Motif ID: NFATC1..3.p2

Z-value: 2.574


Transcription factors associated with NFATC1..3.p2:

Gene SymbolEntrez IDGene Name
NFATC1 4772 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFATC2 4773 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NFATC3 4775 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NFATC1hg19_v1_chr18_+_77155966_771562240.125.2e-01Click!
NFATC2hg19_v1_chr20_-_50179167_50179167-0.125.3e-01Click!
NFATC3hg19_v1_chr16_+_68119332_68119344-0.067.3e-01Click!


Activity profile for motif NFATC1..3.p2.

activity profile for motif NFATC1..3.p2


Sorted Z-values histogram for motif NFATC1..3.p2

Sorted Z-values for motif NFATC1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFATC1..3.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_71532341 15.063 NM_144646
 IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr4_-_71532206 13.537 IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr2_+_189839132 10.111 COL3A1
collagen, type III, alpha 1
chr14_-_106573348 9.796 IGHV4-31
IGHA1
IGHA2
IGHG1
IGHG3
IGHM
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant alpha 2 (A2m marker)
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
immunoglobulin heavy constant mu
chr2_+_189839078 9.591 NM_000090
 COL3A1
collagen, type III, alpha 1
chr2_+_189839113 9.162 COL3A1
collagen, type III, alpha 1
chr14_-_107122358 8.639


chr14_-_107218786 8.577 IGHA1
IGHG1
IGHM
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant mu
chr2_-_238322840 7.536 NM_004369
NM_057164
NM_057165
NM_057166
NM_057167
 COL6A3




collagen, type VI, alpha 3




chr2_-_238322806 7.465 COL6A3
collagen, type VI, alpha 3
chr1_-_169599349 7.438 NM_003005
 SELP
selectin P (granule membrane protein 140kDa, antigen CD62)
chr14_-_107013122 7.249 IGHV4-31
IGHG1
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant gamma 1 (G1m marker)
chr2_-_238322814 7.089 COL6A3
collagen, type VI, alpha 3
chr2_-_238322815 6.934 COL6A3
collagen, type VI, alpha 3
chr2_-_89165652 6.825


chr2_-_238322770 6.803 COL6A3
collagen, type VI, alpha 3
chr14_-_106994001 6.683 IGHV3-48
IGH@
IGHA1
IGHM
immunoglobulin heavy variable 3-48
immunoglobulin heavy locus
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant mu
chr3_-_112359962 6.481 NM_199511
NM_199512
 CCDC80

coiled-coil domain containing 80

chr1_+_171154387 6.299 NM_001460
 FMO2
flavin containing monooxygenase 2 (non-functional)
chr3_-_112359863 6.054 CCDC80
coiled-coil domain containing 80

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 126 entries
Enrichment   P-value GO Accession GO Term
47.04 1.51e-02 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan
47.04 1.51e-02 GO:0021563 glossopharyngeal nerve development
47.04 1.51e-02 GO:0021615 glossopharyngeal nerve morphogenesis
14.70 2.43e-02 GO:0032735 positive regulation of interleukin-12 production
11.29 1.78e-02 GO:0018149 peptide cross-linking
10.98 3.98e-03 GO:0046427 positive regulation of JAK-STAT cascade
10.86 2.28e-02 GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
10.29 6.34e-03 GO:0042509 regulation of tyrosine phosphorylation of STAT protein
9.73 4.45e-02 GO:0010811 positive regulation of cell-substrate adhesion
9.41 2.64e-03 GO:0046425 regulation of JAK-STAT cascade
9.18 3.22e-03 GO:0050871 positive regulation of B cell activation
8.23 3.03e-02 GO:0045582 positive regulation of T cell differentiation
7.84 4.23e-02 GO:0045639 positive regulation of myeloid cell differentiation
7.68 1.31e-02 GO:0042102 positive regulation of T cell proliferation
7.24 2.07e-02 GO:0048771 tissue remodeling
7.19 5.31e-04 GO:0045785 positive regulation of cell adhesion
7.10 2.39e-02 GO:0045580 regulation of T cell differentiation
7.09 6.14e-04 GO:0050671 positive regulation of lymphocyte proliferation
7.06 7.38e-03 GO:0050864 regulation of B cell activation
7.01 1.85e-05 GO:0030198 extracellular matrix organization

Gene overrepresentation in compartment category:

Showing 1 to 20 of 21 entries
Enrichment   P-value GO Accession GO Term
21.38 3.32e-04 GO:0005583 fibrillar collagen
13.07 4.98e-07 GO:0005581 collagen
8.01 1.12e-03 GO:0031093 platelet alpha granule lumen
7.84 1.32e-03 GO:0034774 secretory granule lumen
7.53 1.81e-03 GO:0060205 cytoplasmic membrane-bounded vesicle lumen
7.43 5.61e-04 GO:0031091 platelet alpha granule
7.24 2.45e-03 GO:0031983 vesicle lumen
6.66 4.17e-07 GO:0044420 extracellular matrix part
5.69 1.84e-15 GO:0005578 proteinaceous extracellular matrix
5.21 1.83e-15 GO:0031012 extracellular matrix
5.12 4.86e-05 GO:0009897 external side of plasma membrane
4.28 4.61e-30 GO:0044421 extracellular region part
4.23 7.46e-22 GO:0005615 extracellular space
3.82 1.49e-02 GO:0045121 membrane raft
3.31 2.64e-36 GO:0005576 extracellular region
2.84 2.40e-03 GO:0009986 cell surface
2.16 1.48e-05 GO:0031226 intrinsic to plasma membrane
2.16 1.98e-05 GO:0005887 integral to plasma membrane
1.96 1.14e-07 GO:0044459 plasma membrane part
1.59 6.78e-07 GO:0071944 cell periphery

Gene overrepresentation in function category:

Showing 1 to 20 of 25 entries
Enrichment   P-value GO Accession GO Term
18.82 1.11e-02 GO:0048019 receptor antagonist activity
17.11 1.72e-02 GO:0030547 receptor inhibitor activity
12.94 1.37e-07 GO:0003823 antigen binding
10.69 2.42e-02 GO:0019956 chemokine binding
8.45 4.67e-03 GO:0005518 collagen binding
8.18 1.47e-03 GO:0008009 chemokine activity
7.38 3.27e-03 GO:0042379 chemokine receptor binding
7.06 3.50e-05 GO:0005201 extracellular matrix structural constituent
6.62 2.34e-03 GO:0005178 integrin binding
5.76 7.05e-07 GO:0005539 glycosaminoglycan binding
5.62 3.83e-07 GO:0001871 pattern binding
5.62 3.83e-07 GO:0030247 polysaccharide binding
5.51 2.01e-04 GO:0008201 heparin binding
5.28 8.59e-04 GO:0019838 growth factor binding
4.85 1.89e-06 GO:0005125 cytokine activity
4.79 5.61e-03 GO:0019955 cytokine binding
4.71 1.75e-05 GO:0005126 cytokine receptor binding
3.74 3.66e-07 GO:0030246 carbohydrate binding
3.06 7.25e-13 GO:0005102 receptor binding
2.21 3.38e-02 GO:0005198 structural molecule activity