Motif ID: MYBL2.p2

Z-value: 1.228


Transcription factors associated with MYBL2.p2:

Gene SymbolEntrez IDGene Name
MYBL2 4605 v-myb myeloblastosis viral oncogene homolog (avian)-like 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
MYBL2hg19_v1_chr20_+_42295747_422959230.251.7e-01Click!


Activity profile for motif MYBL2.p2.

activity profile for motif MYBL2.p2


Sorted Z-values histogram for motif MYBL2.p2

Sorted Z-values for motif MYBL2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of MYBL2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_+_80267922 5.340 CD36
CD36 molecule (thrombospondin receptor)
chr7_+_80267972 5.205 CD36
CD36 molecule (thrombospondin receptor)
chr7_+_80267782 5.148 NM_000072
NM_001001548
CD36

CD36 molecule (thrombospondin receptor)

chr2_+_170366211 4.600 NM_006063
KBTBD10
kelch repeat and BTB (POZ) domain containing 10
chr1_+_167064086 4.162 NM_001080426
DUSP27
dual specificity phosphatase 27 (putative)
chr12_-_57642922 4.070


chr12_-_15865847 3.943 EPS8
epidermal growth factor receptor pathway substrate 8
chr3_-_71353910 3.526 NM_001244812
FOXP1
forkhead box P1
chr2_-_152590983 3.370 NM_001164507
NM_001164508
NM_004543
NEB


nebulin


chr1_+_170632274 3.313 PRRX1
paired related homeobox 1
chr12_+_101988746 3.173 NM_002465
NM_206819
NM_206820
NM_206821
MYBPC1



myosin binding protein C, slow type



chr4_+_120056938 2.982 NM_016599
MYOZ2
myozenin 2
chr3_+_141043054 2.830 NM_001080412
ZBTB38
zinc finger and BTB domain containing 38
chrX_+_135278912 2.822 NM_001159701
NM_001159699
FHL1

four and a half LIM domains 1

chr2_+_152214105 2.818 NM_007115
TNFAIP6
tumor necrosis factor, alpha-induced protein 6
chr7_+_104752312 2.531 MLL5
myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila)
chr10_+_17270257 2.505 NM_003380
VIM
vimentin
chr4_-_44653657 2.429 NM_182592
YIPF7
Yip1 domain family, member 7
chr4_-_111563278 2.375 NM_001204397
NM_001204398
NM_001204399
NM_153426
NM_153427
PITX2




paired-like homeodomain 2




chr3_-_15839674 2.364 NM_001195098
ANKRD28
ankyrin repeat domain 28
chr1_-_150780705 2.347 NM_000396
CTSK
cathepsin K
chrX_-_33229428 2.305 NM_004006
DMD
dystrophin
chr3_+_8775485 2.295 NM_001234
NM_033337
CAV3

caveolin 3

chr5_+_155754172 2.152 SGCD
sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
chrX_-_32430370 2.135 NM_004011
NM_004012
DMD

dystrophin

chrX_-_15332680 2.077 NM_001012428
ASB11
ankyrin repeat and SOCS box containing 11
chr14_+_23845932 2.066 NM_001037288
NM_138460
CMTM5

CKLF-like MARVEL transmembrane domain containing 5

chr2_-_228244005 2.041 NM_024795
TM4SF20
transmembrane 4 L six family member 20
chr3_+_189507448 2.037 NM_001114980
NM_001114981
NM_001114982
TP63


tumor protein p63


chr10_+_17270469 1.930 VIM
vimentin
chr1_-_198906536 1.833 LOC100131234
familial acute myelogenous leukemia related factor
chrX_-_21776158 1.774 NM_014332
SMPX
small muscle protein, X-linked
chr15_-_42749710 1.752 NM_022473
ZFP106
zinc finger protein 106 homolog (mouse)
chr5_-_94417185 1.752 MCTP1
multiple C2 domains, transmembrane 1
chr15_+_43809805 1.751 NM_002373
MAP1A
microtubule-associated protein 1A
chr5_-_149669187 1.716 CAMK2A
calcium/calmodulin-dependent protein kinase II alpha
chr7_+_28452143 1.708 NM_182898
CREB5
cAMP responsive element binding protein 5
chr2_-_211168315 1.702 NM_079422
MYL1
myosin, light chain 1, alkali; skeletal, fast
chr5_-_149669400 1.656 NM_015981
NM_171825
CAMK2A

calcium/calmodulin-dependent protein kinase II alpha

chr2_+_102508377 1.620 MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr15_+_67418053 1.518 NM_001145102
SMAD3
SMAD family member 3
chr12_-_26277807 1.516 NM_030762
BHLHE41
basic helix-loop-helix family, member e41
chr4_+_15341559 1.435 NM_001135170
C1QTNF7
C1q and tumor necrosis factor related protein 7
chr17_-_42908178 1.434 NM_001080383
GJC1
gap junction protein, gamma 1, 45kDa
chr5_-_94417544 1.422 NM_001002796
MCTP1
multiple C2 domains, transmembrane 1
chr1_+_35851101 1.363 ZMYM4
zinc finger, MYM-type 4
chr1_-_115300586 1.354 CSDE1
cold shock domain containing E1, RNA-binding
chr1_-_115300583 1.339 CSDE1
cold shock domain containing E1, RNA-binding
chr1_-_115300561 1.312 CSDE1
cold shock domain containing E1, RNA-binding
chr1_-_24434927 1.308 MYOM3
myomesin family, member 3
chr3_+_35721115 1.303 NM_001025068
NM_001025069
ARPP21

cAMP-regulated phosphoprotein, 21kDa

chr21_+_19617145 1.300 NM_024944
CHODL
chondrolectin
chr1_-_115300601 1.287 CSDE1
cold shock domain containing E1, RNA-binding
chr12_-_76478410 1.283 NAP1L1
nucleosome assembly protein 1-like 1
chr10_-_76818271 1.251 NM_001003892
DUPD1
dual specificity phosphatase and pro isomerase domain containing 1
chr1_+_161676761 1.239 NM_001184866
NM_001184867
NM_001184870
NM_001184871
NM_001184872
NM_001184873
NM_032738
FCRLA






Fc receptor-like A






chr14_+_24600674 1.229 NM_203402
FITM1
fat storage-inducing transmembrane protein 1
chr5_-_90610218 1.217 LOC100505994
uncharacterized LOC100505994
chr7_+_28530747 1.200 CREB5
cAMP responsive element binding protein 5
chr10_-_121296044 1.200 NM_002925
RGS10
regulator of G-protein signaling 10
chr1_-_154832187 1.198 NM_170782
KCNN3
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
chr10_-_32667543 1.195 EPC1
enhancer of polycomb homolog 1 (Drosophila)
chr17_-_15554809 1.195 TRIM16
tripartite motif containing 16
chr16_+_12058963 1.189 NM_001192
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr19_-_13947101 1.180 LOC284454
uncharacterized LOC284454
chr7_+_80231503 1.172 NM_001001547
CD36
CD36 molecule (thrombospondin receptor)
chr3_-_44489718 1.168


chr1_+_174844655 1.144 NM_001035230
RABGAP1L
RAB GTPase activating protein 1-like
chr7_+_134233848 1.138 NM_001080538
AKR1B15
aldo-keto reductase family 1, member B15
chrX_-_115594136 1.134 NM_001017978
CXorf61
chromosome X open reading frame 61
chr10_-_105845556 1.127 COL17A1
collagen, type XVII, alpha 1
chr18_+_22040592 1.115 NM_001143828
NM_001160166
NM_021624
HRH4


histamine receptor H4


chr3_+_45927995 1.104 NM_006641
NM_031200
CCR9

chemokine (C-C motif) receptor 9

chr10_-_105845619 1.080 NM_000494
COL17A1
collagen, type XVII, alpha 1
chr21_+_40823779 1.072 NM_007341
SH3BGR
SH3 domain binding glutamic acid-rich protein
chr4_+_119947816 1.070 SYNPO2
synaptopodin 2
chr22_-_38380538 1.065 NM_006941
SOX10
SRY (sex determining region Y)-box 10
chr7_+_20686965 1.064 NM_001163942
NM_001163993
NM_178559
ABCB5


ATP-binding cassette, sub-family B (MDR/TAP), member 5


chr11_-_4718948 1.062 NM_030774
OR51E2
olfactory receptor, family 51, subfamily E, member 2
chr15_-_25650647 1.061 NM_130838
UBE3A
ubiquitin protein ligase E3A
chr14_-_73453651 1.051 NM_178441
ZFYVE1
zinc finger, FYVE domain containing 1
chr10_-_76868853 1.046 NM_001007271
NM_001007272
NM_001007273
DUSP13


dual specificity phosphatase 13


chr14_-_21567069 1.045 NM_001101672
ZNF219
zinc finger protein 219
chr3_+_69985750 1.038 NM_000248
NM_001184968
NM_198158
NM_198178
MITF



microphthalmia-associated transcription factor



chr1_-_9129583 1.029 SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr3_-_71294229 1.026 NM_001244814
FOXP1
forkhead box P1
chr11_-_71791434 1.025 NM_006185
NUMA1
nuclear mitotic apparatus protein 1
chr12_+_54422193 1.001 NM_004503
HOXC6
homeobox C6
chr1_+_151611331 0.986 SNX27
sorting nexin family member 27
chr21_+_37507209 0.966 NM_001236
CBR3
carbonyl reductase 3
chr5_+_155753755 0.963 NM_000337
NM_001128209
NM_172244
SGCD


sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)


chr1_-_9129666 0.959 NM_001135585
NM_003039
SLC2A5

solute carrier family 2 (facilitated glucose/fructose transporter), member 5

chr4_-_177190258 0.936 NM_080874
ASB5
ankyrin repeat and SOCS box containing 5
chr11_+_128564130 0.924 FLI1
Friend leukemia virus integration 1
chr19_-_41812991 0.921


chr4_-_123377471 0.911 NM_000586
IL2
interleukin 2
chr12_-_76478737 0.904 NM_004537
NM_139207
NAP1L1

nucleosome assembly protein 1-like 1

chr3_-_196065243 0.901 NM_001204897
NM_001204898
NM_138461
TM4SF19


transmembrane 4 L six family member 19


chr4_+_148402068 0.900 NM_001166055
NM_001957
EDNRA

endothelin receptor type A

chr15_+_49715374 0.900 NM_002009
FGF7
fibroblast growth factor 7
chr16_-_73082169 0.891 NM_006885
ZFHX3
zinc finger homeobox 3
chrX_+_117526665 0.862 WDR44
WD repeat domain 44
chr6_+_36665627 0.848 RAB44
RAB44, member RAS oncogene family
chr7_+_120629444 0.845 NM_001105533
C7orf58
chromosome 7 open reading frame 58
chr18_+_61575203 0.843 SERPINB10
serpin peptidase inhibitor, clade B (ovalbumin), member 10
chr5_+_43609261 0.839 NNT
nicotinamide nucleotide transhydrogenase
chr9_+_72658496 0.823 NM_153267
MAMDC2
MAM domain containing 2
chr4_-_65275000 0.817 NM_001010874
TECRL
trans-2,3-enoyl-CoA reductase-like
chr8_-_17555158 0.815 NM_020749
MTUS1
microtubule associated tumor suppressor 1
chr17_-_9862765 0.815 NM_003644
GAS7
growth arrest-specific 7
chr10_+_99332197 0.812 NM_001129981
NM_020349
ANKRD2

ankyrin repeat domain 2 (stretch responsive muscle)

chrX_-_135962853 0.810


chr11_-_111782447 0.800 NM_001885
CRYAB
crystallin, alpha B
chr10_-_92680784 0.794 ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr17_+_12569364 0.789 MYOCD
myocardin
chr3_-_187452669 0.787 NM_001134738
BCL6
B-cell CLL/lymphoma 6
chrX_-_19988381 0.786 NM_198279
CXorf23
chromosome X open reading frame 23
chr14_+_32798478 0.783 NM_004274
AKAP6
A kinase (PRKA) anchor protein 6
chr3_+_157154579 0.772 NM_002852
PTX3
pentraxin 3, long
chr7_+_119913688 0.771 NM_012281
KCND2
potassium voltage-gated channel, Shal-related subfamily, member 2
chr14_+_67831484 0.765 EIF2S1
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
chr1_+_84767288 0.765 NM_001134663
SAMD13
sterile alpha motif domain containing 13
chr5_-_56778553 0.760 NM_001017992
ACTBL2
actin, beta-like 2
chr7_+_80275634 0.758 NM_001127443
NM_001127444
CD36

CD36 molecule (thrombospondin receptor)

chr17_+_12569305 0.753 MYOCD
myocardin
chr6_-_169650846 0.750


chr2_+_169929009 0.746 NM_001142270
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr10_-_106098161 0.742 ITPRIP
inositol 1,4,5-trisphosphate receptor interacting protein
chr9_-_5968367 0.741


chr4_-_120549115 0.740 NM_033437
PDE5A
phosphodiesterase 5A, cGMP-specific
chr6_-_127780534 0.739 NM_014702
KIAA0408
KIAA0408
chr22_+_40573879 0.732 NM_001162501
NM_015088
TNRC6B

trinucleotide repeat containing 6B

chr11_+_128563973 0.731 FLI1
Friend leukemia virus integration 1
chr5_-_159846043 0.729 NM_006425
SLU7
SLU7 splicing factor homolog (S. cerevisiae)
chr11_+_59824054 0.728 NM_001031666
NM_001031809
NM_006138
MS4A3


membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)


chr7_+_139528951 0.724 NM_001061
NM_001166253
NM_030984
TBXAS1


thromboxane A synthase 1 (platelet)


chrX_-_135962872 0.722 RBMX
RNA binding motif protein, X-linked
chr1_+_247579457 0.721 NM_001079821
NM_001127461
NLRP3

NLR family, pyrin domain containing 3

chr12_+_78225068 0.719 NM_014903
NAV3
neuron navigator 3
chr13_+_111767586 0.717 NM_001113511
NM_001113512
NM_145735
ARHGEF7


Rho guanine nucleotide exchange factor (GEF) 7


chr20_+_9288446 0.714 NM_000933
PLCB4
phospholipase C, beta 4
chr12_-_40013842 0.712 NM_005164
ABCD2
ATP-binding cassette, sub-family D (ALD), member 2
chr11_-_64825992 0.707 NM_005468
NAALADL1
N-acetylated alpha-linked acidic dipeptidase-like 1
chr1_-_116311398 0.705 NM_001232
CASQ2
calsequestrin 2 (cardiac muscle)
chr5_-_58571916 0.703 NM_001197220
PDE4D
phosphodiesterase 4D, cAMP-specific
chr11_-_19223516 0.699 NM_001127656
NM_003476
CSRP3

cysteine and glycine-rich protein 3 (cardiac LIM protein)

chr12_-_121248679 0.696 SPPL3
signal peptide peptidase-like 3
chr3_-_52294427 0.694 WDR82
WD repeat domain 82
chr15_+_63335904 0.692 TPM1
tropomyosin 1 (alpha)
chr1_+_201159952 0.691 NM_001164586
IGFN1
immunoglobulin-like and fibronectin type III domain containing 1
chr1_-_241799101 0.690 NM_001821
CHML
choroideremia-like (Rab escort protein 2)
chr22_+_38071612 0.681 NM_002305
LGALS1
lectin, galactoside-binding, soluble, 1
chr6_-_46047978 0.674 NM_001114086
CLIC5
chloride intracellular channel 5
chr4_+_15429628 0.670 NM_031911
C1QTNF7
C1q and tumor necrosis factor related protein 7
chr17_-_16097882 0.670 NM_001190438
NM_001190440
NCOR1

nuclear receptor corepressor 1

chr6_-_24877453 0.669 NM_015864
FAM65B
family with sequence similarity 65, member B
chr4_+_148402244 0.661 EDNRA
endothelin receptor type A
chr3_+_16974581 0.661 NM_015184
PLCL2
phospholipase C-like 2
chr3_+_187943192 0.656 NM_001167671
LPP
LIM domain containing preferred translocation partner in lipoma
chr8_-_95274520 0.654 GEM
GTP binding protein overexpressed in skeletal muscle
chr5_+_40841296 0.653 NM_032587
CARD6
caspase recruitment domain family, member 6
chr3_-_112358758 0.652 CCDC80
coiled-coil domain containing 80
chr9_-_124984018 0.651 NM_001242335
LHX6
LIM homeobox 6
chr12_+_32687246 0.651 FGD4
FYVE, RhoGEF and PH domain containing 4
chr11_+_128563993 0.651 FLI1
Friend leukemia virus integration 1
chr1_-_9129620 0.650 SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr1_-_115300615 0.648 NM_001007553
NM_001130523
NM_001242891
NM_001242892
NM_001242893
NM_007158
CSDE1





cold shock domain containing E1, RNA-binding





chr13_-_75901897 0.643 TBC1D4
TBC1 domain family, member 4
chr18_+_72342918 0.639 NM_001146189
NM_001146190
NM_017757
ZNF407


zinc finger protein 407


chr9_-_14086901 0.637 NFIB
nuclear factor I/B
chr9_-_29738 0.633 NM_182905
WASH1
WAS protein family homolog 1
chr12_+_56915587 0.629 NM_002898
RBMS2
RNA binding motif, single stranded interacting protein 2
chr21_-_15579243 0.627 NM_198996
LIPI
lipase, member I
chr12_+_14538232 0.617 ATF7IP
activating transcription factor 7 interacting protein
chr22_-_37403838 0.613 NM_001163857
NM_178552
C22orf33

chromosome 22 open reading frame 33

chr9_+_100745672 0.608 ANP32B
acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
chr1_-_103496768 0.605 COL11A1
collagen, type XI, alpha 1
chr10_-_28571014 0.604 NM_173496
MPP7
membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)
chr17_-_76732944 0.594


chr22_+_44395090 0.592 NM_001003828
PARVB
parvin, beta
chr11_+_59824129 0.589 MS4A3
membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
chrX_-_135962929 0.589 NM_001164803
NM_002139
RBMX

RNA binding motif protein, X-linked

chr1_-_21501229 0.588 NM_001198803
EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr9_+_96846710 0.588 NM_001253829
NM_152422
PTPDC1

protein tyrosine phosphatase domain containing 1

chr3_-_187420344 0.584 NM_001004312
RTP2
receptor (chemosensory) transporter protein 2
chr4_+_148402117 0.581 EDNRA
endothelin receptor type A
chrX_-_77914824 0.579 NM_152694
ZCCHC5
zinc finger, CCHC domain containing 5
chr13_-_20346398 0.576 PSPC1
paraspeckle component 1
chr2_+_68872953 0.573 NM_138964
PROKR1
prokineticin receptor 1
chr1_-_116311161 0.570 CASQ2
calsequestrin 2 (cardiac muscle)
chr1_-_115269672 0.569 CSDE1
cold shock domain containing E1, RNA-binding
chr18_+_32335939 0.566 NM_001390
NM_001391
DTNA

dystrobrevin, alpha

chr3_+_180630431 0.565 FXR1
fragile X mental retardation, autosomal homolog 1
chr11_+_128563772 0.560 NM_001167681
NM_002017
FLI1

Friend leukemia virus integration 1

chr1_-_152779106 0.558 NM_178351
LCE1C
late cornified envelope 1C
chr5_-_88119604 0.558 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr9_+_100745584 0.557 ANP32B
acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
chr3_-_172858959 0.556 NM_031955
SPATA16
spermatogenesis associated 16
chr1_+_179965756 0.554 CEP350
centrosomal protein 350kDa
chr4_-_153273683 0.553 NM_018315
FBXW7
F-box and WD repeat domain containing 7

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
34.08 1.17e-04 GO:0030049 muscle filament sliding
34.08 1.17e-04 GO:0033275 actin-myosin filament sliding
33.18 1.35e-04 GO:0070252 actin-mediated cell contraction
10.97 2.21e-04 GO:0007517 muscle organ development
24.73 6.07e-04 GO:0030048 actin filament-based movement
11.18 1.03e-03 GO:0006936 muscle contraction
10.27 1.81e-03 GO:0003012 muscle system process
7.80 2.82e-03 GO:0061061 muscle structure development
34.38 3.12e-02 GO:0002053 positive regulation of mesenchymal cell proliferation
31.52 4.08e-02 GO:0010464 regulation of mesenchymal cell proliferation

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
17.40 1.60e-06 GO:0030016 myofibril
16.41 2.55e-06 GO:0043292 contractile fiber
15.63 2.79e-05 GO:0044449 contractile fiber part
15.45 2.22e-04 GO:0030017 sarcomere
26.55 1.39e-03 GO:0030018 Z disc
21.02 3.55e-03 GO:0031674 I band
44.49 3.62e-03 GO:0016010 dystrophin-associated glycoprotein complex

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
23.46 2.26e-03 GO:0008307 structural constituent of muscle