Motif ID: NKX2-1,4.p2

Z-value: 1.030


Transcription factors associated with NKX2-1,4.p2:

Gene SymbolEntrez IDGene Name
NKX2-1 7080 NK2 homeobox 1
NKX2-4 644524 NK2 homeobox 4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NKX2-4hg19_v1_chr20_-_21378046_213781820.261.6e-01Click!
NKX2-1hg19_v1_chr14_-_36989333_369894290.086.8e-01Click!


Activity profile for motif NKX2-1,4.p2.

activity profile for motif NKX2-1,4.p2


Sorted Z-values histogram for motif NKX2-1,4.p2

Sorted Z-values for motif NKX2-1,4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-1,4.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_103340335 4.655 NM_001018116
 MURC
muscle-related coiled-coil protein
chr1_+_228395740 3.930 NM_001098623
NM_052843
 OBSCN

obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF

chrX_+_78200828 3.451 NM_014499
NM_198333
 P2RY10

purinergic receptor P2Y, G-protein coupled, 10

chr11_-_19223516 2.932 NM_001127656
NM_003476
 CSRP3

cysteine and glycine-rich protein 3 (cardiac LIM protein)

chr4_+_110834039 2.476 NM_001178130
NM_001178131
NM_001963
 EGF


epidermal growth factor


chr22_-_36019363 2.186 NM_203377
 MB
myoglobin
chr17_-_10452939 2.131 NM_001100112
NM_017534
 MYH2

myosin, heavy chain 2, skeletal muscle, adult

chr8_+_7705401 1.918 NM_058203
NM_001081552
 SPAG11B
SPAG11A
sperm associated antigen 11B
sperm associated antigen 11A
chr10_+_69869249 1.886 NM_032578
 MYPN
myopalladin
chr21_+_38792600 1.832 NM_130438
NM_001396
 DYRK1A

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A

chr19_-_55668956 1.811 NM_000363
 TNNI3
troponin I type 3 (cardiac)
chr2_+_29038862 1.742 NM_001008779
 SPDYA
speedy homolog A (Xenopus laevis)
chr17_+_7905911 1.678 NM_000180
 GUCY2D
guanylate cyclase 2D, membrane (retina-specific)
chr1_-_144994839 1.659 PDE4DIP
phosphodiesterase 4D interacting protein
chr20_+_44350987 1.626 NM_178455
 SPINT4
serine peptidase inhibitor, Kunitz type 4
chr5_-_88119604 1.571 NM_001193348
NM_001193349
 MEF2C

myocyte enhancer factor 2C

chr12_-_7848324 1.539 NM_020634
 GDF3
growth differentiation factor 3
chr11_+_60223281 1.539 NM_021950
NM_152866
 MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr2_+_168043792 1.533 NM_001199144
NM_001199145
 XIRP2

xin actin-binding repeat containing 2

chr7_+_129847699 1.455 NM_145268
 C7orf45
chromosome 7 open reading frame 45

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 1 of 1 entries
Enrichment   P-value GO Accession GO Term
24.71 4.47e-03 GO:0042113 B cell activation

Gene overrepresentation in compartment category:

Showing 1 to 6 of 6 entries
Enrichment   P-value GO Accession GO Term
35.11 4.59e-03 GO:0030018 Z disc
30.67 7.78e-09 GO:0030016 myofibril
28.93 1.25e-08 GO:0043292 contractile fiber
27.80 9.26e-03 GO:0031674 I band
27.23 3.97e-06 GO:0030017 sarcomere
23.62 9.31e-06 GO:0044449 contractile fiber part

Nothing significant found in function category.