Motif ID: NFE2.p2

Z-value: 1.347


Transcription factors associated with NFE2.p2:

Gene SymbolEntrez IDGene Name
NFE2 4778 nuclear factor (erythroid-derived 2), 45kDa

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NFE2hg19_v1_chr12_-_54694647_54694667-0.192.9e-01Click!


Activity profile for motif NFE2.p2.

activity profile for motif NFE2.p2


Sorted Z-values histogram for motif NFE2.p2

Sorted Z-values for motif NFE2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFE2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_27505296 4.840 NM_032546
NM_187841
 TRIM54

tripartite motif containing 54

chr4_+_120056938 4.233 NM_016599
 MYOZ2
myozenin 2
chr5_+_150020201 4.078 NM_001109974
NM_007286
 SYNPO

synaptopodin

chr10_-_76868853 3.713 NM_001007271
NM_001007272
NM_001007273
 DUSP13


dual specificity phosphatase 13


chr3_-_46608039 3.623 NM_024512
 LRRC2
leucine rich repeat containing 2
chr19_-_49658645 3.421 NM_002152
 HRC
histidine rich calcium binding protein
chr7_+_22766765 3.222 NM_000600
 IL6
interleukin 6 (interferon, beta 2)
chr16_+_30077146 3.071 ALDOA
aldolase A, fructose-bisphosphate
chr8_-_82395401 3.040 NM_001442
 FABP4
fatty acid binding protein 4, adipocyte
chrX_-_33229428 2.972 NM_004006
 DMD
dystrophin
chr3_-_39234071 2.868 NM_194293
NM_001198621
 XIRP1

xin actin-binding repeat containing 1

chr16_+_30077120 2.857 ALDOA
aldolase A, fructose-bisphosphate
chr18_+_32290195 2.843 NM_001198941
NM_032978
 DTNA

dystrobrevin, alpha

chr3_-_9920633 2.797 NM_022094
 CIDEC
cell death-inducing DFFA-like effector c
chr10_-_21462987 2.691 NEBL
nebulette
chr1_+_160160284 2.678 NM_001231
 CASQ1
calsequestrin 1 (fast-twitch, skeletal muscle)
chr3_-_9920471 2.667 NM_001199623
 CIDEC
cell death-inducing DFFA-like effector c
chr1_-_119532178 2.611 NM_152380
 TBX15
T-box 15
chr3_+_121312169 2.593 NM_016298
 FBXO40
F-box protein 40
chr19_+_54415990 2.545 NM_031896
 CACNG7
calcium channel, voltage-dependent, gamma subunit 7

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 46 entries
Enrichment   P-value GO Accession GO Term
144.34 3.59e-02 GO:0002384 hepatic immune response
19.07 5.66e-05 GO:0006521 regulation of cellular amino acid metabolic process
18.63 4.48e-02 GO:0035051 cardiac cell differentiation
15.80 2.14e-04 GO:0033238 regulation of cellular amine metabolic process
14.21 2.96e-03 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
14.21 2.96e-03 GO:0072395 signal transduction involved in cell cycle checkpoint
14.21 2.96e-03 GO:0072401 signal transduction involved in DNA integrity checkpoint
14.21 2.96e-03 GO:0072404 signal transduction involved in G1/S transition checkpoint
14.21 2.96e-03 GO:0072413 signal transduction involved in mitotic cell cycle checkpoint
14.21 2.96e-03 GO:0072422 signal transduction involved in DNA damage checkpoint
14.21 2.96e-03 GO:0072431 signal transduction involved in mitotic cell cycle G1/S transition DNA damage checkpoint
14.21 2.96e-03 GO:0072474 signal transduction involved in mitotic cell cycle G1/S checkpoint
13.54 3.93e-03 GO:0071158 positive regulation of cell cycle arrest
12.93 5.15e-03 GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
12.74 5.61e-03 GO:0031571 mitotic cell cycle G1/S transition DNA damage checkpoint
12.38 6.65e-03 GO:0051352 negative regulation of ligase activity
12.38 6.65e-03 GO:0051444 negative regulation of ubiquitin-protein ligase activity
12.21 7.22e-03 GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
11.26 1.16e-02 GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
11.11 1.24e-02 GO:0000216 M/G1 transition of mitotic cell cycle

Gene overrepresentation in compartment category:

Showing 1 to 10 of 10 entries
Enrichment   P-value GO Accession GO Term
96.23 1.76e-02 GO:0005896 interleukin-6 receptor complex
48.12 3.26e-03 GO:0005838 proteasome regulatory particle
36.09 8.41e-03 GO:0022624 proteasome accessory complex
16.05 3.15e-05 GO:0000502 proteasome complex
15.61 1.49e-02 GO:0016529 sarcoplasmic reticulum
15.20 1.66e-02 GO:0016528 sarcoplasm
9.40 2.71e-04 GO:0043292 contractile fiber
8.95 1.65e-03 GO:0044449 contractile fiber part
8.72 1.96e-03 GO:0030016 myofibril
2.22 3.86e-02 GO:0005856 cytoskeleton

Nothing significant found in function category.