Motif ID: IKZF1.p2

Z-value: 1.235


Transcription factors associated with IKZF1.p2:

Gene SymbolEntrez IDGene Name
IKZF1 10320 IKAROS family zinc finger 1 (Ikaros)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
IKZF1hg19_v1_chr7_+_50348255_50348383-0.354.8e-02Click!


Activity profile for motif IKZF1.p2.

activity profile for motif IKZF1.p2


Sorted Z-values histogram for motif IKZF1.p2

Sorted Z-values for motif IKZF1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of IKZF1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_-_49259549 4.235 NM_014470
RND1
Rho family GTPase 1
chr11_-_35440514 3.463 SLC1A2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr12_-_322612 3.171 NM_003044
NM_001122847
SLC6A12

solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12

chr4_-_155533882 2.872 NM_000509
NM_021870
FGG

fibrinogen gamma chain

chr4_-_155533800 2.830 FGG
fibrinogen gamma chain
chr4_-_155533850 2.819 FGG
fibrinogen gamma chain
chr10_+_135340865 2.786 NM_000773
CYP2E1
cytochrome P450, family 2, subfamily E, polypeptide 1
chr11_-_35441501 2.615 NM_001195728
NM_001252652
SLC1A2

solute carrier family 1 (glial high affinity glutamate transporter), member 2

chr1_-_160039946 2.569 NM_002241
KCNJ10
potassium inwardly-rectifying channel, subfamily J, member 10
chr4_-_155533757 2.518 FGG
fibrinogen gamma chain
chr20_+_56136136 2.491 NM_002591
PCK1
phosphoenolpyruvate carboxykinase 1 (soluble)
chr17_+_7517263 2.441 SHBG
sex hormone-binding globulin
chr4_-_176733413 2.403 GPM6A
glycoprotein M6A
chr16_+_56703725 2.227 NM_005951
MT1H
metallothionein 1H
chr4_-_176733901 2.119 GPM6A
glycoprotein M6A
chr2_+_17721806 2.088 NM_003385
VSNL1
visinin-like 1
chr11_-_35441099 2.073 NM_004171
SLC1A2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr18_-_74728963 2.030 MBP
myelin basic protein
chr2_+_17721983 2.016 VSNL1
visinin-like 1
chr18_-_74729049 1.977 NM_001025081
NM_001025090
NM_001025092
NM_002385
MBP



myelin basic protein



chr8_-_17743062 1.961 FGL1
fibrinogen-like 1
chr19_+_19322763 1.954 NM_004386
NCAN
neurocan
chr4_-_176734181 1.915 NM_201591
GPM6A
glycoprotein M6A
chr4_-_72671236 1.900 NM_001204306
GC
group-specific component (vitamin D binding protein)
chr17_-_32483550 1.751 NM_001094
ACCN1
amiloride-sensitive cation channel 1, neuronal
chr17_-_56618178 1.671 NM_001198713
SEPT4
septin 4
chr12_-_56881901 1.664 NM_013267
GLS2
glutaminase 2 (liver, mitochondrial)
chr7_-_126892304 1.607 NM_001127323
GRM8
glutamate receptor, metabotropic 8
chr5_+_76248679 1.474 NM_001882
CRHBP
corticotropin releasing hormone binding protein
chr10_-_74714479 1.453 NM_032562
PLA2G12B
phospholipase A2, group XIIB
chr19_+_4153593 1.441 NM_032607
CREB3L3
cAMP responsive element binding protein 3-like 3
chr10_-_74714563 1.436 PLA2G12B
phospholipase A2, group XIIB
chr13_+_113760101 1.408 NM_000131
NM_019616
F7

coagulation factor VII (serum prothrombin conversion accelerator)

chr11_-_18270167 1.403 NM_001199744
NM_001127380
NM_030754
SAA2-SAA4
SAA2

SAA2-SAA4 readthrough
serum amyloid A2

chr11_+_71903172 1.402 NM_016729
FOLR1
folate receptor 1 (adult)
chr2_-_105467912 1.401 LOC100506421
uncharacterized LOC100506421
chr20_+_36974823 1.381 NM_004139
LBP
lipopolysaccharide binding protein
chr20_+_42187705 1.366 SGK2
serum/glucocorticoid regulated kinase 2
chr14_+_81421708 1.349 NM_000369
NM_001018036
NM_001142626
TSHR


thyroid stimulating hormone receptor


chr2_-_21266915 1.317 NM_000384
APOB
apolipoprotein B (including Ag(x) antigen)
chr15_+_75041182 1.304 NM_000761
CYP1A2
cytochrome P450, family 1, subfamily A, polypeptide 2
chr13_-_99404883 1.298 NM_005073
SLC15A1
solute carrier family 15 (oligopeptide transporter), member 1
chrX_+_30671456 1.293 NM_000167
NM_001128127
NM_001205019
NM_203391
GK



glycerol kinase



chr11_+_62475165 1.283 GNG3
guanine nucleotide binding protein (G protein), gamma 3
chr22_-_18923654 1.279 PRODH
proline dehydrogenase (oxidase) 1
chr11_+_107461807 1.240 NM_001130037
NM_018712
ELMOD1

ELMO/CED-12 domain containing 1

chr2_-_21266893 1.231 APOB
apolipoprotein B (including Ag(x) antigen)
chr17_+_27369917 1.214 NM_016518
PIPOX
pipecolic acid oxidase
chr19_+_15751706 1.212 NM_000896
NM_001199208
NM_001199209
CYP4F3


cytochrome P450, family 4, subfamily F, polypeptide 3


chr17_+_4675175 1.207 NM_003963
TM4SF5
transmembrane 4 L six family member 5
chr1_+_33352071 1.203 NM_002143
HPCA
hippocalcin
chr16_+_56659679 1.202 MT1E
metallothionein 1E
chr2_-_238499317 1.160 RAB17
RAB17, member RAS oncogene family
chr5_+_175298538 1.155 CPLX2
complexin 2
chr3_-_184095927 1.153 NM_000460
NM_001177597
NM_001177598
THPO


thrombopoietin


chr11_-_18258315 1.140 SAA4
serum amyloid A4, constitutive
chr2_+_16080639 1.121 NM_005378
MYCN
v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)
chr13_+_39261172 1.117 NM_207361
FREM2
FRAS1 related extracellular matrix protein 2
chr11_-_66488712 1.097 NM_006946
SPTBN2
spectrin, beta, non-erythrocytic 2
chr16_+_29690464 1.097 QPRT
quinolinate phosphoribosyltransferase
chr19_+_496453 1.093 NM_130760
NM_130762
MADCAM1

mucosal vascular addressin cell adhesion molecule 1

chr9_+_87283453 1.093 NM_001018064
NM_006180
NTRK2

neurotrophic tyrosine kinase, receptor, type 2

chr7_-_100239136 1.091 NM_003227
TFR2
transferrin receptor 2
chr16_+_56659584 1.082 NM_175617
MT1E
metallothionein 1E
chr2_-_165424993 1.068 GRB14
growth factor receptor-bound protein 14
chr2_-_238499713 1.067 NM_022449
RAB17
RAB17, member RAS oncogene family
chr7_+_148036528 1.047 CNTNAP2
contactin associated protein-like 2
chr3_+_35722428 1.039 NM_198399
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr1_-_161207879 1.025 NM_001077469
NM_001077470
NM_001077471
NM_001077472
NM_001077473
NM_001077474
NM_001077475
NM_001077476
NM_001077477
NM_001077478
NM_001077479
NM_001077480
NM_001077481
NM_001077482
NM_005122
NR1I3














nuclear receptor subfamily 1, group I, member 3














chr3_-_47621729 1.022 NM_001206942
NM_001206945
CSPG5

chondroitin sulfate proteoglycan 5 (neuroglycan C)

chr15_+_40697685 1.013 NM_001159508
NM_002225
IVD

isovaleryl-CoA dehydrogenase

chr19_-_19384022 1.012 NM_001001524
TM6SF2
transmembrane 6 superfamily member 2
chr9_+_139846767 1.008 NM_178536
LCN12
lipocalin 12
chr2_-_142889269 1.002 NM_018557
LRP1B
low density lipoprotein receptor-related protein 1B
chr11_+_18287807 1.002 NM_000331
NM_001178006
NM_199161
SAA1


serum amyloid A1


chr19_-_11591439 1.002 NM_001420
NM_032281
ELAVL3

ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)

chr20_+_42187634 0.997 NM_170693
SGK2
serum/glucocorticoid regulated kinase 2
chr13_+_25254548 0.995 NM_001185085
NM_001676
ATP12A

ATPase, H+/K+ transporting, nongastric, alpha polypeptide

chr1_-_203154304 0.986 CHI3L1
chitinase 3-like 1 (cartilage glycoprotein-39)
chr12_+_41086189 0.980 NM_001843
NM_175038
CNTN1

contactin 1

chrX_+_21392396 0.973 NM_001168647
NM_001168648
NM_001168649
NM_014927
CNKSR2



connector enhancer of kinase suppressor of Ras 2



chr20_-_3149070 0.971 NM_014731
ProSAPiP1
ProSAPiP1 protein
chr19_-_36499583 0.970 NM_001039876
C19orf46
chromosome 19 open reading frame 46
chr2_-_230579198 0.956 NM_139072
DNER
delta/notch-like EGF repeat containing
chr3_+_124103551 0.951 KALRN
kalirin, RhoGEF kinase
chr3_-_58563070 0.950 FAM107A
family with sequence similarity 107, member A
chr10_-_21462987 0.946 NEBL
nebulette
chr2_-_11810254 0.943 NM_012344
NTSR2
neurotensin receptor 2
chr1_+_38022514 0.939 NM_003462
DNALI1
dynein, axonemal, light intermediate chain 1
chr10_-_50970321 0.938 NM_001143996
NM_001143997
NM_018245
OGDHL


oxoglutarate dehydrogenase-like


chr2_-_21266809 0.937 APOB
apolipoprotein B (including Ag(x) antigen)
chr8_-_99129385 0.936 NM_005836
HRSP12
heat-responsive protein 12
chr17_-_42992852 0.924 NM_001131019
NM_001242376
NM_002055
GFAP


glial fibrillary acidic protein


chr12_-_21757752 0.919 NM_021957
GYS2
glycogen synthase 2 (liver)
chr5_+_175298604 0.917 CPLX2
complexin 2
chr12_-_58160823 0.915 NM_000785
CYP27B1
cytochrome P450, family 27, subfamily B, polypeptide 1
chr8_-_63951353 0.912 GGH
gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
chr11_+_111789600 0.905 NM_080659
C11orf52
chromosome 11 open reading frame 52
chr2_-_21228189 0.904 APOB
apolipoprotein B (including Ag(x) antigen)
chr12_+_21679190 0.899 NM_030572
C12orf39
chromosome 12 open reading frame 39
chr4_-_168155691 0.893 SPOCK3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chrX_-_55020510 0.885 NM_002625
PFKFB1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr7_-_142985270 0.882


chr2_+_16080559 0.870 MYCN
v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)
chr8_+_133879202 0.864 NM_003235
TG
thyroglobulin
chr1_+_203020310 0.858 NM_015053
PPFIA4
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4
chrX_-_111923273 0.857 NM_178175
LHFPL1
lipoma HMGIC fusion partner-like 1
chr8_-_133493003 0.854 NM_004519
KCNQ3
potassium voltage-gated channel, KQT-like subfamily, member 3
chr10_-_21785873 0.853 C10orf114
chromosome 10 open reading frame 114
chr15_+_59730272 0.851 NM_152450
FAM81A
family with sequence similarity 81, member A
chr11_+_62475113 0.850 NM_012202
GNG3
guanine nucleotide binding protein (G protein), gamma 3
chr8_-_63951609 0.846 NM_003878
GGH
gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
chr11_+_46740769 0.845 F2
coagulation factor II (thrombin)
chr7_-_16505292 0.842 NM_015464
SOSTDC1
sclerostin domain containing 1
chr1_-_230849863 0.836 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr9_+_130911731 0.834 NM_005564
LCN2
lipocalin 2
chrX_-_72434656 0.834 NAP1L2
nucleosome assembly protein 1-like 2
chr19_-_10697907 0.833 NM_005498
AP1M2
adaptor-related protein complex 1, mu 2 subunit
chr1_+_40420837 0.827 MFSD2A
major facilitator superfamily domain containing 2A
chr10_-_21463019 0.826 NM_001173484
NM_213569
NEBL

nebulette

chr16_+_29690328 0.826 NM_014298
QPRT
quinolinate phosphoribosyltransferase
chr3_+_119500866 0.819 NR1I2
nuclear receptor subfamily 1, group I, member 2
chr1_+_155247186 0.811 NM_020897
HCN3
hyperpolarization activated cyclic nucleotide-gated potassium channel 3
chr16_-_70719693 0.807 MTSS1L
metastasis suppressor 1-like
chr5_-_156772672 0.804 NM_001001343
FNDC9
fibronectin type III domain containing 9
chr5_-_36151953 0.802 NM_001007527
LMBRD2
LMBR1 domain containing 2
chr7_-_122526410 0.800 CADPS2
Ca++-dependent secretion activator 2
chr21_+_41239346 0.799 NM_006198
PCP4
Purkinje cell protein 4
chr9_+_17578952 0.797 NM_003026
SH3GL2
SH3-domain GRB2-like 2
chr11_+_22689653 0.791 NM_177553
GAS2
growth arrest-specific 2
chr5_+_125759076 0.791 GRAMD3
GRAM domain containing 3
chr15_+_40697977 0.789 IVD
isovaleryl-CoA dehydrogenase
chr5_-_35938736 0.786 NM_001042625
NM_144647
CAPSL

calcyphosine-like

chr3_-_42305438 0.780 NM_001174138
CCK
cholecystokinin
chr8_-_133492751 0.779 KCNQ3
potassium voltage-gated channel, KQT-like subfamily, member 3
chr3_-_170303774 0.778 NM_020949
SLC7A14
solute carrier family 7 (orphan transporter), member 14
chr10_+_115310589 0.778 NM_001177660
HABP2
hyaluronan binding protein 2
chr5_-_149669187 0.777 CAMK2A
calcium/calmodulin-dependent protein kinase II alpha
chr1_+_100326765 0.777 NM_000645
AGL
amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
chr8_-_133492556 0.777 KCNQ3
potassium voltage-gated channel, KQT-like subfamily, member 3
chr4_-_168155732 0.777 NM_001040159
NM_001204352
NM_001204354
NM_001204355
NM_001204356
NM_001204358
NM_001251967
NM_016950
SPOCK3







sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3







chr12_+_1929432 0.761 NM_001039029
NM_001163925
NM_001163926
LRTM2


leucine-rich repeats and transmembrane domains 2


chr1_+_43638000 0.760 NM_001167965
NM_001195831
NM_152498
WDR65


WD repeat domain 65


chr5_+_125758818 0.754 NM_001146320
NM_001146321
NM_023927
GRAMD3


GRAM domain containing 3


chrX_+_30671537 0.753 GK
glycerol kinase
chr10_-_52645430 0.747 NM_001198818
NM_001198819
NM_001198820
NM_014576
NM_138932
NM_138933
A1CF





APOBEC1 complementation factor





chr2_-_224467142 0.742 NM_003469
SCG2
secretogranin II
chr11_+_61520000 0.742 NM_001127392
C11orf9
chromosome 11 open reading frame 9
chr2_+_231902194 0.736 NM_001144994
C2orf72
chromosome 2 open reading frame 72
chr1_+_176432306 0.734 NM_020318
NM_021936
PAPPA2

pappalysin 2

chr2_-_224467049 0.732 SCG2
secretogranin II
chr4_-_69817478 0.730 NM_024743
UGT2A3
UDP glucuronosyltransferase 2 family, polypeptide A3
chr11_+_107462073 0.729 ELMOD1
ELMO/CED-12 domain containing 1
chr10_+_134901408 0.729 NM_001083909
GPR123
G protein-coupled receptor 123
chr1_+_162332772 0.727 NM_001126060
NOS1AP
nitric oxide synthase 1 (neuronal) adaptor protein
chr12_-_131002409 0.726 NM_015347
RIMBP2
RIMS binding protein 2
chr11_+_107461955 0.725 ELMOD1
ELMO/CED-12 domain containing 1
chr4_+_159690208 0.725 FNIP2
folliculin interacting protein 2
chr4_-_168155576 0.725 NM_001204353
SPOCK3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chr13_-_102068705 0.719 NM_052867
NALCN
sodium leak channel, non-selective
chr7_-_76038894 0.717 NM_080744
SRCRB4D
scavenger receptor cysteine rich domain containing, group B (4 domains)
chr17_+_52978022 0.715 NM_005486
TOM1L1
target of myb1 (chicken)-like 1
chr8_+_145065366 0.710 GRINA
glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)
chr14_+_74486049 0.704 NM_025057
C14orf45
chromosome 14 open reading frame 45
chr11_+_75428864 0.694 NM_025098
MOGAT2
monoacylglycerol O-acyltransferase 2
chr10_+_105036783 0.689 NM_032727
INA
internexin neuronal intermediate filament protein, alpha
chr21_+_34442446 0.683 NM_138983
OLIG1
oligodendrocyte transcription factor 1
chr3_+_52232174 0.683 ALAS1
aminolevulinate, delta-, synthase 1
chr16_+_56691854 0.682 NM_005949
MT1F
metallothionein 1F
chr1_-_230849847 0.675 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr2_-_74669026 0.674 RTKN
rhotekin
chr3_+_52232076 0.672 NM_199166
NM_000688
ALAS1

aminolevulinate, delta-, synthase 1

chr18_+_10526095 0.667 NAPG
N-ethylmaleimide-sensitive factor attachment protein, gamma
chr4_-_176923480 0.664 GPM6A
glycoprotein M6A
chr11_-_18258383 0.663 NM_006512
SAA4
serum amyloid A4, constitutive
chr4_-_47983430 0.663 NM_001142564
CNGA1
cyclic nucleotide gated channel alpha 1
chr3_+_46619075 0.654 NM_003212
TDGF1
teratocarcinoma-derived growth factor 1
chrX_-_102941582 0.652 NM_001142418
NM_001142423
NM_001142424
NM_001142425
NM_001142426
NM_001142429
NM_001142430
NM_012286
MORF4L2







mortality factor 4 like 2







chr21_+_34442550 0.652 OLIG1
oligodendrocyte transcription factor 1
chr1_-_109849613 0.647 NM_001010985
MYBPHL
myosin binding protein H-like
chr1_+_220921576 0.646 NM_017898
MARC2
mitochondrial amidoxime reducing component 2
chr2_+_47596286 0.643 NM_002354
EPCAM
epithelial cell adhesion molecule
chr14_+_66975205 0.642 GPHN
gephyrin
chr5_-_125930604 0.640 NM_001182
NM_001201377
NM_001202404
ALDH7A1


aldehyde dehydrogenase 7 family, member A1


chr18_+_48086402 0.639 NM_002747
MAPK4
mitogen-activated protein kinase 4
chr14_+_74318506 0.638 NM_001146154
NM_001146155
NM_152444
PTGR2


prostaglandin reductase 2


chr18_+_10526022 0.637 NAPG
N-ethylmaleimide-sensitive factor attachment protein, gamma
chrX_+_152801579 0.637 NM_001001344
NM_021949
ATP2B3

ATPase, Ca++ transporting, plasma membrane 3

chr7_-_100240334 0.637 TFR2
transferrin receptor 2
chr15_+_40698000 0.634 IVD
isovaleryl-CoA dehydrogenase
chr1_-_70671160 0.633 LRRC40
leucine rich repeat containing 40
chr4_+_619362 0.632 NM_000283
NM_001145291
PDE6B

phosphodiesterase 6B, cGMP-specific, rod, beta

chr1_+_113933474 0.631 NM_001142782
NM_152900
MAGI3

membrane associated guanylate kinase, WW and PDZ domain containing 3

chr19_+_2476122 0.627 NM_015675
GADD45B
growth arrest and DNA-damage-inducible, beta
chr9_+_22446783 0.623 NM_022160
DMRTA1
DMRT-like family A1
chr2_+_211342405 0.622 NM_001122633
CPS1
carbamoyl-phosphate synthase 1, mitochondrial
chr5_+_6633499 0.622 NM_001047
SRD5A1
steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
chr16_+_8807426 0.620 ABAT
4-aminobutyrate aminotransferase
chr12_+_1929658 0.618 LRTM2
leucine-rich repeats and transmembrane domains 2
chr2_-_224467095 0.613 SCG2
secretogranin II

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
6.30 1.15e-03 GO:0019226 transmission of nerve impulse
6.30 1.15e-03 GO:0035637 multicellular organismal signaling
6.37 3.53e-03 GO:0007268 synaptic transmission
2.64 1.33e-02 GO:0042221 response to chemical stimulus
3.73 2.22e-02 GO:0007154 cell communication
17.89 2.74e-02 GO:0007269 neurotransmitter secretion
4.12 4.51e-02 GO:0007267 cell-cell signaling

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
3.82 7.79e-04 GO:0000267 cell fraction
4.43 8.73e-04 GO:0005624 membrane fraction
4.29 1.21e-03 GO:0005626 insoluble fraction
6.99 1.67e-02 GO:0042598 vesicular fraction
24.14 2.16e-02 GO:0032994 protein-lipid complex
24.14 2.16e-02 GO:0034358 plasma lipoprotein particle
80.43 2.22e-02 GO:0005577 fibrinogen complex
80.43 2.22e-02 GO:0030673 axolemma
2.93 4.63e-02 GO:0005887 integral to plasma membrane

Nothing significant found in function category.