Motif ID: NFE2.p2

Z-value: 1.347


Transcription factors associated with NFE2.p2:

Gene SymbolEntrez IDGene Name
NFE2 4778 nuclear factor (erythroid-derived 2), 45kDa

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NFE2hg19_v1_chr12_-_54694647_54694667-0.192.9e-01Click!


Activity profile for motif NFE2.p2.

activity profile for motif NFE2.p2


Sorted Z-values histogram for motif NFE2.p2

Sorted Z-values for motif NFE2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFE2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_27505296 4.840 NM_032546
NM_187841
TRIM54

tripartite motif containing 54

chr4_+_120056938 4.233 NM_016599
MYOZ2
myozenin 2
chr5_+_150020201 4.078 NM_001109974
NM_007286
SYNPO

synaptopodin

chr10_-_76868853 3.713 NM_001007271
NM_001007272
NM_001007273
DUSP13


dual specificity phosphatase 13


chr3_-_46608039 3.623 NM_024512
LRRC2
leucine rich repeat containing 2
chr19_-_49658645 3.421 NM_002152
HRC
histidine rich calcium binding protein
chr7_+_22766765 3.222 NM_000600
IL6
interleukin 6 (interferon, beta 2)
chr16_+_30077146 3.071 ALDOA
aldolase A, fructose-bisphosphate
chr8_-_82395401 3.040 NM_001442
FABP4
fatty acid binding protein 4, adipocyte
chrX_-_33229428 2.972 NM_004006
DMD
dystrophin
chr3_-_39234071 2.868 NM_194293
NM_001198621
XIRP1

xin actin-binding repeat containing 1

chr16_+_30077120 2.857 ALDOA
aldolase A, fructose-bisphosphate
chr18_+_32290195 2.843 NM_001198941
NM_032978
DTNA

dystrobrevin, alpha

chr3_-_9920633 2.797 NM_022094
CIDEC
cell death-inducing DFFA-like effector c
chr10_-_21462987 2.691 NEBL
nebulette
chr1_+_160160284 2.678 NM_001231
CASQ1
calsequestrin 1 (fast-twitch, skeletal muscle)
chr3_-_9920471 2.667 NM_001199623
CIDEC
cell death-inducing DFFA-like effector c
chr1_-_119532178 2.611 NM_152380
TBX15
T-box 15
chr3_+_121312169 2.593 NM_016298
FBXO40
F-box protein 40
chr19_+_54415990 2.545 NM_031896
CACNG7
calcium channel, voltage-dependent, gamma subunit 7
chr16_+_30386097 2.497 NM_013292
MYLPF
myosin light chain, phosphorylatable, fast skeletal muscle
chr12_+_110719143 2.479 ATP2A2
ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
chr12_-_56101465 2.438 ITGA7
integrin, alpha 7
chr16_+_30076993 2.420 NM_001243177
NM_184041
ALDOA

aldolase A, fructose-bisphosphate

chr19_+_50706868 2.419 NM_001077186
NM_001145809
NM_024729
MYH14


myosin, heavy chain 14, non-muscle


chr2_-_142889269 2.419 NM_018557
LRP1B
low density lipoprotein receptor-related protein 1B
chr22_+_21369441 2.318 NM_001159554
NM_005446
P2RX6

purinergic receptor P2X, ligand-gated ion channel, 6

chr12_+_21679190 2.315 NM_030572
C12orf39
chromosome 12 open reading frame 39
chrX_+_99899162 2.305 NM_014467
SRPX2
sushi-repeat containing protein, X-linked 2
chr12_-_70083055 2.245 NM_152439
BEST3
bestrophin 3
chr12_-_56101667 2.226 NM_001144996
NM_002206
ITGA7

integrin, alpha 7

chr15_-_90294359 2.206 NM_018670
MESP1
mesoderm posterior 1 homolog (mouse)
chr10_-_93392799 2.197 PPP1R3C
protein phosphatase 1, regulatory subunit 3C
chrX_+_135278912 2.157 NM_001159701
NM_001159699
FHL1

four and a half LIM domains 1

chr6_-_139613114 2.144 NM_153235
TXLNB
taxilin beta
chr5_+_148520985 2.142 NM_014945
ABLIM3
actin binding LIM protein family, member 3
chr16_+_56642477 2.117 NM_005953
MT2A
metallothionein 2A
chr18_+_55888750 2.102 NM_001144966
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chrX_+_99899388 2.081 SRPX2
sushi-repeat containing protein, X-linked 2
chr7_+_116312412 2.073 NM_000245
NM_001127500
MET

met proto-oncogene (hepatocyte growth factor receptor)

chr3_-_192126837 2.066 NM_021032
FGF12
fibroblast growth factor 12
chr3_+_133494275 2.056 TF
transferrin
chr12_+_56075418 2.048 METTL7B
methyltransferase like 7B
chr6_-_46293215 2.045 RCAN2
regulator of calcineurin 2
chr10_+_115312777 1.999 NM_004132
HABP2
hyaluronan binding protein 2
chr10_-_93392744 1.975 PPP1R3C
protein phosphatase 1, regulatory subunit 3C
chr10_-_93392857 1.971 NM_005398
PPP1R3C
protein phosphatase 1, regulatory subunit 3C
chr3_+_119316694 1.948 NM_001206960
NM_001206961
NM_015900
PLA1A


phospholipase A1 member A


chr9_+_686640 1.939


chr18_+_32173281 1.928 NM_001128175
NM_001198938
NM_001198939
NM_001198940
DTNA



dystrobrevin, alpha



chr16_+_82068830 1.900 NM_002153
HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr11_-_64527369 1.895 PYGM
phosphorylase, glycogen, muscle
chr10_-_21463019 1.840 NM_001173484
NM_213569
NEBL

nebulette

chr5_+_53751430 1.823 NM_006308
HSPB3
heat shock 27kDa protein 3
chr5_+_145317297 1.798 SH3RF2
SH3 domain containing ring finger 2
chr6_-_84140651 1.794 ME1
malic enzyme 1, NADP(+)-dependent, cytosolic
chrX_-_15402469 1.761 NM_004469
FIGF
c-fos induced growth factor (vascular endothelial growth factor D)
chr12_+_10365415 1.748 NM_031412
GABARAPL1
GABA(A) receptor-associated protein like 1
chr12_+_110719029 1.744 NM_001681
NM_170665
ATP2A2

ATPase, Ca++ transporting, cardiac muscle, slow twitch 2

chr6_-_46293404 1.734 RCAN2
regulator of calcineurin 2
chr19_+_3366575 1.727 NFIC
nuclear factor I/C (CCAAT-binding transcription factor)
chr8_-_12973752 1.711 NM_001164271
DLC1
deleted in liver cancer 1
chr6_-_84140758 1.707 ME1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr19_+_3366589 1.706 NFIC
nuclear factor I/C (CCAAT-binding transcription factor)
chr6_+_64231626 1.662 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr6_-_84140744 1.656 ME1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr19_-_46285645 1.639 DMPK
dystrophia myotonica-protein kinase
chr10_+_88428263 1.639 NM_001080116
NM_001080114
NM_001080115
NM_001171611
NM_007078
LDB3




LIM domain binding 3




chr4_+_110834039 1.638 NM_001178130
NM_001178131
NM_001963
EGF


epidermal growth factor


chr18_+_55888838 1.628 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr12_+_101988746 1.624 NM_002465
NM_206819
NM_206820
NM_206821
MYBPC1



myosin binding protein C, slow type



chr19_-_49243836 1.619 NM_017805
RASIP1
Ras interacting protein 1
chr11_-_65667809 1.605 FOSL1
FOS-like antigen 1
chr4_-_8129378 1.602 ABLIM2
actin binding LIM protein family, member 2
chr18_+_43306917 1.595 NM_001146037
SLC14A1
solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
chr11_-_65667860 1.592 NM_005438
FOSL1
FOS-like antigen 1
chr17_+_7123246 1.587 ACADVL
acyl-CoA dehydrogenase, very long chain
chr12_-_106533810 1.579 NM_014840
NUAK1
NUAK family, SNF1-like kinase, 1
chr10_+_121410751 1.572 NM_004281
BAG3
BCL2-associated athanogene 3
chr15_-_35087748 1.569 NM_005159
ACTC1
actin, alpha, cardiac muscle 1
chr6_+_74405505 1.560 NM_001159587
NM_001159588
NM_133493
CD109


CD109 molecule


chr13_+_53602829 1.555 NM_006418
OLFM4
olfactomedin 4
chr10_+_121411086 1.550 BAG3
BCL2-associated athanogene 3
chr5_-_151150939 1.531 LOC100652758
uncharacterized LOC100652758
chr15_-_40630272 1.519 C15orf52
chromosome 15 open reading frame 52
chr18_+_55888799 1.508 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr10_+_121410891 1.484 BAG3
BCL2-associated athanogene 3
chr19_+_13135809 1.477 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr7_+_28448970 1.468 LOC401317
uncharacterized LOC401317
chr8_-_26724728 1.450


chr19_+_3366536 1.445 NM_001245002
NM_001245004
NM_005597
NFIC


nuclear factor I/C (CCAAT-binding transcription factor)


chr16_+_58534045 1.443 NM_001242833
NM_001242834
NM_001242835
NM_001242836
NDRG4



NDRG family member 4



chr17_+_21191347 1.438 NM_002756
MAP2K3
mitogen-activated protein kinase kinase 3
chr20_+_6748744 1.426 NM_001200
BMP2
bone morphogenetic protein 2
chr3_+_69915374 1.425 NM_198177
MITF
microphthalmia-associated transcription factor
chr10_+_123872440 1.421 TACC2
transforming, acidic coiled-coil containing protein 2
chr6_-_84140854 1.411 NM_002395
ME1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr8_-_26722915 1.402 NM_000680
NM_033302
NM_033303
NM_033304
ADRA1A



adrenergic, alpha-1A-, receptor



chr10_+_121410936 1.399 BAG3
BCL2-associated athanogene 3
chr10_-_88730928 1.388 LOC100133190
uncharacterized LOC100133190
chrX_-_53310748 1.384 NM_001243197
NM_015075
IQSEC2

IQ motif and Sec7 domain 2

chr12_+_56075329 1.377 NM_152637
METTL7B
methyltransferase like 7B
chr2_+_18059923 1.369 NM_002252
KCNS3
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3
chr1_-_162838550 1.368 NM_178550
C1orf110
chromosome 1 open reading frame 110
chr6_+_44195008 1.361 SLC29A1
solute carrier family 29 (nucleoside transporters), member 1
chr14_+_58711599 1.360 PSMA3
proteasome (prosome, macropain) subunit, alpha type, 3
chr16_+_82068958 1.358 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr17_+_7123149 1.343 NM_000018
NM_001033859
ACADVL

acyl-CoA dehydrogenase, very long chain

chr7_+_1577118 1.329 MAFK
v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)
chr6_-_35696359 1.321 NM_001145775
FKBP5
FK506 binding protein 5
chr21_-_35986744 1.309 NM_203417
RCAN1
regulator of calcineurin 1
chr19_+_13135745 1.301 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr6_+_74405764 1.287 CD109
CD109 molecule
chr17_+_18625335 1.285 NM_001037330
TRIM16L
tripartite motif containing 16-like
chr14_+_79745653 1.275 NM_001105250
NM_138970
NRXN3

neurexin 3

chr17_+_9745847 1.274 GLP2R
glucagon-like peptide 2 receptor
chr16_-_69760444 1.261 NM_000903
NM_001025433
NM_001025434
NQO1


NAD(P)H dehydrogenase, quinone 1


chr11_-_65667858 1.252 FOSL1
FOS-like antigen 1
chr6_-_138428477 1.233 NM_022121
PERP
PERP, TP53 apoptosis effector
chr7_-_75988315 1.214 NM_012479
YWHAG
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide
chr16_+_67001377 1.210 NM_001185176
CES3
carboxylesterase 3
chr11_-_47447779 1.204 PSMC3
proteasome (prosome, macropain) 26S subunit, ATPase, 3
chr16_+_74330660 1.202 NM_002811
PSMD7
proteasome (prosome, macropain) 26S subunit, non-ATPase, 7
chr10_+_121411071 1.199 BAG3
BCL2-associated athanogene 3
chr16_+_74330730 1.198 PSMD7
proteasome (prosome, macropain) 26S subunit, non-ATPase, 7
chr16_+_2083264 1.196 NM_001252073
NM_001252075
NM_001252076
SLC9A3R2


solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2


chrX_-_15511710 1.184 NM_001018109
NM_003662
PIR

pirin (iron-binding nuclear protein)

chr19_+_13135368 1.181 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr3_-_149095413 1.180 TM4SF1
transmembrane 4 L six family member 1
chr1_+_32043745 1.177 NM_001204415
TINAGL1
tubulointerstitial nephritis antigen-like 1
chr6_+_74405909 1.169 CD109
CD109 molecule
chr4_+_41258941 1.167 UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr19_-_2038937 1.166 MKNK2
MAP kinase interacting serine/threonine kinase 2
chr18_-_24442534 1.166 NM_004028
AQP4
aquaporin 4
chr2_+_152214105 1.164 NM_007115
TNFAIP6
tumor necrosis factor, alpha-induced protein 6
chr17_+_30771494 1.161 NM_002815
PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr10_+_121411042 1.160 BAG3
BCL2-associated athanogene 3
chr7_+_1570321 1.159 NM_002360
MAFK
v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)
chr3_-_149095458 1.154 TM4SF1
transmembrane 4 L six family member 1
chr19_+_38865184 1.153 NM_002812
PSMD8
proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
chr1_-_6662681 1.151 KLHL21
kelch-like 21 (Drosophila)
chr20_+_48807119 1.142 NM_005194
CEBPB
CCAAT/enhancer binding protein (C/EBP), beta
chr17_-_10741398 1.129 NM_001101387
PIRT
phosphoinositide-interacting regulator of transient receptor potential channels
chr1_+_154377847 1.112 IL6R
interleukin 6 receptor
chr10_-_99531712 1.107 NM_003015
SFRP5
secreted frizzled-related protein 5
chr5_+_179247911 1.105 SQSTM1
sequestosome 1
chr16_+_82068910 1.104 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr16_+_87425874 1.101 MAP1LC3B
microtubule-associated protein 1 light chain 3 beta
chr14_-_89878733 1.100 FOXN3
forkhead box N3
chr9_-_114246225 1.097 KIAA0368
KIAA0368
chr8_-_26724748 1.093 ADRA1A
adrenergic, alpha-1A-, receptor
chr19_-_4559713 1.092 NM_032108
SEMA6B
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
chr18_+_21452981 1.086 NM_000227
NM_001127718
LAMA3

laminin, alpha 3

chr9_-_139922595 1.084 ABCA2
ATP-binding cassette, sub-family A (ABC1), member 2
chr5_+_179247903 1.084 SQSTM1
sequestosome 1
chr11_-_10590078 1.081 NM_006691
LYVE1
lymphatic vessel endothelial hyaluronan receptor 1
chrX_-_15511358 1.078 PIR
pirin (iron-binding nuclear protein)
chr1_+_150480486 1.076 NM_001202858
NM_004425
NM_022664
ECM1


extracellular matrix protein 1


chr17_+_30771522 1.076 PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr17_-_39768939 1.074 NM_005557
KRT16
keratin 16
chr5_+_179247841 1.067 NM_003900
SQSTM1
sequestosome 1
chr11_-_47447915 1.065 NM_002804
PSMC3
proteasome (prosome, macropain) 26S subunit, ATPase, 3
chr16_+_15596122 1.064 NM_001142469
C16orf45
chromosome 16 open reading frame 45
chr2_-_220173693 1.060 NM_001199764
PTPRN
protein tyrosine phosphatase, receptor type, N
chr11_-_47447457 1.059 PSMC3
proteasome (prosome, macropain) 26S subunit, ATPase, 3
chr3_+_184038445 1.048 EIF4G1
eukaryotic translation initiation factor 4 gamma, 1
chr5_-_134914968 1.044 NM_004887
CXCL14
chemokine (C-X-C motif) ligand 14
chr6_-_46293628 1.040 NM_005822
RCAN2
regulator of calcineurin 2
chr12_-_117747214 1.030 NM_001204214
NOS1
nitric oxide synthase 1 (neuronal)
chr17_-_56606534 1.025 SEPT4
septin 4
chr12_-_71182699 1.023 NM_001207015
PTPRR
protein tyrosine phosphatase, receptor type, R
chr1_+_15944059 1.021


chr20_+_48807365 1.018 CEBPB
CCAAT/enhancer binding protein (C/EBP), beta
chr3_-_149095333 1.018 TM4SF1
transmembrane 4 L six family member 1
chr6_+_74405856 1.016 CD109
CD109 molecule
chr1_+_150480584 1.016 ECM1
extracellular matrix protein 1
chr19_-_49944613 1.010 NM_020309
SLC17A7
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7
chr1_-_935469 1.009 NM_001142467
NM_021170
HES4

hairy and enhancer of split 4 (Drosophila)

chr19_-_46285746 1.009 DMPK
dystrophia myotonica-protein kinase
chr10_+_24755459 1.005 KIAA1217
KIAA1217
chr3_+_184016985 1.001 NM_002808
PSMD2
proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
chr8_-_25315746 0.998 KCTD9
potassium channel tetramerisation domain containing 9
chr10_-_71892596 0.997 NM_001198696
NM_032797
AIFM2

apoptosis-inducing factor, mitochondrion-associated, 2

chr17_+_30771532 0.989 PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr7_-_134854225 0.979 NM_001243753
NM_001243755
C7orf49

chromosome 7 open reading frame 49

chr8_-_125384916 0.978 NM_194291
TMEM65
transmembrane protein 65
chr10_+_85899184 0.970 NM_014394
GHITM
growth hormone inducible transmembrane protein
chr9_-_86323117 0.970 NM_013438
NM_053067
UBQLN1

ubiquilin 1

chr1_-_207205996 0.966 NM_001083924
NM_023938
C1orf116

chromosome 1 open reading frame 116

chr1_-_36107032 0.966 PSMB2
proteasome (prosome, macropain) subunit, beta type, 2
chr19_-_46285752 0.963 NM_001081560
NM_001081562
NM_004409
DMPK


dystrophia myotonica-protein kinase


chr16_+_87425946 0.961 MAP1LC3B
microtubule-associated protein 1 light chain 3 beta
chr16_+_215972 0.952 NM_001003938
HBM
hemoglobin, mu
chr8_+_144295067 0.952 NM_178172
GPIHBP1
glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1
chr1_+_110546569 0.949 NM_001242675
NM_001242676
AHCYL1

adenosylhomocysteinase-like 1

chr9_-_86322593 0.941 UBQLN1
ubiquilin 1
chr9_+_103191795 0.938 NM_001198806
C9orf30
chromosome 9 open reading frame 30
chr3_+_184017038 0.937 PSMD2
proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
chr1_-_171621750 0.934 NM_000261
MYOC
myocilin, trabecular meshwork inducible glucocorticoid response
chr10_+_24755440 0.931 KIAA1217
KIAA1217

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
19.07 5.66e-05 GO:0006521 regulation of cellular amino acid metabolic process
15.80 2.14e-04 GO:0033238 regulation of cellular amine metabolic process
9.78 2.66e-04 GO:0010565 regulation of cellular ketone metabolic process
1.92 2.56e-03 GO:0032502 developmental process
14.21 2.96e-03 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
14.21 2.96e-03 GO:0072395 signal transduction involved in cell cycle checkpoint
14.21 2.96e-03 GO:0072401 signal transduction involved in DNA integrity checkpoint
14.21 2.96e-03 GO:0072404 signal transduction involved in G1/S transition checkpoint
14.21 2.96e-03 GO:0072413 signal transduction involved in mitotic cell cycle checkpoint
14.21 2.96e-03 GO:0072422 signal transduction involved in DNA damage checkpoint
14.21 2.96e-03 GO:0072431 signal transduction involved in mitotic cell cycle G1/S transition DNA damage checkpoint
14.21 2.96e-03 GO:0072474 signal transduction involved in mitotic cell cycle G1/S checkpoint
2.11 3.45e-03 GO:0048731 system development
1.97 3.48e-03 GO:0007275 multicellular organismal development
13.54 3.93e-03 GO:0071158 positive regulation of cell cycle arrest
12.93 5.15e-03 GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
12.74 5.61e-03 GO:0031571 mitotic cell cycle G1/S transition DNA damage checkpoint
1.48 5.92e-03 GO:0065007 biological regulation
9.63 6.21e-03 GO:0090068 positive regulation of cell cycle process
1.99 6.44e-03 GO:0048856 anatomical structure development
1.68 6.56e-03 GO:0032501 multicellular organismal process
9.54 6.61e-03 GO:0000077 DNA damage checkpoint
12.38 6.65e-03 GO:0051352 negative regulation of ligase activity
12.38 6.65e-03 GO:0051444 negative regulation of ubiquitin-protein ligase activity
12.21 7.22e-03 GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
8.95 1.01e-02 GO:0031570 DNA integrity checkpoint
4.50 1.13e-02 GO:0043086 negative regulation of catalytic activity
11.26 1.16e-02 GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
11.11 1.24e-02 GO:0000216 M/G1 transition of mitotic cell cycle
11.11 1.24e-02 GO:0031575 mitotic cell cycle G1/S transition checkpoint
11.11 1.24e-02 GO:0051443 positive regulation of ubiquitin-protein ligase activity
11.11 1.24e-02 GO:0071779 G1/S transition checkpoint
10.83 1.44e-02 GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
10.57 1.66e-02 GO:0051351 positive regulation of ligase activity
10.57 1.66e-02 GO:2000045 regulation of G1/S transition of mitotic cell cycle
10.08 2.18e-02 GO:0030330 DNA damage response, signal transduction by p53 class mediator
9.96 2.33e-02 GO:0031397 negative regulation of protein ubiquitination
9.63 2.82e-02 GO:0051438 regulation of ubiquitin-protein ligase activity
4.90 2.91e-02 GO:0006511 ubiquitin-dependent protein catabolic process
4.80 3.44e-02 GO:0019941 modification-dependent protein catabolic process
144.34 3.59e-02 GO:0002384 hepatic immune response
9.22 3.61e-02 GO:0051340 regulation of ligase activity
4.77 3.64e-02 GO:0043632 modification-dependent macromolecule catabolic process
2.06 4.02e-02 GO:0006950 response to stress
4.68 4.29e-02 GO:0051603 proteolysis involved in cellular protein catabolic process
18.63 4.48e-02 GO:0035051 cardiac cell differentiation

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
16.05 3.15e-05 GO:0000502 proteasome complex
9.40 2.71e-04 GO:0043292 contractile fiber
8.95 1.65e-03 GO:0044449 contractile fiber part
8.72 1.96e-03 GO:0030016 myofibril
48.12 3.26e-03 GO:0005838 proteasome regulatory particle
36.09 8.41e-03 GO:0022624 proteasome accessory complex
15.61 1.49e-02 GO:0016529 sarcoplasmic reticulum
15.20 1.66e-02 GO:0016528 sarcoplasm
96.23 1.76e-02 GO:0005896 interleukin-6 receptor complex
2.22 3.86e-02 GO:0005856 cytoskeleton

Nothing significant found in function category.