Motif ID: IKZF2.p2

Z-value: 1.925


Transcription factors associated with IKZF2.p2:

Gene SymbolEntrez IDGene Name
IKZF2 22807 IKAROS family zinc finger 2 (Helios)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
IKZF2hg19_v1_chr2_-_214015053_2140150570.411.9e-02Click!


Activity profile for motif IKZF2.p2.

activity profile for motif IKZF2.p2


Sorted Z-values histogram for motif IKZF2.p2

Sorted Z-values for motif IKZF2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of IKZF2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_159175048 7.587 NM_001122951
 DARC
Duffy blood group, chemokine receptor
chr13_-_38172862 6.225 NM_001135934
NM_001135935
NM_001135936
NM_006475
 POSTN



periostin, osteoblast specific factor



chr8_+_80523376 5.897 STMN2
stathmin-like 2
chr3_-_195310770 5.458 APOD
apolipoprotein D
chr7_-_16505292 5.424 NM_015464
 SOSTDC1
sclerostin domain containing 1
chrX_+_102585113 4.992 NM_152278
 TCEAL7
transcription elongation factor A (SII)-like 7
chr15_+_43885251 4.776 NM_020990
 CKMT1B
CKMT1A
creatine kinase, mitochondrial 1B
creatine kinase, mitochondrial 1A
chr3_-_195310985 4.751 NM_001647
 APOD
apolipoprotein D
chr6_+_153071931 4.651 NM_003381
NM_194435
 VIP

vasoactive intestinal peptide

chr17_-_66951381 4.643 NM_007168
 ABCA8
ATP-binding cassette, sub-family A (ABC1), member 8
chr3_+_112051914 4.507 NM_001004196
NM_005944
 CD200

CD200 molecule

chr11_+_60467046 4.263 NM_031457
 MS4A8B
membrane-spanning 4-domains, subfamily A, member 8B
chr22_-_38380538 4.224 NM_006941
 SOX10
SRY (sex determining region Y)-box 10
chrX_+_100333835 3.967 NM_021637
 TMEM35
transmembrane protein 35
chr7_+_94297448 3.934 PEG10
paternally expressed 10
chr1_+_171217632 3.818 NM_002021
 FMO1
flavin containing monooxygenase 1
chr7_-_14880954 3.767 NM_004080
NM_145695
 DGKB

diacylglycerol kinase, beta 90kDa

chr4_+_88896868 3.732 SPP1
secreted phosphoprotein 1
chr17_+_12623605 3.670 NM_001146313
 MYOCD
myocardin
chr2_+_168675181 3.581 NM_020981
 B3GALT1
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 23 entries
Enrichment   P-value GO Accession GO Term
8.06 5.45e-10 GO:0007156 homophilic cell adhesion
6.74 2.09e-04 GO:0030198 extracellular matrix organization
5.87 1.43e-05 GO:0043062 extracellular structure organization
4.92 2.09e-08 GO:0016337 cell-cell adhesion
4.57 3.07e-02 GO:0001503 ossification
4.02 4.88e-15 GO:0007155 cell adhesion
4.02 4.88e-15 GO:0022610 biological adhesion
2.78 2.52e-02 GO:0007268 synaptic transmission
2.70 2.57e-02 GO:0072358 cardiovascular system development
2.70 2.57e-02 GO:0072359 circulatory system development
2.59 4.61e-02 GO:0019226 transmission of nerve impulse
2.59 4.61e-02 GO:0035637 multicellular organismal signaling
2.39 6.62e-03 GO:0007267 cell-cell signaling
2.27 2.88e-06 GO:0007399 nervous system development
2.13 7.08e-05 GO:0009653 anatomical structure morphogenesis
2.03 5.67e-10 GO:0048731 system development
1.90 9.99e-09 GO:0048856 anatomical structure development
1.83 3.06e-08 GO:0007275 multicellular organismal development
1.77 2.29e-02 GO:0007166 cell surface receptor linked signaling pathway
1.76 7.70e-08 GO:0032502 developmental process

Gene overrepresentation in compartment category:

Showing 1 to 13 of 13 entries
Enrichment   P-value GO Accession GO Term
23.99 1.71e-04 GO:0005583 fibrillar collagen
13.20 2.80e-06 GO:0005581 collagen
7.48 6.30e-08 GO:0044420 extracellular matrix part
5.35 3.62e-12 GO:0005578 proteinaceous extracellular matrix
4.53 3.09e-10 GO:0031012 extracellular matrix
3.27 2.64e-14 GO:0044421 extracellular region part
3.19 6.60e-10 GO:0005615 extracellular space
2.58 1.77e-16 GO:0005576 extracellular region
2.24 3.38e-02 GO:0030054 cell junction
1.69 2.03e-03 GO:0044459 plasma membrane part
1.63 3.05e-07 GO:0005886 plasma membrane
1.61 7.55e-07 GO:0071944 cell periphery
1.26 5.41e-03 GO:0016020 membrane

Gene overrepresentation in function category:

Showing 1 to 7 of 7 entries
Enrichment   P-value GO Accession GO Term
19.19 8.68e-03 GO:0048407 platelet-derived growth factor binding
6.60 5.83e-04 GO:0005201 extracellular matrix structural constituent
5.23 1.84e-03 GO:0008201 heparin binding
4.31 5.22e-03 GO:0005539 glycosaminoglycan binding
3.99 1.14e-02 GO:0001871 pattern binding
3.99 1.14e-02 GO:0030247 polysaccharide binding
2.94 2.19e-06 GO:0005509 calcium ion binding