Motif ID: HOX{A6,A7,B6,B7}.p2

Z-value: 4.212


Transcription factors associated with HOX{A6,A7,B6,B7}.p2:

Gene SymbolEntrez IDGene Name
HOXA6 3203 homeobox A6
HOXA7 3204 homeobox A7
HOXB6 3216 homeobox B6
HOXB7 3217 homeobox B7

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HOXA6hg19_v1_chr7_-_27187367_271873920.318.4e-02Click!
HOXB7hg19_v1_chr17_-_46688362_466883820.271.3e-01Click!
HOXA7hg19_v1_chr7_-_27196163_271963280.232.0e-01Click!
HOXB6hg19_v1_chr17_-_46682333_466823560.232.1e-01Click!


Activity profile for motif HOX{A6,A7,B6,B7}.p2.

activity profile for motif HOX{A6,A7,B6,B7}.p2


Sorted Z-values histogram for motif HOX{A6,A7,B6,B7}.p2

Sorted Z-values for motif HOX{A6,A7,B6,B7}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HOX{A6,A7,B6,B7}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_+_7382750 33.879 NM_145891
NM_145892
NM_145893
 RBFOX1


RNA binding protein, fox-1 homolog (C. elegans) 1


chr12_-_16760935 27.938 NM_001001395
NM_001243609
 LMO3

LIM domain only 3 (rhombotin-like 2)

chr5_+_71502700 24.951 MAP1B
microtubule-associated protein 1B
chr9_-_14086901 22.637 NFIB
nuclear factor I/B
chr12_-_87232635 20.389 NM_013244
 MGAT4C
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr3_+_159557745 20.177 SCHIP1
schwannomin interacting protein 1
chr1_-_217113007 19.395 NM_001243512
NM_001243513
NM_001243510
NM_001243511
 ESRRG



estrogen-related receptor gamma



chr1_-_217250230 18.910 NM_001243507
NM_001243509
 ESRRG

estrogen-related receptor gamma

chr3_+_127641901 18.183 NM_207335
 KBTBD12
kelch repeat and BTB (POZ) domain containing 12
chr9_-_95186559 18.053 NM_005014
 OMD
osteomodulin
chr2_+_170366211 17.810 NM_006063
 KBTBD10
kelch repeat and BTB (POZ) domain containing 10
chr2_-_183387063 17.749 NM_005019
NM_001003683
 PDE1A

phosphodiesterase 1A, calmodulin-dependent

chr18_-_40857245 16.919 NM_020783
 SYT4
synaptotagmin IV
chr3_+_35721115 16.334 NM_001025068
NM_001025069
 ARPP21

cAMP-regulated phosphoprotein, 21kDa

chr3_+_159557649 16.103 NM_001197109
 SCHIP1
schwannomin interacting protein 1
chr12_+_41831484 16.012 NM_013377
 PDZRN4
PDZ domain containing ring finger 4
chr7_-_107880492 15.964 NM_001037132
 NRCAM
neuronal cell adhesion molecule
chr6_-_123957941 15.941 NM_001251987
NM_006073
 TRDN

triadin

chrX_+_102585113 15.915 NM_152278
 TCEAL7
transcription elongation factor A (SII)-like 7
chr3_+_158787040 15.629 NM_001197113
NM_001197114
NM_001042705
NM_001042706
NM_001197100
 IQCJ-SCHIP1

IQCJ


IQCJ-SCHIP1 readthrough

IQ motif containing J



Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 98 entries
Enrichment   P-value GO Accession GO Term
9.14 1.41e-03 GO:0007026 negative regulation of microtubule depolymerization
8.60 2.53e-03 GO:0031114 regulation of microtubule depolymerization
7.62 4.64e-04 GO:0016339 calcium-dependent cell-cell adhesion
6.70 4.22e-24 GO:0007156 homophilic cell adhesion
6.36 3.80e-02 GO:0031111 negative regulation of microtubule polymerization or depolymerization
5.71 1.02e-02 GO:0007416 synapse assembly
5.62 1.93e-05 GO:0050808 synapse organization
5.31 6.54e-06 GO:0007519 skeletal muscle tissue development
4.99 1.97e-05 GO:0060538 skeletal muscle organ development
4.41 4.35e-03 GO:0048704 embryonic skeletal system morphogenesis
4.17 4.02e-04 GO:0048706 embryonic skeletal system development
4.13 3.84e-19 GO:0016337 cell-cell adhesion
3.58 4.10e-08 GO:0007517 muscle organ development
3.56 1.88e-04 GO:0014706 striated muscle tissue development
3.55 8.12e-06 GO:0043062 extracellular structure organization
3.54 5.89e-05 GO:0060537 muscle tissue development
3.51 1.34e-04 GO:0048705 skeletal system morphogenesis
3.45 1.84e-04 GO:0001503 ossification
3.45 2.20e-03 GO:0072001 renal system development
3.13 1.21e-03 GO:0001655 urogenital system development

Gene overrepresentation in compartment category:

Showing 1 to 20 of 38 entries
Enrichment   P-value GO Accession GO Term
10.15 1.68e-02 GO:0031143 pseudopodium
7.31 2.86e-02 GO:0034706 sodium channel complex
7.11 8.92e-03 GO:0005859 muscle myosin complex
7.11 8.92e-03 GO:0032982 myosin filament
6.40 1.97e-02 GO:0016460 myosin II complex
5.36 7.91e-14 GO:0030016 myofibril
5.20 8.00e-14 GO:0043292 contractile fiber
5.01 1.25e-11 GO:0044449 contractile fiber part
4.85 3.32e-09 GO:0030017 sarcomere
4.17 6.45e-05 GO:0014069 postsynaptic density
4.08 1.09e-09 GO:0045211 postsynaptic membrane
4.06 4.24e-02 GO:0030666 endocytic vesicle membrane
3.20 2.83e-15 GO:0045202 synapse
3.07 3.80e-03 GO:0044420 extracellular matrix part
3.05 1.42e-09 GO:0044456 synapse part
2.84 4.66e-03 GO:0034703 cation channel complex
2.75 1.43e-07 GO:0005578 proteinaceous extracellular matrix
2.64 3.81e-04 GO:0034702 ion channel complex
2.58 5.05e-08 GO:0043005 neuron projection
2.58 1.54e-07 GO:0031012 extracellular matrix

Gene overrepresentation in function category:

Showing 1 to 20 of 25 entries
Enrichment   P-value GO Accession GO Term
7.83 2.61e-02 GO:0005248 voltage-gated sodium channel activity
5.53 1.40e-04 GO:0008307 structural constituent of muscle
2.96 1.54e-02 GO:0008201 heparin binding
2.93 7.02e-03 GO:0015276 ligand-gated ion channel activity
2.93 7.02e-03 GO:0022834 ligand-gated channel activity
2.85 1.43e-08 GO:0003779 actin binding
2.76 2.88e-03 GO:0001871 pattern binding
2.76 2.88e-03 GO:0030247 polysaccharide binding
2.74 7.97e-03 GO:0008509 anion transmembrane transporter activity
2.65 4.29e-15 GO:0005509 calcium ion binding
2.61 2.49e-02 GO:0005539 glycosaminoglycan binding
2.37 2.51e-04 GO:0022836 gated channel activity
2.34 4.57e-08 GO:0008092 cytoskeletal protein binding
2.34 7.13e-06 GO:0015267 channel activity
2.33 7.75e-06 GO:0022803 passive transmembrane transporter activity
2.27 4.84e-05 GO:0022838 substrate-specific channel activity
2.21 1.96e-04 GO:0005216 ion channel activity
2.15 2.54e-02 GO:0005261 cation channel activity
1.88 3.02e-04 GO:0043565 sequence-specific DNA binding
1.81 4.94e-04 GO:0015075 ion transmembrane transporter activity