Motif ID: IRF1,2,7.p3

Z-value: 4.460


Transcription factors associated with IRF1,2,7.p3:

Gene SymbolEntrez IDGene Name
IRF1 3659 interferon regulatory factor 1
IRF2 3660 interferon regulatory factor 2
IRF7 3665 interferon regulatory factor 7

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
IRF7hg19_v1_chr11_-_615649_6157270.707.2e-06Click!
IRF1hg19_v1_chr5_-_131826426_1318265360.672.6e-05Click!
IRF2hg19_v1_chr4_-_185395616_1853957460.551.1e-03Click!


Activity profile for motif IRF1,2,7.p3.

activity profile for motif IRF1,2,7.p3


Sorted Z-values histogram for motif IRF1,2,7.p3

Sorted Z-values for motif IRF1,2,7.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of IRF1,2,7.p3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_+_113416267 22.142 NM_001032731
NM_002535
NM_016817
 OAS2


2'-5'-oligoadenylate synthetase 2, 69/71kDa


chr7_+_150382783 19.639 NM_015660
 GIMAP2
GTPase, IMAP family member 2
chr1_+_158901336 17.139 NM_152501
NM_198928
NM_198929
NM_198930
 PYHIN1



pyrin and HIN domain family, member 1



chr7_+_74188308 16.831 NM_000265
 NCF1
NCF1B
neutrophil cytosolic factor 1
neutrophil cytosolic factor 1B pseudogene
chr21_+_42733916 16.330 NM_002463
 LOC100131190
MX2
uncharacterized LOC100131190
myxovirus (influenza virus) resistance 2 (mouse)
chr15_+_45003659 15.592 NM_004048
 B2M
beta-2-microglobulin
chr2_-_89165652 15.554


chr5_+_131746579 15.464 C5orf56
chromosome 5 open reading frame 56
chr2_-_89442551 15.297 IGKC
IGK@
immunoglobulin kappa constant
immunoglobulin kappa locus
chr1_+_79086087 14.959 NM_006820
 IFI44L
interferon-induced protein 44-like
chr2_+_90077732 14.938


chr3_+_122044010 14.698 NM_005213
 CSTA
cystatin A (stefin A)
chr3_-_172241060 14.100 NM_001190943
NM_001190942
NM_003810
 TNFSF10


tumor necrosis factor (ligand) superfamily, member 10


chr20_-_56195446 14.052 NM_001160417
NM_001160418
NM_001160419
NM_030776
 ZBP1



Z-DNA binding protein 1



chr12_+_113376301 13.590 OAS3
2'-5'-oligoadenylate synthetase 3, 100kDa
chr19_+_18284619 13.556 IFI30
interferon, gamma-inducible protein 30
chr12_+_113376001 13.113 OAS3
2'-5'-oligoadenylate synthetase 3, 100kDa
chr19_+_18284578 13.103 NM_006332
 IFI30
interferon, gamma-inducible protein 30
chr5_+_54398473 12.820 NM_006144
 GZMA
granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
chr6_-_133084585 12.669 NM_078488
 VNN2
vanin 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 145 entries
Enrichment   P-value GO Accession GO Term
36.79 1.71e-08 GO:0019883 antigen processing and presentation of endogenous antigen
36.79 2.37e-05 GO:0002483 antigen processing and presentation of endogenous peptide antigen
36.79 2.37e-05 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I
36.79 3.26e-02 GO:0045345 positive regulation of MHC class I biosynthetic process
29.43 4.30e-03 GO:0052564 response to immune response of other organism involved in symbiotic interaction
29.43 4.30e-03 GO:0052572 response to host immune response
25.47 7.95e-09 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
24.53 1.26e-02 GO:0060907 positive regulation of macrophage cytokine production
21.03 2.88e-02 GO:0019884 antigen processing and presentation of exogenous antigen
21.03 2.88e-02 GO:0061081 positive regulation of myeloid leukocyte cytokine production involved in immune response
18.40 4.73e-08 GO:0048002 antigen processing and presentation of peptide antigen
18.40 5.34e-03 GO:0002230 positive regulation of defense response to virus by host
16.73 9.57e-03 GO:0032647 regulation of interferon-alpha production
15.33 1.60e-02 GO:0006568 tryptophan metabolic process
15.19 2.24e-21 GO:0034340 response to type I interferon
15.15 2.63e-04 GO:0050691 regulation of defense response to virus by host
14.84 3.59e-20 GO:0060337 type I interferon-mediated signaling pathway
14.84 3.59e-20 GO:0071357 cellular response to type I interferon
12.27 8.96e-03 GO:0045069 regulation of viral genome replication
11.62 1.28e-02 GO:0042346 positive regulation of NF-kappaB import into nucleus

Gene overrepresentation in compartment category:

Showing 1 to 4 of 4 entries
Enrichment   P-value GO Accession GO Term
4.80 7.77e-06 GO:0009897 external side of plasma membrane
1.88 3.13e-02 GO:0005615 extracellular space
1.50 2.01e-02 GO:0044459 plasma membrane part
1.31 4.90e-02 GO:0005886 plasma membrane

Gene overrepresentation in function category:

Showing 1 to 14 of 14 entries
Enrichment   P-value GO Accession GO Term
11.87 1.79e-06 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
10.12 2.03e-06 GO:0003823 antigen binding
10.04 6.77e-03 GO:0003950 NAD+ ADP-ribosyltransferase activity
9.60 8.95e-03 GO:0019239 deaminase activity
6.40 9.94e-03 GO:0008009 chemokine activity
5.77 2.15e-02 GO:0042379 chemokine receptor binding
4.09 1.25e-02 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
3.89 1.60e-04 GO:0005126 cytokine receptor binding
3.68 3.68e-04 GO:0005529 sugar binding
3.42 2.04e-03 GO:0005125 cytokine activity
2.52 7.93e-03 GO:0030246 carbohydrate binding
1.48 3.50e-02 GO:0016787 hydrolase activity
1.21 4.34e-02 GO:0005515 protein binding
1.16 4.45e-05 GO:0005488 binding