02 GO:0051801 cytolysis in other organism involved in symbiotic interaction
174.10 2.23e-02 GO:0052025 modification by symbiont of host cell membrane
174.10 2.23e-02 GO:0052043 modification by symbiont of host cellular component
174.10 2.23e-02 GO:0052111 modification by symbiont of host structure
174.10 2.23e-02 GO:0052185 modification of structure of other organism involved in symbiotic interaction
174.10 2.23e-02 GO:0052188 modification of cellular component in other organism involved in symbiotic interaction
174.10 2.23e-02 GO:0052331 hemolysis in other organism involved in symbiotic interaction
174.10 2.23e-02 GO:0052332 modification by organism of cell membrane in other organism involved in symbiotic interaction
18.83 3.96e-02 GO:0030049 muscle filament sliding
18.83 3.96e-02 GO:0033275 actin-myosin filament sliding
18.34 4.41e-02 GO:0070252 actin-mediated cell contraction
14.28 1.76e-02 GO:0072376 protein activation cascade
9.47 6.79e-05 GO:0007517 muscle organ development
8.18 2.65e-04 GO:0002253 activation of immune response

Gene overrepresentation in compartment category:

Showing 1 to 10 of 10 entries
Enrichment   P-value GO Accession GO Term
38.70 3.28e-04 GO:0005859 muscle myosin complex
34.83 5.15e-04 GO:0016460 myosin II complex
29.03 1.57e-02 GO:0032982 myosin filament
21.77 3.81e-02 GO:0034364 high-density lipoprotein particle
15.42 1.01e-07 GO:0044449 contractile fiber part
15.02 1.31e-07 GO:0030016 myofibril
14.22 9.99e-06 GO:0030017 sarcomere
14.16 2.33e-07 GO:0043292 contractile fiber
13.61 3.65e-03 GO:0016459 myosin complex
3.28 9.49e-03 GO:0005615 extracellular space

Gene overrepresentation in function category:

Showing 1 to 1 of 1 entries
Enrichment   P-value GO Accession GO Term
16.20 1.49e-02 GO:0008307 structural constituent of muscle