Motif ID: HSF1,2.p2

Z-value: 1.872


Transcription factors associated with HSF1,2.p2:

Gene SymbolEntrez IDGene Name
HSF1 3297 heat shock transcription factor 1
HSF2 3298 heat shock transcription factor 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HSF2hg19_v1_chr6_+_122720685_1227207060.144.6e-01Click!
HSF1hg19_v1_chr8_+_145515285_1455152860.115.4e-01Click!


Activity profile for motif HSF1,2.p2.

activity profile for motif HSF1,2.p2


Sorted Z-values histogram for motif HSF1,2.p2

Sorted Z-values for motif HSF1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HSF1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_-_42947050 4.466 NM_198477
CXCL17
chemokine (C-X-C motif) ligand 17
chr11_-_119294242 4.317 NM_006288
THY1
Thy-1 cell surface antigen
chr5_-_112770537 4.098 NM_032028
TSSK1B
testis-specific serine kinase 1B
chr5_-_110062365 3.995 NM_001039763
TMEM232
transmembrane protein 232
chr1_+_109648593 3.980


chr4_-_159956332 3.447 NM_152543
C4orf45
chromosome 4 open reading frame 45
chr12_+_107078476 3.446 NM_032491
RFX4
regulatory factor X, 4 (influences HLA class II expression)
chr10_+_122216465 3.301 NM_001030059
PPAPDC1A
phosphatidic acid phosphatase type 2 domain containing 1A
chr6_+_159309618 3.211 NM_001195032
C6orf99
chromosome 6 open reading frame 99
chr17_+_9745847 3.175 GLP2R
glucagon-like peptide 2 receptor
chr18_+_29171729 3.164 NM_000371
TTR
transthyretin
chr19_-_14629227 2.956 DNAJB1
DnaJ (Hsp40) homolog, subfamily B, member 1
chr3_-_165555167 2.934 BCHE
butyrylcholinesterase
chr3_+_45067750 2.933 NM_003278
CLEC3B
C-type lectin domain family 3, member B
chr13_+_53602829 2.875 NM_006418
OLFM4
olfactomedin 4
chr6_+_151646634 2.844 NM_144497
AKAP12
A kinase (PRKA) anchor protein 12
chr19_+_6135650 2.806 NM_030924
ACSBG2
acyl-CoA synthetase bubblegum family member 2
chr7_-_120498128 2.791 NM_012338
TSPAN12
tetraspanin 12
chr19_-_14629235 2.752


chr19_-_14629160 2.683 NM_006145
DNAJB1
DnaJ (Hsp40) homolog, subfamily B, member 1
chrY_-_20935503 2.681 NM_001001877
NM_153716
NM_152584
NM_033108
HSFY2

HSFY1

heat shock transcription factor, Y linked 2

heat shock transcription factor, Y-linked 1

chr8_-_26371387 2.648 NM_007257
PNMA2
paraneoplastic antigen MA2
chr17_-_46035109 2.619 NM_024320
PRR15L
proline rich 15-like
chr2_-_217724781 2.595 NM_003284
TNP1
transition protein 1 (during histone to protamine replacement)
chr20_+_18794369 2.561 NM_178483
C20orf79
chromosome 20 open reading frame 79
chr1_+_233749749 2.543 NM_002245
KCNK1
potassium channel, subfamily K, member 1
chr3_-_42452022 2.527 NM_144634
LYZL4
lysozyme-like 4
chr3_-_165555252 2.490 NM_000055
BCHE
butyrylcholinesterase
chr11_+_34654010 2.452 NM_001206616
EHF
ets homologous factor
chr20_+_31870940 2.429 NM_033197
BPIFB1
BPI fold containing family B, member 1
chr19_+_15218141 2.408 NM_033025
SYDE1
synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
chr17_-_60884010 2.357 NM_001100875
MARCH10
membrane-associated ring finger (C3HC4) 10
chr10_+_115511212 2.340 NM_001193434
NM_001193435
NM_024889
C10orf81


chromosome 10 open reading frame 81


chrX_+_134847184 2.332 NM_001017417
CT45A3
CT45A1
cancer/testis antigen family 45, member A3
cancer/testis antigen family 45, member A1
chr7_-_99573637 2.304 NM_001185
AZGP1
alpha-2-glycoprotein 1, zinc-binding
chr10_+_95848811 2.280 NM_001165979
PLCE1
phospholipase C, epsilon 1
chr5_-_135290521 2.273 NM_002302
LECT2
leukocyte cell-derived chemotaxin 2
chr2_+_26915390 2.268 NM_002246
KCNK3
potassium channel, subfamily K, member 3
chr14_-_65409445 2.243 NM_002083
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr9_+_841689 2.235 NM_021951
DMRT1
doublesex and mab-3 related transcription factor 1
chr20_+_55904814 2.214 NM_012444
NM_198265
SPO11

SPO11 meiotic protein covalently bound to DSB homolog (S. cerevisiae)

chr1_-_182369750 2.212 NM_172000
TEDDM1
transmembrane epididymal protein 1
chr15_+_38227456 2.193 NM_152453
TMCO5A
transmembrane and coiled-coil domains 5A
chr11_+_101918168 2.164 NM_001195005
NM_032930
C11orf70

chromosome 11 open reading frame 70

chr17_-_46703613 2.161 NM_024017
HOXB9
homeobox B9
chr2_-_224903324 2.135 NM_001136530
SERPINE2
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
chr8_+_24774587 2.123 NEFM
neurofilament, medium polypeptide
chr4_-_152147520 2.122 NM_001009555
NM_001128923
SH3D19

SH3 domain containing 19

chr17_-_39661803 2.086 NM_002274
NM_153490
KRT13

keratin 13

chr3_-_19975671 2.078 NM_144715
EFHB
EF-hand domain family, member B
chr7_+_134464372 2.072 CALD1
caldesmon 1
chr7_+_134464161 2.070 NM_004342
NM_033138
NM_033157
CALD1


caldesmon 1


chr9_-_34710062 2.035 NM_002989
CCL21
chemokine (C-C motif) ligand 21
chr11_+_27062508 2.023 NM_003986
BBOX1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr11_+_64323089 2.009 NM_018484
SLC22A11
solute carrier family 22 (organic anion/urate transporter), member 11
chr7_+_134464417 1.981 CALD1
caldesmon 1
chr9_+_91926109 1.975 NM_001827
CKS2
CDC28 protein kinase regulatory subunit 2
chr3_+_46539484 1.965 NM_031440
RTP3
receptor (chemosensory) transporter protein 3
chr5_-_92916924 1.940 FLJ42709
uncharacterized LOC441094
chr4_-_101439071 1.920 NM_001159694
NM_016242
EMCN

endomucin

chr14_+_63671101 1.905 NM_020663
RHOJ
ras homolog gene family, member J
chr4_-_16077740 1.870 NM_001145849
NM_001145850
NM_001145851
NM_001145852
NM_006017
PROM1




prominin 1




chr1_+_192544856 1.869 NM_002922
RGS1
regulator of G-protein signaling 1
chr3_-_112359962 1.868 NM_199511
NM_199512
CCDC80

coiled-coil domain containing 80

chr20_-_44259906 1.843 NM_147198
WFDC9
WAP four-disulfide core domain 9
chr3_-_42917191 1.835 CYP8B1
cytochrome P450, family 8, subfamily B, polypeptide 1
chr1_-_173638970 1.822 NM_198493
ANKRD45
ankyrin repeat domain 45
chr5_-_41071404 1.815 NM_173489
HEATR7B2
HEAT repeat family member 7B2
chr9_-_95186559 1.806 NM_005014
OMD
osteomodulin
chr17_-_56494930 1.806 NM_017763
RNF43
ring finger protein 43
chr9_-_91793681 1.805 NM_016848
SHC3
SHC (Src homology 2 domain containing) transforming protein 3
chr1_+_2938045 1.800 NM_080431
ACTRT2
actin-related protein T2
chr12_+_119772516 1.793 NM_178499
CCDC60
coiled-coil domain containing 60
chr19_-_49250023 1.786 NM_182575
IZUMO1
izumo sperm-egg fusion 1
chrX_-_102531673 1.777 NM_001012979
TCEAL5
transcription elongation factor A (SII)-like 5
chr3_+_96533424 1.766 NM_001080448
EPHA6
EPH receptor A6
chr2_+_202671197 1.764 NM_139158
CDK15
cyclin-dependent kinase 15
chr19_-_55866063 1.754 NM_144613
COX6B2
cytochrome c oxidase subunit VIb polypeptide 2 (testis)
chr7_-_100061893 1.735 NM_001004323
C7orf61
chromosome 7 open reading frame 61
chr1_+_12806162 1.733 NM_152290
C1orf158
chromosome 1 open reading frame 158
chr1_+_20396652 1.728 NM_000929
PLA2G5
phospholipase A2, group V
chr18_-_47376156 1.720 MYO5B
myosin VB
chr3_-_112359863 1.716 CCDC80
coiled-coil domain containing 80
chr6_+_31913708 1.715 NM_001710
CFB
complement factor B
chr1_-_168698412 1.711 NM_001937
DPT
dermatopontin
chr7_-_150038689 1.710 NM_002889
RARRES2
retinoic acid receptor responder (tazarotene induced) 2
chr9_-_95298251 1.710 NM_001197295
NM_001197296
NM_001393
ECM2


extracellular matrix protein 2, female organ and adipocyte specific


chr12_-_49488570 1.707 NM_021044
DHH
desert hedgehog
chr9_+_36169384 1.687 NM_005893
CCIN
calicin
chr1_-_205391180 1.665 NM_001001552
NM_001199050
NM_001199051
NM_001199052
LEMD1



LEM domain containing 1



chr9_-_91793375 1.654 SHC3
SHC (Src homology 2 domain containing) transforming protein 3
chr7_+_97361270 1.646 NM_003182
NM_013996
NM_013997
NM_013998
TAC1



tachykinin, precursor 1



chrY_+_20708556 1.621 NM_153716
NM_001001877
NM_033108
NM_152584
HSFY2

HSFY1

heat shock transcription factor, Y linked 2

heat shock transcription factor, Y-linked 1

chr2_-_113542970 1.607 NM_000575
IL1A
interleukin 1, alpha
chr17_-_74137370 1.605 NM_001454
FOXJ1
forkhead box J1
chr2_+_210444364 1.588 NM_002374
NM_031845
NM_031847
MAP2


microtubule-associated protein 2


chr13_-_46679143 1.587 NM_001872
NM_016413
CPB2

carboxypeptidase B2 (plasma)

chr19_+_51358170 1.583 NM_001030047
NM_001030048
NM_001030050
NM_001648
KLK3



kallikrein-related peptidase 3



chr11_-_101454658 1.554 NM_004621
TRPC6
transient receptor potential cation channel, subfamily C, member 6
chr3_-_123411185 1.544 MYLK
myosin light chain kinase
chr11_+_7506599 1.541 NM_198474
OLFML1
olfactomedin-like 1
chr2_+_69240137 1.537 NM_018153
NM_032208
NM_053034
ANTXR1


anthrax toxin receptor 1


chr1_+_92683572 1.535 NM_001012425
C1orf146
chromosome 1 open reading frame 146
chr2_-_217560247 1.533 NM_000599
IGFBP5
insulin-like growth factor binding protein 5
chr6_-_39895317 1.528 NM_005943
MOCS1
molybdenum cofactor synthesis 1
chr2_+_26624776 1.524 NM_145038
CCDC164
coiled-coil domain containing 164
chr4_+_22694547 1.523 NM_001128432
NM_020973
GBA3

glucosidase, beta, acid 3 (cytosolic)

chr4_+_41258941 1.497 UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr14_-_21058880 1.489 NM_001024822
RNASE12
ribonuclease, RNase A family, 12 (non-active)
chrX_+_51075667 1.478 NUDT10
nudix (nucleoside diphosphate linked moiety X)-type motif 10
chr20_+_31805118 1.466 NM_001042439
NM_178466
BPIFA3

BPI fold containing family A, member 3

chr9_+_111624545 1.465 NM_006687
ACTL7A
actin-like 7A
chr16_-_31146992 1.463 PRSS8
protease, serine, 8
chr16_+_71392615 1.461 NM_001740
NM_007088
CALB2

calbindin 2

chrX_-_100129127 1.455 NM_007052
NM_013955
NOX1

NADPH oxidase 1

chr6_+_44126547 1.447 NM_007058
CAPN11
calpain 11
chr8_+_7353367 1.446 NM_001037668
NM_001040705
DEFB107A
DEFB107B
defensin, beta 107A
defensin, beta 107B
chr1_-_20141593 1.442 NM_019062
RNF186
ring finger protein 186
chr4_+_77356252 1.440 NM_020859
SHROOM3
shroom family member 3
chr1_+_53925071 1.438 NM_033067
DMRTB1
DMRT-like family B with proline-rich C-terminal, 1
chr4_-_155533882 1.430 NM_000509
NM_021870
FGG

fibrinogen gamma chain

chr6_+_31913920 1.424 CFB
complement factor B
chr17_+_8243187 1.415 NM_153007
ODF4
outer dense fiber of sperm tails 4
chr15_+_96869156 1.411 NM_001145155
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr11_-_66488712 1.411 NM_006946
SPTBN2
spectrin, beta, non-erythrocytic 2
chr6_+_31913852 1.409 CFB
complement factor B
chr19_+_35606731 1.407 NM_001136007
NM_001136008
NM_001136009
NM_001136010
NM_001136011
NM_001136012
NM_005971
NM_021910
FXYD3







FXYD domain containing ion transport regulator 3







chr11_+_12695851 1.397 NM_021961
TEAD1
TEA domain family member 1 (SV40 transcriptional enhancer factor)
chr1_+_150480486 1.393 NM_001202858
NM_004425
NM_022664
ECM1


extracellular matrix protein 1


chr7_+_129984629 1.392 NM_001127441
NM_001127442
NM_080385
CPA5


carboxypeptidase A5


chr2_-_75788079 1.386 NM_001135032
FAM176A
family with sequence similarity 176, member A
chr1_+_150480584 1.382 ECM1
extracellular matrix protein 1
chrX_+_106163605 1.370 NM_020384
CLDN2
claudin 2
chr15_+_74466887 1.364 NM_201526
ISLR
immunoglobulin superfamily containing leucine-rich repeat
chr7_-_80548666 1.358 NM_006379
SEMA3C
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr1_+_114522029 1.356 NM_020190
OLFML3
olfactomedin-like 3
chr10_-_69597768 1.353 NM_021800
NM_201262
DNAJC12

DnaJ (Hsp40) homolog, subfamily C, member 12

chr4_-_164394885 1.350 NM_032136
TKTL2
transketolase-like 2
chr11_+_1855673 1.345 NM_138567
SYT8
synaptotagmin VIII
chr9_-_27297106 1.342 NM_001161585
NM_020641
C9orf11

chromosome 9 open reading frame 11

chr4_-_155533757 1.342 FGG
fibrinogen gamma chain
chr3_-_185270258 1.335 NM_139248
LIPH
lipase, member H
chr22_+_21128378 1.332 NM_000185
SERPIND1
serpin peptidase inhibitor, clade D (heparin cofactor), member 1
chr8_-_37797646 1.331 NM_152413
GOT1L1
glutamic-oxaloacetic transaminase 1-like 1
chr17_+_68071386 1.329 NM_018658
NM_170741
KCNJ16

potassium inwardly-rectifying channel, subfamily J, member 16

chr4_+_25658085 1.322 NM_001177999
SLC34A2
solute carrier family 34 (sodium phosphate), member 2
chr2_+_198365113 1.319 HSPE1
heat shock 10kDa protein 1 (chaperonin 10)
chr16_-_31147062 1.313 NM_002773
PRSS8
protease, serine, 8
chr6_+_31913763 1.309 CFB
complement factor B
chr20_+_42187705 1.308 SGK2
serum/glucocorticoid regulated kinase 2
chr6_+_31683084 1.298 NM_021246
LY6G6D
lymphocyte antigen 6 complex, locus G6D
chr4_-_41750936 1.292 NM_003924
PHOX2B
paired-like homeobox 2b
chr6_-_46620229 1.285 NM_016593
CYP39A1
cytochrome P450, family 39, subfamily A, polypeptide 1
chr14_+_24540742 1.285 NM_006032
CPNE6
copine VI (neuronal)
chr15_+_90234027 1.280 NM_020212
WDR93
WD repeat domain 93
chr6_+_31082526 1.280 NM_014068
PSORS1C1
psoriasis susceptibility 1 candidate 1
chr8_-_68658577 1.278 NM_020361
CPA6
carboxypeptidase A6
chr10_+_101088794 1.275 NM_020348
CNNM1
cyclin M1
chrX_-_80457440 1.275 NM_030763
HMGN5
high mobility group nucleosome binding domain 5
chr3_+_142375738 1.274 NM_001172312
PLS1
plastin 1
chr4_-_155533850 1.267 FGG
fibrinogen gamma chain
chrX_+_48114796 1.265 NM_005635
SSX1
synovial sarcoma, X breakpoint 1
chr18_+_31319154 1.262 ASXL3
additional sex combs like 3 (Drosophila)
chr7_-_14880954 1.259 NM_004080
NM_145695
DGKB

diacylglycerol kinase, beta 90kDa

chr12_+_119616594 1.257 NM_014365
HSPB8
heat shock 22kDa protein 8
chr6_+_129204285 1.256 NM_000426
NM_001079823
LAMA2

laminin, alpha 2

chr21_-_43786602 1.251 NM_003225
TFF1
trefoil factor 1
chr18_-_73139588 1.249 NM_001037331
C18orf62
chromosome 18 open reading frame 62
chr4_-_155533800 1.248 FGG
fibrinogen gamma chain
chrX_-_2882288 1.246 NM_000047
ARSE
arylsulfatase E (chondrodysplasia punctata 1)
chr5_-_159739482 1.243 NM_024565
CCNJL
cyclin J-like
chr5_+_147443534 1.243 NM_001127698
NM_001127699
NM_006846
SPINK5


serine peptidase inhibitor, Kazal type 5


chr18_-_64271215 1.242 NM_021153
CDH19
cadherin 19, type 2
chr16_+_71392637 1.242 CALB2
calbindin 2
chr6_+_31783280 1.219 NM_005345
HSPA1A
heat shock 70kDa protein 1A
chr7_+_30960914 1.216 NM_001185060
NM_001185061
NM_001185062
AQP1


aquaporin 1 (Colton blood group)


chr2_+_234627423 1.209 NM_007120
UGT1A4
UDP glucuronosyltransferase 1 family, polypeptide A4
chrY_+_6114263 1.206 NM_022573
TSPY2
TSPY1
testis specific protein, Y-linked 2
testis specific protein, Y-linked 1
chr8_-_124219926 1.202


chr2_-_75788027 1.196 FAM176A
family with sequence similarity 176, member A
chr16_+_226678 1.196 NM_000558
HBA1
HBA2
hemoglobin, alpha 1
hemoglobin, alpha 2
chr5_+_68800003 1.188 NM_001205255
OCLN
occludin
chr1_+_233749917 1.187 KCNK1
potassium channel, subfamily K, member 1
chr13_+_46276445 1.176 NM_152719
SPERT
spermatid associated
chr4_+_41258909 1.164 UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr5_+_55062712 1.145 NM_001166534
DDX4
DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
chr2_+_234601511 1.143 NM_001072
UGT1A6
UDP glucuronosyltransferase 1 family, polypeptide A6
chr5_-_146833150 1.142 NM_001387
DPYSL3
dihydropyrimidinase-like 3
chr15_+_72690653 1.141 NM_001080462
TMEM202
transmembrane protein 202
chr11_-_26593667 1.140 NM_001135091
NM_001135092
NM_145650
MUC15


mucin 15, cell surface associated


chr4_+_93225549 1.137 NM_001510
GRID2
glutamate receptor, ionotropic, delta 2
chr11_-_102714240 1.130 NM_002422
MMP3
matrix metallopeptidase 3 (stromelysin 1, progelatinase)
chr6_+_97010423 1.129 NM_001170807
NM_020482
FHL5

four and a half LIM domains 5

chr3_+_39509069 1.128 NM_182935
MOBP
myelin-associated oligodendrocyte basic protein
chr4_+_76481257 1.126 NM_001206981
NM_178497
C4orf26

chromosome 4 open reading frame 26

chr4_+_71263598 1.123 NM_021225
PROL1
proline rich, lacrimal 1
chr2_-_188419185 1.123 NM_001032281
NM_006287
TFPI

tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)

chrX_+_134883487 1.123 NM_001017435
CT45A3
cancer/testis antigen family 45, member A3
chr1_-_228613025 1.122 NM_003493
HIST3H3
histone cluster 3, H3
chr2_+_219824346 1.122 NM_003936
CDK5R2
cyclin-dependent kinase 5, regulatory subunit 2 (p39)

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
1.73 1.34e-03 GO:0007275 multicellular organismal development
1.63 7.47e-03 GO:0032502 developmental process
1.88 8.72e-03 GO:0042221 response to chemical stimulus
14.64 1.35e-02 GO:0071804 cellular potassium ion transport
14.64 1.35e-02 GO:0071805 potassium ion transmembrane transport
1.70 2.93e-02 GO:0048731 system development

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
2.72 6.54e-12 GO:0005576 extracellular region
3.42 8.74e-10 GO:0044421 extracellular region part
3.19 5.58e-06 GO:0005615 extracellular space
3.77 7.36e-04 GO:0031012 extracellular matrix
3.89 2.06e-03 GO:0005578 proteinaceous extracellular matrix

Nothing significant found in function category.