Motif ID: NFATC1..3.p2

Z-value: 2.574


Transcription factors associated with NFATC1..3.p2:

Gene SymbolEntrez IDGene Name
NFATC1 4772 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFATC2 4773 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NFATC3 4775 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NFATC1hg19_v1_chr18_+_77155966_771562240.125.2e-01Click!
NFATC2hg19_v1_chr20_-_50179167_50179167-0.125.3e-01Click!
NFATC3hg19_v1_chr16_+_68119332_68119344-0.067.3e-01Click!


Activity profile for motif NFATC1..3.p2.

activity profile for motif NFATC1..3.p2


Sorted Z-values histogram for motif NFATC1..3.p2

Sorted Z-values for motif NFATC1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFATC1..3.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_-_71532341 15.063 NM_144646
IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr4_-_71532206 13.537 IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr2_+_189839132 10.111 COL3A1
collagen, type III, alpha 1
chr14_-_106573348 9.796 IGHV4-31
IGHA1
IGHA2
IGHG1
IGHG3
IGHM
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant alpha 2 (A2m marker)
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
immunoglobulin heavy constant mu
chr2_+_189839078 9.591 NM_000090
COL3A1
collagen, type III, alpha 1
chr2_+_189839113 9.162 COL3A1
collagen, type III, alpha 1
chr14_-_107122358 8.639


chr14_-_107218786 8.577 IGHA1
IGHG1
IGHM
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant mu
chr2_-_238322840 7.536 NM_004369
NM_057164
NM_057165
NM_057166
NM_057167
COL6A3




collagen, type VI, alpha 3




chr2_-_238322806 7.465 COL6A3
collagen, type VI, alpha 3
chr1_-_169599349 7.438 NM_003005
SELP
selectin P (granule membrane protein 140kDa, antigen CD62)
chr14_-_107013122 7.249 IGHV4-31
IGHG1
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant gamma 1 (G1m marker)
chr2_-_238322814 7.089 COL6A3
collagen, type VI, alpha 3
chr2_-_238322815 6.934 COL6A3
collagen, type VI, alpha 3
chr2_-_89165652 6.825


chr2_-_238322770 6.803 COL6A3
collagen, type VI, alpha 3
chr14_-_106994001 6.683 IGHV3-48
IGH@
IGHA1
IGHM
immunoglobulin heavy variable 3-48
immunoglobulin heavy locus
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant mu
chr3_-_112359962 6.481 NM_199511
NM_199512
CCDC80

coiled-coil domain containing 80

chr1_+_171154387 6.299 NM_001460
FMO2
flavin containing monooxygenase 2 (non-functional)
chr3_-_112359863 6.054 CCDC80
coiled-coil domain containing 80
chrX_-_70331297 6.044 NM_000206
IL2RG
interleukin 2 receptor, gamma
chr1_-_203320185 5.451 FMOD
fibromodulin
chr17_+_48262816 5.328


chr14_-_106746056 5.283


chr21_-_27945267 5.211 NM_052954
CYYR1
cysteine/tyrosine-rich 1
chr8_-_82395401 5.197 NM_001442
FABP4
fatty acid binding protein 4, adipocyte
chr4_-_100242487 5.174 NM_000668
ADH1A
ADH1B
alcohol dehydrogenase 1A (class I), alpha polypeptide
alcohol dehydrogenase 1B (class I), beta polypeptide
chr1_-_203320287 5.074 NM_002023
FMOD
fibromodulin
chr1_-_203320249 5.023


chr14_-_106877689 4.986 IGHV4-31
IGH@
IGHA1
IGHA2
IGHG1
IGHG4
IGHM
immunoglobulin heavy variable 4-31
immunoglobulin heavy locus
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant alpha 2 (A2m marker)
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 4 (G4m marker)
immunoglobulin heavy constant mu
chr14_-_107211131 4.720 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr12_-_91573264 4.660 NM_133503
DCN
decorin
chr2_-_188312872 4.617 NM_005795
CALCRL
calcitonin receptor-like
chr14_-_106926393 4.471 IGHA1
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr7_+_80267782 4.456 NM_000072
NM_001001548
CD36

CD36 molecule (thrombospondin receptor)

chr14_-_107131217 4.433 IGHA1
immunoglobulin heavy constant alpha 1
chr3_+_186560478 4.410 ADIPOQ
adiponectin, C1Q and collagen domain containing
chr7_+_80231503 4.254 NM_001001547
CD36
CD36 molecule (thrombospondin receptor)
chr11_-_102595623 4.228 NM_002424
MMP8
matrix metallopeptidase 8 (neutrophil collagenase)
chr1_+_162602198 4.131 NM_001014796
NM_006182
DDR2

discoidin domain receptor tyrosine kinase 2

chr17_+_1182956 4.090 NM_172367
TUSC5
tumor suppressor candidate 5
chr6_+_152011630 4.081 NM_001122742
ESR1
estrogen receptor 1
chr2_+_113885145 4.070 IL1RN
interleukin 1 receptor antagonist
chr3_+_186560462 4.051 NM_001177800
NM_004797
ADIPOQ

adiponectin, C1Q and collagen domain containing

chr14_-_107170400 4.028 IGHV4-31
IGHV1-69
IGHA1
IGHG1
IGHG3
IGHM
immunoglobulin heavy variable 4-31
immunoglobulin heavy variable 1-69
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
immunoglobulin heavy constant mu
chr1_-_147232684 3.951 NM_181703
GJA5
gap junction protein, alpha 5, 40kDa
chr6_-_31981049 3.939 NM_032470
TNXB
tenascin XB
chr9_-_129884998 3.801 NM_012098
ANGPTL2
angiopoietin-like 2
chrX_-_10544852 3.706 NM_001193277
MID1
midline 1 (Opitz/BBB syndrome)
chr11_-_10590078 3.705 NM_006691
LYVE1
lymphatic vessel endothelial hyaluronan receptor 1
chr4_-_100212085 3.642 NM_000667
ADH1A
alcohol dehydrogenase 1A (class I), alpha polypeptide
chr1_-_150780705 3.584 NM_000396
CTSK
cathepsin K
chr5_+_38445577 3.582 NM_182801
EGFLAM
EGF-like, fibronectin type III and laminin G domains
chr14_-_107170076 3.502 IGHV1-69
IGHG1
immunoglobulin heavy variable 1-69
immunoglobulin heavy constant gamma 1 (G1m marker)
chr12_+_69742140 3.468 LYZ
lysozyme
chr6_-_32013806 3.443 NM_032470
TNXB
tenascin XB
chr4_+_68424444 3.413 NM_012108
STAP1
signal transducing adaptor family member 1
chr1_-_27701302 3.317 NM_003665
NM_173452
FCN3

ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen)

chr3_-_183273407 3.276 NM_130446
KLHL6
kelch-like 6 (Drosophila)
chr8_-_13372183 3.275 NM_024767
NM_182643
DLC1

deleted in liver cancer 1

chr1_+_171217632 3.264 NM_002021
FMO1
flavin containing monooxygenase 1
chr4_+_39408472 3.259 NM_175737
KLB
klotho beta
chr8_+_39771327 3.257 NM_002164
IDO1
indoleamine 2,3-dioxygenase 1
chr9_-_95298251 3.246 NM_001197295
NM_001197296
NM_001393
ECM2


extracellular matrix protein 2, female organ and adipocyte specific


chr14_-_106539099 3.232 IGHA1
IGHG1
IGHG3
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
chr22_+_40297085 3.203 NM_004810
GRAP2
GRB2-related adaptor protein 2
chr16_+_72088507 3.177 NM_001126102
NM_005143
HP

haptoglobin

chr3_+_130279177 3.121 NM_001102608
COL6A6
collagen, type VI, alpha 6
chr13_+_111134933 3.121 COL4A2
collagen, type IV, alpha 2
chr15_+_52201590 3.087 TMOD3
tropomodulin 3 (ubiquitous)
chr2_+_113885137 3.067 NM_173842
IL1RN
interleukin 1 receptor antagonist
chr17_-_34207308 3.051 NM_002985
CCL5
chemokine (C-C motif) ligand 5
chr3_+_12392993 3.051 NM_015869
PPARG
peroxisome proliferator-activated receptor gamma
chr11_-_118084073 3.046 NM_153206
AMICA1
adhesion molecule, interacts with CXADR antigen 1
chr7_+_116164838 3.020 NM_001753
CAV1
caveolin 1, caveolae protein, 22kDa
chr1_+_101185195 3.019 NM_001078
NM_001199834
NM_080682
VCAM1


vascular cell adhesion molecule 1


chr6_+_106546736 3.010 NM_182907
PRDM1
PR domain containing 1, with ZNF domain
chr9_-_95166827 3.009 NM_014057
NM_033014
OGN

osteoglycin

chr4_+_78432905 3.008 NM_006419
CXCL13
chemokine (C-X-C motif) ligand 13
chr7_+_80267922 2.997 CD36
CD36 molecule (thrombospondin receptor)
chr13_-_38172862 2.978 NM_001135934
NM_001135935
NM_001135936
NM_006475
POSTN



periostin, osteoblast specific factor



chr8_-_6420454 2.976 NM_001118887
NM_001118888
NM_001147
ANGPT2


angiopoietin 2


chr7_+_80267972 2.944 CD36
CD36 molecule (thrombospondin receptor)
chr11_-_68780667 2.904 NM_001098515
NM_145015
MRGPRF

MAS-related GPR, member F

chr14_-_106405633 2.872 IGHM
immunoglobulin heavy constant mu
chr4_-_87770267 2.859 NM_197965
SLC10A6
solute carrier family 10 (sodium/bile acid cotransporter family), member 6
chr7_+_23286384 2.831 GPNMB
glycoprotein (transmembrane) nmb
chr9_+_12774988 2.783 NM_203403
C9orf150
chromosome 9 open reading frame 150
chr3_+_132316080 2.783 NM_016557
CCRL1
chemokine (C-C motif) receptor-like 1
chr3_-_149051258 2.763 NM_001184723
NM_138786
TM4SF18

transmembrane 4 L six family member 18

chr3_-_150920946 2.753 NM_013308
GPR171
G protein-coupled receptor 171
chr12_-_9760481 2.751 NM_002258
KLRB1
killer cell lectin-like receptor subfamily B, member 1
chr1_+_32739711 2.743 NM_001042771
LCK
lymphocyte-specific protein tyrosine kinase
chr7_+_23286386 2.721 GPNMB
glycoprotein (transmembrane) nmb
chr12_-_15038724 2.718 NM_000900
NM_001190839
MGP

matrix Gla protein

chr3_+_187943192 2.685 NM_001167671
LPP
LIM domain containing preferred translocation partner in lipoma
chr7_+_23286390 2.674 GPNMB
glycoprotein (transmembrane) nmb
chr6_-_169654047 2.664 NM_003247
THBS2
thrombospondin 2
chr1_+_26644458 2.663 CD52
CD52 molecule
chr12_-_91505215 2.658 LUM
lumican
chr5_+_42565963 2.633 NM_001242460
NM_001242461
NM_001242462
GHR


growth hormone receptor


chr4_+_40198526 2.621 NM_004310
RHOH
ras homolog gene family, member H
chr22_-_36236421 2.614 NM_001031695
NM_001082576
NM_001082577
NM_014309
RBFOX2



RNA binding protein, fox-1 homolog (C. elegans) 2



chr14_+_88471467 2.609 NM_003608
GPR65
G protein-coupled receptor 65
chr19_+_41281281 2.607 NM_006533
MIA
melanoma inhibitory activity
chr7_+_94024201 2.594 COL1A2
collagen, type I, alpha 2
chr7_+_100199881 2.592 NM_002593
PCOLCE
procollagen C-endopeptidase enhancer
chr2_+_27301693 2.585 EMILIN1
elastin microfibril interfacer 1
chr1_+_162602308 2.582 DDR2
discoidin domain receptor tyrosine kinase 2
chr1_-_153518265 2.567 NM_002961
NM_019554
S100A4

S100 calcium binding protein A4

chr14_-_106552313 2.563 IGHA1
IGHD
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant delta
immunoglobulin heavy constant gamma 1 (G1m marker)
chr3_-_112358510 2.558 CCDC80
coiled-coil domain containing 80
chr17_-_46667596 2.535 HOXB3
homeobox B3
chr14_-_106967080 2.529 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr4_+_102734982 2.492 NM_001083907
BANK1
B-cell scaffold protein with ankyrin repeats 1
chr8_-_86290333 2.491 NM_001128829
NM_001128830
NM_001128831
NM_001738
CA1



carbonic anhydrase I



chr12_-_9268475 2.476 A2M
alpha-2-macroglobulin
chr1_+_86046434 2.473 NM_001554
CYR61
cysteine-rich, angiogenic inducer, 61
chr12_+_13349716 2.466 EMP1
epithelial membrane protein 1
chr12_-_9268513 2.465 A2M
alpha-2-macroglobulin
chrX_+_2670092 2.460 NM_001141919
NM_001141920
NM_175569
XGPY2
XG


Xg pseudogene, Y-linked 2
Xg blood group


chr1_+_32712817 2.460 NM_032648
FAM167B
family with sequence similarity 167, member B
chr3_-_112358758 2.458 CCDC80
coiled-coil domain containing 80
chr7_-_27166638 2.455 NM_153631
HOXA3
homeobox A3
chr7_-_131241321 2.454 NM_001018111
NM_005397
PODXL

podocalyxin-like

chr5_+_54398473 2.451 NM_006144
GZMA
granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
chr12_+_69742130 2.443 NM_000239
LYZ
lysozyme
chr22_+_33196801 2.414 NM_000362
TIMP3
TIMP metallopeptidase inhibitor 3
chr19_+_3178735 2.400 NM_003775
S1PR4
sphingosine-1-phosphate receptor 4
chr4_-_76928601 2.386 NM_002416
CXCL9
chemokine (C-X-C motif) ligand 9
chr3_-_112359277 2.378 CCDC80
coiled-coil domain containing 80
chr1_+_26644380 2.366 NM_001803
CD52
CD52 molecule
chr20_+_12989616 2.353 NM_018327
SPTLC3
serine palmitoyltransferase, long chain base subunit 3
chr7_+_23286401 2.342 GPNMB
glycoprotein (transmembrane) nmb
chr3_+_14860468 2.342 NM_152536
FGD5
FYVE, RhoGEF and PH domain containing 5
chr3_-_151176496 2.330 NM_178822
IGSF10
immunoglobulin superfamily, member 10
chr5_-_158526698 2.329 NM_024007
EBF1
early B-cell factor 1
chr21_-_28339405 2.302 NM_007038
ADAMTS5
ADAM metallopeptidase with thrombospondin type 1 motif, 5
chr1_+_117297056 2.278 NM_001767
CD2
CD2 molecule
chr7_-_15726026 2.242 MEOX2
mesenchyme homeobox 2
chr14_-_106691698 2.239


chr14_+_63671101 2.236 NM_020663
RHOJ
ras homolog gene family, member J
chr8_-_95274540 2.235 NM_005261
NM_181702
GEM

GTP binding protein overexpressed in skeletal muscle

chr3_-_112359251 2.234 CCDC80
coiled-coil domain containing 80
chr1_-_85462622 2.230 NM_153259
MCOLN2
mucolipin 2
chr12_+_12938540 2.230 NM_030817
APOLD1
apolipoprotein L domain containing 1
chr12_+_13349601 2.228 NM_001423
EMP1
epithelial membrane protein 1
chr10_+_35484829 2.222 NM_182721
NM_182722
NM_182723
NM_182724
NM_182725
CREM




cAMP responsive element modulator




chr13_-_52980628 2.222 NM_018676
NM_199263
THSD1

thrombospondin, type I, domain containing 1

chr13_+_102104941 2.209 NM_004791
ITGBL1
integrin, beta-like 1 (with EGF-like repeat domains)
chr12_+_13349720 2.191 EMP1
epithelial membrane protein 1
chr22_-_19512859 2.172 NM_001130861
NM_003277
CLDN5

claudin 5

chr1_-_157522151 2.164 NM_001195388
NM_031281
FCRL5

Fc receptor-like 5

chr15_+_73976689 2.157 CD276
CD276 molecule
chrX_+_15518899 2.124 NM_203281
BMX
BMX non-receptor tyrosine kinase
chr14_-_106967528 2.124 IGHA1
IGHA2
IGHG1
IGHM
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant alpha 2 (A2m marker)
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant mu
chr1_-_171621750 2.121 NM_000261
MYOC
myocilin, trabecular meshwork inducible glucocorticoid response
chr6_-_112575766 2.110 NM_001105206
NM_001105207
NM_001105208
NM_001105209
NM_002290
LAMA4




laminin, alpha 4




chr5_-_172755418 2.108 STC2
stanniocalcin 2
chr14_-_106641585 2.104 IGHV4-31
IGHA1
IGHA2
IGHG1
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant alpha 2 (A2m marker)
immunoglobulin heavy constant gamma 1 (G1m marker)
chr15_+_81293286 2.093 NM_022566
MESDC1
mesoderm development candidate 1
chr10_+_17851342 2.088 NM_002438
MRC1
mannose receptor, C type 1
chr17_-_42908178 2.086 NM_001080383
GJC1
gap junction protein, gamma 1, 45kDa
chr12_-_102872329 2.082 NM_001111284
IGF1
insulin-like growth factor 1 (somatomedin C)
chr6_-_46825942 2.078 GPR116
G protein-coupled receptor 116
chr6_-_112575708 2.078 LAMA4
laminin, alpha 4
chr17_-_34344933 2.071 NM_005064
NM_145898
CCL23

chemokine (C-C motif) ligand 23

chr1_-_54483802 2.066 NM_001010978
LDLRAD1
low density lipoprotein receptor class A domain containing 1
chr8_-_95274520 2.063 GEM
GTP binding protein overexpressed in skeletal muscle
chr3_+_45984972 2.061 NM_006564
CXCR6
chemokine (C-X-C motif) receptor 6
chr12_+_86268072 2.046 NM_006183
NTS
neurotensin
chr12_+_57388229 2.036 NM_007264
GPR182
G protein-coupled receptor 182
chr14_-_107048697 2.035 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr12_-_91505541 2.035 NM_002345
LUM
lumican
chr12_-_52886971 2.029 NM_005554
KRT6A
keratin 6A
chr20_+_24929904 2.024 CST7
cystatin F (leukocystatin)
chr6_-_138189313 2.023


chr3_+_361365 2.020 NM_001253388
CHL1
cell adhesion molecule with homology to L1CAM (close homolog of L1)
chr2_-_216259197 1.994 FN1
fibronectin 1
chr3_-_112359565 1.986 CCDC80
coiled-coil domain containing 80
chr1_+_45274153 1.983 NM_001136537
BTBD19
BTB (POZ) domain containing 19
chr14_-_24977421 1.972 NM_001836
CMA1
chymase 1, mast cell
chr10_+_81370694 1.972 NM_001093770
NM_001164644
NM_001164645
NM_001164646
NM_001164647
NM_005411
SFTPA1





surfactant protein A1





chr6_-_169653922 1.945 THBS2
thrombospondin 2
chr14_-_106791054 1.944 IGHV4-31
IGHV3-30
IGHA1
IGHD
IGHG1
IGHG2
IGHG3
IGHM
SCFV
immunoglobulin heavy variable 4-31
immunoglobulin heavy variable 3-30
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant delta
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 2 (G2m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
immunoglobulin heavy constant mu
single-chain Fv fragment
chr1_+_159175048 1.941 NM_001122951
DARC
Duffy blood group, chemokine receptor
chr17_-_38520941 1.918 NM_152219
GJD3
gap junction protein, delta 3, 31.9kDa
chr10_-_81320141 1.917 NM_001098668
SFTPA1
SFTPA2
surfactant protein A1
surfactant protein A2
chr11_-_118095708 1.917 NM_001098526
AMICA1
adhesion molecule, interacts with CXADR antigen 1
chr4_+_124317884 1.916 NM_199327
SPRY1
sprouty homolog 1, antagonist of FGF signaling (Drosophila)
chr14_-_64749530 1.913 NM_001214902
NM_001214903
ESR2

estrogen receptor 2 (ER beta)

chr3_-_149095517 1.910 NM_014220
TM4SF1
transmembrane 4 L six family member 1
chr7_-_16844606 1.906 NM_006408
AGR2
anterior gradient 2 homolog (Xenopus laevis)
chr4_+_90816002 1.900 NM_007351
MMRN1
multimerin 1
chr6_-_46922533 1.900 NM_015234
GPR116
G protein-coupled receptor 116
chr3_+_122334461 1.899 NM_152615
PARP15
poly (ADP-ribose) polymerase family, member 15
chr15_+_74466024 1.899 NM_005545
ISLR
immunoglobulin superfamily containing leucine-rich repeat
chr4_-_152147520 1.892 NM_001009555
NM_001128923
SH3D19

SH3 domain containing 19

chr4_+_74606222 1.881 NM_000584
IL8
interleukin 8
chr15_+_73976621 1.872 NM_001024736
NM_025240
CD276

CD276 molecule


Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
3.51 3.09e-21 GO:0002376 immune system process
3.94 7.50e-16 GO:0006955 immune response
1.65 5.74e-14 GO:0050896 response to stimulus
3.19 6.26e-10 GO:0006952 defense response
2.29 7.93e-10 GO:0048583 regulation of response to stimulus
1.86 2.18e-09 GO:0007165 signal transduction
4.00 5.33e-09 GO:0050776 regulation of immune response
4.95 5.43e-09 GO:0006954 inflammatory response
2.95 6.53e-09 GO:0009611 response to wounding
2.24 1.55e-08 GO:0007166 cell surface receptor linked signaling pathway
3.04 1.87e-08 GO:0048584 positive regulation of response to stimulus
5.46 2.58e-08 GO:0051249 regulation of lymphocyte activation
3.21 2.59e-08 GO:0002682 regulation of immune system process
5.88 4.15e-08 GO:0002696 positive regulation of leukocyte activation
5.78 5.82e-08 GO:0050867 positive regulation of cell activation
2.03 6.69e-08 GO:0042221 response to chemical stimulus
1.74 7.40e-08 GO:0023052 signaling
6.03 7.47e-08 GO:0051251 positive regulation of lymphocyte activation
3.81 8.51e-08 GO:0002684 positive regulation of immune system process
4.95 1.99e-07 GO:0002694 regulation of leukocyte activation
1.40 2.02e-07 GO:0065007 biological regulation
2.96 3.38e-07 GO:0007155 cell adhesion
2.96 3.38e-07 GO:0022610 biological adhesion
4.77 4.46e-07 GO:0050865 regulation of cell activation
5.67 6.59e-07 GO:0050863 regulation of T cell activation
1.41 8.69e-07 GO:0050789 regulation of biological process
1.93 8.81e-07 GO:0006950 response to stress
2.73 1.65e-06 GO:0040011 locomotion
1.63 1.91e-06 GO:0051716 cellular response to stimulus
5.59 2.33e-06 GO:0030155 regulation of cell adhesion
4.22 5.38e-06 GO:0001944 vasculature development
2.56 5.74e-06 GO:0042127 regulation of cell proliferation
5.97 6.21e-06 GO:0050870 positive regulation of T cell activation
4.35 6.36e-06 GO:0001568 blood vessel development
2.15 1.78e-05 GO:0009653 anatomical structure morphogenesis
7.01 1.85e-05 GO:0030198 extracellular matrix organization
5.41 2.85e-05 GO:0050900 leukocyte migration
1.70 3.67e-05 GO:0048856 anatomical structure development
2.43 4.09e-05 GO:0009605 response to external stimulus
1.61 5.59e-05 GO:0032502 developmental process
4.32 7.49e-05 GO:0032101 regulation of response to external stimulus
3.10 7.53e-05 GO:0001775 cell activation
3.17 8.22e-05 GO:0072358 cardiovascular system development
3.17 8.22e-05 GO:0072359 circulatory system development
1.37 1.01e-04 GO:0050794 regulation of cellular process
5.23 1.20e-04 GO:0043062 extracellular structure organization
3.58 1.30e-04 GO:0051240 positive regulation of multicellular organismal process
2.48 1.36e-04 GO:0009888 tissue development
3.82 1.43e-04 GO:0050778 positive regulation of immune response
2.99 1.69e-04 GO:0008284 positive regulation of cell proliferation
1.70 1.99e-04 GO:0048731 system development
1.71 3.57e-04 GO:0048518 positive regulation of biological process
7.19 5.31e-04 GO:0045785 positive regulation of cell adhesion
2.11 6.07e-04 GO:0010033 response to organic substance
7.09 6.14e-04 GO:0050671 positive regulation of lymphocyte proliferation
2.81 6.34e-04 GO:0006928 cellular component movement
4.15 6.34e-04 GO:0048514 blood vessel morphogenesis
7.00 7.07e-04 GO:0032946 positive regulation of mononuclear cell proliferation
6.90 8.13e-04 GO:0070665 positive regulation of leukocyte proliferation
1.58 8.83e-04 GO:0007275 multicellular organismal development
3.10 1.07e-03 GO:0016477 cell migration
3.16 1.28e-03 GO:0010627 regulation of intracellular protein kinase cascade
2.82 1.47e-03 GO:0006935 chemotaxis
2.82 1.47e-03 GO:0042330 taxis
1.84 1.48e-03 GO:0048513 organ development
1.42 1.55e-03 GO:0032501 multicellular organismal process
4.50 2.18e-03 GO:0001525 angiogenesis
5.65 2.27e-03 GO:0050670 regulation of lymphocyte proliferation
2.64 2.38e-03 GO:0042060 wound healing
3.35 2.44e-03 GO:0001501 skeletal system development
5.59 2.53e-03 GO:0032944 regulation of mononuclear cell proliferation
9.41 2.64e-03 GO:0046425 regulation of JAK-STAT cascade
9.18 3.22e-03 GO:0050871 positive regulation of B cell activation
5.43 3.46e-03 GO:0070663 regulation of leukocyte proliferation
3.52 3.73e-03 GO:0010740 positive regulation of intracellular protein kinase cascade
5.38 3.83e-03 GO:0002768 immune response-regulating cell surface receptor signaling pathway
3.51 3.95e-03 GO:0048545 response to steroid hormone stimulus
10.98 3.98e-03 GO:0046427 positive regulation of JAK-STAT cascade
5.33 4.24e-03 GO:0050727 regulation of inflammatory response
3.76 5.32e-03 GO:0002253 activation of immune response
2.82 5.96e-03 GO:0048870 cell motility
2.82 5.96e-03 GO:0051674 localization of cell
10.29 6.34e-03 GO:0042509 regulation of tyrosine phosphorylation of STAT protein
7.06 7.38e-03 GO:0050864 regulation of B cell activation
6.94 8.49e-03 GO:0045619 regulation of lymphocyte differentiation
5.39 9.82e-03 GO:0032103 positive regulation of response to external stimulus
6.62 1.28e-02 GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
7.68 1.31e-02 GO:0042102 positive regulation of T cell proliferation
3.34 1.45e-02 GO:0048534 hemopoietic or lymphoid organ development
3.48 1.48e-02 GO:0045321 leukocyte activation
1.64 1.50e-02 GO:0048522 positive regulation of cellular process
47.04 1.51e-02 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan
47.04 1.51e-02 GO:0021563 glossopharyngeal nerve development
47.04 1.51e-02 GO:0021615 glossopharyngeal nerve morphogenesis
5.13 1.61e-02 GO:0002429 immune response-activating cell surface receptor signaling pathway
3.31 1.62e-02 GO:0001817 regulation of cytokine production
3.82 1.66e-02 GO:0046649 lymphocyte activation
3.06 1.72e-02 GO:0045597 positive regulation of cell differentiation
11.29 1.78e-02 GO:0018149 peptide cross-linking
5.60 1.84e-02 GO:0050730 regulation of peptidyl-tyrosine phosphorylation
7.24 2.07e-02 GO:0048771 tissue remodeling
1.70 2.08e-02 GO:0030154 cell differentiation
10.86 2.28e-02 GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
2.60 2.30e-02 GO:0007599 hemostasis
6.14 2.39e-02 GO:0042129 regulation of T cell proliferation
7.10 2.39e-02 GO:0045580 regulation of T cell differentiation
14.70 2.43e-02 GO:0032735 positive regulation of interleukin-12 production
6.97 2.76e-02 GO:0002526 acute inflammatory response
2.46 2.82e-02 GO:0050878 regulation of body fluid levels
8.23 3.03e-02 GO:0045582 positive regulation of T cell differentiation
3.42 3.31e-02 GO:0030168 platelet activation
2.38 3.57e-02 GO:0009725 response to hormone stimulus
6.72 3.63e-02 GO:0010810 regulation of cell-substrate adhesion
2.48 3.66e-02 GO:0051336 regulation of hydrolase activity
2.22 3.75e-02 GO:2000026 regulation of multicellular organismal development
3.77 3.79e-02 GO:0002764 immune response-regulating signaling pathway
2.65 3.91e-02 GO:0051094 positive regulation of developmental process
3.09 4.05e-02 GO:0002520 immune system development
2.97 4.21e-02 GO:0031347 regulation of defense response
7.84 4.23e-02 GO:0045639 positive regulation of myeloid cell differentiation
9.73 4.45e-02 GO:0010811 positive regulation of cell-substrate adhesion
2.06 4.51e-02 GO:0070887 cellular response to chemical stimulus
5.06 4.55e-02 GO:0050851 antigen receptor-mediated signaling pathway
2.50 4.57e-02 GO:0080134 regulation of response to stress
5.65 4.73e-02 GO:0002576 platelet degranulation
1.65 4.96e-02 GO:0048869 cellular developmental process

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
3.31 2.64e-36 GO:0005576 extracellular region
4.28 4.61e-30 GO:0044421 extracellular region part
4.23 7.46e-22 GO:0005615 extracellular space
5.21 1.83e-15 GO:0031012 extracellular matrix
5.69 1.84e-15 GO:0005578 proteinaceous extracellular matrix
1.96 1.14e-07 GO:0044459 plasma membrane part
6.66 4.17e-07 GO:0044420 extracellular matrix part
13.07 4.98e-07 GO:0005581 collagen
1.59 6.78e-07 GO:0071944 cell periphery
1.59 1.03e-06 GO:0005886 plasma membrane
2.16 1.48e-05 GO:0031226 intrinsic to plasma membrane
2.16 1.98e-05 GO:0005887 integral to plasma membrane
5.12 4.86e-05 GO:0009897 external side of plasma membrane
21.38 3.32e-04 GO:0005583 fibrillar collagen
7.43 5.61e-04 GO:0031091 platelet alpha granule
8.01 1.12e-03 GO:0031093 platelet alpha granule lumen
7.84 1.32e-03 GO:0034774 secretory granule lumen
7.53 1.81e-03 GO:0060205 cytoplasmic membrane-bounded vesicle lumen
2.84 2.40e-03 GO:0009986 cell surface
7.24 2.45e-03 GO:0031983 vesicle lumen
3.82 1.49e-02 GO:0045121 membrane raft

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
3.06 7.25e-13 GO:0005102 receptor binding
12.94 1.37e-07 GO:0003823 antigen binding
3.74 3.66e-07 GO:0030246 carbohydrate binding
5.62 3.83e-07 GO:0001871 pattern binding
5.62 3.83e-07 GO:0030247 polysaccharide binding
5.76 7.05e-07 GO:0005539 glycosaminoglycan binding
4.85 1.89e-06 GO:0005125 cytokine activity
1.93 2.02e-06 GO:0004871 signal transducer activity
1.93 2.02e-06 GO:0060089 molecular transducer activity
2.03 3.90e-06 GO:0004872 receptor activity
4.71 1.75e-05 GO:0005126 cytokine receptor binding
7.06 3.50e-05 GO:0005201 extracellular matrix structural constituent
5.51 2.01e-04 GO:0008201 heparin binding
1.99 8.01e-04 GO:0004888 transmembrane receptor activity
5.28 8.59e-04 GO:0019838 growth factor binding
8.18 1.47e-03 GO:0008009 chemokine activity
6.62 2.34e-03 GO:0005178 integrin binding
1.29 2.42e-03 GO:0005515 protein binding
7.38 3.27e-03 GO:0042379 chemokine receptor binding
8.45 4.67e-03 GO:0005518 collagen binding
4.79 5.61e-03 GO:0019955 cytokine binding
18.82 1.11e-02 GO:0048019 receptor antagonist activity
17.11 1.72e-02 GO:0030547 receptor inhibitor activity
10.69 2.42e-02 GO:0019956 chemokine binding
2.21 3.38e-02 GO:0005198 structural molecule activity