Motif ID: KLF4.p3

Z-value: 2.499


Transcription factors associated with KLF4.p3:

Gene SymbolEntrez IDGene Name
KLF4 9314 Kruppel-like factor 4 (gut)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
KLF4hg19_v1_chr9_-_110251754_1102519260.709.4e-06Click!


Activity profile for motif KLF4.p3.

activity profile for motif KLF4.p3


Sorted Z-values histogram for motif KLF4.p3

Sorted Z-values for motif KLF4.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of KLF4.p3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_38471170 4.829 NM_001243878
NM_004468
 FHL3

four and a half LIM domains 3

chr9_-_110251754 4.552 KLF4
Kruppel-like factor 4 (gut)
chr4_+_154387450 4.474 NM_001131007
NM_015196
 KIAA0922

KIAA0922

chrX_-_153599581 4.465 FLNA
filamin A, alpha
chr18_+_11981457 4.450 IMPA2
inositol(myo)-1(or 4)-monophosphatase 2
chr22_-_36784001 4.412 MYH9
myosin, heavy chain 9, non-muscle
chr18_+_11981552 4.407 IMPA2
inositol(myo)-1(or 4)-monophosphatase 2
chr22_-_36783851 4.238 MYH9
myosin, heavy chain 9, non-muscle
chr8_+_37553269 4.098 NM_025069
 ZNF703
zinc finger protein 703
chr22_-_36783930 4.077 MYH9
myosin, heavy chain 9, non-muscle
chr17_+_81037504 3.941 NM_001004431
 METRNL
meteorin, glial cell differentiation regulator-like
chr1_+_154975041 3.835 NM_001252405
NM_015872
 ZBTB7B

zinc finger and BTB domain containing 7B

chr15_+_90931505 3.729 IQGAP1
IQ motif containing GTPase activating protein 1
chr19_+_54371170 3.699 MYADM
myeloid-associated differentiation marker
chr18_+_11981421 3.677 NM_014214
 IMPA2
inositol(myo)-1(or 4)-monophosphatase 2
chr2_+_85132999 3.666 TMSB10
thymosin beta 10
chr1_-_9189087 3.659 NM_024980
 GPR157
G protein-coupled receptor 157
chrX_+_152990322 3.642 NM_000033
 ABCD1
ATP-binding cassette, sub-family D (ALD), member 1
chr7_-_102257135 3.642 RASA4
RAS p21 protein activator 4
chr15_+_90931489 3.624 IQGAP1
IQ motif containing GTPase activating protein 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 42 entries
Enrichment   P-value GO Accession GO Term
4.04 3.19e-02 GO:0034329 cell junction assembly
3.39 3.34e-03 GO:0030036 actin cytoskeleton organization
3.36 6.62e-04 GO:0030029 actin filament-based process
2.68 8.68e-03 GO:0007243 intracellular protein kinase cascade
2.68 8.68e-03 GO:0023014 signal transduction via phosphorylation event
2.65 2.08e-03 GO:0007010 cytoskeleton organization
2.21 8.20e-07 GO:0035556 intracellular signal transduction
2.19 1.13e-02 GO:0006468 protein phosphorylation
2.15 3.24e-03 GO:0006351 transcription, DNA-dependent
2.15 1.80e-02 GO:0006955 immune response
1.98 1.91e-02 GO:0032774 RNA biosynthetic process
1.96 3.20e-04 GO:0009966 regulation of signal transduction
1.91 4.80e-02 GO:0006793 phosphorus metabolic process
1.91 4.80e-02 GO:0006796 phosphate metabolic process
1.89 2.25e-04 GO:0023051 regulation of signaling
1.84 5.24e-08 GO:0048518 positive regulation of biological process
1.84 2.31e-02 GO:0002376 immune system process
1.83 1.57e-04 GO:0048583 regulation of response to stimulus
1.73 5.38e-05 GO:0048522 positive regulation of cellular process
1.70 1.35e-03 GO:0048523 negative regulation of cellular process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 22 entries
Enrichment   P-value GO Accession GO Term
9.57 3.16e-04 GO:0042641 actomyosin
8.46 1.49e-02 GO:0001725 stress fiber
7.89 2.25e-02 GO:0032432 actin filament bundle
7.08 1.21e-02 GO:0000118 histone deacetylase complex
5.18 3.19e-04 GO:0005925 focal adhesion
4.93 5.62e-04 GO:0005924 cell-substrate adherens junction
4.75 8.64e-04 GO:0030055 cell-substrate junction
4.44 4.67e-02 GO:0009898 internal side of plasma membrane
4.24 3.10e-04 GO:0005912 adherens junction
4.07 2.60e-04 GO:0070161 anchoring junction
3.10 5.77e-03 GO:0016323 basolateral plasma membrane
3.04 1.03e-03 GO:0015629 actin cytoskeleton
1.91 1.26e-07 GO:0005829 cytosol
1.62 3.93e-02 GO:0005856 cytoskeleton
1.40 1.52e-05 GO:0005634 nucleus
1.24 8.55e-04 GO:0005737 cytoplasm
1.22 8.39e-08 GO:0044424 intracellular part
1.21 4.54e-08 GO:0005622 intracellular
1.21 4.28e-03 GO:0043231 intracellular membrane-bounded organelle
1.21 4.72e-03 GO:0043227 membrane-bounded organelle

Gene overrepresentation in function category:

Showing 1 to 18 of 18 entries
Enrichment   P-value GO Accession GO Term
3.46 3.15e-03 GO:0010843 promoter binding
3.32 5.36e-03 GO:0000975 regulatory region DNA binding
3.32 5.36e-03 GO:0001067 regulatory region nucleic acid binding
3.32 5.36e-03 GO:0044212 transcription regulatory region DNA binding
3.01 6.94e-03 GO:0005096 GTPase activator activity
2.76 1.48e-02 GO:0008134 transcription factor binding
2.40 8.99e-03 GO:0030695 GTPase regulator activity
2.34 1.43e-02 GO:0060589 nucleoside-triphosphatase regulator activity
2.30 7.32e-03 GO:0008092 cytoskeletal protein binding
2.27 1.06e-03 GO:0043565 sequence-specific DNA binding
2.21 2.26e-05 GO:0001071 nucleic acid binding transcription factor activity
2.21 2.26e-05 GO:0003700 sequence-specific DNA binding transcription factor activity
2.07 2.79e-04 GO:0030528 transcription regulator activity
1.95 4.48e-02 GO:0019899 enzyme binding
1.90 1.37e-02 GO:0030234 enzyme regulator activity
1.54 9.44e-03 GO:0003677 DNA binding
1.40 4.82e-09 GO:0005515 protein binding
1.17 2.19e-05 GO:0005488 binding