Motif ID: NHLH1,2.p2

Z-value: 1.844


Transcription factors associated with NHLH1,2.p2:

Gene SymbolEntrez IDGene Name
NHLH1 4807 nescient helix loop helix 1
NHLH2 4808 nescient helix loop helix 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NHLH2hg19_v1_chr1_+_116380404_1163805100.569.5e-04Click!
NHLH1hg19_v1_chr1_+_160336856_1603368730.318.7e-02Click!


Activity profile for motif NHLH1,2.p2.

activity profile for motif NHLH1,2.p2


Sorted Z-values histogram for motif NHLH1,2.p2

Sorted Z-values for motif NHLH1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NHLH1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr16_+_330605 5.496 NM_001176
ARHGDIG
Rho GDP dissociation inhibitor (GDI) gamma
chr2_+_79740059 4.440 NM_001164883
NM_004389
CTNNA2

catenin (cadherin-associated protein), alpha 2

chr7_-_137531585 4.211 NM_004717
DGKI
diacylglycerol kinase, iota
chr2_-_230579198 4.142 NM_139072
DNER
delta/notch-like EGF repeat containing
chr5_-_136834231 3.815 SPOCK1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
chr2_+_79740171 3.774 CTNNA2
catenin (cadherin-associated protein), alpha 2
chrX_+_153046422 3.518 NM_001170760
NM_001170761
NM_014370
SRPK3


SRSF protein kinase 3


chr19_+_35521591 3.348 NM_001037
NM_199037
SCN1B

sodium channel, voltage-gated, type I, beta

chr3_-_195306274 3.233 APOD
apolipoprotein D
chr3_-_62860561 3.061


chr8_-_24772229 2.997 NEFM
neurofilament, medium polypeptide
chr8_+_24771276 2.745 NEFM
neurofilament, medium polypeptide
chr1_+_236849753 2.736 NM_001103
ACTN2
actinin, alpha 2
chr19_-_49944613 2.690 NM_020309
SLC17A7
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7
chr17_+_7554415 2.629 ATP1B2
ATPase, Na+/K+ transporting, beta 2 polypeptide
chr6_+_124125068 2.603 NM_001040214
NM_153355
NKAIN2

Na+/K+ transporting ATPase interacting 2

chr6_-_105584982 2.588 NM_001199563
BVES
blood vessel epicardial substance
chr6_+_150464156 2.585 NM_030949
PPP1R14C
protein phosphatase 1, regulatory (inhibitor) subunit 14C
chr5_-_136834418 2.565 SPOCK1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
chr4_-_168155691 2.512 SPOCK3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chr19_-_6502224 2.496 NM_006087
TUBB4A
tubulin, beta 4A class IVa
chr3_-_62861012 2.477 NM_003716
NM_183393
NM_183394
CADPS


Ca++-dependent secretion activator


chr8_+_24771268 2.467 NM_005382
NEFM
neurofilament, medium polypeptide
chr3_-_73673978 2.440 NM_015009
PDZRN3
PDZ domain containing ring finger 3
chr5_+_137774632 2.415 NM_016606
REEP2
receptor accessory protein 2
chr3_-_133614296 2.315 RAB6B
RAB6B, member RAS oncogene family
chr12_-_50297575 2.283 NM_012306
FAIM2
Fas apoptotic inhibitory molecule 2
chr9_-_111929489 2.202 NM_014334
C9orf4
chromosome 9 open reading frame 4
chr1_+_233749749 2.197 NM_002245
KCNK1
potassium channel, subfamily K, member 1
chr11_-_35547144 2.189 NM_001001991
NM_015430
PAMR1

peptidase domain containing associated with muscle regeneration 1

chr19_-_17559375 2.170 NM_001190844
TMEM221
transmembrane protein 221
chr2_-_241759627 2.124 NM_001244008
NM_004321
KIF1A

kinesin family member 1A

chr19_+_18723666 2.123 NM_012109
TMEM59L
transmembrane protein 59-like
chr16_-_30042123 2.050 NM_031478
FAM57B
family with sequence similarity 57, member B
chr11_-_63933493 2.018 NM_014067
MACROD1
MACRO domain containing 1
chr3_+_159943628 1.998 C3orf80
chromosome 3 open reading frame 80
chr6_-_105584542 1.977 NM_007073
BVES
blood vessel epicardial substance
chr2_+_25264913 1.973 NM_014971
EFR3B
EFR3 homolog B (S. cerevisiae)
chr11_-_40315663 1.968 NM_020929
LRRC4C
leucine rich repeat containing 4C
chr18_-_74691951 1.936 MBP
myelin basic protein
chr4_+_176987148 1.928 WDR17
WD repeat domain 17
chr15_-_102264611 1.912 NM_152334
TARSL2
threonyl-tRNA synthetase-like 2
chr15_+_75118950 1.910 NM_001030005
CPLX3
complexin 3
chr19_-_42569921 1.906 NM_002088
GRIK5
glutamate receptor, ionotropic, kainate 5
chr8_-_22014263 1.903 NM_139278
LGI3
leucine-rich repeat LGI family, member 3
chr9_+_134165075 1.902 NM_032728
PPAPDC3
phosphatidic acid phosphatase type 2 domain containing 3
chr2_-_193059599 1.898 NM_016192
TMEFF2
transmembrane protein with EGF-like and two follistatin-like domains 2
chr6_+_29624757 1.889 NM_001008228
NM_001008229
NM_001170418
NM_002433
NM_206809
NM_206810
NM_206811
NM_206812
NM_206814
MOG








myelin oligodendrocyte glycoprotein








chr3_-_149688886 1.885 PFN2
profilin 2
chr4_-_186697065 1.875 NM_001145673
SORBS2
sorbin and SH3 domain containing 2
chr17_+_80693398 1.874 NM_022158
FN3K
fructosamine 3 kinase
chr3_-_12200339 1.847 TIMP4
TIMP metallopeptidase inhibitor 4
chrX_+_12156584 1.841 NM_014728
FRMPD4
FERM and PDZ domain containing 4
chr8_+_56015013 1.836 NM_052898
XKR4
XK, Kell blood group complex subunit-related family, member 4
chr11_+_107462073 1.833 ELMOD1
ELMO/CED-12 domain containing 1
chr10_+_88428263 1.830 NM_001080116
NM_001080114
NM_001080115
NM_001171611
NM_007078
LDB3




LIM domain binding 3




chr5_-_136834887 1.829 NM_004598
SPOCK1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
chr1_+_77747727 1.828 AK5
adenylate kinase 5
chr3_-_133614421 1.824 NM_016577
RAB6B
RAB6B, member RAS oncogene family
chr12_-_104234783 1.790 NT5DC3
5'-nucleotidase domain containing 3
chr3_+_159481880 1.787 SCHIP1
schwannomin interacting protein 1
chr18_+_33877630 1.784 NM_025135
FHOD3
formin homology 2 domain containing 3
chr17_-_27949814 1.783 CORO6
coronin 6
chr13_-_114107838 1.781 NM_138430
ADPRHL1
ADP-ribosylhydrolase like 1
chr4_+_2061238 1.781 NM_178557
NAT8L
N-acetyltransferase 8-like (GCN5-related, putative)
chr9_-_72287097 1.771 NM_001163
APBA1
amyloid beta (A4) precursor protein-binding, family A, member 1
chr2_+_155555092 1.767 NM_002239
KCNJ3
potassium inwardly-rectifying channel, subfamily J, member 3
chr17_+_70117168 1.761 SOX9
SRY (sex determining region Y)-box 9
chrX_+_23352984 1.756 NM_173495
PTCHD1
patched domain containing 1
chr10_+_105036783 1.752 NM_032727
INA
internexin neuronal intermediate filament protein, alpha
chr3_-_118753665 1.752 NM_001015887
IGSF11
immunoglobulin superfamily, member 11
chr11_-_790103 1.719 NM_016564
CEND1
cell cycle exit and neuronal differentiation 1
chr6_-_84419108 1.717 NM_001242793
NM_001242794
NM_014841
SNAP91


synaptosomal-associated protein, 91kDa homolog (mouse)


chrX_+_49126326 1.717 PPP1R3F
protein phosphatase 1, regulatory subunit 3F
chr12_-_104234968 1.709 NM_001031701
NT5DC3
5'-nucleotidase domain containing 3
chr21_+_34442550 1.695 OLIG1
oligodendrocyte transcription factor 1
chr2_+_56411123 1.691 NM_001080433
CCDC85A
coiled-coil domain containing 85A
chr5_+_7396030 1.687 NM_020546
ADCY2
adenylate cyclase 2 (brain)
chr4_-_177190258 1.679 NM_080874
ASB5
ankyrin repeat and SOCS box containing 5
chr3_+_12045803 1.674 NM_003178
NM_133625
SYN2

synapsin II

chr11_-_63933204 1.674 MACROD1
MACRO domain containing 1
chr4_-_168155576 1.669 NM_001204353
SPOCK3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chr1_+_46269283 1.667 NM_015112
MAST2
microtubule associated serine/threonine kinase 2
chr1_+_16330730 1.665 NM_178840
C1orf64
chromosome 1 open reading frame 64
chr17_+_70117154 1.662 NM_000346
SOX9
SRY (sex determining region Y)-box 9
chr5_+_113698304 1.655 KCNN2
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
chr9_+_95947211 1.641 NM_006648
WNK2
WNK lysine deficient protein kinase 2
chr14_+_100150596 1.622 NM_006668
CYP46A1
cytochrome P450, family 46, subfamily A, polypeptide 1
chr9_-_35689902 1.609 NM_003289
NM_213674
TPM2

tropomyosin 2 (beta)

chr8_+_85095452 1.602 NM_001100392
NM_001100393
RALYL

RALY RNA binding protein-like

chr1_-_31712733 1.600 NM_024522
NKAIN1
Na+/K+ transporting ATPase interacting 1
chr2_-_178937472 1.596 NM_016953
PDE11A
phosphodiesterase 11A
chr7_+_137531690 1.594


chr9_-_35689799 1.579 TPM2
tropomyosin 2 (beta)
chr3_+_183948216 1.578 NM_138345
VWA5B2
von Willebrand factor A domain containing 5B2
chr10_+_123923104 1.577 NM_006997
NM_206860
TACC2

transforming, acidic coiled-coil containing protein 2

chr1_-_6662681 1.567 KLHL21
kelch-like 21 (Drosophila)
chr13_-_36705432 1.564 DCLK1
doublecortin-like kinase 1
chr14_-_103988829 1.555 CKB
creatine kinase, brain
chr6_-_84419018 1.543 SNAP91
synaptosomal-associated protein, 91kDa homolog (mouse)
chr1_+_233749917 1.538 KCNK1
potassium channel, subfamily K, member 1
chr19_-_35625610 1.532 LGI4
leucine-rich repeat LGI family, member 4
chr1_+_70034029 1.518 LRRC7
leucine rich repeat containing 7
chr22_+_29876180 1.511 NM_021076
NEFH
neurofilament, heavy polypeptide
chr6_-_146056561 1.510 EPM2A
epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
chr14_-_45603658 1.506 FKBP3
FK506 binding protein 3, 25kDa
chr9_-_138591318 1.496 NM_001012415
NM_001101677
SOHLH1

spermatogenesis and oogenesis specific basic helix-loop-helix 1

chr7_+_98246595 1.483 NM_002523
NPTX2
neuronal pentraxin II
chr17_-_17399494 1.481 NM_001199989
NM_016084
RASD1

RAS, dexamethasone-induced 1

chr20_+_10199455 1.480 NM_003081
NM_130811
SNAP25

synaptosomal-associated protein, 25kDa

chr22_-_39239733 1.476


chr8_-_16859540 1.474 NM_019851
FGF20
fibroblast growth factor 20
chr1_-_201438150 1.469 NM_012396
PHLDA3
pleckstrin homology-like domain, family A, member 3
chrX_-_152939256 1.465 PNCK
pregnancy up-regulated non-ubiquitously expressed CaM kinase
chr13_-_36705466 1.460 DCLK1
doublecortin-like kinase 1
chr1_-_144994943 1.460 NM_001002812
NM_014644
NM_001002810
NM_001198834
NM_001195261
PDE4DIP




phosphodiesterase 4D interacting protein




chr14_+_93389491 1.459 CHGA
chromogranin A (parathyroid secretory protein 1)
chr14_-_45603668 1.458 NM_002013
FKBP3
FK506 binding protein 3, 25kDa
chr4_-_8160435 1.452 NM_001130083
NM_001130084
NM_001130085
NM_001130086
NM_001130087
NM_001130088
NM_032432
ABLIM2






actin binding LIM protein family, member 2






chr11_-_125366048 1.444 NM_005103
NM_022549
FEZ1

fasciculation and elongation protein zeta 1 (zygin I)

chr14_-_77737549 1.435 NM_021257
NGB
neuroglobin
chrX_-_13956530 1.433 GPM6B
glycoprotein M6B
chr14_-_91526731 1.432


chr8_-_139509064 1.428 NM_015912
FAM135B
family with sequence similarity 135, member B
chr1_+_202317798 1.427 NM_001167857
NM_001167858
NM_002481
PPP1R12B


protein phosphatase 1, regulatory subunit 12B


chr17_+_70117177 1.421 SOX9
SRY (sex determining region Y)-box 9
chr2_+_233498206 1.418 NM_025202
EFHD1
EF-hand domain family, member D1
chr1_-_33338081 1.414 NM_001171941
FNDC5
fibronectin type III domain containing 5
chr19_+_12949258 1.413 NM_014975
MAST1
microtubule associated serine/threonine kinase 1
chr2_-_102003923 1.411 NM_153836
CREG2
cellular repressor of E1A-stimulated genes 2
chrX_-_13956445 1.403


chrX_-_99665270 1.401 NM_001105243
NM_001184880
NM_020766
PCDH19


protocadherin 19


chr20_-_61885802 1.399 NM_152864
NKAIN4
Na+/K+ transporting ATPase interacting 4
chr13_+_96743092 1.398 NM_153456
HS6ST3
heparan sulfate 6-O-sulfotransferase 3
chr15_-_44487237 1.395 NM_032892
FRMD5
FERM domain containing 5
chr1_-_144994908 1.393 PDE4DIP
phosphodiesterase 4D interacting protein
chr6_-_146056654 1.393 EPM2A
epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
chr4_+_176986984 1.390 NM_170710
NM_181265
WDR17

WD repeat domain 17

chr19_-_45826131 1.387 CKM
creatine kinase, muscle
chr12_+_79258794 1.385 SYT1
synaptotagmin I
chr17_-_15165860 1.383 PMP22
peripheral myelin protein 22
chr1_+_156611874 1.380 BCAN
brevican
chr18_+_11689135 1.380 NM_182978
GNAL
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
chr16_+_58497628 1.377 NDRG4
NDRG family member 4
chr13_-_36705513 1.373 NM_004734
DCLK1
doublecortin-like kinase 1
chr9_-_140444835 1.370 NM_001098537
NM_152286
PNPLA7

patatin-like phospholipase domain containing 7

chr4_+_62066945 1.350 LPHN3
latrophilin 3
chr6_-_46459010 1.346 NM_001251974
RCAN2
regulator of calcineurin 2
chr5_+_74161717 1.345 LOC441086
uncharacterized LOC441086
chr1_-_31712399 1.341 NKAIN1
Na+/K+ transporting ATPase interacting 1
chr12_+_79258588 1.336 SYT1
synaptotagmin I
chr11_+_113930430 1.334 NM_006006
ZBTB16
zinc finger and BTB domain containing 16
chr12_+_79258517 1.325 SYT1
synaptotagmin I
chr19_+_3094528 1.316 GNA11
guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
chr10_+_103348040 1.312 NM_015448
DPCD
deleted in primary ciliary dyskinesia homolog (mouse)
chr1_+_240255171 1.308 NM_020066
FMN2
formin 2
chrX_-_13956644 1.306 NM_001001994
GPM6B
glycoprotein M6B
chr11_-_1619481 1.297 NM_001004325
KRTAP5-2
keratin associated protein 5-2
chr7_-_32110460 1.296 NM_001191056
NM_001191057
PDE1C

phosphodiesterase 1C, calmodulin-dependent 70kDa

chr16_-_4292052 1.292 NM_001098814
SRL
sarcalumenin
chr6_-_84418705 1.291 NM_001242792
SNAP91
synaptosomal-associated protein, 91kDa homolog (mouse)
chr6_+_125474800 1.286 NM_001003396
NM_001003397
NM_003287
TPD52L1


tumor protein D52-like 1


chr22_-_18923654 1.277 PRODH
proline dehydrogenase (oxidase) 1
chr11_+_107461955 1.277 ELMOD1
ELMO/CED-12 domain containing 1
chr16_+_7382750 1.270 NM_145891
NM_145892
NM_145893
RBFOX1


RNA binding protein, fox-1 homolog (C. elegans) 1


chr2_-_11810254 1.268 NM_012344
NTSR2
neurotensin receptor 2
chr17_-_56609387 1.263 NM_080415
NM_080416
SEPT4

septin 4

chr8_+_85095501 1.260 NM_173848
RALYL
RALY RNA binding protein-like
chr22_+_26138110 1.257 NM_032608
MYO18B
myosin XVIIIB
chr12_+_5153084 1.248 NM_002234
KCNA5
potassium voltage-gated channel, shaker-related subfamily, member 5
chr2_+_11052062 1.247 NM_002236
KCNF1
potassium voltage-gated channel, subfamily F, member 1
chr2_-_220436010 1.239 OBSL1
obscurin-like 1
chr5_-_132112887 1.238 NM_001098811
NM_001098812
NM_015146
SEPT8


septin 8


chr19_+_36359346 1.233 NM_001024807
NM_005166
APLP1

amyloid beta (A4) precursor-like protein 1

chr16_+_58497548 1.219 NM_020465
NDRG4
NDRG family member 4
chr3_+_167453431 1.216 NM_001122752
NM_005025
SERPINI1

serpin peptidase inhibitor, clade I (neuroserpin), member 1

chr11_-_18813127 1.212 NM_001039970
NM_006906
NM_032781
PTPN5


protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)


chr13_-_26625164 1.204 NM_001007538
SHISA2
shisa homolog 2 (Xenopus laevis)
chr17_+_47653474 1.200 NXPH3
neurexophilin 3
chr1_-_145039631 1.199 NM_001198832
PDE4DIP
phosphodiesterase 4D interacting protein
chr19_-_46974789 1.198 NM_001103149
NM_018215
PNMAL1

PNMA-like 1

chr8_-_17270800 1.197 MTMR7
myotubularin related protein 7
chrX_+_49126299 1.196 NM_001184745
NM_033215
PPP1R3F

protein phosphatase 1, regulatory subunit 3F

chr4_-_46125929 1.193 NM_173536
GABRG1
gamma-aminobutyric acid (GABA) A receptor, gamma 1
chr16_-_74808474 1.191 FA2H
fatty acid 2-hydroxylase
chr8_+_143545376 1.191 NM_001702
BAI1
brain-specific angiogenesis inhibitor 1
chr8_+_21881587 1.184 NPM2
nucleophosmin/nucleoplasmin 2
chr3_-_118753428 1.181 IGSF11
immunoglobulin superfamily, member 11
chr4_+_95373044 1.179 PDLIM5
PDZ and LIM domain 5
chr19_-_19006868 1.179 NM_021267
NM_198207
NM_001492
CERS1

GDF1
ceramide synthase 1

growth differentiation factor 1
chr6_-_18122850 1.168 NM_198586
NHLRC1
NHL repeat containing 1
chr10_-_133795447 1.167 BNIP3
BCL2/adenovirus E1B 19kDa interacting protein 3
chr4_-_21950373 1.163 NM_147182
KCNIP4
Kv channel interacting protein 4
chr14_-_65346554 1.161 SPTB
spectrin, beta, erythrocytic
chr1_-_21949010 1.158 RAP1GAP
RAP1 GTPase activating protein
chr5_+_43603287 1.156 NNT
nicotinamide nucleotide transhydrogenase
chr11_-_35441501 1.153 NM_001195728
NM_001252652
SLC1A2

solute carrier family 1 (glial high affinity glutamate transporter), member 2

chr6_-_166721870 1.152 NM_175922
PRR18
proline rich 18
chr19_-_4517715 1.152 NM_001080400
PLIN4
perilipin 4
chr4_+_157997181 1.151 NM_000824
NM_001166061
NM_001166060
GLRB


glycine receptor, beta



Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
5.30 4.80e-08 GO:0007268 synaptic transmission
2.91 1.38e-07 GO:0007399 nervous system development
4.72 4.68e-07 GO:0019226 transmission of nerve impulse
4.72 4.68e-07 GO:0035637 multicellular organismal signaling
3.35 7.85e-05 GO:0007267 cell-cell signaling
1.61 3.57e-04 GO:0032501 multicellular organismal process
1.84 4.64e-03 GO:0048731 system development
2.53 1.25e-02 GO:0007154 cell communication
1.69 1.46e-02 GO:0007275 multicellular organismal development
45.89 1.62e-02 GO:0060052 neurofilament cytoskeleton organization
1.69 4.27e-02 GO:0048856 anatomical structure development

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
5.45 6.92e-09 GO:0045202 synapse
3.89 2.20e-06 GO:0030054 cell junction
5.10 1.82e-05 GO:0044456 synapse part
4.32 3.53e-05 GO:0043005 neuron projection
5.86 1.75e-04 GO:0030425 dendrite
7.13 8.27e-04 GO:0030016 myofibril
2.24 8.35e-04 GO:0005856 cytoskeleton
6.72 1.34e-03 GO:0043292 contractile fiber
7.50 1.93e-03 GO:0030017 sarcomere
6.50 5.46e-03 GO:0044449 contractile fiber part
39.34 7.10e-03 GO:0005883 neurofilament
7.39 7.55e-03 GO:0008021 synaptic vesicle
34.42 1.13e-02 GO:0060053 neurofilament cytoskeleton
4.42 1.60e-02 GO:0034702 ion channel complex
7.25 2.96e-02 GO:0033267 axon part
1.51 3.55e-02 GO:0071944 cell periphery
4.97 3.64e-02 GO:0045211 postsynaptic membrane
2.36 3.92e-02 GO:0042995 cell projection
1.51 4.26e-02 GO:0005886 plasma membrane

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
4.58 2.21e-04 GO:0022836 gated channel activity
3.62 3.83e-03 GO:0005216 ion channel activity
3.56 4.60e-03 GO:0022838 substrate-specific channel activity
3.46 6.54e-03 GO:0015267 channel activity
3.45 6.73e-03 GO:0022803 passive transmembrane transporter activity
18.36 1.15e-02 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
5.83 1.43e-02 GO:0005267 potassium channel activity
7.76 2.45e-02 GO:0005200 structural constituent of cytoskeleton
27.54 2.87e-02 GO:0030276 clathrin binding
3.83 3.10e-02 GO:0005261 cation channel activity
2.86 3.38e-02 GO:0008092 cytoskeletal protein binding
25.04 3.92e-02 GO:0017075 syntaxin-1 binding
13.60 3.92e-02 GO:0019905 syntaxin binding
4.42 4.28e-02 GO:0005244 voltage-gated ion channel activity
4.42 4.28e-02 GO:0022832 voltage-gated channel activity