Motif ID: NHLH1,2.p2

Z-value: 1.844


Transcription factors associated with NHLH1,2.p2:

Gene SymbolEntrez IDGene Name
NHLH1 4807 nescient helix loop helix 1
NHLH2 4808 nescient helix loop helix 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NHLH2hg19_v1_chr1_+_116380404_1163805100.569.5e-04Click!
NHLH1hg19_v1_chr1_+_160336856_1603368730.318.7e-02Click!


Activity profile for motif NHLH1,2.p2.

activity profile for motif NHLH1,2.p2


Sorted Z-values histogram for motif NHLH1,2.p2

Sorted Z-values for motif NHLH1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NHLH1,2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_+_330605 5.496 NM_001176
 ARHGDIG
Rho GDP dissociation inhibitor (GDI) gamma
chr2_+_79740059 4.440 NM_001164883
NM_004389
 CTNNA2

catenin (cadherin-associated protein), alpha 2

chr7_-_137531585 4.211 NM_004717
 DGKI
diacylglycerol kinase, iota
chr2_-_230579198 4.142 NM_139072
 DNER
delta/notch-like EGF repeat containing
chr5_-_136834231 3.815 SPOCK1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
chr2_+_79740171 3.774 CTNNA2
catenin (cadherin-associated protein), alpha 2
chrX_+_153046422 3.518 NM_001170760
NM_001170761
NM_014370
 SRPK3


SRSF protein kinase 3


chr19_+_35521591 3.348 NM_001037
NM_199037
 SCN1B

sodium channel, voltage-gated, type I, beta

chr3_-_195306274 3.233 APOD
apolipoprotein D
chr3_-_62860561 3.061


chr8_-_24772229 2.997 NEFM
neurofilament, medium polypeptide
chr8_+_24771276 2.745 NEFM
neurofilament, medium polypeptide
chr1_+_236849753 2.736 NM_001103
 ACTN2
actinin, alpha 2
chr19_-_49944613 2.690 NM_020309
 SLC17A7
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7
chr17_+_7554415 2.629 ATP1B2
ATPase, Na+/K+ transporting, beta 2 polypeptide
chr6_+_124125068 2.603 NM_001040214
NM_153355
 NKAIN2

Na+/K+ transporting ATPase interacting 2

chr6_-_105584982 2.588 NM_001199563
 BVES
blood vessel epicardial substance
chr6_+_150464156 2.585 NM_030949
 PPP1R14C
protein phosphatase 1, regulatory (inhibitor) subunit 14C
chr5_-_136834418 2.565 SPOCK1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
chr4_-_168155691 2.512 SPOCK3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 11 of 11 entries
Enrichment   P-value GO Accession GO Term
45.89 1.62e-02 GO:0060052 neurofilament cytoskeleton organization
5.30 4.80e-08 GO:0007268 synaptic transmission
4.72 4.68e-07 GO:0019226 transmission of nerve impulse
4.72 4.68e-07 GO:0035637 multicellular organismal signaling
3.35 7.85e-05 GO:0007267 cell-cell signaling
2.91 1.38e-07 GO:0007399 nervous system development
2.53 1.25e-02 GO:0007154 cell communication
1.84 4.64e-03 GO:0048731 system development
1.69 1.46e-02 GO:0007275 multicellular organismal development
1.69 4.27e-02 GO:0048856 anatomical structure development
1.61 3.57e-04 GO:0032501 multicellular organismal process

Gene overrepresentation in compartment category:

Showing 1 to 19 of 19 entries
Enrichment   P-value GO Accession GO Term
39.34 7.10e-03 GO:0005883 neurofilament
34.42 1.13e-02 GO:0060053 neurofilament cytoskeleton
7.50 1.93e-03 GO:0030017 sarcomere
7.39 7.55e-03 GO:0008021 synaptic vesicle
7.25 2.96e-02 GO:0033267 axon part
7.13 8.27e-04 GO:0030016 myofibril
6.72 1.34e-03 GO:0043292 contractile fiber
6.50 5.46e-03 GO:0044449 contractile fiber part
5.86 1.75e-04 GO:0030425 dendrite
5.45 6.92e-09 GO:0045202 synapse
5.10 1.82e-05 GO:0044456 synapse part
4.97 3.64e-02 GO:0045211 postsynaptic membrane
4.42 1.60e-02 GO:0034702 ion channel complex
4.32 3.53e-05 GO:0043005 neuron projection
3.89 2.20e-06 GO:0030054 cell junction
2.36 3.92e-02 GO:0042995 cell projection
2.24 8.35e-04 GO:0005856 cytoskeleton
1.51 3.55e-02 GO:0071944 cell periphery
1.51 4.26e-02 GO:0005886 plasma membrane

Gene overrepresentation in function category:

Showing 1 to 15 of 15 entries
Enrichment   P-value GO Accession GO Term
27.54 2.87e-02 GO:0030276 clathrin binding
25.04 3.92e-02 GO:0017075 syntaxin-1 binding
18.36 1.15e-02 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
13.60 3.92e-02 GO:0019905 syntaxin binding
7.76 2.45e-02 GO:0005200 structural constituent of cytoskeleton
5.83 1.43e-02 GO:0005267 potassium channel activity
4.58 2.21e-04 GO:0022836 gated channel activity
4.42 4.28e-02 GO:0005244 voltage-gated ion channel activity
4.42 4.28e-02 GO:0022832 voltage-gated channel activity
3.83 3.10e-02 GO:0005261 cation channel activity
3.62 3.83e-03 GO:0005216 ion channel activity
3.56 4.60e-03 GO:0022838 substrate-specific channel activity
3.46 6.54e-03 GO:0015267 channel activity
3.45 6.73e-03 GO:0022803 passive transmembrane transporter activity
2.86 3.38e-02 GO:0008092 cytoskeletal protein binding