Motif ID: IKZF2.p2

Z-value: 1.925


Transcription factors associated with IKZF2.p2:

Gene SymbolEntrez IDGene Name
IKZF2 22807 IKAROS family zinc finger 2 (Helios)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
IKZF2hg19_v1_chr2_-_214015053_2140150570.411.9e-02Click!


Activity profile for motif IKZF2.p2.

activity profile for motif IKZF2.p2


Sorted Z-values histogram for motif IKZF2.p2

Sorted Z-values for motif IKZF2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of IKZF2.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_159175048 7.587 NM_001122951
DARC
Duffy blood group, chemokine receptor
chr13_-_38172862 6.225 NM_001135934
NM_001135935
NM_001135936
NM_006475
POSTN



periostin, osteoblast specific factor



chr8_+_80523376 5.897 STMN2
stathmin-like 2
chr3_-_195310770 5.458 APOD
apolipoprotein D
chr7_-_16505292 5.424 NM_015464
SOSTDC1
sclerostin domain containing 1
chrX_+_102585113 4.992 NM_152278
TCEAL7
transcription elongation factor A (SII)-like 7
chr15_+_43885251 4.776 NM_020990
CKMT1B
CKMT1A
creatine kinase, mitochondrial 1B
creatine kinase, mitochondrial 1A
chr3_-_195310985 4.751 NM_001647
APOD
apolipoprotein D
chr6_+_153071931 4.651 NM_003381
NM_194435
VIP

vasoactive intestinal peptide

chr17_-_66951381 4.643 NM_007168
ABCA8
ATP-binding cassette, sub-family A (ABC1), member 8
chr3_+_112051914 4.507 NM_001004196
NM_005944
CD200

CD200 molecule

chr11_+_60467046 4.263 NM_031457
MS4A8B
membrane-spanning 4-domains, subfamily A, member 8B
chr22_-_38380538 4.224 NM_006941
SOX10
SRY (sex determining region Y)-box 10
chrX_+_100333835 3.967 NM_021637
TMEM35
transmembrane protein 35
chr7_+_94297448 3.934 PEG10
paternally expressed 10
chr1_+_171217632 3.818 NM_002021
FMO1
flavin containing monooxygenase 1
chr7_-_14880954 3.767 NM_004080
NM_145695
DGKB

diacylglycerol kinase, beta 90kDa

chr4_+_88896868 3.732 SPP1
secreted phosphoprotein 1
chr17_+_12623605 3.670 NM_001146313
MYOCD
myocardin
chr2_+_168675181 3.581 NM_020981
B3GALT1
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1
chr4_+_88896838 3.552 SPP1
secreted phosphoprotein 1
chr20_+_5891973 3.495 NM_001819
CHGB
chromogranin B (secretogranin 1)
chr20_+_9198036 3.407 NM_182797
PLCB4
phospholipase C, beta 4
chr22_-_38379868 3.381 SOX10
SRY (sex determining region Y)-box 10
chr5_+_140602914 3.325 NM_018934
PCDHB14
protocadherin beta 14
chr1_+_162602198 3.318 NM_001014796
NM_006182
DDR2

discoidin domain receptor tyrosine kinase 2

chr7_-_137028533 3.264 NM_002825
PTN
pleiotrophin
chr16_+_81272293 3.183 NM_017429
BCMO1
beta-carotene 15,15'-monooxygenase 1
chr3_-_12586962 3.180 NM_001195279
LOC100129480
uncharacterized LOC100129480
chr3_+_178276487 3.171 NM_005832
KCNMB2
potassium large conductance calcium-activated channel, subfamily M, beta member 2
chr1_+_155853546 3.128 SYT11
synaptotagmin XI
chr1_+_111889194 3.013 NM_181643
C1orf88
chromosome 1 open reading frame 88
chr1_-_163113938 2.996 RGS5
regulator of G-protein signaling 5
chr12_-_15038724 2.987 NM_000900
NM_001190839
MGP

matrix Gla protein

chr3_+_186560478 2.976 ADIPOQ
adiponectin, C1Q and collagen domain containing
chr8_+_39771327 2.928 NM_002164
IDO1
indoleamine 2,3-dioxygenase 1
chr18_+_32290195 2.913 NM_001198941
NM_032978
DTNA

dystrobrevin, alpha

chr14_+_85996512 2.891 FLRT2
fibronectin leucine rich transmembrane protein 2
chr5_+_140552201 2.821 NM_018940
PCDHB7
protocadherin beta 7
chr3_+_186560462 2.774 NM_001177800
NM_004797
ADIPOQ

adiponectin, C1Q and collagen domain containing

chr3_-_58563070 2.739 FAM107A
family with sequence similarity 107, member A
chr18_+_32335939 2.718 NM_001390
NM_001391
DTNA

dystrobrevin, alpha

chr2_+_207406815 2.675 ADAM23
ADAM metallopeptidase domain 23
chr2_-_142889269 2.665 NM_018557
LRP1B
low density lipoprotein receptor-related protein 1B
chr11_+_34654010 2.655 NM_001206616
EHF
ets homologous factor
chr3_+_29322802 2.648 NM_001003792
NM_001003793
NM_001177711
NM_001177712
NM_014483
RBMS3




RNA binding motif, single stranded interacting protein 3




chr4_-_101439071 2.641 NM_001159694
NM_016242
EMCN

endomucin

chrX_+_103031797 2.623 PLP1
proteolipid protein 1
chr4_-_87281374 2.607 NM_138980
NM_138982
MAPK10

mitogen-activated protein kinase 10

chr17_-_8424217 2.562 MYH10
myosin, heavy chain 10, non-muscle
chr5_-_87969135 2.558 LINC00461
long intergenic non-protein coding RNA 461
chr4_+_88896801 2.555 NM_000582
NM_001040058
NM_001040060
NM_001251829
NM_001251830
SPP1




secreted phosphoprotein 1




chr1_-_242612757 2.543 NM_001195811
NM_001195812
PLD5

phospholipase D family, member 5

chr5_+_137203559 2.538 MYOT
myotilin
chr8_-_145838887 2.523 NM_025251
ARHGAP39
Rho GTPase activating protein 39
chr3_-_58563490 2.515 NM_001076778
NM_007177
FAM107A

family with sequence similarity 107, member A

chrX_+_103031753 2.508 NM_000533
NM_199478
PLP1

proteolipid protein 1

chr4_-_87281177 2.500 MAPK10
mitogen-activated protein kinase 10
chr18_-_40695483 2.496 NM_002930
RIT2
Ras-like without CAAX 2
chrX_-_117119282 2.478 NM_001168299
KLHL13
kelch-like 13 (Drosophila)
chr4_+_88896899 2.470 SPP1
secreted phosphoprotein 1
chr2_+_191301020 2.449 MFSD6
major facilitator superfamily domain containing 6
chr1_+_163038934 2.447 NM_001113381
RGS4
regulator of G-protein signaling 4
chr12_+_119616594 2.433 NM_014365
HSPB8
heat shock 22kDa protein 8
chr12_-_91573264 2.432 NM_133503
DCN
decorin
chr15_+_43985083 2.432 NM_001015001
CKMT1A
creatine kinase, mitochondrial 1A
chr15_+_63050761 2.412 TLN2
talin 2
chr11_+_71903172 2.405 NM_016729
FOLR1
folate receptor 1 (adult)
chrX_+_103031433 2.401 NM_001128834
PLP1
proteolipid protein 1
chr1_+_87012758 2.397 NM_012128
CLCA4
chloride channel accessory 4
chr15_-_58306185 2.393 NM_170697
ALDH1A2
aldehyde dehydrogenase 1 family, member A2
chr6_+_121756744 2.372 NM_000165
GJA1
gap junction protein, alpha 1, 43kDa
chr2_+_36923902 2.359 VIT
vitrin
chr7_-_137028433 2.358 PTN
pleiotrophin
chr2_+_223916861 2.344 NM_080671
KCNE4
potassium voltage-gated channel, Isk-related family, member 4
chr7_-_137028275 2.329 PTN
pleiotrophin
chr14_+_24837225 2.325 NM_001198965
NM_004554
NFATC4

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4

chr2_+_48796158 2.321 NM_172311
STON1-GTF2A1L
STON1-GTF2A1L readthrough
chr5_+_140180782 2.312 NM_018906
NM_031497
PCDHA3

protocadherin alpha 3

chr4_+_113739203 2.310 NM_001127493
ANK2
ankyrin 2, neuronal
chr5_-_146833150 2.304 NM_001387
DPYSL3
dihydropyrimidinase-like 3
chr9_-_95166827 2.295 NM_014057
NM_033014
OGN

osteoglycin

chr2_+_189839113 2.295 COL3A1
collagen, type III, alpha 1
chr2_+_202671197 2.294 NM_139158
CDK15
cyclin-dependent kinase 15
chr7_-_137028370 2.291 PTN
pleiotrophin
chr2_+_189839078 2.287 NM_000090
COL3A1
collagen, type III, alpha 1
chr8_-_82359620 2.282 NM_002677
PMP2
peripheral myelin protein 2
chr16_-_65155965 2.269 CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
chr12_+_101988746 2.264 NM_002465
NM_206819
NM_206820
NM_206821
MYBPC1



myosin binding protein C, slow type



chr9_-_14910992 2.250 NM_144966
FREM1
FRAS1 related extracellular matrix 1
chr11_+_118477212 2.248 NM_015157
PHLDB1
pleckstrin homology-like domain, family B, member 1
chr1_+_160051343 2.246 NM_004983
KCNJ9
potassium inwardly-rectifying channel, subfamily J, member 9
chr12_+_41086189 2.243 NM_001843
NM_175038
CNTN1

contactin 1

chr9_-_97356007 2.239 NM_003837
FBP2
fructose-1,6-bisphosphatase 2
chr10_+_95848811 2.231 NM_001165979
PLCE1
phospholipase C, epsilon 1
chr5_+_140710203 2.225 NM_018912
NM_031993
PCDHGA1

protocadherin gamma subfamily A, 1

chr3_+_112052020 2.225 CD200
CD200 molecule
chrX_+_100805415 2.222 NM_016608
ARMCX1
armadillo repeat containing, X-linked 1
chr9_-_93405066 2.217 NM_017594
DIRAS2
DIRAS family, GTP-binding RAS-like 2
chr4_+_134070443 2.203 NM_020815
NM_032961
PCDH10

protocadherin 10

chr1_-_79472360 2.201 NM_022159
ELTD1
EGF, latrophilin and seven transmembrane domain containing 1
chr11_+_101983170 2.195 NM_001195045
YAP1
Yes-associated protein 1
chr5_+_140718353 2.190 NM_018915
NM_032009
PCDHGA2

protocadherin gamma subfamily A, 2

chr5_-_92916924 2.185 FLJ42709
uncharacterized LOC441094
chr18_-_64271215 2.183 NM_021153
CDH19
cadherin 19, type 2
chr2_+_189839132 2.175 COL3A1
collagen, type III, alpha 1
chr12_-_18243052 2.164 NM_024730
RERGL
RERG/RAS-like
chr5_+_140174443 2.134 NM_018905
NM_031495
PCDHA2

protocadherin alpha 2

chr1_+_162602308 2.130 DDR2
discoidin domain receptor tyrosine kinase 2
chr17_+_48262816 2.122


chr15_+_74466171 2.114 ISLR
immunoglobulin superfamily containing leucine-rich repeat
chr22_-_38379790 2.112 SOX10
SRY (sex determining region Y)-box 10
chr2_-_217560247 2.112 NM_000599
IGFBP5
insulin-like growth factor binding protein 5
chr7_+_153584383 2.110 NM_001039350
DPP6
dipeptidyl-peptidase 6
chr5_+_137203544 2.108 NM_001135940
NM_006790
MYOT

myotilin

chr3_+_12392993 2.091 NM_015869
PPARG
peroxisome proliferator-activated receptor gamma
chr10_-_7682741 2.076 ITIH5
inter-alpha-trypsin inhibitor heavy chain family, member 5
chr12_+_26348268 2.067 NM_001135823
SSPN
sarcospan (Kras oncogene-associated gene)
chr17_-_29624249 2.065 NM_002544
OMG
oligodendrocyte myelin glycoprotein
chr4_-_120243257 2.062 NM_000134
FABP2
fatty acid binding protein 2, intestinal
chrX_+_56755666 2.056 LOC550643
uncharacterized LOC550643
chr8_+_75896707 2.054 NM_031461
CRISPLD1
cysteine-rich secretory protein LCCL domain containing 1
chr3_-_123135188 2.053 NM_001199642
ADCY5
adenylate cyclase 5
chrX_-_6145887 2.048 NM_020742
NLGN4X
neuroligin 4, X-linked
chr7_+_134576187 2.030 CALD1
caldesmon 1
chr1_+_163038564 2.026 NM_005613
RGS4
regulator of G-protein signaling 4
chr3_-_112358510 2.013 CCDC80
coiled-coil domain containing 80
chr3_-_161089747 2.010 NM_001040100
SPTSSB
serine palmitoyltransferase, small subunit B
chr17_-_42908178 2.002 NM_001080383
GJC1
gap junction protein, gamma 1, 45kDa
chr11_+_101918168 1.991 NM_001195005
NM_032930
C11orf70

chromosome 11 open reading frame 70

chr7_+_94024201 1.964 COL1A2
collagen, type I, alpha 2
chrX_-_133119475 1.944 GPC3
glypican 3
chr5_-_96478502 1.937 NM_153234
LIX1
Lix1 homolog (chicken)
chr19_-_42931500 1.932 NM_005357
LIPE
lipase, hormone-sensitive
chr6_-_47009992 1.932 NM_025048
NM_153840
GPR110

G protein-coupled receptor 110

chr10_+_63422718 1.931 NM_173554
C10orf107
chromosome 10 open reading frame 107
chr5_-_146460991 1.923 NM_181677
NM_181678
PPP2R2B

protein phosphatase 2, regulatory subunit B, beta

chr11_+_62475165 1.912 GNG3
guanine nucleotide binding protein (G protein), gamma 3
chr8_-_95274520 1.910 GEM
GTP binding protein overexpressed in skeletal muscle
chr5_+_155754172 1.905 SGCD
sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
chr16_-_66952729 1.899 NM_001204744
NM_001204745
NM_001204746
NM_004062
CDH16



cadherin 16, KSP-cadherin



chr4_-_87374282 1.895 NM_002753
MAPK10
mitogen-activated protein kinase 10
chr2_-_238322770 1.891 COL6A3
collagen, type VI, alpha 3
chr4_+_124317884 1.866 NM_199327
SPRY1
sprouty homolog 1, antagonist of FGF signaling (Drosophila)
chr3_+_238274 1.866 NM_001253387
NM_006614
CHL1

cell adhesion molecule with homology to L1CAM (close homolog of L1)

chr6_+_123100860 1.852 FABP7
fatty acid binding protein 7, brain
chr5_+_140625146 1.850 NM_018935
PCDHB15
protocadherin beta 15
chr16_-_65155984 1.846 CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
chr2_+_167744996 1.844 NM_001079810
NM_001199143
NM_152381
XIRP2


xin actin-binding repeat containing 2


chr7_+_142829169 1.843 NM_002652
PIP
prolactin-induced protein
chr2_-_238322806 1.819 COL6A3
collagen, type VI, alpha 3
chr17_+_34391639 1.809 NM_002988
CCL18
chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
chr5_+_80529138 1.802 NM_001099735
NM_001099736
NM_001825
CKMT2


creatine kinase, mitochondrial 2 (sarcomeric)


chr8_-_95274540 1.802 NM_005261
NM_181702
GEM

GTP binding protein overexpressed in skeletal muscle

chr2_+_74120132 1.795 ACTG2
actin, gamma 2, smooth muscle, enteric
chr4_-_138453628 1.795 NM_019035
PCDH18
protocadherin 18
chr3_-_93747453 1.787 NM_001001850
STX19
syntaxin 19
chr12_+_78225068 1.787 NM_014903
NAV3
neuron navigator 3
chrX_-_133119624 1.786 NM_001164617
NM_001164618
NM_001164619
NM_004484
GPC3



glypican 3



chr8_-_6420454 1.785 NM_001118887
NM_001118888
NM_001147
ANGPT2


angiopoietin 2


chr3_+_361365 1.773 NM_001253388
CHL1
cell adhesion molecule with homology to L1CAM (close homolog of L1)
chr5_+_173472692 1.770 NM_015980
HMP19
HMP19 protein
chr12_-_91505215 1.769 LUM
lumican
chr3_-_116164363 1.768 NM_002338
LSAMP
limbic system-associated membrane protein
chr5_-_96478438 1.768 LIX1
Lix1 homolog (chicken)
chr3_+_115342302 1.766 GAP43
growth associated protein 43
chr8_+_24771276 1.764 NEFM
neurofilament, medium polypeptide
chr12_-_71551564 1.763 TSPAN8
tetraspanin 8
chr5_+_140247767 1.758 NM_018902
NM_031861
PCDHA11

protocadherin alpha 11

chr4_-_159093523 1.758 FAM198B
family with sequence similarity 198, member B
chr1_+_100111430 1.753 NM_017734
PALMD
palmdelphin
chr1_+_101185195 1.746 NM_001078
NM_001199834
NM_080682
VCAM1


vascular cell adhesion molecule 1


chr2_+_27301693 1.742 EMILIN1
elastin microfibril interfacer 1
chr8_-_108510094 1.738 NM_001146
NM_001199859
ANGPT1

angiopoietin 1

chr5_-_142077508 1.730 NM_001144934
NM_001144935
FGF1

fibroblast growth factor 1 (acidic)

chr13_+_23755059 1.724 NM_000231
SGCG
sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
chrX_+_135251454 1.722 NM_001159704
FHL1
four and a half LIM domains 1
chr8_+_17433941 1.720 NM_006207
PDGFRL
platelet-derived growth factor receptor-like
chr2_-_217540722 1.714 IGFBP5
insulin-like growth factor binding protein 5
chr21_-_27945267 1.710 NM_052954
CYYR1
cysteine/tyrosine-rich 1
chr2_-_238322814 1.708 COL6A3
collagen, type VI, alpha 3
chr1_-_203320185 1.705 FMOD
fibromodulin
chr12_+_175872 1.704 NM_001170738
IQSEC3
IQ motif and Sec7 domain 3
chr1_+_171154387 1.703 NM_001460
FMO2
flavin containing monooxygenase 2 (non-functional)
chr11_-_118047145 1.685 SCN2B
sodium channel, voltage-gated, type II, beta
chr12_+_26348488 1.680 NM_005086
SSPN
sarcospan (Kras oncogene-associated gene)
chr7_-_83824216 1.676 NM_006080
SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr4_+_151503076 1.672 NM_006439
MAB21L2
mab-21-like 2 (C. elegans)
chr18_-_3874688 1.671 NM_001242762
NM_001242763
DLGAP1

discs, large (Drosophila) homolog-associated protein 1

chr11_-_40314510 1.664 LRRC4C
leucine rich repeat containing 4C
chr11_-_68780667 1.657 NM_001098515
NM_145015
MRGPRF

MAS-related GPR, member F

chr5_+_92918924 1.651 NM_005654
NR2F1
nuclear receptor subfamily 2, group F, member 1
chr7_+_86273219 1.645 NM_000840
GRM3
glutamate receptor, metabotropic 3
chr16_-_65155881 1.642 NM_001797
CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
chr12_-_91576579 1.636 DCN
decorin
chr8_-_22089517 1.634 PHYHIP
phytanoyl-CoA 2-hydroxylase interacting protein
chr4_+_55095433 1.633 PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chr11_+_62475113 1.632 NM_012202
GNG3
guanine nucleotide binding protein (G protein), gamma 3
chr2_+_27301434 1.627 NM_007046
EMILIN1
elastin microfibril interfacer 1
chr1_-_36565849 1.619 NM_005202
COL8A2
collagen, type VIII, alpha 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
4.02 4.88e-15 GO:0007155 cell adhesion
4.02 4.88e-15 GO:0022610 biological adhesion
8.06 5.45e-10 GO:0007156 homophilic cell adhesion
2.03 5.67e-10 GO:0048731 system development
1.90 9.99e-09 GO:0048856 anatomical structure development
1.62 1.10e-08 GO:0032501 multicellular organismal process
4.92 2.09e-08 GO:0016337 cell-cell adhesion
1.83 3.06e-08 GO:0007275 multicellular organismal development
1.76 7.70e-08 GO:0032502 developmental process
2.27 2.88e-06 GO:0007399 nervous system development
5.87 1.43e-05 GO:0043062 extracellular structure organization
2.13 7.08e-05 GO:0009653 anatomical structure morphogenesis
6.74 2.09e-04 GO:0030198 extracellular matrix organization
1.56 9.91e-04 GO:0023052 signaling
1.55 6.55e-03 GO:0007165 signal transduction
2.39 6.62e-03 GO:0007267 cell-cell signaling
1.77 2.29e-02 GO:0007166 cell surface receptor linked signaling pathway
2.78 2.52e-02 GO:0007268 synaptic transmission
2.70 2.57e-02 GO:0072358 cardiovascular system development
2.70 2.57e-02 GO:0072359 circulatory system development
4.57 3.07e-02 GO:0001503 ossification
2.59 4.61e-02 GO:0019226 transmission of nerve impulse
2.59 4.61e-02 GO:0035637 multicellular organismal signaling

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
2.58 1.77e-16 GO:0005576 extracellular region
3.27 2.64e-14 GO:0044421 extracellular region part
5.35 3.62e-12 GO:0005578 proteinaceous extracellular matrix
4.53 3.09e-10 GO:0031012 extracellular matrix
3.19 6.60e-10 GO:0005615 extracellular space
7.48 6.30e-08 GO:0044420 extracellular matrix part
1.63 3.05e-07 GO:0005886 plasma membrane
1.61 7.55e-07 GO:0071944 cell periphery
13.20 2.80e-06 GO:0005581 collagen
23.99 1.71e-04 GO:0005583 fibrillar collagen
1.69 2.03e-03 GO:0044459 plasma membrane part
1.26 5.41e-03 GO:0016020 membrane
2.24 3.38e-02 GO:0030054 cell junction

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
2.94 2.19e-06 GO:0005509 calcium ion binding
6.60 5.83e-04 GO:0005201 extracellular matrix structural constituent
5.23 1.84e-03 GO:0008201 heparin binding
4.31 5.22e-03 GO:0005539 glycosaminoglycan binding
19.19 8.68e-03 GO:0048407 platelet-derived growth factor binding
3.99 1.14e-02 GO:0001871 pattern binding
3.99 1.14e-02 GO:0030247 polysaccharide binding