Motif ID: IRF1,2,7.p3

Z-value: 4.460


Transcription factors associated with IRF1,2,7.p3:

Gene SymbolEntrez IDGene Name
IRF1 3659 interferon regulatory factor 1
IRF2 3660 interferon regulatory factor 2
IRF7 3665 interferon regulatory factor 7

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
IRF7hg19_v1_chr11_-_615649_6157270.707.2e-06Click!
IRF1hg19_v1_chr5_-_131826426_1318265360.672.6e-05Click!
IRF2hg19_v1_chr4_-_185395616_1853957460.551.1e-03Click!


Activity profile for motif IRF1,2,7.p3.

activity profile for motif IRF1,2,7.p3


Sorted Z-values histogram for motif IRF1,2,7.p3

Sorted Z-values for motif IRF1,2,7.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of IRF1,2,7.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_+_113416267 22.142 NM_001032731
NM_002535
NM_016817
OAS2


2'-5'-oligoadenylate synthetase 2, 69/71kDa


chr7_+_150382783 19.639 NM_015660
GIMAP2
GTPase, IMAP family member 2
chr1_+_158901336 17.139 NM_152501
NM_198928
NM_198929
NM_198930
PYHIN1



pyrin and HIN domain family, member 1



chr7_+_74188308 16.831 NM_000265
NCF1
NCF1B
neutrophil cytosolic factor 1
neutrophil cytosolic factor 1B pseudogene
chr21_+_42733916 16.330 NM_002463
LOC100131190
MX2
uncharacterized LOC100131190
myxovirus (influenza virus) resistance 2 (mouse)
chr15_+_45003659 15.592 NM_004048
B2M
beta-2-microglobulin
chr2_-_89165652 15.554


chr5_+_131746579 15.464 C5orf56
chromosome 5 open reading frame 56
chr2_-_89442551 15.297 IGKC
IGK@
immunoglobulin kappa constant
immunoglobulin kappa locus
chr1_+_79086087 14.959 NM_006820
IFI44L
interferon-induced protein 44-like
chr2_+_90077732 14.938


chr3_+_122044010 14.698 NM_005213
CSTA
cystatin A (stefin A)
chr3_-_172241060 14.100 NM_001190943
NM_001190942
NM_003810
TNFSF10


tumor necrosis factor (ligand) superfamily, member 10


chr20_-_56195446 14.052 NM_001160417
NM_001160418
NM_001160419
NM_030776
ZBP1



Z-DNA binding protein 1



chr12_+_113376301 13.590 OAS3
2'-5'-oligoadenylate synthetase 3, 100kDa
chr19_+_18284619 13.556 IFI30
interferon, gamma-inducible protein 30
chr12_+_113376001 13.113 OAS3
2'-5'-oligoadenylate synthetase 3, 100kDa
chr19_+_18284578 13.103 NM_006332
IFI30
interferon, gamma-inducible protein 30
chr5_+_54398473 12.820 NM_006144
GZMA
granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
chr6_-_133084585 12.669 NM_078488
VNN2
vanin 2
chr11_-_615920 12.619 IRF7
interferon regulatory factor 7
chr11_-_615998 12.510 NM_001572
NM_004029
IRF7

interferon regulatory factor 7

chr10_+_91087601 12.371 NM_001549
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr4_-_76944585 12.326 NM_001565
CXCL10
chemokine (C-X-C motif) ligand 10
chr6_+_26402464 12.194 NM_001145008
NM_001145009
NM_007048
NM_194441
BTN3A1



butyrophilin, subfamily 3, member A1



chr12_+_113376226 12.180 NM_006187
OAS3
2'-5'-oligoadenylate synthetase 3, 100kDa
chr1_+_12227075 12.110 TNFRSF1B
tumor necrosis factor receptor superfamily, member 1B
chr1_+_27668499 11.756 SYTL1
synaptotagmin-like 1
chr2_+_204571379 11.724 CD28
CD28 molecule
chr19_+_18284631 11.462 IFI30
interferon, gamma-inducible protein 30
chr6_+_26440699 11.426 NM_001242803
NM_006994
NM_197974
BTN3A3


butyrophilin, subfamily 3, member A3


chr1_+_158801105 11.331 NM_002432
MNDA
myeloid cell nuclear differentiation antigen
chr8_+_39771327 11.207 NM_002164
IDO1
indoleamine 2,3-dioxygenase 1
chr16_-_67970651 11.177 PSMB10
proteasome (prosome, macropain) subunit, beta type, 10
chr22_+_36044412 11.089 NM_030641
APOL6
apolipoprotein L, 6
chr16_-_67970734 11.077 NM_002801
PSMB10
proteasome (prosome, macropain) subunit, beta type, 10
chr19_-_7766978 11.076 NM_001220500
NM_002002
FCER2

Fc fragment of IgE, low affinity II, receptor for (CD23)

chr11_-_104916041 11.010 NM_001017534
NM_052889
CARD16

caspase recruitment domain family, member 16

chr6_+_36973409 10.899 NM_173558
FGD2
FYVE, RhoGEF and PH domain containing 2
chr19_-_18197632 10.850 NM_005535
NM_153701
IL12RB1

interleukin 12 receptor, beta 1

chr3_+_187086167 10.621 NM_022147
RTP4
receptor (chemosensory) transporter protein 4
chr5_+_96212167 10.522 ERAP2
endoplasmic reticulum aminopeptidase 2
chr6_+_116782555 10.502 NM_001010919
FAM26F
family with sequence similarity 26, member F
chr1_+_948846 10.437 NM_005101
ISG15
ISG15 ubiquitin-like modifier
chrX_+_37639306 10.427 CYBB
cytochrome b-245, beta polypeptide
chr11_-_104972147 10.264 NM_001007232
NM_001223
NM_033292
NM_033293
NM_033294
NM_033295
CARD17
CASP1




caspase recruitment domain family, member 17
caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)




chr1_-_25291474 10.094 NM_001031680
RUNX3
runt-related transcription factor 3
chr1_-_27998719 10.023 NM_002038
NM_022872
NM_022873
IFI6


interferon, alpha-inducible protein 6


chr15_-_45003513 9.961


chr1_+_27668462 9.892 NM_001193308
NM_032872
SYTL1

synaptotagmin-like 1

chr1_-_161039745 9.880 NM_001025598
NM_181720
ARHGAP30

Rho GTPase activating protein 30

chr6_+_26365397 9.789 NM_001197247
NM_001197249
NM_007047
NM_001197248
BTN3A2



butyrophilin, subfamily 3, member A2



chrX_+_37639246 9.731 NM_000397
CYBB
cytochrome b-245, beta polypeptide
chr7_+_80267922 9.484 CD36
CD36 molecule (thrombospondin receptor)
chr14_-_106586333 9.382 IGHV4-31
immunoglobulin heavy variable 4-31
chr12_+_94542239 9.264 NM_005761
PLXNC1
plexin C1
chr6_-_30655671 9.227 NM_133471
PPP1R18
protein phosphatase 1, regulatory subunit 18
chr1_-_27998700 9.165 IFI6
interferon, alpha-inducible protein 6
chr22_+_39353526 9.161 NM_001193289
NM_145699
APOBEC3A

apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A

chr1_-_27998658 9.145 IFI6
interferon, alpha-inducible protein 6
chr8_-_22926490 8.863 NM_003842
NM_147187
TNFRSF10B

tumor necrosis factor receptor superfamily, member 10b

chr6_-_32821412 8.854 TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr6_-_32821592 8.844 TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr6_-_32821743 8.828 NM_000593
TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr11_+_5710816 8.814 NM_001199573
NM_006074
TRIM22

tripartite motif containing 22

chr1_+_12227050 8.808 NM_001066
TNFRSF1B
tumor necrosis factor receptor superfamily, member 1B
chr12_+_8276227 8.690 NM_016184
NM_194447
NM_194448
NM_194450
CLEC4A



C-type lectin domain family 4, member A



chr6_-_32812189 8.682 PSMB8
proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
chr2_+_7017795 8.594 NM_080657
RSAD2
radical S-adenosyl methionine domain containing 2
chr2_-_152146133 8.552 NMI
N-myc (and STAT) interactor
chr2_-_7005764 8.549 NM_207315
CMPK2
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr19_-_43032525 8.539 NM_001024912
NM_001184813
NM_001184815
NM_001184816
NM_001205344
NM_001712
CEACAM1





carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)





chr17_+_25958217 8.504 LGALS9
lectin, galactoside-binding, soluble, 9
chr20_+_825284 8.479 NM_031424
FAM110A
family with sequence similarity 110, member A
chr10_+_91092238 8.472 NM_001031683
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr12_-_10021932 8.439 CLEC2B
C-type lectin domain family 2, member B
chr11_+_124933197 8.343 SLC37A2
solute carrier family 37 (glycerol-3-phosphate transporter), member 2
chr1_+_247579457 8.287 NM_001079821
NM_001127461
NLRP3

NLR family, pyrin domain containing 3

chr12_-_8693391 8.234 NM_014358
CLEC4E
C-type lectin domain family 4, member E
chr11_+_124933007 8.194 NM_001145290
NM_198277
SLC37A2

solute carrier family 37 (glycerol-3-phosphate transporter), member 2

chr7_-_92777657 8.158 NM_152703
SAMD9L
sterile alpha motif domain containing 9-like
chr22_-_17700265 8.150 CECR1
cat eye syndrome chromosome region, candidate 1
chr15_+_89182038 8.149 NM_002201
ISG20
interferon stimulated exonuclease gene 20kDa
chr1_+_158149736 8.130 NM_001766
CD1D
CD1d molecule
chr19_-_47735858 8.103 NM_001127240
NM_001127241
NM_001127242
BBC3


BCL2 binding component 3


chr3_-_49851217 8.099 UBA7
ubiquitin-like modifier activating enzyme 7
chr17_+_25958257 8.080 LGALS9
lectin, galactoside-binding, soluble, 9
chr16_-_50715116 8.072 SNX20
sorting nexin 20
chr1_-_47695442 8.066 NM_003189
TAL1
T-cell acute lymphocytic leukemia 1
chr2_+_204571197 8.063 NM_001243077
NM_001243078
NM_006139
CD28


CD28 molecule


chr1_-_161601251 8.042 NM_001244753
FCGR3B
Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
chr2_-_231084600 8.040 NM_004509
NM_004510
NM_080424
SP110


SP110 nuclear body protein


chr9_-_100881462 8.021 NM_014788
NM_033219
NM_033220
TRIM14


tripartite motif containing 14


chr11_-_615649 8.019 NM_004031
IRF7
interferon regulatory factor 7
chr12_+_8608521 7.914 NM_001007033
CLEC6A
C-type lectin domain family 6, member A
chr17_+_25958245 7.913 LGALS9
lectin, galactoside-binding, soluble, 9
chr14_-_107218786 7.879 IGHA1
IGHG1
IGHM
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant mu
chr7_-_92747317 7.875 NM_001193307
NM_017654
SAMD9

sterile alpha motif domain containing 9

chr6_+_32821924 7.866 NM_002800
PSMB9
proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)
chr6_+_6588933 7.823 NM_004271
LY86
lymphocyte antigen 86
chr1_-_167487701 7.742 NM_000734
NM_198053
CD247

CD247 molecule

chr19_-_2282174 7.729 NM_198532
C19orf35
chromosome 19 open reading frame 35
chr17_+_25958151 7.728 NM_002308
NM_009587
LGALS9

lectin, galactoside-binding, soluble, 9

chr16_+_57023411 7.708 NLRC5
NLR family, CARD domain containing 5
chr3_-_49851356 7.702 NM_003335
UBA7
ubiquitin-like modifier activating enzyme 7
chr1_-_161039703 7.596 ARHGAP30
Rho GTPase activating protein 30
chr4_+_36285643 7.564 NM_001170700
DTHD1
death domain containing 1
chr11_-_104839263 7.550 NM_001225
CASP4
caspase 4, apoptosis-related cysteine peptidase
chr12_-_54778456 7.508 NM_015481
ZNF385A
zinc finger protein 385A
chr16_-_50715240 7.456 NM_001144972
NM_153337
NM_182854
SNX20


sorting nexin 20


chr17_+_25958192 7.419 LGALS9
lectin, galactoside-binding, soluble, 9
chr3_+_46448678 7.378 NM_003965
NM_001130910
CCRL2

chemokine (C-C motif) receptor-like 2

chr4_-_169239816 7.353 NM_017631
DDX60
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
chr13_-_43566301 7.340 NM_001002264
NM_033255
EPSTI1

epithelial stromal interaction 1 (breast)

chr6_-_138189313 7.213


chr16_+_10971038 7.172 NM_000246
CIITA
class II, major histocompatibility complex, transactivator
chr9_-_97402556 7.033 FBP1
fructose-1,6-bisphosphatase 1
chr7_+_128580725 7.032 NM_001098627
IRF5
interferon regulatory factor 5
chr1_+_79115476 6.997 NM_006417
IFI44
interferon-induced protein 44
chr11_+_63304272 6.947 NM_004585
RARRES3
retinoic acid receptor responder (tazarotene induced) 3
chr6_-_32811773 6.918 NM_148919
PSMB8
proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
chr17_-_4642638 6.872 CXCL16
chemokine (C-X-C motif) ligand 16
chr17_-_40264687 6.854 NM_024119
DHX58
DEXH (Asp-Glu-X-His) box polypeptide 58
chr2_-_192711923 6.834 NM_004657
SDPR
serum deprivation response
chr11_-_60719116 6.817 NM_016582
SLC15A3
solute carrier family 15, member 3
chr9_-_100881515 6.782 TRIM14
tripartite motif containing 14
chr22_+_36044475 6.778 APOL6
apolipoprotein L, 6
chr3_+_122399665 6.739 NM_017554
PARP14
poly (ADP-ribose) polymerase family, member 14
chr9_-_97402530 6.723 NM_001127628
FBP1
fructose-1,6-bisphosphatase 1
chr19_+_17516502 6.721 LOC100507535
uncharacterized LOC100507535
chr12_-_10022457 6.708 NM_005127
CLEC2B
C-type lectin domain family 2, member B
chr17_-_4643162 6.702 NM_001100812
NM_022059
CXCL16

chemokine (C-X-C motif) ligand 16

chr19_+_55174425 6.673 LILRB4
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
chr12_+_40618786 6.666 NM_198578
LRRK2
leucine-rich repeat kinase 2
chr17_-_20370819 6.631 NM_001042685
LGALS9B
lectin, galactoside-binding, soluble, 9B
chr8_+_18079176 6.617 NM_001160174
NAT1
N-acetyltransferase 1 (arylamine N-acetyltransferase)
chr19_+_55174405 6.607 LILRB4
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
chr17_-_80291639 6.598 SECTM1
secreted and transmembrane 1
chr13_-_41635072 6.593 ELF1
E74-like factor 1 (ets domain transcription factor)
chr7_-_76829109 6.579 NM_006682
FGL2
fibrinogen-like 2
chr7_+_80267782 6.570 NM_000072
NM_001001548
CD36

CD36 molecule (thrombospondin receptor)

chr5_-_95158365 6.542 GLRX
glutaredoxin (thioltransferase)
chr7_-_150329285 6.539 GIMAP6
GTPase, IMAP family member 6
chr14_-_25103365 6.429 NM_004131
GZMB
granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
chr3_+_154797910 6.427 NM_007288
MME
membrane metallo-endopeptidase
chr2_-_152146373 6.415 NM_004688
NMI
N-myc (and STAT) interactor
chr17_-_80291610 6.312 SECTM1
secreted and transmembrane 1
chr7_-_92747269 6.284 SAMD9
sterile alpha motif domain containing 9
chr5_+_49962920 6.269 PARP8
poly (ADP-ribose) polymerase family, member 8
chr2_+_169929009 6.239 NM_001142270
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr11_-_57335080 6.188 NM_004223
UBE2L6
ubiquitin-conjugating enzyme E2L 6
chr11_-_4414887 6.186 NM_003141
TRIM21
tripartite motif containing 21
chr1_-_89488412 6.177 NM_018284
GBP3
guanylate binding protein 3
chr7_+_134832765 6.134 NM_018295
TMEM140
transmembrane protein 140
chr6_-_133035180 6.107 NM_004666
VNN1
vanin 1
chr2_-_242800989 6.103 NM_005018
PDCD1
programmed cell death 1
chr22_+_39473009 6.094 NM_021822
APOBEC3G
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
chr6_+_31540092 6.053 NM_000595
LTA
lymphotoxin alpha (TNF superfamily, member 1)
chr22_+_39417117 6.050 NM_152426
APOBEC3D
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D
chr19_+_52264452 6.010 NM_001005738
FPR2
formyl peptide receptor 2
chr5_-_149792335 5.992


chr5_-_149792276 5.984 CD74
CD74 molecule, major histocompatibility complex, class II invariant chain
chr13_+_31309644 5.925 NM_001629
ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr14_-_107122358 5.913


chr22_+_40297085 5.912 NM_004810
GRAP2
GRB2-related adaptor protein 2
chr11_+_71710662 5.896 NM_001145057
IL18BP
interleukin 18 binding protein
chr5_-_95158465 5.896 NM_001118890
NM_001243658
NM_001243659
NM_002064
GLRX



glutaredoxin (thioltransferase)



chr17_+_6659356 5.882 XAF1
XIAP associated factor 1
chr1_+_158979681 5.711 NM_001206567
NM_005531
IFI16

interferon, gamma-inducible protein 16

chr6_-_33281790 5.706 TAPBP
TAP binding protein (tapasin)
chr4_+_155484131 5.695 NM_001184741
NM_005141
FGB

fibrinogen beta chain

chr6_-_33282006 5.683 NM_003190
NM_172208
NM_172209
TAPBP


TAP binding protein (tapasin)


chr17_+_6659155 5.677 NM_017523
NM_199139
XAF1

XIAP associated factor 1

chr2_+_90211704 5.668


chr21_+_42792441 5.626 NM_001144925
MX1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr12_+_113344811 5.486 OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr1_+_221052735 5.483 NM_021958
HLX
H2.0-like homeobox
chr17_+_72462780 5.480 CD300A
CD300a molecule
chr8_-_66701175 5.464 NM_002603
PDE7A
phosphodiesterase 7A
chr12_-_54778298 5.409 ZNF385A
zinc finger protein 385A
chr16_-_11350038 5.372 NM_003745
SOCS1
suppressor of cytokine signaling 1
chr19_+_6887576 5.339 NM_001974
EMR1
egf-like module containing, mucin-like, hormone receptor-like 1
chr17_+_18380097 5.336 NM_001040078
LGALS9B
LGALS9C
lectin, galactoside-binding, soluble, 9B
lectin, galactoside-binding, soluble, 9C
chr6_-_33281847 5.306 TAPBP
TAP binding protein (tapasin)
chr17_+_41363845 5.286 NM_145041
TMEM106A
transmembrane protein 106A
chr6_-_31239489 5.273 HLA-B
HLA-C
major histocompatibility complex, class I, B
major histocompatibility complex, class I, C
chr5_-_149792370 5.244 NM_001025158
NM_001025159
NM_004355
CD74


CD74 molecule, major histocompatibility complex, class II invariant chain


chr9_-_32526164 5.214 NM_014314
DDX58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr16_-_74734687 5.213 NM_001142497
NM_152649
MLKL

mixed lineage kinase domain-like

chr10_+_91061705 5.204 NM_001547
IFIT2
interferon-induced protein with tetratricopeptide repeats 2
chr1_-_89530890 5.155 NM_002053
GBP1
guanylate binding protein 1, interferon-inducible
chr1_+_221052845 5.150 HLX
H2.0-like homeobox
chr13_+_31309690 5.128 ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr3_+_122283139 5.121 NM_138287
DTX3L
deltex 3-like (Drosophila)
chr11_-_58980321 5.103 NM_001039396
MPEG1
macrophage expressed 1
chr4_+_142557722 5.082 NM_000585
NM_172175
IL15

interleukin 15

chr3_+_154798078 5.072 NM_007289
MME
membrane metallo-endopeptidase
chr4_-_169401603 5.053 NM_001012967
DDX60L
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like
chr2_+_169937616 5.013 NM_001142271
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr3_+_113251217 5.009 NM_017699
SIDT1
SID1 transmembrane family, member 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
4.59 8.17e-53 GO:0002376 immune system process
5.73 6.44e-48 GO:0006955 immune response
6.97 4.44e-33 GO:0045087 innate immune response
4.58 1.02e-32 GO:0006952 defense response
15.19 2.24e-21 GO:0034340 response to type I interferon
14.84 3.59e-20 GO:0060337 type I interferon-mediated signaling pathway
14.84 3.59e-20 GO:0071357 cellular response to type I interferon
7.22 6.07e-20 GO:0071345 cellular response to cytokine stimulus
7.60 1.10e-19 GO:0019221 cytokine-mediated signaling pathway
3.91 7.05e-19 GO:0002682 regulation of immune system process
5.85 8.51e-19 GO:0034097 response to cytokine stimulus
2.28 3.40e-18 GO:0006950 response to stress
7.46 2.04e-15 GO:0009615 response to virus
4.38 3.83e-15 GO:0050776 regulation of immune response
1.57 6.03e-14 GO:0050896 response to stimulus
4.24 7.09e-14 GO:0002684 positive regulation of immune system process
4.18 2.90e-12 GO:0051707 response to other organism
4.52 2.36e-11 GO:0031347 regulation of defense response
2.87 5.83e-11 GO:0051704 multi-organism process
3.59 1.58e-10 GO:0009607 response to biotic stimulus
8.74 5.07e-10 GO:0034341 response to interferon-gamma
9.20 3.70e-09 GO:0071346 cellular response to interferon-gamma
4.35 4.56e-09 GO:0050778 positive regulation of immune response
25.47 7.95e-09 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
9.50 9.72e-09 GO:0060333 interferon-gamma-mediated signaling pathway
36.79 1.71e-08 GO:0019883 antigen processing and presentation of endogenous antigen
4.80 2.37e-08 GO:0051249 regulation of lymphocyte activation
4.31 2.71e-08 GO:0001817 regulation of cytokine production
5.39 2.80e-08 GO:0051251 positive regulation of lymphocyte activation
5.14 3.01e-08 GO:0050867 positive regulation of cell activation
18.40 4.73e-08 GO:0048002 antigen processing and presentation of peptide antigen
2.01 6.48e-08 GO:0048583 regulation of response to stimulus
3.20 8.15e-08 GO:0080134 regulation of response to stress
1.68 1.02e-07 GO:0007165 signal transduction
2.68 1.03e-07 GO:0048584 positive regulation of response to stimulus
4.35 1.08e-07 GO:0050865 regulation of cell activation
1.59 1.08e-07 GO:0051716 cellular response to stimulus
5.02 1.28e-07 GO:0002696 positive regulation of leukocyte activation
4.36 2.25e-07 GO:0002694 regulation of leukocyte activation
9.37 2.54e-07 GO:0019882 antigen processing and presentation
6.62 3.04e-07 GO:0050670 regulation of lymphocyte proliferation
6.56 3.60e-07 GO:0032944 regulation of mononuclear cell proliferation
2.84 4.77e-07 GO:0071310 cellular response to organic substance
7.45 5.02e-07 GO:0043900 regulation of multi-organism process
6.37 5.95e-07 GO:0070663 regulation of leukocyte proliferation
5.26 8.28e-07 GO:0002697 regulation of immune effector process
5.49 9.72e-07 GO:0050870 positive regulation of T cell activation
1.35 1.00e-06 GO:0050789 regulation of biological process
4.88 1.38e-06 GO:0050863 regulation of T cell activation
1.33 1.40e-06 GO:0065007 biological regulation
1.94 2.92e-06 GO:0007166 cell surface receptor linked signaling pathway
1.58 3.62e-06 GO:0023052 signaling
5.38 3.77e-06 GO:0001819 positive regulation of cytokine production
9.20 6.61e-06 GO:0032479 regulation of type I interferon production
2.35 7.46e-06 GO:0070887 cellular response to chemical stimulus
1.70 8.98e-06 GO:0048518 positive regulation of biological process
10.12 9.86e-06 GO:0071260 cellular response to mechanical stimulus
4.42 2.05e-05 GO:0002764 immune response-regulating signaling pathway
36.79 2.37e-05 GO:0002483 antigen processing and presentation of endogenous peptide antigen
36.79 2.37e-05 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I
4.36 5.78e-05 GO:0045088 regulation of innate immune response
1.33 6.03e-05 GO:0050794 regulation of cellular process
4.80 6.18e-05 GO:0043122 regulation of I-kappaB kinase/NF-kappaB cascade
2.15 1.09e-04 GO:0043067 regulation of programmed cell death
6.55 1.19e-04 GO:0050671 positive regulation of lymphocyte proliferation
6.47 1.41e-04 GO:0032946 positive regulation of mononuclear cell proliferation
6.38 1.67e-04 GO:0070665 positive regulation of leukocyte proliferation
2.12 1.84e-04 GO:0010941 regulation of cell death
2.13 2.00e-04 GO:0042981 regulation of apoptosis
1.67 2.44e-04 GO:0048522 positive regulation of cellular process
3.08 2.45e-04 GO:0044419 interspecies interaction between organisms
15.15 2.63e-04 GO:0050691 regulation of defense response to virus by host
6.69 3.00e-04 GO:0071214 cellular response to abiotic stimulus
4.09 3.48e-04 GO:0002757 immune response-activating signal transduction
7.23 4.29e-04 GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
1.68 4.33e-04 GO:0042221 response to chemical stimulus
5.37 5.04e-04 GO:0032103 positive regulation of response to external stimulus
4.67 5.14e-04 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB cascade
7.10 5.19e-04 GO:0002819 regulation of adaptive immune response
4.41 5.21e-04 GO:0002252 immune effector process
3.63 6.17e-04 GO:0002253 activation of immune response
7.67 8.46e-04 GO:0050729 positive regulation of inflammatory response
2.88 9.51e-04 GO:0010627 regulation of intracellular protein kinase cascade
8.72 9.90e-04 GO:0030888 regulation of B cell proliferation
7.51 1.04e-03 GO:0050688 regulation of defense response to virus
5.89 1.27e-03 GO:0002699 positive regulation of immune effector process
2.59 1.58e-03 GO:0001775 cell activation
4.86 1.74e-03 GO:0050727 regulation of inflammatory response
3.18 1.78e-03 GO:0006954 inflammatory response
3.36 2.18e-03 GO:0045321 leukocyte activation
2.53 2.52e-03 GO:0043068 positive regulation of programmed cell death
3.91 2.84e-03 GO:0031349 positive regulation of defense response
3.19 2.97e-03 GO:0010740 positive regulation of intracellular protein kinase cascade
2.11 3.05e-03 GO:0008219 cell death
2.10 3.49e-03 GO:0016265 death
2.08 3.55e-03 GO:0009611 response to wounding
4.93 3.56e-03 GO:0002683 negative regulation of immune system process
2.49 3.63e-03 GO:0010942 positive regulation of cell death
4.52 4.22e-03 GO:0042110 T cell activation
29.43 4.30e-03 GO:0052564 response to immune response of other organism involved in symbiotic interaction
29.43 4.30e-03 GO:0052572 response to host immune response
18.40 5.34e-03 GO:0002230 positive regulation of defense response to virus by host
2.47 6.20e-03 GO:0043065 positive regulation of apoptosis
3.87 6.46e-03 GO:0071496 cellular response to external stimulus
1.85 7.00e-03 GO:0051239 regulation of multicellular organismal process
12.27 8.96e-03 GO:0045069 regulation of viral genome replication
1.84 9.48e-03 GO:0010033 response to organic substance
16.73 9.57e-03 GO:0032647 regulation of interferon-alpha production
4.51 9.75e-03 GO:0043281 regulation of caspase activity
5.94 9.89e-03 GO:0002831 regulation of response to biotic stimulus
5.94 9.89e-03 GO:0030217 T cell differentiation
5.94 9.89e-03 GO:0031294 lymphocyte costimulation
5.94 9.89e-03 GO:0031295 T cell costimulation
2.80 1.01e-02 GO:0051240 positive regulation of multicellular organismal process
5.26 1.15e-02 GO:0043280 positive regulation of caspase activity
9.20 1.23e-02 GO:0030890 positive regulation of B cell proliferation
9.20 1.23e-02 GO:0051607 defense response to virus
24.53 1.26e-02 GO:0060907 positive regulation of macrophage cytokine production
11.62 1.28e-02 GO:0042346 positive regulation of NF-kappaB import into nucleus
3.21 1.37e-02 GO:0032101 regulation of response to external stimulus
5.66 1.53e-02 GO:0006919 activation of caspase activity
8.88 1.59e-02 GO:0042345 regulation of NF-kappaB import into nucleus
15.33 1.60e-02 GO:0006568 tryptophan metabolic process
11.04 1.79e-02 GO:0009595 detection of biotic stimulus
8.59 2.02e-02 GO:0032480 negative regulation of type I interferon production
8.59 2.02e-02 GO:0032642 regulation of chemokine production
3.38 2.04e-02 GO:0046649 lymphocyte activation
3.08 2.43e-02 GO:0030097 hemopoiesis
1.55 2.45e-02 GO:0048519 negative regulation of biological process
4.46 2.50e-02 GO:0009612 response to mechanical stimulus
21.03 2.88e-02 GO:0019884 antigen processing and presentation of exogenous antigen
21.03 2.88e-02 GO:0061081 positive regulation of myeloid leukocyte cytokine production involved in immune response
5.91 2.98e-02 GO:0002706 regulation of lymphocyte mediated immunity
2.50 3.09e-02 GO:0007243 intracellular protein kinase cascade
2.50 3.09e-02 GO:0023014 signal transduction via phosphorylation event
36.79 3.26e-02 GO:0045345 positive regulation of MHC class I biosynthetic process
10.04 3.28e-02 GO:0032722 positive regulation of chemokine production
3.02 3.31e-02 GO:0051241 negative regulation of multicellular organismal process
6.69 3.44e-02 GO:0045621 positive regulation of lymphocyte differentiation
2.90 3.57e-02 GO:0048534 hemopoietic or lymphoid organ development
4.65 3.78e-02 GO:0010952 positive regulation of peptidase activity
1.90 3.79e-02 GO:0009605 response to external stimulus
2.07 4.08e-02 GO:0012501 programmed cell death
4.21 4.56e-02 GO:0002768 immune response-regulating cell surface receptor signaling pathway
4.55 4.70e-02 GO:0001818 negative regulation of cytokine production

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
4.80 7.77e-06 GO:0009897 external side of plasma membrane
1.50 2.01e-02 GO:0044459 plasma membrane part
1.88 3.13e-02 GO:0005615 extracellular space
1.31 4.90e-02 GO:0005886 plasma membrane

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
11.87 1.79e-06 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
10.12 2.03e-06 GO:0003823 antigen binding
1.16 4.45e-05 GO:0005488 binding
3.89 1.60e-04 GO:0005126 cytokine receptor binding
3.68 3.68e-04 GO:0005529 sugar binding
3.42 2.04e-03 GO:0005125 cytokine activity
10.04 6.77e-03 GO:0003950 NAD+ ADP-ribosyltransferase activity
2.52 7.93e-03 GO:0030246 carbohydrate binding
9.60 8.95e-03 GO:0019239 deaminase activity
6.40 9.94e-03 GO:0008009 chemokine activity
4.09 1.25e-02 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
5.77 2.15e-02 GO:0042379 chemokine receptor binding
1.48 3.50e-02 GO:0016787 hydrolase activity
1.21 4.34e-02 GO:0005515 protein binding