Motif ID: LEF1_TCF7_TCF7L1,2.p2

Z-value: 1.461


Transcription factors associated with LEF1_TCF7_TCF7L1,2.p2:

Gene SymbolEntrez IDGene Name
LEF1 51176 lymphoid enhancer-binding factor 1
TCF7 6932 transcription factor 7 (T-cell specific, HMG-box)
TCF7L1 83439 transcription factor 7-like 1 (T-cell specific, HMG-box)
TCF7L2 6934 transcription factor 7-like 2 (T-cell specific, HMG-box)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
TCF7L1hg19_v1_chr2_+_85360373_853609460.476.5e-03Click!
TCF7L2hg19_v1_chr10_+_114709963_1147106410.468.8e-03Click!
TCF7hg19_v1_chr5_+_133450353_133450685-0.281.2e-01Click!
LEF1hg19_v1_chr4_-_109087876_109087952-0.202.8e-01Click!


Activity profile for motif LEF1_TCF7_TCF7L1,2.p2.

activity profile for motif LEF1_TCF7_TCF7L1,2.p2


Sorted Z-values histogram for motif LEF1_TCF7_TCF7L1,2.p2

Sorted Z-values for motif LEF1_TCF7_TCF7L1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of LEF1_TCF7_TCF7L1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_+_73245192 4.732 NM_001305
CLDN4
claudin 4
chr17_-_46035109 4.064 NM_024320
PRR15L
proline rich 15-like
chr2_+_47596447 3.851 EPCAM
epithelial cell adhesion molecule
chr14_-_65409445 3.678 NM_002083
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr8_-_119964059 3.100 NM_002546
TNFRSF11B
tumor necrosis factor receptor superfamily, member 11b
chr15_+_43885251 3.066 NM_020990
CKMT1B
CKMT1A
creatine kinase, mitochondrial 1B
creatine kinase, mitochondrial 1A
chr2_+_69240137 2.633 NM_018153
NM_032208
NM_053034
ANTXR1


anthrax toxin receptor 1


chr2_+_47596286 2.559 NM_002354
EPCAM
epithelial cell adhesion molecule
chr7_-_16505292 2.558 NM_015464
SOSTDC1
sclerostin domain containing 1
chr9_+_133971902 2.481 AIF1L
allograft inflammatory factor 1-like
chr20_+_57875481 2.386 NM_000114
NM_207032
NM_207033
NM_207034
EDN3



endothelin 3



chr12_-_16759939 2.321 NM_001243613
LMO3
LIM domain only 3 (rhombotin-like 2)
chr12_-_16759531 2.301 NM_018640
LMO3
LIM domain only 3 (rhombotin-like 2)
chr12_+_57943843 2.068 NM_004984
KIF5A
kinesin family member 5A
chr11_-_13517525 2.022 NM_000315
PTH
parathyroid hormone
chr19_-_7990974 2.014 NM_206833
CTXN1
cortexin 1
chr20_+_36149606 1.972 NM_005386
NM_181689
NNAT

neuronatin

chr7_-_120498128 1.960 NM_012338
TSPAN12
tetraspanin 12
chr2_+_233734993 1.951 NM_206895
C2orf82
chromosome 2 open reading frame 82
chr20_+_17207596 1.890 NM_001201529
NM_002594
PCSK2

proprotein convertase subtilisin/kexin type 2

chr7_+_142982039 1.876 NM_001242773
NM_001242774
NM_001242775
NM_001242776
NM_001242777
NM_153345
TMEM139





transmembrane protein 139





chr12_-_91573264 1.875 NM_133503
DCN
decorin
chr8_+_133879202 1.865 NM_003235
TG
thyroglobulin
chrX_+_46937744 1.854 NM_004683
NM_152869
RGN

regucalcin (senescence marker protein-30)

chr3_+_132757170 1.849 NM_001136469
NM_023943
TMEM108

transmembrane protein 108

chr10_-_91295310 1.841 NM_213606
SLC16A12
solute carrier family 16, member 12 (monocarboxylic acid transporter 12)
chr5_+_140235594 1.824 NM_018901
NM_031859
NM_031860
PCDHA10


protocadherin alpha 10


chr13_+_111137249 1.790 COL4A2
collagen, type IV, alpha 2
chr7_-_107643330 1.780 NM_002291
LAMB1
laminin, beta 1
chrX_-_128788913 1.759 NM_017413
APLN
apelin
chr18_-_24445652 1.736 NM_001650
AQP4
aquaporin 4
chr10_-_123356158 1.735 NM_001144915
FGFR2
fibroblast growth factor receptor 2
chr20_+_57875647 1.720 EDN3
endothelin 3
chr21_-_43735462 1.706 TFF3
trefoil factor 3 (intestinal)
chr2_-_170218972 1.692 LRP2
low density lipoprotein receptor-related protein 2
chr5_+_131593388 1.644 PDLIM4
PDZ and LIM domain 4
chr3_-_149375584 1.642 NM_001168280
NM_015472
WWTR1

WW domain containing transcription regulator 1

chr4_-_5894695 1.634 NM_001014809
CRMP1
collapsin response mediator protein 1
chr20_+_17206751 1.626 NM_001201528
PCSK2
proprotein convertase subtilisin/kexin type 2
chr7_+_94023872 1.626 NM_000089
COL1A2
collagen, type I, alpha 2
chr1_+_82266081 1.588 NM_012302
LPHN2
latrophilin 2
chr11_+_69455884 1.586 CCND1
cyclin D1
chr9_-_34381497 1.585 NM_001252195
NM_147168
NM_147169
C9orf24


chromosome 9 open reading frame 24


chr2_-_75788079 1.574 NM_001135032
FAM176A
family with sequence similarity 176, member A
chr15_-_41166336 1.569 NM_133639
RHOV
ras homolog gene family, member V
chr2_-_107503517 1.547 NM_001142352
NM_032528
ST6GAL2

ST6 beta-galactosamide alpha-2,6-sialyltranferase 2

chr5_+_131593331 1.544 NM_001131027
NM_003687
PDLIM4

PDZ and LIM domain 4

chr3_+_29322802 1.543 NM_001003792
NM_001003793
NM_001177711
NM_001177712
NM_014483
RBMS3




RNA binding motif, single stranded interacting protein 3




chrX_+_152760346 1.534 NM_001711
BGN
biglycan
chr12_-_16759430 1.518 LMO3
LIM domain only 3 (rhombotin-like 2)
chr12_+_19282402 1.512 NM_001143821
NM_001190860
NM_019012
PLEKHA5


pleckstrin homology domain containing, family A member 5


chr6_+_43968303 1.498 NM_001171992
NM_153246
C6orf223

chromosome 6 open reading frame 223

chr3_-_134093235 1.478 NM_016201
AMOTL2
angiomotin like 2
chr17_+_31254927 1.468 NM_001033504
NM_015544
TMEM98

transmembrane protein 98

chr9_-_27005649 1.464 NM_022901
LRRC19
leucine rich repeat containing 19
chr14_-_21572374 1.461


chr7_+_94024201 1.456 COL1A2
collagen, type I, alpha 2
chrX_+_152760452 1.449 BGN
biglycan
chr13_+_111138079 1.444 COL4A2
collagen, type IV, alpha 2
chr11_+_69455938 1.439 CCND1
cyclin D1
chr1_-_151345156 1.435 NM_003944
SELENBP1
selenium binding protein 1
chr9_+_97766414 1.434 C9orf3
chromosome 9 open reading frame 3
chr13_+_24144402 1.420 NM_001204459
NM_148957
TNFRSF19

tumor necrosis factor receptor superfamily, member 19

chr16_-_49315682 1.416 NM_004352
CBLN1
cerebellin 1 precursor
chr9_+_17578952 1.413 NM_003026
SH3GL2
SH3-domain GRB2-like 2
chr13_-_33760215 1.404 NM_001243466
NM_178007
STARD13

StAR-related lipid transfer (START) domain containing 13

chr1_+_17846818 1.401 ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chr7_-_137028533 1.398 NM_002825
PTN
pleiotrophin
chr5_+_34684611 1.396 NM_001145521
NM_001145525
RAI14

retinoic acid induced 14

chr8_-_6914251 1.394 NM_021010
DEFA5
defensin, alpha 5, Paneth cell-specific
chr7_-_91794589 1.387 NM_001161528
LRRD1
leucine-rich repeats and death domain containing 1
chr11_+_69455837 1.372 NM_053056
CCND1
cyclin D1
chr7_+_128828712 1.367 NM_005631
SMO
smoothened, frizzled family receptor
chr5_+_131593377 1.361 PDLIM4
PDZ and LIM domain 4
chr2_-_75788027 1.345 FAM176A
family with sequence similarity 176, member A
chr3_+_151488214 1.338 LOC201651
arylacetamide deacetylase (esterase) pseudogene
chr3_+_132757216 1.332 TMEM108
transmembrane protein 108
chr4_-_152096655 1.330 NM_001128924
SH3D19
SH3 domain containing 19
chr4_-_186877413 1.325 SORBS2
sorbin and SH3 domain containing 2
chr1_+_209878135 1.321 NM_005525
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr13_+_111134933 1.306 COL4A2
collagen, type IV, alpha 2
chr15_+_50474357 1.304 NM_001159629
NM_003645
SLC27A2

solute carrier family 27 (fatty acid transporter), member 2

chr16_-_49315472 1.300 CBLN1
cerebellin 1 precursor
chr10_-_123353330 1.297 NM_001144913
NM_001144914
FGFR2

fibroblast growth factor receptor 2

chr11_-_87908551 1.292 NM_022337
RAB38
RAB38, member RAS oncogene family
chr5_-_16738346 1.283 MYO10
myosin X
chr14_+_93389444 1.279 NM_001275
CHGA
chromogranin A (parathyroid secretory protein 1)
chrX_+_65384078 1.275 NM_001130860
NM_014799
HEPH

hephaestin

chr8_+_22019167 1.264 NM_001172357
NM_001172410
NM_003018
SFTPC


surfactant protein C


chr1_+_16330730 1.245 NM_178840
C1orf64
chromosome 1 open reading frame 64
chr2_+_11680079 1.234 NM_148903
GREB1
growth regulation by estrogen in breast cancer 1
chr1_+_185703470 1.220 NM_031935
HMCN1
hemicentin 1
chr10_-_88717319 1.216 NM_024756
MMRN2
multimerin 2
chr12_-_16759733 1.215 NM_001243610
LMO3
LIM domain only 3 (rhombotin-like 2)
chr9_+_133971862 1.212 NM_001185095
NM_001185096
NM_031426
AIF1L


allograft inflammatory factor 1-like


chr5_-_16936371 1.192 NM_012334
MYO10
myosin X
chr3_-_57199313 1.187 IL17RD
interleukin 17 receptor D
chr2_+_234621637 1.185 NM_019078
UGT1A5
UDP glucuronosyltransferase 1 family, polypeptide A5
chr15_-_65670325 1.185 NM_004884
IGDCC3
immunoglobulin superfamily, DCC subclass, member 3
chr10_+_15085894 1.180 NM_001039702
NM_018324
OLAH

oleoyl-ACP hydrolase

chr1_-_95392501 1.154 NM_001839
CNN3
calponin 3, acidic
chr12_-_16759420 1.152 LMO3
LIM domain only 3 (rhombotin-like 2)
chr3_-_57199402 1.146 NM_017563
IL17RD
interleukin 17 receptor D
chrX_+_48620153 1.143 NM_001080489
GLOD5
glyoxalase domain containing 5
chr11_-_72385411 1.134 NM_002599
PDE2A
phosphodiesterase 2A, cGMP-stimulated
chr4_-_138453628 1.132 NM_019035
PCDH18
protocadherin 18
chr18_-_31802433 1.130 NM_001198547
NOL4
nucleolar protein 4
chr10_-_118765087 1.125 NM_001127211
NM_018330
KIAA1598

KIAA1598

chr17_+_3379295 1.123 NM_000049
ASPA
aspartoacylase
chr8_-_22089517 1.117 PHYHIP
phytanoyl-CoA 2-hydroxylase interacting protein
chr15_+_41136178 1.109 NM_003710
NM_181642
SPINT1

serine peptidase inhibitor, Kunitz type 1

chr1_-_225840660 1.103 NM_001008493
NM_018212
ENAH

enabled homolog (Drosophila)

chr20_-_43977023 1.096 NM_002999
SDC4
syndecan 4
chr9_-_14398981 1.094 NM_001190738
NFIB
nuclear factor I/B
chr4_-_85419386 1.092 NM_006168
NKX6-1
NK6 homeobox 1
chr13_+_102104941 1.087 NM_004791
ITGBL1
integrin, beta-like 1 (with EGF-like repeat domains)
chr1_+_13911966 1.078 NM_001006624
NM_001006625
PDPN

podoplanin

chr3_-_124653571 1.074 NM_033049
MUC13
mucin 13, cell surface associated
chr16_-_18812691 1.063 NM_015161
ARL6IP1
ADP-ribosylation factor-like 6 interacting protein 1
chr10_-_123353771 1.060 NM_001144916
FGFR2
fibroblast growth factor receptor 2
chr10_+_102123420 1.057


chr12_+_70759974 1.056 NM_014505
KCNMB4
potassium large conductance calcium-activated channel, subfamily M, beta member 4
chr11_+_69455978 1.055 CCND1
cyclin D1
chr19_+_18062110 1.055 NM_002248
KCNN1
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1
chr5_+_140174443 1.048 NM_018905
NM_031495
PCDHA2

protocadherin alpha 2

chrX_-_13835012 1.047 GPM6B
glycoprotein M6B
chr1_-_6479880 1.047 NM_019089
HES2
hairy and enhancer of split 2 (Drosophila)
chr4_-_187527219 1.035


chr10_+_71561643 1.029 NM_001130103
NM_080798
NM_080800
NM_080801
NM_080802
NM_080805
COL13A1





collagen, type XIII, alpha 1





chr15_+_41136622 1.026 NM_001032367
SPINT1
serine peptidase inhibitor, Kunitz type 1
chr9_-_102582143 1.018


chr5_-_16936290 1.008 MYO10
myosin X
chr21_-_27372461 1.002 APP
amyloid beta (A4) precursor protein
chr4_-_16077740 1.002 NM_001145849
NM_001145850
NM_001145851
NM_001145852
NM_006017
PROM1




prominin 1




chr12_+_26205490 1.001 NM_001164746
RASSF8
Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
chr12_-_28124915 0.999 NM_002820
NM_198965
PTHLH

parathyroid hormone-like hormone

chr14_-_23451704 0.996 NM_032876
AJUBA
ajuba LIM protein
chr12_-_122296619 0.995 NM_002150
HPD
4-hydroxyphenylpyruvate dioxygenase
chr13_+_53602829 0.994 NM_006418
OLFM4
olfactomedin 4
chr14_+_74486049 0.993 NM_025057
C14orf45
chromosome 14 open reading frame 45
chr8_-_6783574 0.990 NM_001926
DEFA6
defensin, alpha 6, Paneth cell-specific
chr5_-_114515733 0.985 NM_001017397
NM_001017398
NM_018700
TRIM36


tripartite motif containing 36


chr1_-_116383323 0.975 NM_001111061
NHLH2
nescient helix loop helix 2
chr2_+_27070962 0.968 NM_020134
NM_001253723
NM_001253724
DPYSL5


dihydropyrimidinase-like 5


chr15_+_65822842 0.967 PTPLAD1
protein tyrosine phosphatase-like A domain containing 1
chr7_+_94292737 0.965 PEG10
paternally expressed 10
chr15_+_65822738 0.960 NM_016395
PTPLAD1
protein tyrosine phosphatase-like A domain containing 1
chr7_+_154002194 0.957 NM_001936
DPP6
dipeptidyl-peptidase 6
chr8_+_80523048 0.952 NM_001199214
NM_007029
STMN2

stathmin-like 2

chr3_-_9921933 0.951 NM_001199551
NM_001199552
CIDEC

cell death-inducing DFFA-like effector c

chr6_-_89827605 0.946 NM_080743
SRSF12
serine/arginine-rich splicing factor 12
chr11_-_117747331 0.945 FXYD6
FXYD domain containing ion transport regulator 6
chr6_-_52668599 0.940 NM_145740
GSTA1
glutathione S-transferase alpha 1
chr17_+_38171613 0.937 NM_000759
NM_001178147
NM_172219
NM_172220
CSF3



colony stimulating factor 3 (granulocyte)



chr10_+_135160843 0.937 NM_001145201
NM_145202
PRAP1

proline-rich acidic protein 1

chr7_-_137028370 0.918 PTN
pleiotrophin
chr6_+_121756744 0.914 NM_000165
GJA1
gap junction protein, alpha 1, 43kDa
chr21_-_43735705 0.912 NM_003226
TFF3
trefoil factor 3 (intestinal)
chr2_+_105471745 0.912 NM_006236
POU3F3
POU class 3 homeobox 3
chr8_-_22089850 0.910 NM_001099335
NM_014759
PHYHIP

phytanoyl-CoA 2-hydroxylase interacting protein

chr11_-_76155704 0.910


chr8_-_42234562 0.899 NM_014420
DKK4
dickkopf homolog 4 (Xenopus laevis)
chr1_+_170633312 0.899 NM_006902
NM_022716
PRRX1

paired related homeobox 1

chr4_-_41216455 0.897 NM_001166050
NM_004307
NM_173075
APBB2


amyloid beta (A4) precursor protein-binding, family B, member 2


chr12_+_53491417 0.896 NM_002178
IGFBP6
insulin-like growth factor binding protein 6
chr14_-_58618807 0.895 NM_001001872
C14orf37
chromosome 14 open reading frame 37
chr4_-_120243257 0.895 NM_000134
FABP2
fatty acid binding protein 2, intestinal
chr22_+_24105207 0.887 NM_182520
C22orf15
chromosome 22 open reading frame 15
chr3_-_112359863 0.884 CCDC80
coiled-coil domain containing 80
chr5_+_140753480 0.884 NM_018919
NM_032086
PCDHGA6

protocadherin gamma subfamily A, 6

chr19_-_14169970 0.884 NM_001145028
PALM3
paralemmin 3
chr3_-_112359962 0.883 NM_199511
NM_199512
CCDC80

coiled-coil domain containing 80

chr11_-_124805896 0.881 HEPACAM
hepatic and glial cell adhesion molecule
chr3_-_112359565 0.869 CCDC80
coiled-coil domain containing 80
chr7_+_30951414 0.868 NM_198098
AQP1
aquaporin 1 (Colton blood group)
chr7_+_94292816 0.865 PEG10
paternally expressed 10
chr5_+_149546340 0.861 NM_001804
CDX1
caudal type homeobox 1
chr3_+_42850963 0.859 NM_001296
CCBP2
chemokine binding protein 2
chr2_+_16080639 0.858 NM_005378
MYCN
v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)
chr1_+_24882565 0.854 NM_001010980
C1orf130
chromosome 1 open reading frame 130
chr11_+_75428864 0.853 NM_025098
MOGAT2
monoacylglycerol O-acyltransferase 2
chr4_-_139163222 0.848 NM_014331
SLC7A11
solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
chr8_+_80523351 0.837 STMN2
stathmin-like 2
chr12_-_16760935 0.836 NM_001001395
NM_001243609
LMO3

LIM domain only 3 (rhombotin-like 2)

chr17_-_42081836 0.831 NM_004160
PYY
peptide YY
chr17_-_56494930 0.829 NM_017763
RNF43
ring finger protein 43
chr18_-_25756946 0.827 CDH2
cadherin 2, type 1, N-cadherin (neuronal)
chr15_+_80696569 0.823 NM_014862
ARNT2
aryl-hydrocarbon receptor nuclear translocator 2
chr2_+_171571800 0.822 NM_001003845
SP5
Sp5 transcription factor
chr5_+_34656482 0.816 RAI14
retinoic acid induced 14
chr1_+_212797788 0.814 NM_153606
FAM71A
family with sequence similarity 71, member A
chr4_-_138453564 0.814 PCDH18
protocadherin 18
chr11_+_101983170 0.813 NM_001195045
YAP1
Yes-associated protein 1
chr7_+_140103842 0.813 NM_001008749
RAB19
RAB19, member RAS oncogene family
chr5_+_140480056 0.812 NM_018937
PCDHB3
protocadherin beta 3
chr15_+_43985083 0.809 NM_001015001
CKMT1A
creatine kinase, mitochondrial 1A
chr14_-_21502943 0.806 NM_001012264
RNASE13
ribonuclease, RNase A family, 13 (non-active)
chr1_-_110933635 0.800 SLC16A4
solute carrier family 16, member 4 (monocarboxylic acid transporter 5)
chr20_-_44175995 0.795 NM_001198986
NM_020398
SPINLW1-WFDC6
SPINLW1
SPINLW1-WFDC6 readthrough
serine peptidase inhibitor-like, with Kunitz and WAP domains 1 (eppin)
chr8_+_80523304 0.795 STMN2
stathmin-like 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
2.34 4.23e-05 GO:0048856 anatomical structure development
2.40 1.00e-04 GO:0048731 system development
1.85 2.63e-04 GO:0032501 multicellular organismal process
2.15 4.45e-04 GO:0007275 multicellular organismal development
3.03 5.36e-04 GO:0007399 nervous system development
2.01 1.70e-03 GO:0032502 developmental process
4.21 6.03e-03 GO:0000902 cell morphogenesis
3.89 6.53e-03 GO:0030182 neuron differentiation
2.74 8.42e-03 GO:0009653 anatomical structure morphogenesis
3.99 1.05e-02 GO:0032989 cellular component morphogenesis
2.23 2.54e-02 GO:0042221 response to chemical stimulus
4.24 2.86e-02 GO:0000904 cell morphogenesis involved in differentiation
4.21 3.03e-02 GO:0048858 cell projection morphogenesis
4.17 3.28e-02 GO:0032990 cell part morphogenesis
5.11 3.46e-02 GO:0007411 axon guidance
4.53 3.68e-02 GO:0007409 axonogenesis
4.37 4.94e-02 GO:0048667 cell morphogenesis involved in neuron differentiation

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
4.15 3.83e-07 GO:0044421 extracellular region part
12.34 3.11e-05 GO:0044420 extracellular matrix part
2.66 4.95e-05 GO:0005576 extracellular region
3.75 5.11e-04 GO:0005615 extracellular space
5.32 7.72e-04 GO:0031012 extracellular matrix
5.70 1.14e-03 GO:0005578 proteinaceous extracellular matrix
19.35 6.24e-03 GO:0005581 collagen

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
10.89 9.29e-03 GO:0005201 extracellular matrix structural constituent
7.12 1.93e-02 GO:0005539 glycosaminoglycan binding
6.58 2.95e-02 GO:0001871 pattern binding
6.58 2.95e-02 GO:0030247 polysaccharide binding