Motif ID: HOX{A5,B5}.p2

Z-value: 1.554


Transcription factors associated with HOX{A5,B5}.p2:

Gene SymbolEntrez IDGene Name
HOXA5 3202 homeobox A5
HOXB5 3215 homeobox B5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HOXB5hg19_v1_chr17_-_46671043_466711580.383.1e-02Click!
HOXA5hg19_v1_chr7_-_27183225_271832860.183.2e-01Click!


Activity profile for motif HOX{A5,B5}.p2.

activity profile for motif HOX{A5,B5}.p2


Sorted Z-values histogram for motif HOX{A5,B5}.p2

Sorted Z-values for motif HOX{A5,B5}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HOX{A5,B5}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_161193190 7.981 APOA2
apolipoprotein A-II
chr1_-_161193375 7.677 NM_001643
 APOA2
apolipoprotein A-II
chr19_+_41515495 7.323 CYP2B6
cytochrome P450, family 2, subfamily B, polypeptide 6
chr12_+_50497790 7.198 NM_005276
 GPD1
glycerol-3-phosphate dehydrogenase 1 (soluble)
chr13_-_46679143 6.867 NM_001872
NM_016413
 CPB2

carboxypeptidase B2 (plasma)

chr3_-_164914448 6.440 NM_014926
 SLITRK3
SLIT and NTRK-like family, member 3
chr11_-_2018885 6.222 H19
RPS12
H19, imprinted maternally expressed transcript (non-protein coding)
ribosomal protein S12
chr7_-_99381703 6.220 NM_001202855
NM_017460
 CYP3A4

cytochrome P450, family 3, subfamily A, polypeptide 4

chr2_-_88427535 6.138 NM_001443
 FABP1
fatty acid binding protein 1, liver
chr11_-_2019007 5.822 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr10_+_104590430 5.395


chr7_+_5322553 5.068 NM_001040661
NM_153247
 SLC29A4

solute carrier family 29 (nucleoside transporters), member 4

chr12_-_9268513 5.067 A2M
alpha-2-macroglobulin
chr12_+_56075329 4.989 NM_152637
 METTL7B
methyltransferase like 7B
chr14_+_21498344 4.921 NM_173846
 TPPP2
tubulin polymerization-promoting protein family member 2
chr5_-_35048239 4.607 NM_031900
 AGXT2
alanine--glyoxylate aminotransferase 2
chr12_-_91572328 4.536 NM_133504
NM_133505
NM_133506
NM_133507
 DCN



decorin



chr20_+_42984088 4.535 HNF4A
hepatocyte nuclear factor 4, alpha
chr2_+_234601511 4.490 NM_001072
 UGT1A6
UDP glucuronosyltransferase 1 family, polypeptide A6
chr16_-_71610948 4.479 NM_000353
 TAT
tyrosine aminotransferase

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 4 of 4 entries
Enrichment   P-value GO Accession GO Term
8.69 2.72e-06 GO:0006805 xenobiotic metabolic process
8.69 2.72e-06 GO:0071466 cellular response to xenobiotic stimulus
8.63 2.98e-06 GO:0009410 response to xenobiotic stimulus
2.63 1.21e-02 GO:0009611 response to wounding

Gene overrepresentation in compartment category:

Showing 1 to 9 of 9 entries
Enrichment   P-value GO Accession GO Term
9.46 2.81e-02 GO:0031093 platelet alpha granule lumen
9.26 3.11e-02 GO:0034774 secretory granule lumen
8.89 3.78e-02 GO:0060205 cytoplasmic membrane-bounded vesicle lumen
8.55 4.55e-02 GO:0031983 vesicle lumen
4.18 1.09e-02 GO:0005792 microsome
4.05 1.48e-02 GO:0042598 vesicular fraction
2.99 1.51e-04 GO:0005615 extracellular space
2.76 5.98e-05 GO:0044421 extracellular region part
2.33 8.96e-07 GO:0005576 extracellular region

Gene overrepresentation in function category:

Showing 1 to 15 of 15 entries
Enrichment   P-value GO Accession GO Term
88.88 2.63e-02 GO:0004854 xanthine dehydrogenase activity
88.88 2.63e-02 GO:0016726 oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor
35.56 6.40e-04 GO:0016725 oxidoreductase activity, acting on CH or CH2 groups
29.63 2.33e-02 GO:0004022 alcohol dehydrogenase (NAD) activity
22.23 5.26e-03 GO:0008395 steroid hydroxylase activity
20.21 7.95e-04 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen
13.68 3.96e-02 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
11.86 2.18e-03 GO:0019825 oxygen binding
8.89 6.57e-04 GO:0004497 monooxygenase activity
7.48 6.76e-04 GO:0019838 growth factor binding
6.51 2.13e-03 GO:0020037 heme binding
6.28 1.02e-04 GO:0009055 electron carrier activity
6.11 3.54e-03 GO:0046906 tetrapyrrole binding
5.20 3.29e-02 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
4.73 4.69e-03 GO:0005506 iron ion binding