Motif ID: LEF1_TCF7_TCF7L1,2.p2

Z-value: 1.461


Transcription factors associated with LEF1_TCF7_TCF7L1,2.p2:

Gene SymbolEntrez IDGene Name
LEF1 51176 lymphoid enhancer-binding factor 1
TCF7 6932 transcription factor 7 (T-cell specific, HMG-box)
TCF7L1 83439 transcription factor 7-like 1 (T-cell specific, HMG-box)
TCF7L2 6934 transcription factor 7-like 2 (T-cell specific, HMG-box)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
TCF7L1hg19_v1_chr2_+_85360373_853609460.476.5e-03Click!
TCF7L2hg19_v1_chr10_+_114709963_1147106410.468.8e-03Click!
TCF7hg19_v1_chr5_+_133450353_133450685-0.281.2e-01Click!
LEF1hg19_v1_chr4_-_109087876_109087952-0.202.8e-01Click!


Activity profile for motif LEF1_TCF7_TCF7L1,2.p2.

activity profile for motif LEF1_TCF7_TCF7L1,2.p2


Sorted Z-values histogram for motif LEF1_TCF7_TCF7L1,2.p2

Sorted Z-values for motif LEF1_TCF7_TCF7L1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of LEF1_TCF7_TCF7L1,2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_+_73245192 4.732 NM_001305
CLDN4
claudin 4
chr17_-_46035109 4.064 NM_024320
PRR15L
proline rich 15-like
chr2_+_47596447 3.851 EPCAM
epithelial cell adhesion molecule
chr14_-_65409445 3.678 NM_002083
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr8_-_119964059 3.100 NM_002546
TNFRSF11B
tumor necrosis factor receptor superfamily, member 11b
chr15_+_43885251 3.066 NM_020990
CKMT1B
CKMT1A
creatine kinase, mitochondrial 1B
creatine kinase, mitochondrial 1A
chr2_+_69240137 2.633 NM_018153
NM_032208
NM_053034
ANTXR1


anthrax toxin receptor 1


chr2_+_47596286 2.559 NM_002354
EPCAM
epithelial cell adhesion molecule
chr7_-_16505292 2.558 NM_015464
SOSTDC1
sclerostin domain containing 1
chr9_+_133971902 2.481 AIF1L
allograft inflammatory factor 1-like
chr20_+_57875481 2.386 NM_000114
NM_207032
NM_207033
NM_207034
EDN3



endothelin 3



chr12_-_16759939 2.321 NM_001243613
LMO3
LIM domain only 3 (rhombotin-like 2)
chr12_-_16759531 2.301 NM_018640
LMO3
LIM domain only 3 (rhombotin-like 2)
chr12_+_57943843 2.068 NM_004984
KIF5A
kinesin family member 5A
chr11_-_13517525 2.022 NM_000315
PTH
parathyroid hormone
chr19_-_7990974 2.014 NM_206833
CTXN1
cortexin 1
chr20_+_36149606 1.972 NM_005386
NM_181689
NNAT

neuronatin

chr7_-_120498128 1.960 NM_012338
TSPAN12
tetraspanin 12
chr2_+_233734993 1.951 NM_206895
C2orf82
chromosome 2 open reading frame 82
chr20_+_17207596 1.890 NM_001201529
NM_002594
PCSK2

proprotein convertase subtilisin/kexin type 2


Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 17 of 17 entries
Enrichment   P-value GO Accession GO Term
5.11 3.46e-02 GO:0007411 axon guidance
4.53 3.68e-02 GO:0007409 axonogenesis
4.37 4.94e-02 GO:0048667 cell morphogenesis involved in neuron differentiation
4.24 2.86e-02 GO:0000904 cell morphogenesis involved in differentiation
4.21 6.03e-03 GO:0000902 cell morphogenesis
4.21 3.03e-02 GO:0048858 cell projection morphogenesis
4.17 3.28e-02 GO:0032990 cell part morphogenesis
3.99 1.05e-02 GO:0032989 cellular component morphogenesis
3.89 6.53e-03 GO:0030182 neuron differentiation
3.03 5.36e-04 GO:0007399 nervous system development
2.74 8.42e-03 GO:0009653 anatomical structure morphogenesis
2.40 1.00e-04 GO:0048731 system development
2.34 4.23e-05 GO:0048856 anatomical structure development
2.23 2.54e-02 GO:0042221 response to chemical stimulus
2.15 4.45e-04 GO:0007275 multicellular organismal development
2.01 1.70e-03 GO:0032502 developmental process
1.85 2.63e-04 GO:0032501 multicellular organismal process

Gene overrepresentation in compartment category:

Showing 1 to 7 of 7 entries
Enrichment   P-value GO Accession GO Term
19.35 6.24e-03 GO:0005581 collagen
12.34 3.11e-05 GO:0044420 extracellular matrix part
5.70 1.14e-03 GO:0005578 proteinaceous extracellular matrix
5.32 7.72e-04 GO:0031012 extracellular matrix
4.15 3.83e-07 GO:0044421 extracellular region part
3.75 5.11e-04 GO:0005615 extracellular space
2.66 4.95e-05 GO:0005576 extracellular region

Gene overrepresentation in function category:

Showing 1 to 4 of 4 entries
Enrichment   P-value GO Accession GO Term
10.89 9.29e-03 GO:0005201 extracellular matrix structural constituent
7.12 1.93e-02 GO:0005539 glycosaminoglycan binding
6.58 2.95e-02 GO:0001871 pattern binding
6.58 2.95e-02 GO:0030247 polysaccharide binding