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• Activity deltas table
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Motif ID: NFE2L2.p2

Z-value: 1.948

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr22_+_23010757	10.609
chr22_+_23154240	8.844
chr20_+_44637539	6.000	NM_004994	MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
chr22_+_22676814	5.493
chr5_+_35856990	5.340	NM_002185	IL7R	interleukin 7 receptor
chr22_+_23063107	5.340		IGLJ3	immunoglobulin lambda joining 3
chr22_+_22712091	5.258		IGLV1-44 IGL@	immunoglobulin lambda variable 1-44 immunoglobulin lambda locus
chr22_+_22735202	5.077
chr6_-_24877453	5.050	NM_015864	FAM65B	family with sequence similarity 65, member B
chr10_+_115312777	5.041	NM_004132	HABP2	hyaluronan binding protein 2
chr22_+_22723972	5.037
chr9_-_116840551	5.033		AMBP	alpha-1-microglobulin/bikunin precursor
chr22_+_23029175	5.029		IGLV3-25	immunoglobulin lambda variable 3-25
chr22_+_22764094	4.938
chr22_+_23040394	4.929		IGL@	immunoglobulin lambda locus
chr22_+_22569155	4.745
chr22_+_22786283	4.691
chr19_-_6670598	4.403	NM_003807 NM_172014	TNFSF14	tumor necrosis factor (ligand) superfamily, member 14
chr12_-_10151689	4.380	NM_001099431 NM_016509	CLEC1B	C-type lectin domain family 1, member B
chr5_-_95158465	4.341	NM_001118890 NM_001243658 NM_001243659 NM_002064	GLRX	glutaredoxin (thioltransferase)
chr22_+_22735207	4.312		IGLJ3	immunoglobulin lambda joining 3
chr4_-_39033981	4.311	NM_024943	TMEM156	transmembrane protein 156
chr5_-_95158365	4.253		GLRX	glutaredoxin (thioltransferase)
chr22_+_22735134	4.201		CYAT1	immunoglobulin lambda light chain-like
chr16_+_56642477	4.191	NM_005953	MT2A	metallothionein 2A
chr14_-_106967528	4.134		IGHA1 IGHA2 IGHG1 IGHM	immunoglobulin heavy constant alpha 1 immunoglobulin heavy constant alpha 2 (A2m marker) immunoglobulin heavy constant gamma 1 (G1m marker) immunoglobulin heavy constant mu
chr7_+_139528951	4.106	NM_001061 NM_001166253 NM_030984	TBXAS1	thromboxane A synthase 1 (platelet)
chr9_-_116840673	4.100	NM_001633	AMBP	alpha-1-microglobulin/bikunin precursor
chr22_+_23165273	3.953
chr19_-_7764283	3.951	NM_001207019	FCER2	Fc fragment of IgE, low affinity II, receptor for (CD23)
chr20_+_24929862	3.902	NM_003650	CST7	cystatin F (leukocystatin)
chrX_-_100641143	3.777	NM_000061	BTK	Bruton agammaglobulinemia tyrosine kinase
chr14_-_106641585	3.751		IGHV4-31 IGHA1 IGHA2 IGHG1	immunoglobulin heavy variable 4-31 immunoglobulin heavy constant alpha 1 immunoglobulin heavy constant alpha 2 (A2m marker) immunoglobulin heavy constant gamma 1 (G1m marker)
chr20_+_24929904	3.649		CST7	cystatin F (leukocystatin)
chr14_-_25078818	3.647	NM_033423	GZMH	granzyme H (cathepsin G-like 2, protein h-CCPX)
chr18_+_21693316	3.619		TTC39C	tetratricopeptide repeat domain 39C
chr5_-_176936857	3.608	NM_024872	DOK3	docking protein 3
chr9_-_116840460	3.581		AMBP	alpha-1-microglobulin/bikunin precursor
chr12_+_56075329	3.543	NM_152637	METTL7B	methyltransferase like 7B
chr14_-_94856926	3.538	NM_001002235 NM_001002236 NM_001127700 NM_001127701 NM_001127702 NM_001127703 NM_001127704 NM_001127705 NM_001127706 NM_001127707	SERPINA1	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr19_+_51645556	3.412	NM_014385 NM_016543	SIGLEC7	sialic acid binding Ig-like lectin 7
chr19_+_51628136	3.396	NM_001198558 NM_014441	SIGLEC9	sialic acid binding Ig-like lectin 9
chr16_+_31366529	3.392		ITGAX	integrin, alpha X (complement component 3 receptor 4 subunit)
chr14_-_106539099	3.372		IGHA1 IGHG1 IGHG3	immunoglobulin heavy constant alpha 1 immunoglobulin heavy constant gamma 1 (G1m marker) immunoglobulin heavy constant gamma 3 (G3m marker)
chr19_-_6670078	3.345		TNFSF14	tumor necrosis factor (ligand) superfamily, member 14
chr9_-_116840545	3.344		AMBP	alpha-1-microglobulin/bikunin precursor
chr7_-_115670828	3.342	NM_001018058 NM_012252	TFEC	transcription factor EC
chr17_+_14204326	3.328	NM_006041	HS3ST3B1	heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1
chr9_-_116840604	3.323		AMBP	alpha-1-microglobulin/bikunin precursor
chr1_+_17634689	3.308	NM_012387	PADI4	peptidyl arginine deiminase, type IV
chr14_-_106733392	3.264		IGHG1 IGHG3	immunoglobulin heavy constant gamma 1 (G1m marker) immunoglobulin heavy constant gamma 3 (G3m marker)
chr3_-_58200397	3.255	NM_004944	DNASE1L3	deoxyribonuclease I-like 3
chr12_+_56075418	3.190		METTL7B	methyltransferase like 7B
chr14_-_106791054	3.106		IGHV4-31 IGHV3-30 IGHA1 IGHD IGHG1 IGHG2 IGHG3 IGHM SCFV	immunoglobulin heavy variable 4-31 immunoglobulin heavy variable 3-30 immunoglobulin heavy constant alpha 1 immunoglobulin heavy constant delta immunoglobulin heavy constant gamma 1 (G1m marker) immunoglobulin heavy constant gamma 2 (G2m marker) immunoglobulin heavy constant gamma 3 (G3m marker) immunoglobulin heavy constant mu single-chain Fv fragment
chr7_-_115670774	3.099		TFEC	transcription factor EC
chr1_+_154377847	3.032		IL6R	interleukin 6 receptor
chr5_-_39270708	2.991	NM_001243093	FYB	FYN binding protein
chr11_+_10476665	2.991	NM_001025389	AMPD3	adenosine monophosphate deaminase 3
chr3_+_121312169	2.934	NM_016298	FBXO40	F-box protein 40
chr6_+_160542862	2.903	NM_003057 NM_153187	SLC22A1	solute carrier family 22 (organic cation transporter), member 1
chr4_-_987163	2.880	NM_022042 NM_134425 NM_213613	SLC26A1	solute carrier family 26 (sulfate transporter), member 1
chr3_-_150920946	2.872	NM_013308	GPR171	G protein-coupled receptor 171
chr14_-_106967080	2.824		IGHG1	immunoglobulin heavy constant gamma 1 (G1m marker)
chr17_-_38721701	2.811	NM_001838	CCR7	chemokine (C-C motif) receptor 7
chrX_-_19688991	2.780	NM_001184960	SH3KBP1	SH3-domain kinase binding protein 1
chr14_-_107122358	2.707
chr3_-_186262114	2.670	NM_017541	CRYGS	crystallin, gamma S
chr1_+_154377668	2.655	NM_000565 NM_001206866 NM_181359	IL6R	interleukin 6 receptor
chr2_-_99871569	2.630	NM_175735	LYG2	lysozyme G-like 2
chr12_-_10282680	2.625	NM_022570 NM_197947 NM_197948 NM_197949 NM_197950 NM_197954	CLEC7A	C-type lectin domain family 7, member A
chr7_+_150434679	2.605		GIMAP5	GTPase, IMAP family member 5
chr17_+_43299277	2.605	NM_005892	FMNL1	formin-like 1
chr16_+_31366519	2.602		ITGAX	integrin, alpha X (complement component 3 receptor 4 subunit)
chr22_+_23229959	2.578	NM_001178126	IGLL5 IGLC1	immunoglobulin lambda-like polypeptide 5 immunoglobulin lambda constant 1 (Mcg marker)
chr22_+_22758538	2.557
chr11_-_65150107	2.553	NM_001077241 NM_182556	SLC25A45	solute carrier family 25, member 45
chr16_+_56685810	2.529	NM_005947	MT1B	metallothionein 1B
chr7_-_115670811	2.504		TFEC	transcription factor EC
chr14_-_107170400	2.495		IGHV4-31 IGHV1-69 IGHA1 IGHG1 IGHG3 IGHM	immunoglobulin heavy variable 4-31 immunoglobulin heavy variable 1-69 immunoglobulin heavy constant alpha 1 immunoglobulin heavy constant gamma 1 (G1m marker) immunoglobulin heavy constant gamma 3 (G3m marker) immunoglobulin heavy constant mu
chr14_-_107211131	2.491		IGHG1	immunoglobulin heavy constant gamma 1 (G1m marker)
chr19_-_54804172	2.491	NM_001172654 NM_006865	LILRA3 LILRA6	leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
chr16_-_28620648	2.475	NM_177530 NM_177534	SULT1A1	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
chr11_+_10477480	2.467	NM_001025390	AMPD3	adenosine monophosphate deaminase 3
chr10_+_134901408	2.453	NM_001083909	GPR123	G protein-coupled receptor 123
chr16_+_27438578	2.447	NM_021798	IL21R	interleukin 21 receptor
chr5_-_90610218	2.440		LOC100505994	uncharacterized LOC100505994
chr16_+_31366468	2.424	NM_000887	ITGAX	integrin, alpha X (complement component 3 receptor 4 subunit)
chrX_+_153770458	2.420	NM_001099856	IKBKG	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
chr17_+_30771532	2.400		PSMD11	proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr18_+_61637262	2.396	NM_001031848 NM_002640 NM_198833	SERPINB8	serpin peptidase inhibitor, clade B (ovalbumin), member 8
chr11_+_118958696	2.383	NM_001024382	HMBS	hydroxymethylbilane synthase
chr11_+_2924504	2.343		SLC22A18	solute carrier family 22, member 18
chr1_-_203155813	2.337		CHI3L1	chitinase 3-like 1 (cartilage glycoprotein-39)
chr9_-_86323117	2.309	NM_013438 NM_053067	UBQLN1	ubiquilin 1
chr9_+_139921915	2.271	NM_207511	C9orf139	chromosome 9 open reading frame 139
chr14_-_24777064	2.244
chr3_-_120401401	2.230	NM_000187	HGD	homogentisate 1,2-dioxygenase
chr14_-_106714594	2.222
chr1_-_45987548	2.216	NM_002574 NM_181696 NM_181697	PRDX1	peroxiredoxin 1
chr7_+_150434435	2.212	NM_018384	GIMAP5	GTPase, IMAP family member 5
chr3_+_184038445	2.204		EIF4G1	eukaryotic translation initiation factor 4 gamma, 1
chrX_+_30671602	2.204		GK	glycerol kinase
chr17_+_30771494	2.204	NM_002815	PSMD11	proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr20_+_62368035	2.196		LIME1	Lck interacting transmembrane adaptor 1
chr9_+_95736717	2.196	NM_033086	FGD3	FYVE, RhoGEF and PH domain containing 3
chr1_-_115238091	2.186	NM_000036 NM_001172626	AMPD1	adenosine monophosphate deaminase 1
chr1_+_223889253	2.153	NM_001146068	CAPN2	calpain 2, (m/II) large subunit
chr1_+_154378044	2.128		IL6R	interleukin 6 receptor
chr17_+_30771522	2.127		PSMD11	proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr9_-_86322593	2.125		UBQLN1	ubiquilin 1
chr7_-_150930300	2.095
chr5_+_176875325	2.056	NM_001174102	PRR7	proline rich 7 (synaptic)
chr22_+_23134980	2.017
chr1_-_35920081	1.926		KIAA0319L	KIAA0319-like
chr3_-_120400957	1.918		HGD	homogentisate 1,2-dioxygenase
chr3_+_45984972	1.912	NM_006564	CXCR6	chemokine (C-X-C motif) receptor 6
chr17_-_33390676	1.889	NM_001017368	RFFL	ring finger and FYVE-like domain containing 1
chr6_+_106546736	1.881	NM_182907	PRDM1	PR domain containing 1, with ZNF domain
chr9_-_86322861	1.875		UBQLN1	ubiquilin 1
chr19_+_1040079	1.874	NM_019112	ABCA7	ATP-binding cassette, sub-family A (ABC1), member 7
chr9_-_86322870	1.837		UBQLN1	ubiquilin 1
chr17_+_30771485	1.819		PSMD11	proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr1_-_160549226	1.788		CD84	CD84 molecule
chr3_+_184038050	1.785	NM_004953	EIF4G1	eukaryotic translation initiation factor 4 gamma, 1
chr6_+_64281910	1.784	NM_003463	PTP4A1	protein tyrosine phosphatase type IVA, member 1
chr8_-_26724728	1.780
chr17_-_73150769	1.769	NM_001002032 NM_001002033 NM_016185	HN1	hematological and neurological expressed 1
chr6_-_35696359	1.765	NM_001145775	FKBP5	FK506 binding protein 5
chr8_-_26724748	1.761		ADRA1A	adrenergic, alpha-1A-, receptor
chr9_-_97402530	1.755	NM_001127628	FBP1	fructose-1,6-bisphosphatase 1
chr13_-_99959649	1.753	NM_004951	GPR183	G protein-coupled receptor 183
chr20_+_48807365	1.746		CEBPB	CCAAT/enhancer binding protein (C/EBP), beta
chr17_+_28707495	1.742	NM_001199775	CPD	carboxypeptidase D
chr20_-_633844	1.732	NM_080725	SRXN1	sulfiredoxin 1
chr12_-_102591547	1.724	NM_002674	PMCH	pro-melanin-concentrating hormone
chr7_-_134854225	1.718	NM_001243753 NM_001243755	C7orf49	chromosome 7 open reading frame 49
chr19_-_2038937	1.708		MKNK2	MAP kinase interacting serine/threonine kinase 2
chr14_-_24777153	1.702		CIDEB	cell death-inducing DFFA-like effector b
chr9_-_86322844	1.698		UBQLN1	ubiquilin 1
chr6_-_154677868	1.690	NM_001130700 NM_015553	IPCEF1	interaction protein for cytohesin exchange factors 1
chr14_-_107170076	1.688		IGHV1-69 IGHG1	immunoglobulin heavy variable 1-69 immunoglobulin heavy constant gamma 1 (G1m marker)
chr9_-_123688352	1.688		TRAF1	TNF receptor-associated factor 1
chr11_-_3862183	1.661	NM_001665	RHOG	ras homolog gene family, member G (rho G)
chr22_+_23222897	1.660		CYAT1	immunoglobulin lambda light chain-like
chr8_-_125740378	1.659		MTSS1	metastasis suppressor 1
chr19_-_54746599	1.652	NM_024318	LILRB3 LILRA6	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
chr14_-_106926393	1.651		IGHA1 IGHG1	immunoglobulin heavy constant alpha 1 immunoglobulin heavy constant gamma 1 (G1m marker)
chr9_-_86322854	1.642		UBQLN1	ubiquilin 1
chr11_-_14541867	1.615		PSMA1	proteasome (prosome, macropain) subunit, alpha type, 1
chr1_+_154966061	1.599	NM_018655	LENEP	lens epithelial protein
chr5_+_179247841	1.580	NM_003900	SQSTM1	sequestosome 1
chr11_-_14541886	1.564	NM_001143937 NM_002786	PSMA1	proteasome (prosome, macropain) subunit, alpha type, 1
chr1_+_172628157	1.551	NM_000639	FASLG	Fas ligand (TNF superfamily, member 6)
chr17_+_75372164	1.537	NM_001113494	SEPT9	septin 9
chr6_+_84569364	1.529	NM_016230	CYB5R4	cytochrome b5 reductase 4
chr12_-_70083055	1.519	NM_152439	BEST3	bestrophin 3
chr5_-_176936834	1.509		DOK3	docking protein 3
chr12_-_15114495	1.502	NM_001175	ARHGDIB	Rho GDP dissociation inhibitor (GDI) beta
chr19_+_18699494	1.501	NM_001100418 NM_001100419	C19orf60	chromosome 19 open reading frame 60
chr14_+_23352430	1.495	NM_173527	REM2	RAS (RAD and GEM)-like GTP binding 2
chr12_-_113841654	1.492	NM_006843	SDS	serine dehydratase
chr5_+_179247903	1.479		SQSTM1	sequestosome 1
chr2_+_113875469	1.472	NM_000577 NM_173841 NM_173843	IL1RN	interleukin 1 receptor antagonist
chrX_+_119738542	1.466	NM_001137554	MCTS1	malignant T cell amplified sequence 1
chr9_-_97402556	1.465		FBP1	fructose-1,6-bisphosphatase 1
chr10_-_6019880	1.453	NM_001243539	IL15RA	interleukin 15 receptor, alpha
chr17_+_47287588	1.451	NM_001135186 NM_016428	ABI3	ABI family, member 3
chr14_-_107199126	1.448		IGHG3	immunoglobulin heavy constant gamma 3 (G3m marker)
chr10_-_6019454	1.438	NM_002189 NM_172200	IL15RA	interleukin 15 receptor, alpha
chr5_+_132209354	1.437	NM_052971	LEAP2	liver expressed antimicrobial peptide 2
chr6_-_134496833	1.412		SGK1	serum/glucocorticoid regulated kinase 1
chr22_+_38035447	1.403
chr3_-_170587947	1.402	NM_001099645	RPL22L1	ribosomal protein L22-like 1
chr12_-_8765438	1.394	NM_020661	AICDA	activation-induced cytidine deaminase
chr15_+_89182038	1.391	NM_002201	ISG20	interferon stimulated exonuclease gene 20kDa
chr17_+_30771520	1.385		PSMD11	proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chrX_-_154493736	1.380	NM_171998	RAB39B	RAB39B, member RAS oncogene family
chr16_-_28621279	1.378	NM_001055 NM_177529	SULT1A1	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
chr14_-_23588819	1.378	NM_001805	CEBPE	CCAAT/enhancer binding protein (C/EBP), epsilon
chr15_+_81517639	1.375	NM_172217	IL16	interleukin 16
chr17_-_29641087	1.360		EVI2B	ecotropic viral integration site 2B
chr2_-_89292396	1.357		IGKC	immunoglobulin kappa constant
chr6_+_43266008	1.355		SLC22A7	solute carrier family 22 (organic anion transporter), member 7
chr20_+_48807460	1.345		CEBPB	CCAAT/enhancer binding protein (C/EBP), beta
chr20_+_48807119	1.345	NM_005194	CEBPB	CCAAT/enhancer binding protein (C/EBP), beta
chr5_+_179247911	1.340		SQSTM1	sequestosome 1
chr10_+_49892860	1.335		WDFY4	WDFY family member 4
chr2_+_231921625	1.311		PSMD1	proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
chr6_+_84569394	1.305		CYB5R4	cytochrome b5 reductase 4
chr16_-_28607694	1.302	NM_177528	SULT1A2	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
chr17_-_79881304	1.289	NM_032711	MAFG	v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian)
chr11_-_3862137	1.279		RHOG	ras homolog gene family, member G (rho G)
chr8_-_145025043	1.259	NM_201380	PLEC	plectin
chr22_-_27013959	1.256	NM_001887	CRYBB1	crystallin, beta B1
chr4_+_144106083	1.255		USP38	ubiquitin specific peptidase 38
chrX_+_12993224	1.238	NM_021109	TMSB4X	thymosin beta 4, X-linked
chr1_-_94374949	1.238		GCLM	glutamate-cysteine ligase, modifier subunit
chr20_+_62367945	1.236	NM_017806	LIME1	Lck interacting transmembrane adaptor 1
chr7_+_102290771	1.235	NM_001166339 NM_001031618	SPDYE2L SPDYE2	WBSCR19-like protein 3 speedy homolog E2 (Xenopus laevis)
chr6_-_134497069	1.231	NM_001143678	SGK1	serum/glucocorticoid regulated kinase 1

Gene overrepresentation in process category:

Enrichment	P-value	GO Accession	GO Term
3.36	4.06e-08	GO:0002376	immune system process
4.16	1.18e-07	GO:0006955	immune response
1.71	4.70e-07	GO:0050896	response to stimulus
2.19	9.70e-05	GO:0006950	response to stress
2.88	1.15e-02	GO:0006952	defense response
1.64	2.41e-02	GO:0051716	cellular response to stimulus
2.68	3.38e-02	GO:0042592	homeostatic process
3.34	4.10e-02	GO:0001775	cell activation

Gene overrepresentation in compartment category:

Enrichment	P-value	GO Accession	GO Term
8.03	4.99e-02	GO:0000502	proteasome complex

Gene overrepresentation in function category:

Enrichment	P-value	GO Accession	GO Term
30.34	4.74e-13	GO:0003823	antigen binding
5.33	3.61e-03	GO:0005529	sugar binding
6.56	1.80e-02	GO:0019955	cytokine binding
9.03	4.14e-02	GO:0004896	cytokine receptor activity