Motif ID: LHX3,4.p2

Z-value: 1.922


Transcription factors associated with LHX3,4.p2:

Gene SymbolEntrez IDGene Name
LHX3 8022 LIM homeobox 3
LHX4 89884 LIM homeobox 4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
LHX4hg19_v1_chr1_+_180199432_1801994410.251.7e-01Click!
LHX3hg19_v1_chr9_-_139094886_1390950900.241.9e-01Click!


Activity profile for motif LHX3,4.p2.

activity profile for motif LHX3,4.p2


Sorted Z-values histogram for motif LHX3,4.p2

Sorted Z-values for motif LHX3,4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of LHX3,4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_-_51920841 7.898 NM_001171156
NM_001171157
NM_001171158
NM_001171159
NM_001171160
NM_001171161
NM_033130
SIGLEC10






sialic acid binding Ig-like lectin 10






chr12_-_10282680 7.206 NM_022570
NM_197947
NM_197948
NM_197949
NM_197950
NM_197954
CLEC7A





C-type lectin domain family 7, member A





chr1_+_198608216 6.714 PTPRC
protein tyrosine phosphatase, receptor type, C
chrX_+_107288199 6.552 NM_001170553
NM_182607
VSIG1

V-set and immunoglobulin domain containing 1

chr1_+_155853546 6.344 SYT11
synaptotagmin XI
chr3_-_57234279 6.179 NM_003865
HESX1
HESX homeobox 1
chr1_+_159259503 6.009 NM_002001
FCER1A
Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
chr13_-_46425756 5.932 NM_198849
SIAH3
seven in absentia homolog 3 (Drosophila)
chr5_+_175108463 5.339 NM_022304
HRH2
histamine receptor H2
chr6_+_12717036 4.902 NM_001242648
NM_030948
PHACTR1

phosphatase and actin regulator 1

chr1_+_117544371 4.861 NM_004258
CD101
CD101 molecule
chr13_-_99910548 4.658 NM_001098200
NM_005292
GPR18

G protein-coupled receptor 18

chr3_-_157221362 4.582 NM_001167915
NM_001167916
VEPH1

ventricular zone expressed PH domain homolog 1 (zebrafish)

chr2_+_162272800 4.529 TBR1
T-box, brain, 1
chr12_+_8666135 4.463 NM_080387
CLEC4D
C-type lectin domain family 4, member D
chr8_-_108510094 4.387 NM_001146
NM_001199859
ANGPT1

angiopoietin 1

chr11_-_71524890 4.244 LOC285407
asparagine-linked glycosylation 1 homolog pseudogene
chr12_+_9980076 4.230 NM_016523
KLRF1
killer cell lectin-like receptor subfamily F, member 1
chrX_-_102531673 4.226 NM_001012979
TCEAL5
transcription elongation factor A (SII)-like 5
chr16_+_12058963 4.184 NM_001192
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr1_+_168250277 4.152 NM_005149
TBX19
T-box 19
chr2_+_162272892 4.137 TBR1
T-box, brain, 1
chr2_-_175462428 4.088 WIPF1
WAS/WASL interacting protein family, member 1
chr22_-_22863504 4.077 NM_080764
ZNF280B
zinc finger protein 280B
chr14_+_92788924 4.045 NM_153648
SLC24A4
solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
chrX_+_153533408 3.995 NM_001145934
TKTL1
transketolase-like 1
chr2_+_162272619 3.934 NM_006593
TBR1
T-box, brain, 1
chr3_-_167191808 3.856 NM_006217
SERPINI2
serpin peptidase inhibitor, clade I (pancpin), member 2
chrX_-_142605218 3.611 NM_001009609
SPANXN3
SPANX family, member N3
chr7_-_92777657 3.549 NM_152703
SAMD9L
sterile alpha motif domain containing 9-like
chr7_+_141695678 3.533 NM_004668
MGAM
maltase-glucoamylase (alpha-glucosidase)
chr11_+_99426872 3.505 NM_175566
CNTN5
contactin 5
chr17_-_39093671 3.488 NM_015515
KRT23
keratin 23 (histone deacetylase inducible)
chrX_-_24690740 3.236 NM_001163264
PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr15_+_94899163 3.183 NM_001159644
MCTP2
multiple C2 domains, transmembrane 2
chr14_-_101036130 3.180 NM_020836
BEGAIN
brain-enriched guanylate kinase-associated homolog (rat)
chr7_-_38313232 3.180 NM_001003799
NM_001003806
TARP

TRGV9
TCR gamma alternate reading frame protein

T cell receptor gamma variable 9
chr1_+_198608244 3.094 PTPRC
protein tyrosine phosphatase, receptor type, C
chr7_+_129984629 3.059 NM_001127441
NM_001127442
NM_080385
CPA5


carboxypeptidase A5


chr2_-_99871569 3.043 NM_175735
LYG2
lysozyme G-like 2
chrX_+_144908927 3.038 NM_004709
CXorf1
chromosome X open reading frame 1
chr17_-_39092714 3.027 KRT23
keratin 23 (histone deacetylase inducible)
chrX_+_78426468 2.992 NM_032553
GPR174
G protein-coupled receptor 174
chrX_+_37639246 2.886 NM_000397
CYBB
cytochrome b-245, beta polypeptide
chrX_-_138724851 2.852 NM_001171877
NM_001171878
NM_001171879
NM_005369
MCF2



MCF.2 cell line derived transforming sequence



chr7_-_107880492 2.842 NM_001037132
NRCAM
neuronal cell adhesion molecule
chr3_+_46411632 2.793 NM_000579
NM_001100168
CCR5

chemokine (C-C motif) receptor 5

chr1_-_92952429 2.779 NM_005263
GFI1
growth factor independent 1 transcription repressor
chr7_+_110731061 2.771 NM_001099658
NM_001099660
NM_018334
LRRN3


leucine rich repeat neuronal 3


chr2_-_31352489 2.767 NM_001253827
GALNT14
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)
chr14_+_101295409 2.743 MEG3
maternally expressed 3 (non-protein coding)
chr8_-_132052834 2.719 NM_001115
ADCY8
adenylate cyclase 8 (brain)
chr5_-_88119604 2.697 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr4_-_57547845 2.686 NM_001145460
NM_032495
NM_139212
HOPX


HOP homeobox


chr12_+_8332789 2.683 FAM66C
family with sequence similarity 66, member C
chr2_+_29038862 2.639 NM_001008779
SPDYA
speedy homolog A (Xenopus laevis)
chr17_-_72527512 2.631 CD300LB
CD300 molecule-like family member b
chr9_-_215892 2.615 NM_152569
C9orf66
chromosome 9 open reading frame 66
chr12_-_9760481 2.598 NM_002258
KLRB1
killer cell lectin-like receptor subfamily B, member 1
chr3_+_63953419 2.573 NM_001128149
ATXN7
ataxin 7
chr2_-_175712276 2.553 NM_001206602
CHN1
chimerin (chimaerin) 1
chr10_+_90521162 2.549 NM_001102469
LIPN
lipase, family member N
chr1_+_198608136 2.503 NM_002838
NM_080921
NM_080923
PTPRC


protein tyrosine phosphatase, receptor type, C


chr2_+_169926084 2.495 DHRS9
dehydrogenase/reductase (SDR family) member 9
chr17_-_9923204 2.429 GAS7
growth arrest-specific 7
chr1_+_12806162 2.337 NM_152290
C1orf158
chromosome 1 open reading frame 158
chr7_-_87342569 2.336 NM_000927
ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
chrX_+_135730335 2.317 NM_000074
CD40LG
CD40 ligand
chr13_+_53035227 2.308 CKAP2
cytoskeleton associated protein 2
chr5_+_156696351 2.287 NM_014376
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr17_+_19976828 2.284 SPECC1
sperm antigen with calponin homology and coiled-coil domains 1
chr22_+_40297085 2.283 NM_004810
GRAP2
GRB2-related adaptor protein 2
chr1_+_43253660 2.279 NM_001242750
LOC100129924
uncharacterized LOC100129924
chr9_+_111624545 2.261 NM_006687
ACTL7A
actin-like 7A
chr19_+_9296269 2.226 NM_175883
OR7D2
olfactory receptor, family 7, subfamily D, member 2
chr10_+_118083939 2.226 NM_198515
C10orf96
chromosome 10 open reading frame 96
chr3_-_25679655 2.181 TOP2B
topoisomerase (DNA) II beta 180kDa
chr15_+_34261088 2.178 NM_012125
CHRM5
cholinergic receptor, muscarinic 5
chrX_+_37639306 2.173 CYBB
cytochrome b-245, beta polypeptide
chr14_+_29236171 2.142 NM_005249
FOXG1
forkhead box G1
chr17_-_72527592 2.124 NM_174892
CD300LB
CD300 molecule-like family member b
chr17_-_9923323 2.122 GAS7
growth arrest-specific 7
chr5_+_126984712 2.099 NM_001048252
CTXN3
cortexin 3
chr3_+_68040733 2.093 NM_001252216
FAM19A1
family with sequence similarity 19 (chemokine (C-C motif)-like), member A1
chr20_+_24929904 2.093 CST7
cystatin F (leukocystatin)
chr11_-_74800757 2.074 NM_001005285
OR2AT4
olfactory receptor, family 2, subfamily AT, member 4
chr1_+_192127591 2.074 NM_130782
RGS18
regulator of G-protein signaling 18
chr14_-_106926393 2.068 IGHA1
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr12_-_53600999 2.062 NM_000889
ITGB7
integrin, beta 7
chr4_-_76944585 2.022 NM_001565
CXCL10
chemokine (C-X-C motif) ligand 10
chr10_+_91152321 2.018 NM_001548
IFIT1
interferon-induced protein with tetratricopeptide repeats 1
chr22_+_40297183 2.006 GRAP2
GRB2-related adaptor protein 2
chr18_+_61582744 1.996 NM_005024
SERPINB10
serpin peptidase inhibitor, clade B (ovalbumin), member 10
chr2_-_158300517 1.993 NM_004288
CYTIP
cytohesin 1 interacting protein
chr1_-_197552304 1.986 DENND1B
DENN/MADD domain containing 1B
chr4_-_189026401 1.980 NM_173553
TRIML2
tripartite motif family-like 2
chr9_+_12693385 1.978 NM_000550
TYRP1
tyrosinase-related protein 1
chr9_+_135854097 1.946 NM_001135031
NM_004188
GFI1B

growth factor independent 1B transcription repressor

chr3_-_112564789 1.922 NM_001008784
NM_001199215
CD200R1L

CD200 receptor 1-like

chr6_-_87804773 1.901 NM_000735
NM_001252383
CGA

glycoprotein hormones, alpha polypeptide

chr8_+_32785485 1.886


chr14_+_62462540 1.872 NM_031914
SYT16
synaptotagmin XVI
chr12_+_54410893 1.869 HOXC5
HOXC6
homeobox C5
homeobox C6
chr8_-_134087255 1.862 SLA
Src-like-adaptor
chr1_-_160549271 1.858 NM_001184879
NM_001184881
NM_001184882
NM_003874
CD84



CD84 molecule



chr1_-_150738232 1.853 CTSS
cathepsin S
chr8_+_66933790 1.819 NM_033105
DNAJC5B
DnaJ (Hsp40) homolog, subfamily C, member 5 beta
chr10_+_45406629 1.801 NM_001123376
TMEM72
transmembrane protein 72
chr2_+_68961912 1.789 NM_001007231
NM_001166277
ARHGAP25

Rho GTPase activating protein 25

chr6_-_75965845 1.787 TMEM30A
transmembrane protein 30A
chr4_+_36283243 1.781 NM_001136536
DTHD1
death domain containing 1
chr4_+_74606222 1.780 NM_000584
IL8
interleukin 8
chr1_-_114414245 1.772 NM_001193431
NM_012411
NM_015967
PTPN22


protein tyrosine phosphatase, non-receptor type 22 (lymphoid)


chr5_+_57787260 1.763 NM_152687
GAPT
GRB2-binding adaptor protein, transmembrane
chr12_+_10163225 1.747 NM_001129998
NM_205852
CLEC12B

C-type lectin domain family 12, member B

chr1_+_168545710 1.744 NM_002995
XCL1
chemokine (C motif) ligand 1
chr6_-_49931817 1.742 NM_001037499
DEFB114
defensin, beta 114
chr16_-_21663962 1.738 NM_005849
IGSF6
immunoglobulin superfamily, member 6
chr7_-_36764000 1.738 NM_001177506
NM_001177507
NM_001637
AOAH


acyloxyacyl hydrolase (neutrophil)


chr21_-_36231794 1.733 RUNX1
runt-related transcription factor 1
chr15_+_81489218 1.732 NM_001172128
IL16
interleukin 16
chr12_+_8608521 1.727 NM_001007033
CLEC6A
C-type lectin domain family 6, member A
chr17_+_28268622 1.718 NM_198529
EFCAB5
EF-hand calcium binding domain 5
chr5_-_22853435 1.716 CDH12
cadherin 12, type 2 (N-cadherin 2)
chr7_-_135613197 1.714 LUZP6
leucine zipper protein 6
chr7_+_90339146 1.712 CDK14
cyclin-dependent kinase 14
chr20_-_29978285 1.707 NM_153289
NM_153323
NM_173460
DEFB119


defensin, beta 119


chr2_+_102508333 1.706 MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr6_-_24877453 1.705 NM_015864
FAM65B
family with sequence similarity 65, member B
chr2_-_166930130 1.700 NM_001165963
NM_001165964
NM_006920
SCN1A


sodium channel, voltage-gated, type I, alpha subunit


chr3_+_98250742 1.699 NM_005290
GPR15
G protein-coupled receptor 15
chr5_-_137475076 1.697 NM_003551
NME5
non-metastatic cells 5, protein expressed in (nucleoside-diphosphate kinase)
chr3_-_157213138 1.696 NM_001167917
VEPH1
ventricular zone expressed PH domain homolog 1 (zebrafish)
chr11_+_71900958 1.694 NM_000802
FOLR1
folate receptor 1 (adult)
chr7_+_28452143 1.687 NM_182898
CREB5
cAMP responsive element binding protein 5
chr18_+_29769986 1.684 NM_005925
MEP1B
meprin A, beta
chr1_-_150738292 1.677 NM_001199739
NM_004079
CTSS

cathepsin S

chr11_-_88781039 1.662 NM_001143831
GRM5
glutamate receptor, metabotropic 5
chr6_-_24583454 1.643 NM_001252328
KIAA0319
KIAA0319
chr3_-_108672547 1.642 NM_005459
GUCA1C
guanylate cyclase activator 1C
chr4_-_76957139 1.635 NM_005409
CXCL11
chemokine (C-X-C motif) ligand 11
chr15_+_58430394 1.626 NM_020980
AQP9
aquaporin 9
chr14_-_106733392 1.624 IGHG1
IGHG3
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
chr12_-_42983412 1.612 NM_153026
PRICKLE1
prickle homolog 1 (Drosophila)
chr21_-_36252872 1.605 RUNX1
runt-related transcription factor 1
chr12_-_15091441 1.603 NM_152321
ERP27
endoplasmic reticulum protein 27
chr3_+_178276487 1.603 NM_005832
KCNMB2
potassium large conductance calcium-activated channel, subfamily M, beta member 2
chr1_-_150738255 1.600 CTSS
cathepsin S
chr4_-_122148620 1.597 NM_001244764
TNIP3
TNFAIP3 interacting protein 3
chr12_-_53601051 1.596 ITGB7
integrin, beta 7
chr12_-_52225700 1.569 NM_001013690
FIGNL2
fidgetin-like 2
chr1_-_160924530 1.569 NM_080878
ITLN2
intelectin 2
chr2_+_166095911 1.554 NM_001040142
SCN2A
sodium channel, voltage-gated, type II, alpha subunit
chr13_+_32313678 1.550 NM_001166058
NM_130806
RXFP2

relaxin/insulin-like family peptide receptor 2

chr4_+_102734982 1.548 NM_001083907
BANK1
B-cell scaffold protein with ankyrin repeats 1
chr14_+_62164339 1.543 NM_001243084
HIF1A
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
chr16_-_21663908 1.530 IGSF6
immunoglobulin superfamily, member 6
chr5_-_111093792 1.528 NM_001142477
NM_001142476
C5orf13

chromosome 5 open reading frame 13

chr6_+_31553955 1.514 NM_205838
NM_205839
LST1

leukocyte specific transcript 1

chr12_-_102512277 1.507 NM_024057
NUP37
nucleoporin 37kDa
chr2_-_224866616 1.506 SERPINE2
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
chr7_+_129015483 1.499 NM_001130722
AHCYL2
adenosylhomocysteinase-like 2
chr10_+_91498724 1.490 KIF20B
kinesin family member 20B
chr6_+_12716887 1.478 PHACTR1
phosphatase and actin regulator 1
chr20_+_31870940 1.476 NM_033197
BPIFB1
BPI fold containing family B, member 1
chr19_+_7504573 1.473 NM_001130955
ARHGEF18
Rho/Rac guanine nucleotide exchange factor (GEF) 18
chrX_-_18690187 1.458 NM_000330
RS1
retinoschisin 1
chr4_+_175839508 1.456 NM_001130703
NM_001130704
NM_001130705
NM_014269
ADAM29



ADAM metallopeptidase domain 29



chr10_+_68685791 1.454 NM_178011
LRRTM3
leucine rich repeat transmembrane neuronal 3
chr1_-_103496768 1.453 COL11A1
collagen, type XI, alpha 1
chr13_+_78109808 1.452 NM_001160706
NM_003843
NM_144777
SCEL


sciellin


chr3_+_113616317 1.442 NM_001172105
GRAMD1C
GRAM domain containing 1C
chr7_+_37723378 1.435


chr19_+_21264952 1.427 NM_182515
ZNF714
zinc finger protein 714
chr17_-_40833840 1.421 NM_016602
CCR10
chemokine (C-C motif) receptor 10
chr18_-_3845295 1.410 NM_001003809
NM_001242765
NM_001242766
DLGAP1


discs, large (Drosophila) homolog-associated protein 1


chr7_+_133812051 1.402 NM_144648
LRGUK
leucine-rich repeats and guanylate kinase domain containing
chrX_+_85517970 1.393 NM_001139515
DACH2
dachshund homolog 2 (Drosophila)
chr2_-_134179325 1.391 NCKAP5
NCK-associated protein 5
chr14_-_47812394 1.391 NM_182830
MDGA2
MAM domain containing glycosylphosphatidylinositol anchor 2
chr21_+_43823970 1.376 NM_001001895
NM_001243467
NM_018961
UBASH3A


ubiquitin associated and SH3 domain containing A


chr19_+_14693895 1.363 NM_001204118
NM_207390
CLEC17A

C-type lectin domain family 17, member A

chrX_+_70765479 1.351 OGT
O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
chrX_+_28605558 1.331 NM_014271
IL1RAPL1
interleukin 1 receptor accessory protein-like 1
chr19_+_21324826 1.330 NM_133473
ZNF431
zinc finger protein 431
chr1_-_205325915 1.326 NM_018203
KLHDC8A
kelch domain containing 8A
chr3_+_45927995 1.326 NM_006641
NM_031200
CCR9

chemokine (C-C motif) receptor 9

chr9_-_117265452 1.308 NM_001083885
DFNB31
deafness, autosomal recessive 31
chr2_-_99279935 1.305 NM_001160154
MGAT4A
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr8_-_134087171 1.298 SLA
Src-like-adaptor
chr4_+_88529680 1.297 NM_014208
DSPP
dentin sialophosphoprotein
chr12_-_54653317 1.289 NM_001127322
CBX5
chromobox homolog 5
chr8_+_55528626 1.288 NM_006269
RP1
retinitis pigmentosa 1 (autosomal dominant)
chr12_+_15699544 1.281 PTPRO
protein tyrosine phosphatase, receptor type, O
chr7_-_139763520 1.274 NM_022750
PARP12
poly (ADP-ribose) polymerase family, member 12
chr16_-_11375094 1.272 NM_002761
PRM1
protamine 1
chr17_-_38956146 1.268 NM_181535
KRT28
keratin 28
chr5_+_88185090 1.263


chrX_-_72434623 1.248 NAP1L2
nucleosome assembly protein 1-like 2
chr11_-_58343308 1.247 NM_004811
LPXN
leupaxin

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
2.66 7.56e-05 GO:0002376 immune system process
3.23 1.08e-04 GO:0006955 immune response
2.63 1.78e-02 GO:0006952 defense response
22.52 1.91e-02 GO:0050854 regulation of antigen receptor-mediated signaling pathway
1.96 2.43e-02 GO:0048583 regulation of response to stimulus
2.68 4.91e-02 GO:0002682 regulation of immune system process

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
1.47 3.41e-02 GO:0071944 cell periphery
1.47 3.94e-02 GO:0005886 plasma membrane

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
5.34 4.90e-04 GO:0005529 sugar binding
3.24 2.06e-02 GO:0030246 carbohydrate binding