Motif ID: NFIL3.p2

Z-value: 1.704


Transcription factors associated with NFIL3.p2:

Gene SymbolEntrez IDGene Name
NFIL3 4783 nuclear factor, interleukin 3 regulated

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NFIL3hg19_v1_chr9_-_94185959_94186129-0.421.7e-02Click!


Activity profile for motif NFIL3.p2.

activity profile for motif NFIL3.p2


Sorted Z-values histogram for motif NFIL3.p2

Sorted Z-values for motif NFIL3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFIL3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_+_74269971 22.835 NM_000477
ALB
albumin
chr10_+_135340865 20.788 NM_000773
CYP2E1
cytochrome P450, family 2, subfamily E, polypeptide 1
chr10_-_95360959 19.989 NM_006744
RBP4
retinol binding protein 4, plasma
chr3_+_133494275 15.858 TF
transferrin
chr10_-_82049178 12.715 NM_000429
MAT1A
methionine adenosyltransferase I, alpha
chr3_+_186383770 11.244 NM_000412
HRG
histidine-rich glycoprotein
chr1_+_57320442 11.132 NM_000562
C8A
complement component 8, alpha polypeptide
chr4_+_155484131 10.480 NM_001184741
NM_005141
FGB

fibrinogen beta chain

chr1_+_196946666 8.882 NM_030787
CFHR5
complement factor H-related 5
chr9_-_104198045 8.699 NM_000035
ALDOB
aldolase B, fructose-bisphosphate
chr14_-_70263871 7.861 NM_003049
SLC10A1
solute carrier family 10 (sodium/bile acid cotransporter family), member 1
chr19_+_41497182 7.837 NM_000767
CYP2B6
cytochrome P450, family 2, subfamily B, polypeptide 6
chr8_-_17752847 7.823 NM_147203
NM_201553
NM_004467
NM_201552
FGL1



fibrinogen-like 1



chr19_+_41430123 7.127 CYP2B7P1
cytochrome P450, family 2, subfamily B, polypeptide 7 pseudogene 1
chr1_-_203155910 6.875 NM_001276
CHI3L1
chitinase 3-like 1 (cartilage glycoprotein-39)
chr1_-_203155813 6.553 CHI3L1
chitinase 3-like 1 (cartilage glycoprotein-39)
chr1_-_203155745 6.520 CHI3L1
chitinase 3-like 1 (cartilage glycoprotein-39)
chr1_-_203155827 6.410 CHI3L1
chitinase 3-like 1 (cartilage glycoprotein-39)
chr19_-_41388656 6.375 NM_000764
NM_030589
CYP2A7

cytochrome P450, family 2, subfamily A, polypeptide 7

chr6_+_131894343 6.250 NM_000045
NM_001244438
ARG1

arginase, liver

chr2_-_31637598 6.059 NM_000379
XDH
xanthine dehydrogenase
chr1_-_203155867 5.990 CHI3L1
chitinase 3-like 1 (cartilage glycoprotein-39)
chr3_+_119501556 5.930 NM_022002
NR1I2
nuclear receptor subfamily 1, group I, member 2
chr19_+_41497284 5.460 CYP2B6
cytochrome P450, family 2, subfamily B, polypeptide 6
chr4_+_187187342 5.140 F11
coagulation factor XI
chr2_-_31637553 5.111 XDH
xanthine dehydrogenase
chr11_-_116663106 5.077 NM_001166598
NM_052968
APOA5

apolipoprotein A-V

chr3_+_186330844 5.076 NM_001622
AHSG
alpha-2-HS-glycoprotein
chr8_-_110661007 4.782 NM_001099747
NM_001099748
NM_001099749
NM_001099750
NM_017786
SYBU




syntabulin (syntaxin-interacting)




chr7_-_31380507 4.766 NM_022728
NEUROD6
neurogenic differentiation 6
chr6_-_133035180 4.534 NM_004666
VNN1
vanin 1
chr5_-_140013285 4.441 NM_001040021
NM_001174104
NM_001174105
CD14


CD14 molecule


chr10_-_52645430 4.277 NM_001198818
NM_001198819
NM_001198820
NM_014576
NM_138932
NM_138933
A1CF





APOBEC1 complementation factor





chr1_+_207262211 4.251 NM_001017365
NM_001017366
C4BPB

complement component 4 binding protein, beta

chr19_+_41594367 4.155 NM_000766
CYP2A13
cytochrome P450, family 2, subfamily A, polypeptide 13
chr1_+_25757381 4.074 NM_018202
TMEM57
transmembrane protein 57
chr4_+_118955499 4.043 NM_004784
NDST3
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
chr14_+_24563369 3.938 NM_001018073
NM_004563
PCK2

phosphoenolpyruvate carboxykinase 2 (mitochondrial)

chr6_-_24489738 3.830 NM_177483
NM_001503
GPLD1

glycosylphosphatidylinositol specific phospholipase D1

chr12_-_75603510 3.676 NM_139136
NM_139137
NM_153748
KCNC2


potassium voltage-gated channel, Shaw-related subfamily, member 2


chr16_+_76311175 3.634 NM_033401
CNTNAP4
contactin associated protein-like 4
chr4_-_69536314 3.611 NM_001076
UGT2B15
UDP glucuronosyltransferase 2 family, polypeptide B15
chr5_-_140012730 3.538 CD14
CD14 molecule
chr6_-_136847609 3.486 MAP7
microtubule-associated protein 7
chr12_-_105322056 3.343 NM_032148
SLC41A2
solute carrier family 41, member 2
chr6_-_136847078 3.319 NM_001198608
NM_001198609
NM_001198611
MAP7


microtubule-associated protein 7


chr3_+_186330859 3.305 AHSG
alpha-2-HS-glycoprotein
chr8_-_27941387 3.042 NM_001010906
C8orf80
chromosome 8 open reading frame 80
chr11_+_69061599 2.804 NM_138768
MYEOV
myeloma overexpressed (in a subset of t(11;14) positive multiple myelomas)
chr16_+_72097124 2.736 NM_020995
HPR
haptoglobin-related protein
chr2_+_211421322 2.723 NM_001875
CPS1
carbamoyl-phosphate synthase 1, mitochondrial
chr13_+_97999289 2.694


chr2_-_21228189 2.668 APOB
apolipoprotein B (including Ag(x) antigen)
chr10_-_69597768 2.622 NM_021800
NM_201262
DNAJC12

DnaJ (Hsp40) homolog, subfamily C, member 12

chr5_-_14871555 2.619 NM_054027
ANKH
ankylosis, progressive homolog (mouse)
chr1_+_209878135 2.611 NM_005525
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr2_-_167005641 2.582 NM_001202435
SCN1A
sodium channel, voltage-gated, type I, alpha subunit
chr1_+_196621007 2.581 NM_000186
NM_001014975
CFH

complement factor H

chr10_+_96522457 2.487 NM_000769
CYP2C19
cytochrome P450, family 2, subfamily C, polypeptide 19
chr15_-_83621350 2.451 NM_004839
NM_199330
HOMER2

homer homolog 2 (Drosophila)

chr5_-_140013034 2.436 NM_000591
CD14
CD14 molecule
chr4_+_170581212 2.408 NM_001243374
CLCN3
chloride channel 3
chr19_-_17414083 2.345 NM_024527
ABHD8
abhydrolase domain containing 8
chr21_+_45138973 2.291 NM_003681
PDXK
pyridoxal (pyridoxine, vitamin B6) kinase
chr14_-_94849552 2.275 SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr11_-_119599253 2.255 NM_002855
NM_203285
NM_203286
PVRL1


poliovirus receptor-related 1 (herpesvirus entry mediator C)


chr9_+_71819926 2.209 NM_001170415
NM_001170416
TJP2

tight junction protein 2 (zona occludens 2)

chr12_-_10282680 2.206 NM_022570
NM_197947
NM_197948
NM_197949
NM_197950
NM_197954
CLEC7A





C-type lectin domain family 7, member A





chr6_+_150690027 2.201 NM_001164694
NM_001164695
NM_203395
IYD


iodotyrosine deiodinase


chrX_-_131547536 2.169 NM_001170701
NM_001170702
NM_001170703
MBNL3


muscleblind-like 3 (Drosophila)


chr13_-_25746304 2.102 FAM123A
family with sequence similarity 123A
chr8_+_120079423 2.038 NM_006438
COLEC10
collectin sub-family member 10 (C-type lectin)
chr2_-_88427535 2.037 NM_001443
FABP1
fatty acid binding protein 1, liver
chr11_+_112047088 1.960 NM_001037290
BCO2
beta-carotene oxygenase 2
chr5_+_36606667 1.914 SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr11_-_83984230 1.913 NM_001142700
DLG2
discs, large homolog 2 (Drosophila)
chr3_+_186330711 1.859 AHSG
alpha-2-HS-glycoprotein
chr13_+_97874540 1.858 NM_144778
NM_207304
MBNL2

muscleblind-like 2 (Drosophila)

chr9_-_19786886 1.857 NM_001193288
NM_020344
SLC24A2

solute carrier family 24 (sodium/potassium/calcium exchanger), member 2

chr2_-_178753464 1.853 NM_001077196
PDE11A
phosphodiesterase 11A
chr4_-_110354914 1.844 1/2-SBSRNA4
lncRNA_BC009800
chr2_-_105467912 1.843 LOC100506421
uncharacterized LOC100506421
chr3_+_151488214 1.835 LOC201651
arylacetamide deacetylase (esterase) pseudogene
chr16_+_7382750 1.830 NM_145891
NM_145892
NM_145893
RBFOX1


RNA binding protein, fox-1 homolog (C. elegans) 1


chr17_-_29648631 1.796 NM_001003927
NM_014210
EVI2A

ecotropic viral integration site 2A

chr15_-_56209305 1.794 NM_198400
NEDD4
neural precursor cell expressed, developmentally down-regulated 4
chr4_+_74702272 1.792 NM_002993
CXCL6
chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)
chr3_-_190580464 1.763 NM_001146686
GMNC
geminin coiled-coil domain containing
chr1_-_161207879 1.735 NM_001077469
NM_001077470
NM_001077471
NM_001077472
NM_001077473
NM_001077474
NM_001077475
NM_001077476
NM_001077477
NM_001077478
NM_001077479
NM_001077480
NM_001077481
NM_001077482
NM_005122
NR1I3














nuclear receptor subfamily 1, group I, member 3














chr4_-_176733901 1.705 GPM6A
glycoprotein M6A
chr7_-_111428944 1.669 DOCK4
dedicator of cytokinesis 4
chr2_+_201756639 1.669 NM_001142356
NIF3L1
NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae)
chr3_-_58200397 1.637 NM_004944
DNASE1L3
deoxyribonuclease I-like 3
chr5_-_87969135 1.627 LINC00461
long intergenic non-protein coding RNA 461
chr6_+_134758840 1.626 LOC154092
uncharacterized LOC154092
chr21_+_45138987 1.624 PDXK
pyridoxal (pyridoxine, vitamin B6) kinase
chr13_+_97928414 1.588 MBNL2
muscleblind-like 2 (Drosophila)
chr16_+_72088507 1.582 NM_001126102
NM_005143
HP

haptoglobin

chr5_+_36606456 1.579 NM_001166696
NM_004172
SLC1A3

solute carrier family 1 (glial high affinity glutamate transporter), member 3

chr18_-_48346297 1.564 NM_001127175
NM_001127176
NM_031939
MRO


maestro


chr12_-_7656285 1.538 NM_004244
NM_203416
CD163

CD163 molecule

chr11_+_123431036 1.534 GRAMD1B
GRAM domain containing 1B
chr8_+_99076749 1.532 NM_001170806
NM_173549
C8orf47

chromosome 8 open reading frame 47

chr3_+_101546833 1.474 NM_001005474
NFKBIZ
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
chr16_-_31439650 1.473 NM_005205
COX6A2
cytochrome c oxidase subunit VIa polypeptide 2
chr20_+_58296264 1.471 NM_183244
NM_183246
PHACTR3

phosphatase and actin regulator 3

chr13_-_101185944 1.467 NM_033110
A2LD1
AIG2-like domain 1
chr7_+_142982039 1.457 NM_001242773
NM_001242774
NM_001242775
NM_001242776
NM_001242777
NM_153345
TMEM139





transmembrane protein 139





chr10_+_5238756 1.449 NM_001818
AKR1C4
aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
chr2_+_102927961 1.435 NM_016232
IL18R1
IL1RL1
interleukin 18 receptor 1
interleukin 1 receptor-like 1
chr8_-_110620220 1.417 SYBU
syntabulin (syntaxin-interacting)
chr5_+_156696351 1.328 NM_014376
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr16_-_55866972 1.326 CES1
carboxylesterase 1
chr17_+_61678218 1.324 NM_016360
TACO1
translational activator of mitochondrially encoded cytochrome c oxidase I
chr17_-_38821286 1.310 NM_152349
KRT222
keratin 222
chr3_-_169487602 1.295 NM_032487
ARPM1
actin related protein M1
chr2_+_179184970 1.292 NM_145739
OSBPL6
oxysterol binding protein-like 6
chr8_+_24774587 1.278 NEFM
neurofilament, medium polypeptide
chrX_+_38663450 1.278 MID1IP1
MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish))
chr8_-_72274278 1.266 EYA1
eyes absent homolog 1 (Drosophila)
chr3_+_128532267 1.242


chr17_-_61850953 1.219 NM_020198
CCDC47
coiled-coil domain containing 47
chr3_-_194188967 1.211 NM_024524
ATP13A3
ATPase type 13A3
chr1_-_110155672 1.190 NM_005272
GNAT2
guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
chr5_-_43557520 1.180 NM_183323
PAIP1
poly(A) binding protein interacting protein 1
chrX_+_118108575 1.175 LONRF3
LON peptidase N-terminal domain and ring finger 3
chr4_-_70518964 1.145 NM_001252274
NM_001252275
NM_006798
UGT2A1


UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus


chr1_-_112106562 1.136 NM_001081976
ADORA3
adenosine A3 receptor
chr17_-_61850890 1.133 CCDC47
coiled-coil domain containing 47
chr15_-_90222572 1.129 NM_001145311
NM_002666
PLIN1

perilipin 1

chr18_-_24722757 1.125 NM_001243848
CHST9
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9
chr19_+_3762650 1.122 NM_172251
MRPL54
mitochondrial ribosomal protein L54
chr10_-_74283693 1.110 NM_001195519
MICU1
mitochondrial calcium uptake 1
chrX_+_38663072 1.103 NM_021242
MID1IP1
MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish))
chr4_-_70080448 1.089 NM_001073
UGT2B11
UGT2B10
UDP glucuronosyltransferase 2 family, polypeptide B11
UDP glucuronosyltransferase 2 family, polypeptide B10
chr1_-_54411245 1.076 NM_016126
HSPB11
heat shock protein family B (small), member 11
chr10_+_5005601 1.065 AKR1C1
AKR1C3
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr2_+_201473942 1.045 AOX1
aldehyde oxidase 1
chr22_-_50523853 1.023 MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr8_+_67405490 1.021 NM_152765
C8orf46
chromosome 8 open reading frame 46
chr1_+_232940637 1.019 NM_019090
KIAA1383
KIAA1383
chr19_+_3762671 1.019 MRPL54
mitochondrial ribosomal protein L54
chr2_-_203103214 1.011 NM_001005781
NM_001005782
NM_003352
SUMO1


SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)


chr3_-_148939784 1.005 NM_000096
CP
ceruloplasmin (ferroxidase)
chr10_+_5005453 1.004 NM_001353
AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr8_-_72274466 0.997 NM_000503
EYA1
eyes absent homolog 1 (Drosophila)
chr21_-_27423423 0.992


chr19_+_49259343 0.988 NM_019113
FGF21
fibroblast growth factor 21
chr4_-_186578122 0.979 NM_001145674
NM_001145675
SORBS2

sorbin and SH3 domain containing 2

chr2_-_69098502 0.978 NM_014482
BMP10
bone morphogenetic protein 10
chr1_+_50575465 0.977 ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr21_-_27512668 0.972 NM_001136016
APP
amyloid beta (A4) precursor protein
chr4_-_153273683 0.966 NM_018315
FBXW7
F-box and WD repeat domain containing 7
chr14_-_67826414 0.965 NM_015994
ATP6V1D
ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
chr20_-_55934877 0.965 NM_001190472
MTRNR2L3
MT-RNR2-like 3
chr4_+_111397181 0.948 NM_001977
ENPEP
glutamyl aminopeptidase (aminopeptidase A)
chr5_-_32388595 0.938 ZFR
zinc finger RNA binding protein
chr5_+_86676620 0.918


chr20_+_2082527 0.895 NM_080836
STK35
serine/threonine kinase 35
chr5_+_125695787 0.892 NM_001146319
GRAMD3
GRAM domain containing 3
chr16_-_55867016 0.892 NM_001025194
NM_001025195
NM_001266
CES1


carboxylesterase 1


chr10_-_69455926 0.886 NM_013266
CTNNA3
catenin (cadherin-associated protein), alpha 3
chr4_+_110354927 0.870 NM_001042734
NM_006323
SEC24B

SEC24 family, member B (S. cerevisiae)

chr1_+_84647342 0.843 NM_001242862
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr18_+_21032786 0.839 NM_003831
RIOK3
RIO kinase 3 (yeast)
chr14_+_62462540 0.839 NM_031914
SYT16
synaptotagmin XVI
chr10_-_94257470 0.811 NM_001165946
IDE
insulin-degrading enzyme
chr4_-_69434215 0.807 NM_001077
UGT2B15
UGT2B17
UDP glucuronosyltransferase 2 family, polypeptide B15
UDP glucuronosyltransferase 2 family, polypeptide B17
chr18_+_21572736 0.803 NM_153211
TTC39C
tetratricopeptide repeat domain 39C
chr8_+_104831415 0.797 NM_014677
RIMS2
regulating synaptic membrane exocytosis 2
chr13_-_25745778 0.796 NM_152704
NM_199138
FAM123A

family with sequence similarity 123A

chr9_-_112191105 0.792 NM_001145371
NM_001145372
PTPN3

protein tyrosine phosphatase, non-receptor type 3

chr1_+_248084319 0.790 NM_001005522
OR2T8
olfactory receptor, family 2, subfamily T, member 8
chrX_+_118108595 0.787 NM_001031855
NM_024778
LONRF3

LON peptidase N-terminal domain and ring finger 3

chr8_+_17396285 0.775 NM_001164771
NM_003046
SLC7A2

solute carrier family 7 (cationic amino acid transporter, y+ system), member 2

chr1_+_232941111 0.761 KIAA1383
KIAA1383
chr8_+_22210311 0.749 PIWIL2
piwi-like 2 (Drosophila)
chr4_-_156787377 0.742 NM_017419
ACCN5
amiloride-sensitive cation channel 5, intestinal
chr4_+_110354971 0.737 SEC24B
SEC24 family, member B (S. cerevisiae)
chr5_+_161277702 0.728 NM_001127648
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr10_+_5005685 0.726 AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr17_+_57743498 0.723 CLTC
clathrin, heavy chain (Hc)
chr10_-_5045967 0.720 NM_001135241
AKR1C2
aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)
chr18_+_32621299 0.719 NM_014268
MAPRE2
microtubule-associated protein, RP/EB family, member 2
chr5_-_52405287 0.718 NM_004531
MOCS2
molybdenum cofactor synthesis 2
chr8_+_27179918 0.716 NM_004103
PTK2B
PTK2B protein tyrosine kinase 2 beta
chr2_-_133429069 0.714 NM_001077427
LYPD1
LY6/PLAUR domain containing 1
chr16_-_48266181 0.707 NM_033151
ABCC11
ATP-binding cassette, sub-family C (CFTR/MRP), member 11
chr5_-_137848517 0.707 ETF1
eukaryotic translation termination factor 1
chr17_-_685385 0.704 NM_016080
GLOD4
glyoxalase domain containing 4
chrX_+_49832214 0.703 NM_000084
CLCN5
chloride channel 5
chr8_+_94929991 0.701 NM_001161778
PDP1
pyruvate dehyrogenase phosphatase catalytic subunit 1
chr19_-_6720585 0.685 NM_000064
C3
complement component 3
chr12_-_16757944 0.682 LMO3
LIM domain only 3 (rhombotin-like 2)
chr1_+_40839368 0.667 NM_022733
SMAP2
small ArfGAP2
chr8_+_42396716 0.639 NM_138436
NM_001135674
NM_001135675
C8orf40


chromosome 8 open reading frame 40


chr1_-_109935869 0.638 NM_001205228
SORT1
sortilin 1
chr11_-_31014232 0.629 NM_020869
DCDC5
doublecortin domain containing 5
chr3_-_74570262 0.629 NM_020872
CNTN3
contactin 3 (plasmacytoma associated)
chr21_-_27253197 0.629 APP
amyloid beta (A4) precursor protein

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
7.58 1.34e-04 GO:0008202 steroid metabolic process
3.71 2.07e-04 GO:0009611 response to wounding
3.89 2.13e-04 GO:0006952 defense response
2.36 5.26e-04 GO:0006950 response to stress
9.08 1.71e-03 GO:0006805 xenobiotic metabolic process
9.08 1.71e-03 GO:0071466 cellular response to xenobiotic stimulus
9.01 1.81e-03 GO:0009410 response to xenobiotic stimulus
37.70 1.89e-03 GO:0015721 bile acid and bile salt transport
3.34 2.08e-03 GO:0006629 lipid metabolic process
35.49 2.45e-03 GO:0019433 triglyceride catabolic process
33.51 3.14e-03 GO:0044269 glycerol ether catabolic process
33.51 3.14e-03 GO:0046461 neutral lipid catabolic process
33.51 3.14e-03 GO:0046464 acylglycerol catabolic process
2.30 3.32e-03 GO:0042221 response to chemical stimulus
2.35 3.38e-03 GO:0065008 regulation of biological quality
3.32 4.12e-03 GO:0055114 oxidation-reduction process
5.68 6.51e-03 GO:0006954 inflammatory response
27.42 7.35e-03 GO:0046503 glycerolipid catabolic process
56.55 9.35e-03 GO:0042738 exogenous drug catabolic process
25.14 1.06e-02 GO:0017144 drug metabolic process
45.24 1.98e-02 GO:0042737 drug catabolic process
12.37 3.11e-02 GO:0072376 protein activation cascade
5.25 3.38e-02 GO:0010035 response to inorganic substance
34.80 4.66e-02 GO:0006957 complement activation, alternative pathway

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
7.10 5.58e-05 GO:0005792 microsome
6.86 7.79e-05 GO:0042598 vesicular fraction
3.45 1.01e-03 GO:0005615 extracellular space
2.30 1.62e-03 GO:0005576 extracellular region
2.97 2.37e-03 GO:0044421 extracellular region part
14.51 3.06e-03 GO:0031983 vesicle lumen
3.16 5.53e-03 GO:0005624 membrane fraction
3.06 8.11e-03 GO:0005626 insoluble fraction
2.63 1.96e-02 GO:0000267 cell fraction
12.84 3.39e-02 GO:0031093 platelet alpha granule lumen
12.57 3.67e-02 GO:0034774 secretory granule lumen
12.07 4.30e-02 GO:0060205 cytoplasmic membrane-bounded vesicle lumen

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
113.09 2.19e-04 GO:0047023 androsterone dehydrogenase activity
16.76 2.24e-03 GO:0019825 oxygen binding
7.10 3.35e-03 GO:0009055 electron carrier activity
25.14 3.40e-03 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
23.21 4.74e-03 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
4.55 5.90e-03 GO:0030246 carbohydrate binding
21.55 6.42e-03 GO:0016229 steroid dehydrogenase activity
3.39 6.69e-03 GO:0016491 oxidoreductase activity
150.79 8.47e-03 GO:0004854 xanthine dehydrogenase activity
150.79 8.47e-03 GO:0016726 oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor
150.79 8.47e-03 GO:0047042 androsterone dehydrogenase (B-specific) activity
150.79 8.47e-03 GO:0047718 indanol dehydrogenase activity
5.84 1.37e-02 GO:0005506 iron ion binding
6.65 1.75e-02 GO:0001871 pattern binding
6.65 1.75e-02 GO:0030247 polysaccharide binding
3.99 1.95e-02 GO:0008289 lipid binding
9.43 3.67e-02 GO:0004497 monooxygenase activity
25.14 4.18e-02 GO:0004033 aldo-keto reductase activity