Motif ID: LMO2.p2

Z-value: 1.290


Transcription factors associated with LMO2.p2:

Gene SymbolEntrez IDGene Name
LMO2 4005 LIM domain only 2 (rhombotin-like 1)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
LMO2hg19_v1_chr11_-_33891258_338912860.327.1e-02Click!


Activity profile for motif LMO2.p2.

activity profile for motif LMO2.p2


Sorted Z-values histogram for motif LMO2.p2

Sorted Z-values for motif LMO2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of LMO2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_79740059 5.577 NM_001164883
NM_004389
CTNNA2

catenin (cadherin-associated protein), alpha 2

chr19_+_38755097 4.731 NM_001166103
NM_021102
SPINT2

serine peptidase inhibitor, Kunitz type, 2

chr19_+_38755238 4.596 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr19_+_38755422 4.131 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr15_-_44487237 3.710 NM_032892
FRMD5
FERM domain containing 5
chr1_-_75139421 3.559 NM_001002912
C1orf173
chromosome 1 open reading frame 173
chr2_+_79740171 3.408 CTNNA2
catenin (cadherin-associated protein), alpha 2
chr9_+_37650996 3.255 NM_014907
FRMPD1
FERM and PDZ domain containing 1
chr2_+_223289285 3.247 NM_152386
SGPP2
sphingosine-1-phosphate phosphatase 2
chr19_-_7939325 2.999 NM_001190467
FLJ22184
putative uncharacterized protein FLJ22184
chr1_+_233749749 2.845 NM_002245
KCNK1
potassium channel, subfamily K, member 1
chr7_-_766875 2.718 NM_001164760
PRKAR1B
protein kinase, cAMP-dependent, regulatory, type I, beta
chr6_-_132722564 2.711 NM_015529
MOXD1
monooxygenase, DBH-like 1
chr20_+_13976263 2.700 MACROD2
MACRO domain containing 2
chr22_+_21738039 2.570 NM_001128635
RIMBP3B
RIMS binding protein 3B
chr2_-_135476541 2.527 NM_030923
TMEM163
transmembrane protein 163
chrX_-_13956445 2.484


chr1_+_1981902 2.448 NM_002744
PRKCZ
protein kinase C, zeta
chr1_-_26232890 2.412 NM_001145454
NM_005563
STMN1

stathmin 1

chr22_-_21905372 2.388 NM_001128635
RIMBP3B
RIMS binding protein 3B
chr21_-_42219038 2.383 NM_001389
DSCAM
Down syndrome cell adhesion molecule
chr14_+_62584120 2.356 FLJ43390
uncharacterized LOC646113
chr15_-_44487468 2.318 FRMD5
FERM domain containing 5
chr2_-_133427624 2.246 LYPD1
LY6/PLAUR domain containing 1
chr2_-_224702200 2.228 AP1S3
adaptor-related protein complex 1, sigma 3 subunit
chr15_-_38856830 2.192 NM_001128602
NM_005739
RASGRP1

RAS guanyl releasing protein 1 (calcium and DAG-regulated)

chr1_+_233749917 2.102 KCNK1
potassium channel, subfamily K, member 1
chrX_+_152908819 2.086 DUSP9
dual specificity phosphatase 9
chr1_+_110655061 2.071 NM_203412
UBL4B
ubiquitin-like 4B
chr18_+_67068134 2.060 NM_152721
DOK6
docking protein 6
chr3_-_50383009 2.039 NM_015896
ZMYND10
zinc finger, MYND-type containing 10
chr2_+_223289212 2.021 SGPP2
sphingosine-1-phosphate phosphatase 2
chrX_+_153524026 2.019 NM_001145933
NM_012253
TKTL1

transketolase-like 1

chr22_-_37823503 1.989 NM_052906
ELFN2
extracellular leucine-rich repeat and fibronectin type III domain containing 2
chr16_+_23847271 1.983 NM_002738
NM_212535
PRKCB

protein kinase C, beta

chr17_-_16395084 1.970 FAM211A
family with sequence similarity 211, member A
chr5_+_167718485 1.936 NM_001161661
NM_001161662
NM_015238
WWC1


WW and C2 domain containing 1


chr4_-_36245893 1.919 NM_015230
ARAP2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr20_+_13976014 1.899 NM_080676
MACROD2
MACRO domain containing 2
chr11_+_66045645 1.878 NM_182553
CNIH2
cornichon homolog 2 (Drosophila)
chr21_+_34442446 1.817 NM_138983
OLIG1
oligodendrocyte transcription factor 1
chr12_+_27933162 1.785 NM_020782
KLHDC5
kelch domain containing 5
chr15_-_48470453 1.779 NM_016132
MYEF2
myelin expression factor 2
chr19_+_4304590 1.743 NM_024333
FSD1
fibronectin type III and SPRY domain containing 1
chr4_+_7194317 1.724 NM_020777
SORCS2
sortilin-related VPS10 domain containing receptor 2
chr16_+_87636492 1.724 NM_020655
JPH3
junctophilin 3
chr19_+_54926604 1.720 NM_001005367
NM_001201461
NM_020659
TTYH1


tweety homolog 1 (Drosophila)


chr7_-_150675236 1.717 NM_000238
NM_172056
KCNH2

potassium voltage-gated channel, subfamily H (eag-related), member 2

chr5_-_114515733 1.705 NM_001017397
NM_001017398
NM_018700
TRIM36


tripartite motif containing 36


chr19_-_42498320 1.685 NM_152296
ATP1A3
ATPase, Na+/K+ transporting, alpha 3 polypeptide
chr16_-_57318452 1.676 PLLP
plasmolipin
chr9_+_17578952 1.666 NM_003026
SH3GL2
SH3-domain GRB2-like 2
chrX_-_13956644 1.661 NM_001001994
GPM6B
glycoprotein M6B
chr2_+_219745243 1.660 NM_025216
WNT10A
wingless-type MMTV integration site family, member 10A
chr7_-_767286 1.649 NM_001164758
NM_001164759
PRKAR1B

protein kinase, cAMP-dependent, regulatory, type I, beta

chr19_-_7990974 1.640 NM_206833
CTXN1
cortexin 1
chr10_-_98945662 1.629 NM_003061
SLIT1
slit homolog 1 (Drosophila)
chr4_-_6474172 1.613 PPP2R2C
protein phosphatase 2, regulatory subunit B, gamma
chr1_+_233463513 1.613 NM_032435
KIAA1804
mixed lineage kinase 4
chr15_-_48470319 1.570 MYEF2
myelin expression factor 2
chr2_-_224702300 1.555 NM_001039569
AP1S3
adaptor-related protein complex 1, sigma 3 subunit
chr4_+_2420671 1.552 NM_001193282
LOC402160
uncharacterized LOC402160
chr5_-_146258143 1.533 NM_004576
NM_181675
NM_001127381
PPP2R2B


protein phosphatase 2, regulatory subunit B, beta


chr1_-_26232643 1.525 NM_203401
STMN1
stathmin 1
chr9_-_104357202 1.515 NM_147180
PPP3R2
protein phosphatase 3, regulatory subunit B, beta
chr19_-_46974663 1.513 PNMAL1
PNMA-like 1
chr2_-_73496595 1.505 NM_001080410
FBXO41
F-box protein 41
chr16_+_58497628 1.492 NDRG4
NDRG family member 4
chr22_+_29876180 1.460 NM_021076
NEFH
neurofilament, heavy polypeptide
chrX_-_13956530 1.460 GPM6B
glycoprotein M6B
chr17_-_8702438 1.457 NM_152599
MFSD6L
major facilitator superfamily domain containing 6-like
chr16_+_23847359 1.441 PRKCB
protein kinase C, beta
chr1_-_169396654 1.440 NM_021179
C1orf114
chromosome 1 open reading frame 114
chr19_+_57154526 1.438 NM_001193628
LOC147670
uncharacterized LOC147670
chr7_-_994008 1.436 ADAP1
ArfGAP with dual PH domains 1
chr10_+_22634373 1.435 NM_001253854
NM_001253855
NM_012443
NM_172242
SPAG6



sperm associated antigen 6



chrX_-_118827116 1.420 SEPT6
septin 6
chr16_+_1031807 1.412 NM_014587
SOX8
SRY (sex determining region Y)-box 8
chr10_+_102505337 1.405 NM_000278
NM_003987
NM_003988
NM_003989
NM_003990
PAX2




paired box 2




chr16_+_23847321 1.404 PRKCB
protein kinase C, beta
chr16_+_84178864 1.401 NM_178452
DNAAF1
dynein, axonemal, assembly factor 1
chr16_+_68679229 1.401 CDH3
cadherin 3, type 1, P-cadherin (placental)
chr3_+_119421865 1.398 NM_033364
C3orf15
chromosome 3 open reading frame 15
chr19_-_6502224 1.388 NM_006087
TUBB4A
tubulin, beta 4A class IVa
chr1_+_3773844 1.376 NM_004402
DFFB
DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
chr3_+_77089248 1.371 NM_002942
ROBO2
roundabout, axon guidance receptor, homolog 2 (Drosophila)
chr8_-_139509064 1.353 NM_015912
FAM135B
family with sequence similarity 135, member B
chr16_+_58497993 1.341 NM_001130487
NDRG4
NDRG family member 4
chr5_+_156693051 1.321 NM_001037333
NM_001037332
CYFIP2

cytoplasmic FMR1 interacting protein 2

chr1_+_65720091 1.320 LOC645195
DNAJC6
uncharacterized LOC645195
DnaJ (Hsp40) homolog, subfamily C, member 6
chr19_+_35782988 1.312 NM_001199216
NM_002361
NM_080600
MAG


myelin associated glycoprotein


chr2_+_149632772 1.310 NM_004522
KIF5C
kinesin family member 5C
chr15_+_74833517 1.307 NM_006465
ARID3B
AT rich interactive domain 3B (BRIGHT-like)
chr19_-_19738973 1.305 NM_004720
LPAR2
lysophosphatidic acid receptor 2
chr16_+_89989686 1.304 NM_006086
TUBB3
tubulin, beta 3 class III
chr16_+_67465019 1.304 NM_000196
HSD11B2
hydroxysteroid (11-beta) dehydrogenase 2
chr19_-_46974789 1.296 NM_001103149
NM_018215
PNMAL1

PNMA-like 1

chr1_-_182922002 1.296 SHCBP1L
SHC SH2-domain binding protein 1-like
chrX_-_118827155 1.286 SEPT6
septin 6
chr8_-_91094924 1.277 NM_004929
CALB1
calbindin 1, 28kDa
chr1_-_40782924 1.272 NM_001852
COL9A2
collagen, type IX, alpha 2
chr4_-_16085593 1.264 NM_001145847
NM_001145848
PROM1

prominin 1

chr13_-_20806533 1.260 NM_001110219
NM_001110220
NM_001110221
GJB6


gap junction protein, beta 6, 30kDa


chr1_+_203097427 1.259 ADORA1
adenosine A1 receptor
chr16_+_58497548 1.253 NM_020465
NDRG4
NDRG family member 4
chr6_+_138483024 1.250 NM_020340
KIAA1244
KIAA1244
chr16_+_87636574 1.247 JPH3
junctophilin 3
chr2_+_14772839 1.243 FAM84A
family with sequence similarity 84, member A
chr8_-_38008332 1.235 NM_000349
STAR
steroidogenic acute regulatory protein
chrX_-_152939256 1.229 PNCK
pregnancy up-regulated non-ubiquitously expressed CaM kinase
chr16_+_87636669 1.227 JPH3
junctophilin 3
chr10_-_118764559 1.226 KIAA1598
KIAA1598
chr14_-_23822025 1.221 NM_016609
SLC22A17
solute carrier family 22, member 17
chr17_+_7554415 1.219 ATP1B2
ATPase, Na+/K+ transporting, beta 2 polypeptide
chr22_-_37608352 1.216 NM_001051
SSTR3
somatostatin receptor 3
chr21_-_42218587 1.209 DSCAM
Down syndrome cell adhesion molecule
chr2_-_170550859 1.199 NM_001085447
C2orf77
chromosome 2 open reading frame 77
chr4_+_2061238 1.195 NM_178557
NAT8L
N-acetyltransferase 8-like (GCN5-related, putative)
chr1_-_40782826 1.192 COL9A2
collagen, type IX, alpha 2
chr2_-_154335181 1.188 NM_019845
RPRM
reprimo, TP53 dependent G2 arrest mediator candidate
chr5_-_132112887 1.183 NM_001098811
NM_001098812
NM_015146
SEPT8


septin 8


chrX_-_118827060 1.182 SEPT6
septin 6
chr4_-_657424 1.166


chr16_+_23847496 1.165 PRKCB
protein kinase C, beta
chr6_-_84419108 1.159 NM_001242793
NM_001242794
NM_014841
SNAP91


synaptosomal-associated protein, 91kDa homolog (mouse)


chr20_-_61885802 1.158 NM_152864
NKAIN4
Na+/K+ transporting ATPase interacting 4
chr1_+_24742244 1.157 NM_020448
NIPAL3
NIPA-like domain containing 3
chr4_+_4388804 1.147 D4S234E
DNA segment on chromosome 4 (unique) 234 expressed sequence
chr8_+_11561710 1.143 NM_002052
GATA4
GATA binding protein 4
chr12_+_106994914 1.139 NM_001206691
RFX4
regulatory factor X, 4 (influences HLA class II expression)
chr16_-_4838316 1.138 NM_001154458
NM_144605
SEPT12

septin 12

chr16_+_1032063 1.128 SOX8
SRY (sex determining region Y)-box 8
chr1_-_40782981 1.126 COL9A2
collagen, type IX, alpha 2
chr2_-_7005764 1.101 NM_207315
CMPK2
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr1_+_205012427 1.099 CNTN2
contactin 2 (axonal)
chr1_+_205012329 1.098 NM_005076
CNTN2
contactin 2 (axonal)
chr11_+_129245834 1.097 NM_003658
BARX2
BARX homeobox 2
chr17_-_46703613 1.093 NM_024017
HOXB9
homeobox B9
chr2_-_193059599 1.088 NM_016192
TMEFF2
transmembrane protein with EGF-like and two follistatin-like domains 2
chr2_+_149633173 1.085


chr4_+_153457407 1.085 DKFZP434I0714
uncharacterized protein DKFZP434I0714
chr17_+_16593571 1.085 NM_014695
CCDC144B
CCDC144A
coiled-coil domain containing 144B (pseudogene)
coiled-coil domain containing 144A
chr1_+_60280462 1.084 NM_015888
HOOK1
hook homolog 1 (Drosophila)
chr19_-_7701852 1.083


chr9_+_129677046 1.080 NM_001190729
NM_001190730
NM_014636
RALGPS1


Ral GEF with PH domain and SH3 binding motif 1


chr2_+_177053306 1.073 NM_024501
HOXD1
homeobox D1
chr22_+_26825220 1.069 NM_020437
ASPHD2
aspartate beta-hydroxylase domain containing 2
chr17_+_42836546 1.068 NM_002390
ADAM11
ADAM metallopeptidase domain 11
chr1_+_42846427 1.067 NM_173642
RIMKLA
ribosomal modification protein rimK-like family member A
chr16_+_2039945 1.063 NM_004209
SYNGR3
synaptogyrin 3
chr15_+_23810808 1.063 MKRN3
makorin ring finger protein 3
chr7_-_124405029 1.061 GPR37
G protein-coupled receptor 37 (endothelin receptor type B-like)
chr2_+_219824346 1.055 NM_003936
CDK5R2
cyclin-dependent kinase 5, regulatory subunit 2 (p39)
chr4_-_6202251 1.055 NM_001099433
NM_144720
JAKMIP1

janus kinase and microtubule interacting protein 1

chr2_-_193059249 1.051 TMEFF2
transmembrane protein with EGF-like and two follistatin-like domains 2
chr6_+_36098261 1.047 NM_002754
MAPK13
mitogen-activated protein kinase 13
chr20_+_10199455 1.045 NM_003081
NM_130811
SNAP25

synaptosomal-associated protein, 25kDa

chr3_-_47620186 1.044 NM_001206943
NM_001206944
NM_006574
CSPG5


chondroitin sulfate proteoglycan 5 (neuroglycan C)


chr19_-_42498221 1.041 ATP1A3
ATPase, Na+/K+ transporting, alpha 3 polypeptide
chr19_-_51472816 1.041 NM_002774
KLK6
kallikrein-related peptidase 6
chr10_+_38645293 1.039 HSD17B7P2
hydroxysteroid (17-beta) dehydrogenase 7 pseudogene 2
chr14_+_100150596 1.036 NM_006668
CYP46A1
cytochrome P450, family 46, subfamily A, polypeptide 1
chr4_-_21950373 1.029 NM_147182
KCNIP4
Kv channel interacting protein 4
chr3_+_50712671 1.029 NM_004947
DOCK3
dedicator of cytokinesis 3
chr16_+_68679198 1.027 CDH3
cadherin 3, type 1, P-cadherin (placental)
chr5_-_1295022 1.026 NM_001193376
NM_198253
TERT

telomerase reverse transcriptase

chr1_+_224804175 1.022 NM_152495
CNIH3
cornichon homolog 3 (Drosophila)
chr1_+_203096835 1.021 NM_000674
NM_001048230
ADORA1

adenosine A1 receptor

chr9_-_93405066 1.016 NM_017594
DIRAS2
DIRAS family, GTP-binding RAS-like 2
chr2_-_241759627 1.016 NM_001244008
NM_004321
KIF1A

kinesin family member 1A

chr3_-_118753665 1.015 NM_001015887
IGSF11
immunoglobulin superfamily, member 11
chr16_-_74808699 1.008 NM_024306
FA2H
fatty acid 2-hydroxylase
chr12_+_51785100 0.990 SLC4A8
solute carrier family 4, sodium bicarbonate cotransporter, member 8
chr2_+_95691428 0.988 NM_002371
NM_022438
NM_022439
NM_022440
MAL



mal, T-cell differentiation protein



chr19_-_11591439 0.984 NM_001420
NM_032281
ELAVL3

ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)

chr18_-_34408948 0.981 TPGS2
tubulin polyglutamylase complex subunit 2
chrX_+_107288199 0.979 NM_001170553
NM_182607
VSIG1

V-set and immunoglobulin domain containing 1

chr9_+_91150015 0.979 NM_001161625
NM_145283
NXNL2

nucleoredoxin-like 2

chr5_+_141016987 0.974 RELL2
RELT-like 2
chr15_+_81071708 0.972 NM_018689
KIAA1199
KIAA1199
chr15_+_52043738 0.970 NM_001142885
NM_014548
TMOD2

tropomodulin 2 (neuronal)

chr12_-_68726036 0.966 NM_001205028
NM_001205029
NM_017440
NM_020128
MDM1



Mdm1 nuclear protein homolog (mouse)



chr7_+_12610202 0.965 NM_001112706
SCIN
scinderin
chrX_+_150884506 0.958 NM_033085
FATE1
fetal and adult testis expressed 1
chr7_+_103969103 0.953 NM_199000
LHFPL3
lipoma HMGIC fusion partner-like 3
chr20_+_49348050 0.943 NM_032521
PARD6B
par-6 partitioning defective 6 homolog beta (C. elegans)
chr6_+_34433849 0.936 NM_020804
PACSIN1
protein kinase C and casein kinase substrate in neurons 1
chr11_+_71249070 0.935 NM_021046
KRTAP5-8
keratin associated protein 5-8
chr4_+_4388717 0.930 D4S234E
DNA segment on chromosome 4 (unique) 234 expressed sequence
chr5_+_55033844 0.928 NM_001142549
NM_001166533
NM_024415
DDX4


DEAD (Asp-Glu-Ala-Asp) box polypeptide 4


chr7_+_128355425 0.925 NM_032599
FAM71F1
family with sequence similarity 71, member F1
chr1_-_23857284 0.923 E2F2
E2F transcription factor 2
chr7_-_32110460 0.923 NM_001191056
NM_001191057
PDE1C

phosphodiesterase 1C, calmodulin-dependent 70kDa

chr13_+_25946084 0.922 NM_016529
ATP8A2
ATPase, aminophospholipid transporter, class I, type 8A, member 2
chr2_+_73144603 0.922 NM_004097
EMX1
empty spiracles homeobox 1
chr18_-_34409084 0.919 NM_015476
TPGS2
tubulin polyglutamylase complex subunit 2
chr19_+_55996537 0.918 NM_020378
NAT14
N-acetyltransferase 14 (GCN5-related, putative)
chr11_-_18813127 0.918 NM_001039970
NM_006906
NM_032781
PTPN5


protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)


chr13_-_36788665 0.915 NM_017826
SOHLH2
spermatogenesis and oogenesis specific basic helix-loop-helix 2
chr12_-_63328857 0.915 PPM1H
protein phosphatase, Mg2+/Mn2+ dependent, 1H

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
2.78 1.37e-03 GO:0007399 nervous system development
4.79 1.89e-03 GO:0048667 cell morphogenesis involved in neuron differentiation
4.71 2.29e-03 GO:0048812 neuron projection morphogenesis
4.27 6.60e-03 GO:0031175 neuron projection development
4.59 7.23e-03 GO:0007409 axonogenesis
4.22 7.43e-03 GO:0000904 cell morphogenesis involved in differentiation
4.20 7.97e-03 GO:0048858 cell projection morphogenesis
4.16 8.74e-03 GO:0032990 cell part morphogenesis
25.55 9.67e-03 GO:0050807 regulation of synapse organization
21.76 1.88e-02 GO:0050803 regulation of synapse structure and activity
3.58 2.15e-02 GO:0030030 cell projection organization
3.69 3.06e-02 GO:0048666 neuron development
3.55 4.50e-02 GO:0000902 cell morphogenesis

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
6.68 3.49e-03 GO:0030424 axon
40.06 6.31e-03 GO:0031105 septin complex
40.06 6.31e-03 GO:0032156 septin cytoskeleton
36.72 8.37e-03 GO:0043209 myelin sheath
3.84 3.69e-02 GO:0043005 neuron projection
22.04 4.17e-02 GO:0044304 main axon
3.77 4.26e-02 GO:0044463 cell projection part

Nothing significant found in function category.