Motif ID: NFKB1_REL_RELA.p2

Z-value: 3.109


Transcription factors associated with NFKB1_REL_RELA.p2:

Gene SymbolEntrez IDGene Name
NFKB1 4790 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
REL 5966 v-rel reticuloendotheliosis viral oncogene homolog (avian)
RELA 5970 v-rel reticuloendotheliosis viral oncogene homolog A (avian)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NFKB1hg19_v1_chr4_+_103422730_1034227940.646.8e-05Click!
RELhg19_v1_chr2_+_61108775_611087990.593.6e-04Click!
RELAhg19_v1_chr11_-_65430427_654304550.494.9e-03Click!


Activity profile for motif NFKB1_REL_RELA.p2.

activity profile for motif NFKB1_REL_RELA.p2


Sorted Z-values histogram for motif NFKB1_REL_RELA.p2

Sorted Z-values for motif NFKB1_REL_RELA.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFKB1_REL_RELA.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_219745243 8.672 NM_025216
 WNT10A
wingless-type MMTV integration site family, member 10A
chr19_+_42381189 8.654 NM_001783
NM_021601
 CD79A

CD79a molecule, immunoglobulin-associated alpha

chr19_+_35940616 7.362 NM_005306
 FFAR2
free fatty acid receptor 2
chr19_-_41859519 7.265 TGFB1
transforming growth factor, beta 1
chr19_-_41859830 6.733 NM_000660
 TGFB1
transforming growth factor, beta 1
chr19_-_41859332 6.707 TGFB1
transforming growth factor, beta 1
chr22_+_22764094 6.632


chr22_+_23134980 6.392


chr17_-_34207308 6.289 NM_002985
 CCL5
chemokine (C-C motif) ligand 5
chr22_-_37545944 6.044 NM_000878
 IL2RB
interleukin 2 receptor, beta
chr19_+_50922194 5.884 NM_001243998
NM_001243999
NM_001244000
NM_003121
 SPIB



Spi-B transcription factor (Spi-1/PU.1 related)



chr22_-_37640287 5.691 NM_002872
 RAC2
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr11_+_102188180 5.666 NM_001165
NM_182962
 BIRC3

baculoviral IAP repeat containing 3

chr22_-_37640187 5.595 RAC2
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr1_-_202130677 5.461 NM_001199797
NM_002832
 PTPN7

protein tyrosine phosphatase, non-receptor type 7

chr14_-_96180402 5.418 NM_001098725
NM_021966
 TCL1A

T-cell leukemia/lymphoma 1A

chr19_-_41859767 5.391 TGFB1
transforming growth factor, beta 1
chr4_-_76944585 5.389 NM_001565
 CXCL10
chemokine (C-X-C motif) ligand 10
chr20_+_814355 5.331 NM_001042353
 FAM110A
family with sequence similarity 110, member A
chr10_+_104155431 5.264 NM_002502
 NFKB2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 299 entries
Enrichment   P-value GO Accession GO Term
45.28 4.12e-04 GO:0045630 positive regulation of T-helper 2 cell differentiation
45.28 1.88e-02 GO:0071224 cellular response to peptidoglycan
36.22 2.02e-03 GO:0045628 regulation of T-helper 2 cell differentiation
32.34 1.83e-04 GO:0045624 positive regulation of T-helper cell differentiation
31.69 4.86e-07 GO:0002828 regulation of type 2 immune response
25.87 1.37e-02 GO:0070234 positive regulation of T cell apoptosis
22.64 1.62e-04 GO:0043372 positive regulation of CD4-positive, alpha-beta T cell differentiation
22.64 1.62e-04 GO:0045622 regulation of T-helper cell differentiation
22.64 1.62e-04 GO:2000516 positive regulation of CD4-positive, alpha-beta T cell activation
22.64 2.69e-02 GO:0045830 positive regulation of isotype switching
22.64 2.69e-02 GO:0052173 response to defenses of other organism involved in symbiotic interaction
22.64 2.69e-02 GO:0052200 response to host defenses
22.64 2.69e-02 GO:0070230 positive regulation of lymphocyte apoptosis
22.64 2.69e-02 GO:0075136 response to host
22.64 2.69e-02 GO:2000108 positive regulation of leukocyte apoptosis
20.12 4.75e-02 GO:0045911 positive regulation of DNA recombination
18.87 6.28e-03 GO:0032494 response to peptidoglycan
18.87 6.28e-03 GO:0045191 regulation of isotype switching
18.64 6.88e-05 GO:0043370 regulation of CD4-positive, alpha-beta T cell differentiation
18.64 6.88e-05 GO:2000514 regulation of CD4-positive, alpha-beta T cell activation

Gene overrepresentation in compartment category:

Showing 1 to 13 of 13 entries
Enrichment   P-value GO Accession GO Term
36.22 2.69e-04 GO:0033256 I-kappaB/NF-kappaB complex
12.94 4.59e-02 GO:0042613 MHC class II protein complex
5.66 2.40e-03 GO:0009898 internal side of plasma membrane
4.60 5.38e-04 GO:0009897 external side of plasma membrane
4.06 9.97e-03 GO:0043235 receptor complex
2.80 6.67e-08 GO:0005615 extracellular space
2.73 5.22e-03 GO:0009986 cell surface
2.34 4.34e-06 GO:0044421 extracellular region part
1.65 4.17e-03 GO:0005829 cytosol
1.64 5.71e-03 GO:0005576 extracellular region
1.62 4.42e-03 GO:0044459 plasma membrane part
1.44 1.08e-03 GO:0071944 cell periphery
1.43 2.52e-03 GO:0005886 plasma membrane

Gene overrepresentation in function category:

Showing 1 to 20 of 20 entries
Enrichment   P-value GO Accession GO Term
13.32 7.51e-03 GO:0043027 caspase inhibitor activity
11.92 1.36e-02 GO:0005164 tumor necrosis factor receptor binding
11.32 3.42e-06 GO:0003823 antigen binding
10.83 1.05e-06 GO:0008009 chemokine activity
9.77 3.38e-06 GO:0042379 chemokine receptor binding
7.28 1.02e-03 GO:0004896 cytokine receptor activity
5.79 3.55e-09 GO:0005126 cytokine receptor binding
5.37 1.67e-08 GO:0005125 cytokine activity
5.03 1.39e-03 GO:0019955 cytokine binding
4.48 8.20e-05 GO:0001664 G-protein-coupled receptor binding
3.36 1.32e-02 GO:0000975 regulatory region DNA binding
3.36 1.32e-02 GO:0001067 regulatory region nucleic acid binding
3.36 1.32e-02 GO:0044212 transcription regulatory region DNA binding
3.27 3.21e-02 GO:0010843 promoter binding
2.42 1.24e-06 GO:0005102 receptor binding
2.00 5.76e-03 GO:0001071 nucleic acid binding transcription factor activity
2.00 5.76e-03 GO:0003700 sequence-specific DNA binding transcription factor activity
1.60 1.92e-02 GO:0004871 signal transducer activity
1.60 1.92e-02 GO:0060089 molecular transducer activity
1.44 5.85e-10 GO:0005515 protein binding