Motif ID: NFKB1_REL_RELA.p2

Z-value: 3.109


Transcription factors associated with NFKB1_REL_RELA.p2:

Gene SymbolEntrez IDGene Name
NFKB1 4790 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
REL 5966 v-rel reticuloendotheliosis viral oncogene homolog (avian)
RELA 5970 v-rel reticuloendotheliosis viral oncogene homolog A (avian)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NFKB1hg19_v1_chr4_+_103422730_1034227940.646.8e-05Click!
RELhg19_v1_chr2_+_61108775_611087990.593.6e-04Click!
RELAhg19_v1_chr11_-_65430427_654304550.494.9e-03Click!


Activity profile for motif NFKB1_REL_RELA.p2.

activity profile for motif NFKB1_REL_RELA.p2


Sorted Z-values histogram for motif NFKB1_REL_RELA.p2

Sorted Z-values for motif NFKB1_REL_RELA.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFKB1_REL_RELA.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_219745243 8.672 NM_025216
WNT10A
wingless-type MMTV integration site family, member 10A
chr19_+_42381189 8.654 NM_001783
NM_021601
CD79A

CD79a molecule, immunoglobulin-associated alpha

chr19_+_35940616 7.362 NM_005306
FFAR2
free fatty acid receptor 2
chr19_-_41859519 7.265 TGFB1
transforming growth factor, beta 1
chr19_-_41859830 6.733 NM_000660
TGFB1
transforming growth factor, beta 1
chr19_-_41859332 6.707 TGFB1
transforming growth factor, beta 1
chr22_+_22764094 6.632


chr22_+_23134980 6.392


chr17_-_34207308 6.289 NM_002985
CCL5
chemokine (C-C motif) ligand 5
chr22_-_37545944 6.044 NM_000878
IL2RB
interleukin 2 receptor, beta
chr19_+_50922194 5.884 NM_001243998
NM_001243999
NM_001244000
NM_003121
SPIB



Spi-B transcription factor (Spi-1/PU.1 related)



chr22_-_37640287 5.691 NM_002872
RAC2
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr11_+_102188180 5.666 NM_001165
NM_182962
BIRC3

baculoviral IAP repeat containing 3

chr22_-_37640187 5.595 RAC2
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr1_-_202130677 5.461 NM_001199797
NM_002832
PTPN7

protein tyrosine phosphatase, non-receptor type 7

chr14_-_96180402 5.418 NM_001098725
NM_021966
TCL1A

T-cell leukemia/lymphoma 1A

chr19_-_41859767 5.391 TGFB1
transforming growth factor, beta 1
chr4_-_76944585 5.389 NM_001565
CXCL10
chemokine (C-X-C motif) ligand 10
chr20_+_814355 5.331 NM_001042353
FAM110A
family with sequence similarity 110, member A
chr10_+_104155431 5.264 NM_002502
NFKB2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
chr11_+_118754474 5.259 NM_001716
CXCR5
chemokine (C-X-C motif) receptor 5
chr19_+_17638064 5.251 FAM129C
family with sequence similarity 129, member C
chr20_+_43803539 5.244 NM_002638
PI3
peptidase inhibitor 3, skin-derived
chr6_+_29910246 5.165 NM_001242758
NM_002116
HLA-A

major histocompatibility complex, class I, A

chr6_-_31324975 5.134 NM_005514
HLA-B
major histocompatibility complex, class I, B
chr14_-_35873823 5.131 NM_020529
NFKBIA
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
chr22_+_22758538 4.982


chr6_-_31324955 4.791 HLA-B
major histocompatibility complex, class I, B
chr19_-_41859253 4.780 TGFB1
transforming growth factor, beta 1
chr12_+_7055736 4.631 NM_080548
PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr4_-_74864296 4.619 NM_002994
CXCL5
chemokine (C-X-C motif) ligand 5
chr10_+_30722856 4.519 NM_001244134
NM_005204
MAP3K8

mitogen-activated protein kinase kinase kinase 8

chr1_-_202129731 4.493 PTPN7
protein tyrosine phosphatase, non-receptor type 7
chr16_+_85932766 4.472 NM_002163
IRF8
interferon regulatory factor 8
chr10_+_104154228 4.463 NM_001077493
NM_001077494
NFKB2

nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)

chrX_+_78200828 4.399 NM_014499
NM_198333
P2RY10

purinergic receptor P2Y, G-protein coupled, 10

chr11_-_3862137 4.374 RHOG
ras homolog gene family, member G (rho G)
chr19_+_45251933 4.332 NM_005178
BCL3
B-cell CLL/lymphoma 3
chr11_-_3862183 4.323 NM_001665
RHOG
ras homolog gene family, member G (rho G)
chr19_-_7766978 4.303 NM_001220500
NM_002002
FCER2

Fc fragment of IgE, low affinity II, receptor for (CD23)

chr7_-_45018559 4.301 MYO1G
myosin IG
chr22_+_22712091 4.248 IGLV1-44
IGL@
immunoglobulin lambda variable 1-44
immunoglobulin lambda locus
chr17_-_16875388 4.221 NM_012452
TNFRSF13B
tumor necrosis factor receptor superfamily, member 13B
chr16_+_50731049 4.218 NM_022162
NOD2
nucleotide-binding oligomerization domain containing 2
chr7_-_45018677 4.165 NM_033054
MYO1G
myosin IG
chr12_+_7055753 4.042 PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr1_-_92949045 3.986 GFI1
growth factor independent 1 transcription repressor
chr6_+_32605182 3.978 NM_002122
HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
chr19_+_45504686 3.956 NM_006509
RELB
v-rel reticuloendotheliosis viral oncogene homolog B
chr2_+_228678556 3.938 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr17_-_73840422 3.938 UNC13D
unc-13 homolog D (C. elegans)
chrX_-_30595883 3.928 NM_025159
CXorf21
chromosome X open reading frame 21
chr1_-_47655603 3.922 PDZK1IP1
PDZK1 interacting protein 1
chr22_+_23213671 3.871 IGLV4-3
immunoglobulin lambda variable 4-3
chr13_+_108921976 3.829 NM_001145645
NM_006573
TNFSF13B

tumor necrosis factor (ligand) superfamily, member 13b

chr17_+_38474472 3.818 NM_001145301
NM_001145302
RARA

retinoic acid receptor, alpha

chr2_+_208394615 3.811 NM_004379
NM_134442
CREB1

cAMP responsive element binding protein 1

chr15_-_40398286 3.704 NM_001003942
NM_001003943
BMF

Bcl2 modifying factor

chr16_+_50776012 3.685 NM_001042412
CYLD
cylindromatosis (turban tumor syndrome)
chr4_-_109087876 3.674 NM_001166119
LEF1
lymphoid enhancer-binding factor 1
chr6_-_31324898 3.621 HLA-B
major histocompatibility complex, class I, B
chr22_+_23063107 3.621 IGLJ3
immunoglobulin lambda joining 3
chr19_+_1067536 3.620 HMHA1
histocompatibility (minor) HA-1
chr1_-_202129118 3.597 NM_080588
PTPN7
protein tyrosine phosphatase, non-receptor type 7
chr17_+_40440481 3.593 STAT5A
signal transducer and activator of transcription 5A
chr17_-_73840587 3.577 NM_199242
UNC13D
unc-13 homolog D (C. elegans)
chr2_+_68961912 3.574 NM_001007231
NM_001166277
ARHGAP25

Rho GTPase activating protein 25

chr19_-_44285012 3.562 KCNN4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr19_-_17958814 3.534 NM_000215
JAK3
Janus kinase 3
chr1_-_27961623 3.522 NM_005248
FGR
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog
chr9_-_139927291 3.521 NM_004479
FUT7
fucosyltransferase 7 (alpha (1,3) fucosyltransferase)
chr16_+_50775960 3.515 NM_001042355
NM_015247
CYLD

cylindromatosis (turban tumor syndrome)

chr13_+_108922205 3.505 TNFSF13B
tumor necrosis factor (ligand) superfamily, member 13b
chr1_-_202129705 3.504 PTPN7
protein tyrosine phosphatase, non-receptor type 7
chr9_-_117568292 3.499 NM_005118
TNFSF15
tumor necrosis factor (ligand) superfamily, member 15
chr4_+_74735107 3.486 NM_001511
CXCL1
chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
chr14_+_75988765 3.481 NM_006399
BATF
basic leucine zipper transcription factor, ATF-like
chr16_+_3096681 3.464 NM_022468
MMP25
matrix metallopeptidase 25
chr10_-_135090325 3.464 NM_001109
NM_001164489
NM_001164490
ADAM8


ADAM metallopeptidase domain 8


chr15_-_89438741 3.455 NM_178232
HAPLN3
hyaluronan and proteoglycan link protein 3
chr5_-_131826426 3.440 NM_002198
IRF1
interferon regulatory factor 1
chr6_+_29974352 3.437 HLA-J
major histocompatibility complex, class I, J (pseudogene)
chr7_-_45018650 3.434 MYO1G
myosin IG
chr2_-_197036301 3.404 NM_004226
STK17B
serine/threonine kinase 17b
chr14_-_107013122 3.387 IGHV4-31
IGHG1
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant gamma 1 (G1m marker)
chr19_-_17958773 3.349 JAK3
Janus kinase 3
chr2_-_197036262 3.347 STK17B
serine/threonine kinase 17b
chr19_-_44285407 3.347 NM_002250
KCNN4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr6_+_106534188 3.346 NM_001198
PRDM1
PR domain containing 1, with ZNF domain
chr1_-_47655723 3.345 NM_005764
PDZK1IP1
PDZK1 interacting protein 1
chr1_+_111770280 3.342 NM_001025197
NM_004000
CHI3L2

chitinase 3-like 2

chr19_-_6591012 3.334 CD70
CD70 molecule
chr14_+_75988838 3.319 BATF
basic leucine zipper transcription factor, ATF-like
chr12_-_54813010 3.311 NM_002205
ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr11_+_60739114 3.284 NM_006725
CD6
CD6 molecule
chr9_-_136344182 3.265 NM_001145099
NM_017585
SLC2A6

solute carrier family 2 (facilitated glucose transporter), member 6

chr17_-_39092714 3.257 KRT23
keratin 23 (histone deacetylase inducible)
chr2_-_231789940 3.253 NM_005683
GPR55
G protein-coupled receptor 55
chr5_-_141338626 3.251 NM_016580
PCDH12
protocadherin 12
chr6_-_32551993 3.239 HLA-DRB1
HLA-DRB4
HLA-DRB5
major histocompatibility complex, class II, DR beta 1
major histocompatibility complex, class II, DR beta 4
major histocompatibility complex, class II, DR beta 5
chr11_-_75062650 3.239 NM_004041
NM_020251
ARRB1

arrestin, beta 1

chr16_+_3115312 3.227 NM_001012631
NM_001012633
NM_001012718
NM_004221
IL32



interleukin 32



chr20_-_56195446 3.211 NM_001160417
NM_001160418
NM_001160419
NM_030776
ZBP1



Z-DNA binding protein 1



chr14_-_106692107 3.206 IGHV4-31
IGHA1
IGHD
IGHG1
IGHG3
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant delta
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
chr6_+_31540092 3.202 NM_000595
LTA
lymphotoxin alpha (TNF superfamily, member 1)
chr17_+_7461591 3.181 NM_001198622
NM_001198623
NM_001198624
NM_003808
NM_172087
NM_172088
TNFSF13





tumor necrosis factor (ligand) superfamily, member 13





chr2_+_233925035 3.165 NM_001017915
NM_005541
INPP5D

inositol polyphosphate-5-phosphatase, 145kDa

chr22_+_39353526 3.161 NM_001193289
NM_145699
APOBEC3A

apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A

chr6_+_106534210 3.159 PRDM1
PR domain containing 1, with ZNF domain
chr10_-_6104113 3.159 NM_000417
IL2RA
interleukin 2 receptor, alpha
chr16_+_28996146 3.152 NM_001014989
LAT
linker for activation of T cells
chr2_+_69001932 3.146 NM_001166276
NM_014882
ARHGAP25

Rho GTPase activating protein 25

chr8_+_22019167 3.132 NM_001172357
NM_001172410
NM_003018
SFTPC


surfactant protein C


chr3_-_111851967 3.106 NM_001190259
NM_001190260
NM_152785
GCET2


germinal center expressed transcript 2


chr16_+_3115611 3.096 NM_001012635
IL32
interleukin 32
chr2_+_233925104 3.072 INPP5D
inositol polyphosphate-5-phosphatase, 145kDa
chr15_+_81589240 3.041 NM_004513
IL16
interleukin 16
chr1_+_167599329 3.035 NM_052862
RCSD1
RCSD domain containing 1
chr17_+_38474513 3.024 RARA
retinoic acid receptor, alpha
chr19_+_14142611 3.014 IL27RA
interleukin 27 receptor, alpha
chr22_+_23222897 3.006 CYAT1
immunoglobulin lambda light chain-like
chr12_-_55375621 3.001 NM_001098815
KIAA0748
KIAA0748
chr6_+_31674639 2.961 NM_001003693
LY6G6F
lymphocyte antigen 6 complex, locus G6F
chr5_-_149792276 2.960 CD74
CD74 molecule, major histocompatibility complex, class II invariant chain
chr17_+_38474544 2.956 RARA
retinoic acid receptor, alpha
chr20_-_50179338 2.937 NFATC2
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
chr11_-_5271035 2.926 NM_000559
HBG1
hemoglobin, gamma A
chr2_-_43453724 2.921 ZFP36L2
zinc finger protein 36, C3H type-like 2
chr19_-_4540035 2.916 NM_052972
LRG1
leucine-rich alpha-2-glycoprotein 1
chr2_-_235405692 2.915 NM_005737
ARL4C
ADP-ribosylation factor-like 4C
chr14_+_52734430 2.915 NM_000953
PTGDR
prostaglandin D2 receptor (DP)
chr13_-_46756326 2.900 NM_002298
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr11_+_118307072 2.897 NM_001197104
NM_005933
MLL

myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)

chr17_+_72462521 2.897 NM_007261
CD300A
CD300a molecule
chr16_+_3115638 2.891 NM_001012634
IL32
interleukin 32
chr16_+_3115639 2.874 IL32
interleukin 32
chr1_+_37940180 2.870 ZC3H12A
zinc finger CCCH-type containing 12A
chr2_-_109605668 2.868 NM_022336
EDAR
ectodysplasin A receptor
chr4_+_74702272 2.867 NM_002993
CXCL6
chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)
chr10_-_73533196 2.849 NM_022153
C10orf54
chromosome 10 open reading frame 54
chr19_+_14142459 2.824 IL27RA
interleukin 27 receptor, alpha
chr10_+_30723050 2.775 MAP3K8
mitogen-activated protein kinase kinase kinase 8
chr19_+_16187315 2.745 TPM4
tropomyosin 4
chr6_+_135502445 2.729 NM_001130172
NM_001130173
NM_001161656
NM_001161657
NM_001161658
NM_001161659
NM_001161660
NM_005375
MYB







v-myb myeloblastosis viral oncogene homolog (avian)







chr2_-_43453146 2.718 ZFP36L2
zinc finger protein 36, C3H type-like 2
chr13_+_108922560 2.703 TNFSF13B
tumor necrosis factor (ligand) superfamily, member 13b
chr20_-_4795768 2.693 NM_170774
RASSF2
Ras association (RalGDS/AF-6) domain family member 2
chr12_-_54812936 2.684 ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr1_-_25256767 2.668 NM_004350
RUNX3
runt-related transcription factor 3
chr12_-_54813002 2.645 ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr5_-_149792370 2.639 NM_001025158
NM_001025159
NM_004355
CD74


CD74 molecule, major histocompatibility complex, class II invariant chain


chr9_+_36136710 2.636 NM_022343
GLIPR2
GLI pathogenesis-related 2
chr19_-_6591082 2.578 CD70
CD70 molecule
chr6_-_31324564 2.573 HLA-B
HLA-C
major histocompatibility complex, class I, B
major histocompatibility complex, class I, C
chr15_+_89182038 2.573 NM_002201
ISG20
interferon stimulated exonuclease gene 20kDa
chr20_-_50179167 2.566 NM_001136021
NFATC2
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
chr2_-_43453737 2.542 NM_006887
ZFP36L2
zinc finger protein 36, C3H type-like 2
chr1_-_159895258 2.540 TAGLN2
transgelin 2
chr1_-_85462622 2.505 NM_153259
MCOLN2
mucolipin 2
chr19_+_54371125 2.502 NM_001020819
NM_138373
MYADM

myeloid-associated differentiation marker

chr19_+_42364322 2.499 RPS19
ribosomal protein S19
chr13_-_50699775 2.499 DLEU2
deleted in lymphocytic leukemia 2 (non-protein coding)
chr19_-_47734215 2.496 NM_014417
BBC3
BCL2 binding component 3
chr5_-_171615239 2.492 STK10
serine/threonine kinase 10
chr10_-_125851850 2.480 NM_014863
NM_015892
CHST15

carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15

chr20_-_50159247 2.474 NM_012340
NM_173091
NFATC2

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2

chr4_-_120549115 2.461 NM_033437
PDE5A
phosphodiesterase 5A, cGMP-specific
chr7_-_38389575 2.461 TRGV5
T cell receptor gamma variable 5
chr2_+_61108702 2.456 REL
v-rel reticuloendotheliosis viral oncogene homolog (avian)
chr19_-_11688441 2.451 ACP5
acid phosphatase 5, tartrate resistant
chr5_-_149792335 2.448


chr19_-_52133589 2.443 NM_003830
SIGLEC5
sialic acid binding Ig-like lectin 5
chr7_-_38389424 2.432


chr19_+_54371150 2.416 MYADM
myeloid-associated differentiation marker
chr11_+_72525463 2.415 ATG16L2
ATG16 autophagy related 16-like 2 (S. cerevisiae)
chr2_+_61108775 2.409 REL
v-rel reticuloendotheliosis viral oncogene homolog (avian)
chr5_-_171615320 2.406 NM_005990
STK10
serine/threonine kinase 10
chr2_+_208394756 2.394 CREB1
cAMP responsive element binding protein 1
chr19_+_859673 2.390 CFD
complement factor D (adipsin)
chr20_+_44637539 2.380 NM_004994
MMP9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
chr2_-_89513056 2.376 IGKC
immunoglobulin kappa constant
chr21_+_34775740 2.373 IFNGR2
interferon gamma receptor 2 (interferon gamma transducer 1)
chr14_-_106610338 2.362 IGHV4-31
IGHG1
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant gamma 1 (G1m marker)
chr4_-_74904329 2.340 NM_002090
CXCL3
chemokine (C-X-C motif) ligand 3
chr16_-_74734687 2.334 NM_001142497
NM_152649
MLKL

mixed lineage kinase domain-like

chr1_+_26856252 2.318 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr15_+_85923739 2.287 NM_006738
NM_007200
AKAP13

A kinase (PRKA) anchor protein 13

chr4_+_103422730 2.282 NFKB1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
chr19_+_54371170 2.278 MYADM
myeloid-associated differentiation marker
chr17_+_16318911 2.278 TRPV2
transient receptor potential cation channel, subfamily V, member 2
chr7_+_143078358 2.278 NM_001010972
NM_003461
ZYX

zyxin

chr14_-_24615772 2.265 PSME2
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr14_+_103243813 2.245 NM_001199427
NM_003300
NM_145725
NM_145726
TRAF3



TNF receptor-associated factor 3



chr1_-_186649421 2.244 NM_000963
PTGS2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
chr2_+_61108724 2.229 NM_002908
REL
v-rel reticuloendotheliosis viral oncogene homolog (avian)
chr6_+_14117486 2.221 NM_001251901
CD83
CD83 molecule
chr5_-_171615199 2.217 STK10
serine/threonine kinase 10
chr21_+_34775780 2.213 IFNGR2
interferon gamma receptor 2 (interferon gamma transducer 1)
chrX_+_64887510 2.199 NM_002444
MSN
moesin
chr19_+_42363987 2.199 NM_001022
RPS19
ribosomal protein S19

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
4.76 1.49e-45 GO:0002376 immune system process
5.99 1.03e-41 GO:0006955 immune response
5.10 2.27e-27 GO:0002682 regulation of immune system process
4.54 2.20e-25 GO:0006952 defense response
2.60 2.30e-25 GO:0048518 positive regulation of biological process
5.77 1.01e-21 GO:0002684 positive regulation of immune system process
2.22 1.73e-20 GO:0007165 signal transduction
2.53 2.70e-20 GO:0048522 positive regulation of cellular process
5.50 8.20e-20 GO:0050776 regulation of immune response
6.90 1.77e-18 GO:0001817 regulation of cytokine production
7.35 2.19e-18 GO:0002694 regulation of leukocyte activation
1.98 6.77e-18 GO:0051716 cellular response to stimulus
7.66 7.09e-18 GO:0051249 regulation of lymphocyte activation
7.07 8.68e-18 GO:0050865 regulation of cell activation
1.70 2.47e-17 GO:0050896 response to stimulus
2.04 4.21e-17 GO:0023052 signaling
2.56 5.34e-15 GO:0048583 regulation of response to stimulus
2.29 1.85e-14 GO:0006950 response to stress
3.60 2.42e-14 GO:0048584 positive regulation of response to stimulus
8.32 2.96e-14 GO:0002697 regulation of immune effector process
3.18 3.84e-14 GO:0010941 regulation of cell death
7.46 3.99e-14 GO:0002696 positive regulation of leukocyte activation
3.21 4.34e-14 GO:0042981 regulation of apoptosis
7.73 5.50e-14 GO:0051251 positive regulation of lymphocyte activation
3.05 5.52e-14 GO:0010604 positive regulation of macromolecule metabolic process
7.34 6.41e-14 GO:0050867 positive regulation of cell activation
3.18 6.68e-14 GO:0043067 regulation of programmed cell death
1.53 2.40e-13 GO:0050789 regulation of biological process
2.88 3.87e-13 GO:0009893 positive regulation of metabolic process
5.02 3.97e-13 GO:0045087 innate immune response
2.49 4.14e-13 GO:0007166 cell surface receptor linked signaling pathway
5.27 1.45e-12 GO:0031347 regulation of defense response
1.54 1.72e-12 GO:0050794 regulation of cellular process
5.52 2.57e-12 GO:0050778 positive regulation of immune response
11.47 3.65e-12 GO:0002699 positive regulation of immune effector process
1.46 4.41e-11 GO:0065007 biological regulation
5.71 5.77e-11 GO:0045321 leukocyte activation
7.34 1.29e-10 GO:0002252 immune effector process
3.98 1.60e-10 GO:0001775 cell activation
2.98 1.95e-10 GO:0042127 regulation of cell proliferation
6.79 2.11e-10 GO:0031349 positive regulation of defense response
12.08 2.57e-10 GO:0050864 regulation of B cell activation
3.30 2.96e-10 GO:0010557 positive regulation of macromolecule biosynthetic process
6.55 4.85e-10 GO:0050863 regulation of T cell activation
14.41 5.80e-10 GO:0045621 positive regulation of lymphocyte differentiation
3.01 6.93e-10 GO:0009611 response to wounding
2.67 1.27e-09 GO:0031325 positive regulation of cellular metabolic process
4.18 1.50e-09 GO:0051707 response to other organism
6.21 1.58e-09 GO:0002764 immune response-regulating signaling pathway
7.32 1.69e-09 GO:0001819 positive regulation of cytokine production
4.80 2.07e-09 GO:0034097 response to cytokine stimulus
3.75 2.22e-09 GO:0080134 regulation of response to stress
11.14 5.49e-09 GO:0045619 regulation of lymphocyte differentiation
6.16 5.60e-09 GO:0045088 regulation of innate immune response
6.09 7.19e-09 GO:0002757 immune response-activating signal transduction
3.27 7.83e-09 GO:0010628 positive regulation of gene expression
11.96 1.01e-08 GO:0045580 regulation of T cell differentiation
2.95 1.20e-08 GO:0009891 positive regulation of biosynthetic process
4.77 1.43e-08 GO:0006954 inflammatory response
5.32 1.79e-08 GO:0002253 activation of immune response
2.86 2.25e-08 GO:0051704 multi-organism process
3.63 2.33e-08 GO:0043065 positive regulation of apoptosis
6.76 2.67e-08 GO:0050870 positive regulation of T cell activation
3.61 2.81e-08 GO:0043068 positive regulation of programmed cell death
5.63 3.74e-08 GO:0046649 lymphocyte activation
3.55 4.34e-08 GO:0008284 positive regulation of cell proliferation
5.33 4.45e-08 GO:0071345 cellular response to cytokine stimulus
3.54 4.62e-08 GO:0010942 positive regulation of cell death
1.99 5.42e-08 GO:0048519 negative regulation of biological process
13.58 6.43e-08 GO:0045582 positive regulation of T cell differentiation
2.88 7.56e-08 GO:0031328 positive regulation of cellular biosynthetic process
13.25 8.92e-08 GO:0050871 positive regulation of B cell activation
3.54 9.15e-08 GO:0009607 response to biotic stimulus
8.14 1.69e-07 GO:0001818 negative regulation of cytokine production
7.40 2.10e-07 GO:0070663 regulation of leukocyte proliferation
4.74 2.22e-07 GO:0009617 response to bacterium
5.42 2.23e-07 GO:0019221 cytokine-mediated signaling pathway
2.89 2.75e-07 GO:0051173 positive regulation of nitrogen compound metabolic process
6.74 2.99e-07 GO:0045089 positive regulation of innate immune response
3.14 4.64e-07 GO:0045893 positive regulation of transcription, DNA-dependent
31.69 4.86e-07 GO:0002828 regulation of type 2 immune response
2.35 8.12e-07 GO:0051239 regulation of multicellular organismal process
3.47 1.01e-06 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
3.01 1.02e-06 GO:0051254 positive regulation of RNA metabolic process
7.25 1.04e-06 GO:0050670 regulation of lymphocyte proliferation
2.62 1.11e-06 GO:0070887 cellular response to chemical stimulus
2.85 1.17e-06 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
7.17 1.21e-06 GO:0032944 regulation of mononuclear cell proliferation
7.81 1.22e-06 GO:0002443 leukocyte mediated immunity
6.64 1.23e-06 GO:0042742 defense response to bacterium
8.57 1.26e-06 GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
3.03 1.34e-06 GO:0071310 cellular response to organic substance
2.58 1.40e-06 GO:0006357 regulation of transcription from RNA polymerase II promoter
8.34 1.83e-06 GO:0002250 adaptive immune response
7.38 2.74e-06 GO:0002758 innate immune response-activating signal transduction
1.91 2.86e-06 GO:0042221 response to chemical stimulus
8.92 3.05e-06 GO:0002703 regulation of leukocyte mediated immunity
7.23 3.73e-06 GO:0002218 activation of innate immune response
5.74 4.29e-06 GO:0002237 response to molecule of bacterial origin
9.70 4.68e-06 GO:0002706 regulation of lymphocyte mediated immunity
9.70 4.68e-06 GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
7.08 5.04e-06 GO:0032103 positive regulation of response to external stimulus
1.93 5.76e-06 GO:0048523 negative regulation of cellular process
9.53 5.81e-06 GO:0002819 regulation of adaptive immune response
5.97 6.56e-06 GO:0032496 response to lipopolysaccharide
3.76 6.95e-06 GO:0006917 induction of apoptosis
3.75 7.43e-06 GO:0012502 induction of programmed cell death
1.69 7.86e-06 GO:0060255 regulation of macromolecule metabolic process
7.46 8.43e-06 GO:0002224 toll-like receptor signaling pathway
7.12 1.56e-05 GO:0002221 pattern recognition receptor signaling pathway
1.60 1.75e-05 GO:0019222 regulation of metabolic process
3.97 1.87e-05 GO:0002520 immune system development
13.58 1.91e-05 GO:0050830 defense response to Gram-positive bacterium
4.10 2.04e-05 GO:0010740 positive regulation of intracellular protein kinase cascade
4.10 2.04e-05 GO:0048534 hemopoietic or lymphoid organ development
5.84 2.58e-05 GO:0002521 leukocyte differentiation
2.14 2.82e-05 GO:0009966 regulation of signal transduction
7.45 3.04e-05 GO:0043900 regulation of multi-organism process
2.48 3.18e-05 GO:0050793 regulation of developmental process
15.75 3.41e-05 GO:0002712 regulation of B cell mediated immunity
15.75 3.41e-05 GO:0002889 regulation of immunoglobulin mediated immune response
3.68 4.23e-05 GO:0045597 positive regulation of cell differentiation
1.79 4.33e-05 GO:0010556 regulation of macromolecule biosynthetic process
2.39 5.02e-05 GO:0009605 response to external stimulus
3.03 5.03e-05 GO:0010647 positive regulation of cell communication
7.88 5.70e-05 GO:0034130 toll-like receptor 1 signaling pathway
7.88 5.70e-05 GO:0034134 toll-like receptor 2 signaling pathway
3.01 5.82e-05 GO:0023056 positive regulation of signaling
3.07 5.90e-05 GO:0009967 positive regulation of signal transduction
2.19 6.08e-05 GO:0010033 response to organic substance
3.21 6.40e-05 GO:0051094 positive regulation of developmental process
18.64 6.88e-05 GO:0043370 regulation of CD4-positive, alpha-beta T cell differentiation
18.64 6.88e-05 GO:2000514 regulation of CD4-positive, alpha-beta T cell activation
3.58 7.01e-05 GO:0051240 positive regulation of multicellular organismal process
2.61 8.68e-05 GO:2000026 regulation of multicellular organismal development
9.84 8.72e-05 GO:0002700 regulation of production of molecular mediator of immune response
9.84 8.72e-05 GO:0032675 regulation of interleukin-6 production
7.44 1.10e-04 GO:0002755 MyD88-dependent toll-like receptor signaling pathway
7.44 1.10e-04 GO:0050671 positive regulation of lymphocyte proliferation
3.60 1.21e-04 GO:0051098 regulation of binding
7.34 1.28e-04 GO:0032946 positive regulation of mononuclear cell proliferation
9.43 1.34e-04 GO:0050729 positive regulation of inflammatory response
4.61 1.41e-04 GO:0070201 regulation of establishment of protein localization
13.42 1.43e-04 GO:0032655 regulation of interleukin-12 production
7.25 1.50e-04 GO:0070665 positive regulation of leukocyte proliferation
4.16 1.50e-04 GO:0032101 regulation of response to external stimulus
5.98 1.54e-04 GO:0050727 regulation of inflammatory response
22.64 1.62e-04 GO:0043372 positive regulation of CD4-positive, alpha-beta T cell differentiation
22.64 1.62e-04 GO:0045622 regulation of T-helper cell differentiation
22.64 1.62e-04 GO:2000516 positive regulation of CD4-positive, alpha-beta T cell activation
7.15 1.75e-04 GO:0008063 Toll signaling pathway
7.15 1.75e-04 GO:0034142 toll-like receptor 4 signaling pathway
1.20 1.75e-04 GO:0009987 cellular process
32.34 1.83e-04 GO:0045624 positive regulation of T-helper cell differentiation
4.78 1.87e-04 GO:0051223 regulation of protein transport
7.06 2.03e-04 GO:0042035 regulation of cytokine biosynthetic process
7.91 2.06e-04 GO:0034138 toll-like receptor 3 signaling pathway
7.66 2.87e-04 GO:0002756 MyD88-independent toll-like receptor signaling pathway
3.99 2.91e-04 GO:0030097 hemopoiesis
6.20 2.92e-04 GO:0030098 lymphocyte differentiation
3.79 3.43e-04 GO:0051101 regulation of DNA binding
5.61 3.47e-04 GO:0090047 positive regulation of transcription regulator activity
12.08 3.55e-04 GO:0032642 regulation of chemokine production
6.07 3.75e-04 GO:0002683 negative regulation of immune system process
5.56 3.88e-04 GO:0042110 T cell activation
45.28 4.12e-04 GO:0045630 positive regulation of T-helper 2 cell differentiation
3.91 4.15e-04 GO:0051241 negative regulation of multicellular organismal process
1.68 5.08e-04 GO:0009889 regulation of biosynthetic process
3.86 5.11e-04 GO:0090046 regulation of transcription regulator activity
2.59 5.26e-04 GO:0045595 regulation of cell differentiation
2.05 5.38e-04 GO:0035556 intracellular signal transduction
1.76 5.39e-04 GO:0051252 regulation of RNA metabolic process
7.22 5.41e-04 GO:0002449 lymphocyte mediated immunity
1.56 5.87e-04 GO:0031323 regulation of cellular metabolic process
7.12 6.30e-04 GO:0051092 positive regulation of NF-kappaB transcription factor activity
1.70 6.88e-04 GO:0010468 regulation of gene expression
1.93 7.32e-04 GO:0023051 regulation of signaling
3.16 7.64e-04 GO:0010627 regulation of intracellular protein kinase cascade
3.08 7.71e-04 GO:0007243 intracellular protein kinase cascade
3.08 7.71e-04 GO:0023014 signal transduction via phosphorylation event
2.39 8.35e-04 GO:0044093 positive regulation of molecular function
5.61 9.58e-04 GO:0002768 immune response-regulating cell surface receptor signaling pathway
2.96 9.68e-04 GO:0060548 negative regulation of cell death
1.76 9.85e-04 GO:0006355 regulation of transcription, DNA-dependent
4.04 1.03e-03 GO:0032880 regulation of protein localization
2.81 1.06e-03 GO:0006935 chemotaxis
2.81 1.06e-03 GO:0042330 taxis
13.21 1.07e-03 GO:0002637 regulation of immunoglobulin production
13.21 1.07e-03 GO:0032755 positive regulation of interleukin-6 production
8.86 1.08e-03 GO:0032649 regulation of interferon-gamma production
8.86 1.08e-03 GO:0032680 regulation of tumor necrosis factor production
1.97 1.15e-03 GO:0065009 regulation of molecular function
5.40 1.48e-03 GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
2.97 1.53e-03 GO:0043066 negative regulation of apoptosis
3.05 1.55e-03 GO:0051247 positive regulation of protein metabolic process
8.49 1.58e-03 GO:0002263 cell activation involved in immune response
8.49 1.58e-03 GO:0002366 leukocyte activation involved in immune response
8.49 1.58e-03 GO:0002685 regulation of leukocyte migration
8.49 1.58e-03 GO:0032479 regulation of type I interferon production
3.73 1.71e-03 GO:0051090 regulation of sequence-specific DNA binding transcription factor activity
2.94 1.84e-03 GO:0043069 negative regulation of programmed cell death
5.78 1.88e-03 GO:0033157 regulation of intracellular protein transport
36.22 2.02e-03 GO:0045628 regulation of T-helper 2 cell differentiation
4.53 2.12e-03 GO:0040017 positive regulation of locomotion
1.63 2.24e-03 GO:0051171 regulation of nitrogen compound metabolic process
1.65 2.27e-03 GO:0031326 regulation of cellular biosynthetic process
6.23 2.50e-03 GO:0034341 response to interferon-gamma
9.53 2.54e-03 GO:0030888 regulation of B cell proliferation
11.74 2.60e-03 GO:0046637 regulation of alpha-beta T cell differentiation
7.84 3.20e-03 GO:0042108 positive regulation of cytokine biosynthetic process
6.08 3.21e-03 GO:0042306 regulation of protein import into nucleus
6.08 3.21e-03 GO:0045637 regulation of myeloid cell differentiation
4.38 3.22e-03 GO:0051272 positive regulation of cellular component movement
1.67 3.78e-03 GO:2000112 regulation of cellular macromolecule biosynthetic process
2.14 3.83e-03 GO:0006793 phosphorus metabolic process
2.14 3.83e-03 GO:0006796 phosphate metabolic process
4.60 4.05e-03 GO:0051099 positive regulation of binding
4.95 4.05e-03 GO:0043388 positive regulation of DNA binding
5.38 4.08e-03 GO:0002429 immune response-activating cell surface receptor signaling pathway
5.93 4.10e-03 GO:0050730 regulation of peptidyl-tyrosine phosphorylation
3.37 4.28e-03 GO:0051270 regulation of cellular component movement
10.93 4.39e-03 GO:0042345 regulation of NF-kappaB import into nucleus
7.41 5.21e-03 GO:0016064 immunoglobulin mediated immune response
7.41 5.21e-03 GO:0060326 cell chemotaxis
2.09 5.59e-03 GO:0010646 regulation of cell communication
7.28 6.09e-03 GO:0019724 B cell mediated immunity
18.87 6.28e-03 GO:0032494 response to peptidoglycan
18.87 6.28e-03 GO:0045191 regulation of isotype switching
10.23 7.12e-03 GO:0046635 positive regulation of alpha-beta T cell activation
2.27 7.62e-03 GO:0031399 regulation of protein modification process
2.94 7.89e-03 GO:0032270 positive regulation of cellular protein metabolic process
12.94 8.06e-03 GO:0043901 negative regulation of multi-organism process
4.29 9.27e-03 GO:0050900 leukocyte migration
2.75 9.66e-03 GO:0008283 cell proliferation
2.31 9.73e-03 GO:0006468 protein phosphorylation
8.05 9.80e-03 GO:0002274 myeloid leukocyte activation
5.42 1.01e-02 GO:0051222 positive regulation of protein transport
1.50 1.03e-02 GO:0080090 regulation of primary metabolic process
3.17 1.08e-02 GO:0031401 positive regulation of protein modification process
12.35 1.09e-02 GO:0032722 positive regulation of chemokine production
12.35 1.09e-02 GO:0046638 positive regulation of alpha-beta T cell differentiation
9.61 1.11e-02 GO:0032663 regulation of interleukin-2 production
7.88 1.16e-02 GO:0042990 regulation of transcription factor import into nucleus
4.85 1.22e-02 GO:0032386 regulation of intracellular transport
4.15 1.36e-02 GO:0009615 response to virus
25.87 1.37e-02 GO:0070234 positive regulation of T cell apoptosis
9.32 1.38e-02 GO:0045638 negative regulation of myeloid cell differentiation
6.57 1.45e-02 GO:0030217 T cell differentiation
6.57 1.45e-02 GO:0060333 interferon-gamma-mediated signaling pathway
2.57 1.46e-02 GO:0044092 negative regulation of molecular function
1.59 1.47e-02 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
4.12 1.47e-02 GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter
3.21 1.52e-02 GO:0040012 regulation of locomotion
16.17 1.53e-02 GO:0002286 T cell activation involved in immune response
5.19 1.54e-02 GO:0046822 regulation of nucleocytoplasmic transport
6.47 1.66e-02 GO:0050920 regulation of chemotaxis
9.06 1.69e-02 GO:0032088 negative regulation of NF-kappaB transcription factor activity
3.61 1.86e-02 GO:0043193 positive regulation of gene-specific transcription
45.28 1.88e-02 GO:0071224 cellular response to peptidoglycan
6.37 1.89e-02 GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
7.39 1.90e-02 GO:0051250 negative regulation of lymphocyte activation
2.12 1.94e-02 GO:0031324 negative regulation of cellular metabolic process
2.46 2.18e-02 GO:0050878 regulation of body fluid levels
15.09 2.25e-02 GO:0044126 regulation of growth of symbiont in host
15.09 2.25e-02 GO:0044130 negative regulation of growth of symbiont in host
15.09 2.25e-02 GO:0044144 modulation of growth of symbiont involved in interaction with host
15.09 2.25e-02 GO:0044146 negative regulation of growth of symbiont involved in interaction with host
2.10 2.48e-02 GO:0010605 negative regulation of macromolecule metabolic process
22.64 2.69e-02 GO:0045830 positive regulation of isotype switching
22.64 2.69e-02 GO:0052173 response to defenses of other organism involved in symbiotic interaction
22.64 2.69e-02 GO:0052200 response to host defenses
22.64 2.69e-02 GO:0070230 positive regulation of lymphocyte apoptosis
22.64 2.69e-02 GO:0075136 response to host
22.64 2.69e-02 GO:2000108 positive regulation of leukocyte apoptosis
8.34 2.99e-02 GO:0046634 regulation of alpha-beta T cell activation
5.99 3.14e-02 GO:0071346 cellular response to interferon-gamma
14.15 3.22e-02 GO:0032735 positive regulation of interleukin-12 production
14.15 3.22e-02 GO:0043903 regulation of symbiosis, encompassing mutualism through parasitism
2.84 3.38e-02 GO:0044419 interspecies interaction between organisms
3.44 3.42e-02 GO:0048011 nerve growth factor receptor signaling pathway
6.84 3.45e-02 GO:0002761 regulation of myeloid leukocyte differentiation
2.83 3.53e-02 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
4.06 3.58e-02 GO:0030335 positive regulation of cell migration
4.06 3.58e-02 GO:2000147 positive regulation of cell motility
2.30 3.70e-02 GO:0010558 negative regulation of macromolecule biosynthetic process
10.06 3.93e-02 GO:0032729 positive regulation of interferon-gamma production
2.10 4.02e-02 GO:0040011 locomotion
2.52 4.18e-02 GO:0007596 blood coagulation
2.52 4.18e-02 GO:0050817 coagulation
2.37 4.19e-02 GO:0042060 wound healing
13.32 4.48e-02 GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
13.32 4.48e-02 GO:0032660 regulation of interleukin-17 production
6.59 4.56e-02 GO:0019882 antigen processing and presentation
2.02 4.57e-02 GO:0032774 RNA biosynthetic process
2.51 4.67e-02 GO:0007599 hemostasis
2.20 4.71e-02 GO:0012501 programmed cell death
20.12 4.75e-02 GO:0045911 positive regulation of DNA recombination
2.24 4.76e-02 GO:0009890 negative regulation of biosynthetic process
2.62 4.98e-02 GO:0032583 regulation of gene-specific transcription

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
2.80 6.67e-08 GO:0005615 extracellular space
2.34 4.34e-06 GO:0044421 extracellular region part
36.22 2.69e-04 GO:0033256 I-kappaB/NF-kappaB complex
4.60 5.38e-04 GO:0009897 external side of plasma membrane
1.44 1.08e-03 GO:0071944 cell periphery
5.66 2.40e-03 GO:0009898 internal side of plasma membrane
1.43 2.52e-03 GO:0005886 plasma membrane
1.65 4.17e-03 GO:0005829 cytosol
1.62 4.42e-03 GO:0044459 plasma membrane part
2.73 5.22e-03 GO:0009986 cell surface
1.64 5.71e-03 GO:0005576 extracellular region
4.06 9.97e-03 GO:0043235 receptor complex
12.94 4.59e-02 GO:0042613 MHC class II protein complex

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
1.44 5.85e-10 GO:0005515 protein binding
5.79 3.55e-09 GO:0005126 cytokine receptor binding
5.37 1.67e-08 GO:0005125 cytokine activity
10.83 1.05e-06 GO:0008009 chemokine activity
2.42 1.24e-06 GO:0005102 receptor binding
9.77 3.38e-06 GO:0042379 chemokine receptor binding
11.32 3.42e-06 GO:0003823 antigen binding
4.48 8.20e-05 GO:0001664 G-protein-coupled receptor binding
7.28 1.02e-03 GO:0004896 cytokine receptor activity
5.03 1.39e-03 GO:0019955 cytokine binding
2.00 5.76e-03 GO:0001071 nucleic acid binding transcription factor activity
2.00 5.76e-03 GO:0003700 sequence-specific DNA binding transcription factor activity
13.32 7.51e-03 GO:0043027 caspase inhibitor activity
3.36 1.32e-02 GO:0000975 regulatory region DNA binding
3.36 1.32e-02 GO:0001067 regulatory region nucleic acid binding
3.36 1.32e-02 GO:0044212 transcription regulatory region DNA binding
11.92 1.36e-02 GO:0005164 tumor necrosis factor receptor binding
1.60 1.92e-02 GO:0004871 signal transducer activity
1.60 1.92e-02 GO:0060089 molecular transducer activity
3.27 3.21e-02 GO:0010843 promoter binding