Motif ID: NKX2-1,4.p2

Z-value: 1.030


Transcription factors associated with NKX2-1,4.p2:

Gene SymbolEntrez IDGene Name
NKX2-1 7080 NK2 homeobox 1
NKX2-4 644524 NK2 homeobox 4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NKX2-4hg19_v1_chr20_-_21378046_213781820.261.6e-01Click!
NKX2-1hg19_v1_chr14_-_36989333_369894290.086.8e-01Click!


Activity profile for motif NKX2-1,4.p2.

activity profile for motif NKX2-1,4.p2


Sorted Z-values histogram for motif NKX2-1,4.p2

Sorted Z-values for motif NKX2-1,4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-1,4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_+_103340335 4.655 NM_001018116
MURC
muscle-related coiled-coil protein
chr1_+_228395740 3.930 NM_001098623
NM_052843
OBSCN

obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF

chrX_+_78200828 3.451 NM_014499
NM_198333
P2RY10

purinergic receptor P2Y, G-protein coupled, 10

chr11_-_19223516 2.932 NM_001127656
NM_003476
CSRP3

cysteine and glycine-rich protein 3 (cardiac LIM protein)

chr4_+_110834039 2.476 NM_001178130
NM_001178131
NM_001963
EGF


epidermal growth factor


chr22_-_36019363 2.186 NM_203377
MB
myoglobin
chr17_-_10452939 2.131 NM_001100112
NM_017534
MYH2

myosin, heavy chain 2, skeletal muscle, adult

chr8_+_7705401 1.918 NM_058203
NM_001081552
SPAG11B
SPAG11A
sperm associated antigen 11B
sperm associated antigen 11A
chr10_+_69869249 1.886 NM_032578
MYPN
myopalladin
chr21_+_38792600 1.832 NM_130438
NM_001396
DYRK1A

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A

chr19_-_55668956 1.811 NM_000363
TNNI3
troponin I type 3 (cardiac)
chr2_+_29038862 1.742 NM_001008779
SPDYA
speedy homolog A (Xenopus laevis)
chr17_+_7905911 1.678 NM_000180
GUCY2D
guanylate cyclase 2D, membrane (retina-specific)
chr1_-_144994839 1.659 PDE4DIP
phosphodiesterase 4D interacting protein
chr20_+_44350987 1.626 NM_178455
SPINT4
serine peptidase inhibitor, Kunitz type 4
chr5_-_88119604 1.571 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr12_-_7848324 1.539 NM_020634
GDF3
growth differentiation factor 3
chr11_+_60223281 1.539 NM_021950
NM_152866
MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr2_+_168043792 1.533 NM_001199144
NM_001199145
XIRP2

xin actin-binding repeat containing 2

chr7_+_129847699 1.455 NM_145268
C7orf45
chromosome 7 open reading frame 45
chr15_-_83474805 1.438 NM_001007122
FSD2
fibronectin type III and SPRY domain containing 2
chr5_-_131879172 1.373 NM_000879
IL5
interleukin 5 (colony-stimulating factor, eosinophil)
chr10_+_70980058 1.365 NM_025130
HKDC1
hexokinase domain containing 1
chr16_+_12058963 1.360 NM_001192
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr1_-_217250230 1.350 NM_001243507
NM_001243509
ESRRG

estrogen-related receptor gamma

chr8_-_7321028 1.345 NM_016512
NM_058200
NM_058201
NM_058202
NM_058203
SPAG11B




sperm associated antigen 11B




chr10_-_32667543 1.242 EPC1
enhancer of polycomb homolog 1 (Drosophila)
chr22_-_29457793 1.239 NM_015370
C22orf31
chromosome 22 open reading frame 31
chr1_-_144994908 1.238 PDE4DIP
phosphodiesterase 4D interacting protein
chr19_+_4769144 1.221 MIR7-3HG
MIR7-3 host gene (non-protein coding)
chr11_+_118754474 1.206 NM_001716
CXCR5
chemokine (C-X-C motif) receptor 5
chr17_-_42976774 1.202 EFTUD2
elongation factor Tu GTP binding domain containing 2
chr6_+_101846668 1.201 GRIK2
glutamate receptor, ionotropic, kainate 2
chrX_+_129139163 1.184 NM_021946
BCORL1
BCL6 corepressor-like 1
chr4_+_102734982 1.179 NM_001083907
BANK1
B-cell scaffold protein with ankyrin repeats 1
chr4_+_74719012 1.172 NM_002620
PF4V1
platelet factor 4 variant 1
chr8_-_30706532 1.167 NM_031271
TEX15
testis expressed 15
chr6_-_119031230 1.154 NM_001178035
CEP85L
centrosomal protein 85kDa-like
chr17_-_42976792 1.153 EFTUD2
elongation factor Tu GTP binding domain containing 2
chr1_-_160492982 1.142 NM_001184714
NM_001184715
NM_001184716
NM_052931
SLAMF6



SLAM family member 6



chr1_-_144994943 1.108 NM_001002812
NM_014644
NM_001002810
NM_001198834
NM_001195261
PDE4DIP




phosphodiesterase 4D interacting protein




chr15_-_31523049 1.106 NM_001243538
LOC283710
uncharacterized LOC283710
chr17_-_42976825 1.096 EFTUD2
elongation factor Tu GTP binding domain containing 2
chr20_+_4702499 1.091 NM_012409
PRND
prion protein 2 (dublet)
chr13_-_103346847 1.062 NM_001010977
METTL21C
methyltransferase like 21C
chr10_-_115423640 1.045 NM_006175
NM_198060
NRAP

nebulin-related anchoring protein

chr2_+_179184970 1.020 NM_145739
OSBPL6
oxysterol binding protein-like 6
chr2_-_217724781 1.011 NM_003284
TNP1
transition protein 1 (during histone to protamine replacement)
chr16_+_58010338 1.009 NM_199046
NM_199456
TEPP

testis, prostate and placenta expressed

chr14_-_95599794 0.980 NM_001195573
DICER1
dicer 1, ribonuclease type III
chr14_+_64682671 0.971 NM_182910
SYNE2
spectrin repeat containing, nuclear envelope 2
chr2_+_162272619 0.969 NM_006593
TBR1
T-box, brain, 1
chr3_+_68053358 0.959 NM_213609
FAM19A1
family with sequence similarity 19 (chemokine (C-C motif)-like), member A1
chr12_-_102591547 0.957 NM_002674
PMCH
pro-melanin-concentrating hormone
chr17_+_65908038 0.939 BPTF
bromodomain PHD finger transcription factor
chr1_-_179833581 0.889


chr1_+_158323485 0.877 NM_001042583
NM_001042584
NM_001042585
NM_001042586
NM_001042587
NM_001185107
NM_001185108
NM_001185110
NM_001185112
NM_001185113
NM_001185114
NM_001185115
NM_030893
CD1E












CD1e molecule












chr2_+_170366211 0.873 NM_006063
KBTBD10
kelch repeat and BTB (POZ) domain containing 10
chr17_-_29641094 0.870 NM_006495
EVI2B
ecotropic viral integration site 2B
chr10_-_76868853 0.856 NM_001007271
NM_001007272
NM_001007273
DUSP13


dual specificity phosphatase 13


chr1_-_157746863 0.826 NM_030764
FCRL2
Fc receptor-like 2
chr5_-_134782797 0.823 NM_130848
C5orf20
chromosome 5 open reading frame 20
chr1_+_84864214 0.798 NM_021233
DNASE2B
deoxyribonuclease II beta
chr1_-_8003224 0.791 NM_001561
TNFRSF9
tumor necrosis factor receptor superfamily, member 9
chr3_-_51996855 0.790 NM_033010
PCBP4
poly(rC) binding protein 4
chr7_-_115608366 0.785 NM_001244583
TFEC
transcription factor EC
chr16_+_76343734 0.772 NM_138994
CNTNAP4
contactin associated protein-like 4
chr1_-_26393984 0.770 NM_032588
TRIM63
tripartite motif containing 63
chr2_-_192015751 0.768 STAT4
signal transducer and activator of transcription 4
chr16_+_28943259 0.761 NM_001178098
NM_001770
CD19

CD19 molecule

chr1_+_165513439 0.754 NM_001005214
LRRC52
leucine rich repeat containing 52
chr5_+_156820161 0.748 CYFIP2
cytoplasmic FMR1 interacting protein 2
chr17_-_42976843 0.735 NM_001142605
NM_004247
EFTUD2

elongation factor Tu GTP binding domain containing 2

chr3_+_189349215 0.722 NM_001114978
NM_001114979
NM_003722
TP63


tumor protein p63


chr4_-_123377471 0.708 NM_000586
IL2
interleukin 2
chr10_-_75335415 0.708 NM_152586
USP54
ubiquitin specific peptidase 54
chr9_+_131445933 0.707 NM_001122821
SET
SET nuclear oncogene
chr15_-_42749710 0.691 NM_022473
ZFP106
zinc finger protein 106 homolog (mouse)
chr10_-_69455926 0.686 NM_013266
CTNNA3
catenin (cadherin-associated protein), alpha 3
chr2_-_192015733 0.685 STAT4
signal transducer and activator of transcription 4
chrX_-_132162297 0.680 NM_031907
USP26
ubiquitin specific peptidase 26
chr7_-_113559048 0.679 NM_002711
PPP1R3A
protein phosphatase 1, regulatory subunit 3A
chr17_+_67498391 0.673 MAP2K6
mitogen-activated protein kinase kinase 6
chr2_+_207406815 0.667 ADAM23
ADAM metallopeptidase domain 23
chr2_-_192016293 0.661 NM_001243835
STAT4
signal transducer and activator of transcription 4
chr9_-_3223007 0.661


chr1_+_32716839 0.650 NM_005356
LCK
lymphocyte-specific protein tyrosine kinase
chrX_+_48542159 0.645 NM_000377
WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr6_-_155777036 0.634 NM_015718
NOX3
NADPH oxidase 3
chr1_+_152850797 0.629 NM_030663
SMCP
sperm mitochondria-associated cysteine-rich protein
chr10_+_86131546 0.623 FAM190B
family with sequence similarity 190, member B
chr10_+_112344076 0.619 SMC3
structural maintenance of chromosomes 3
chr5_+_150040402 0.617 NM_001122853
NM_133371
MYOZ3

myozenin 3

chr8_+_67039130 0.616 NM_033058
NM_184085
NM_184086
NM_184087
TRIM55



tripartite motif containing 55



chr12_-_53601051 0.608 ITGB7
integrin, beta 7
chr1_-_42801529 0.602 NM_001198850
FOXJ3
forkhead box J3
chr10_-_81320141 0.602 NM_001098668
SFTPA1
SFTPA2
surfactant protein A1
surfactant protein A2
chr20_+_30407175 0.601 NM_033118
MYLK2
myosin light chain kinase 2
chr5_-_58882274 0.600 NM_006203
PDE4D
phosphodiesterase 4D, cAMP-specific
chr2_+_103378489 0.589 NM_144632
TMEM182
transmembrane protein 182
chr7_-_104909442 0.587 NM_182691
SRPK2
SRSF protein kinase 2
chr1_-_231560789 0.581 NM_022051
EGLN1
egl nine homolog 1 (C. elegans)
chr4_-_69111333 0.580 NM_182502
TMPRSS11B
transmembrane protease, serine 11B
chr17_-_29641087 0.579 EVI2B
ecotropic viral integration site 2B
chr19_-_55767103 0.570 PPP6R1
protein phosphatase 6, regulatory subunit 1
chr14_+_56078735 0.568 KTN1
kinectin 1 (kinesin receptor)
chr2_-_163695028 0.559 KCNH7
potassium voltage-gated channel, subfamily H (eag-related), member 7
chr2_-_192015934 0.555 NM_003151
STAT4
signal transducer and activator of transcription 4
chr20_+_31823801 0.551 NM_001243193
NM_016583
NM_130852
BPIFA1


BPI fold containing family A, member 1


chrX_-_110655384 0.551 NM_178151
NM_001195553
NM_178152
NM_178153
DCX



doublecortin



chr3_+_63428752 0.547 NM_144642
SYNPR
synaptoporin
chr1_+_109648593 0.540


chr12_-_27235454 0.535 NM_001080406
C12orf71
chromosome 12 open reading frame 71
chr16_-_71318761 0.534 FTSJD1
FtsJ methyltransferase domain containing 1
chr1_-_110155672 0.524 NM_005272
GNAT2
guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
chr11_-_16424391 0.519 NM_001145819
NM_017508
SOX6

SRY (sex determining region Y)-box 6

chr15_+_38227456 0.516 NM_152453
TMCO5A
transmembrane and coiled-coil domains 5A
chr17_+_20108298 0.505 SPECC1
sperm antigen with calponin homology and coiled-coil domains 1
chr1_-_21437875 0.504 NM_003760
EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr2_-_163695239 0.492 NM_033272
NM_173162
KCNH7

potassium voltage-gated channel, subfamily H (eag-related), member 7

chr8_-_82373757 0.484 NM_001080526
FABP9
fatty acid binding protein 9, testis
chr1_-_25256364 0.482 RUNX3
runt-related transcription factor 3
chrX_+_49363615 0.479 NM_001040663
NM_001468
GAGE1

G antigen 1

chr5_-_22212873 0.476 CDH12
cadherin 12, type 2 (N-cadherin 2)
chr13_-_26789062 0.472 RNF6
ring finger protein (C3H2C3 type) 6
chr1_-_9129620 0.467 SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr12_-_27924208 0.466 NM_001146221
MANSC4
MANSC domain containing 4
chr1_+_174933904 0.465 NM_001243764
RABGAP1L
RAB GTPase activating protein 1-like
chr3_+_186915273 0.463 NM_153708
RTP1
receptor (chemosensory) transporter protein 1
chr3_-_149510609 0.461 NM_001144960
ANKUB1
ankyrin repeat and ubiquitin domain containing 1
chr1_-_9129666 0.460 NM_001135585
NM_003039
SLC2A5

solute carrier family 2 (facilitated glucose/fructose transporter), member 5

chr10_-_104211244 0.460 NM_024886
C10orf95
chromosome 10 open reading frame 95
chr5_-_134787987 0.457 NM_001099221
TIFAB
TRAF-interacting protein with forkhead-associated domain, family member B
chr6_-_66417069 0.454 NM_001142800
NM_001142801
EYS

eyes shut homolog (Drosophila)

chr6_+_87964925 0.451 ZNF292
zinc finger protein 292
chrX_+_111119278 0.448 NM_001195576
NM_001195578
LOC100329135

uncharacterized LOC100329135

chr1_-_108231122 0.445 NM_001079874
VAV3
vav 3 guanine nucleotide exchange factor
chr6_+_45296053 0.442 NM_001015051
NM_001024630
RUNX2

runt-related transcription factor 2

chr15_+_81517639 0.440 NM_172217
IL16
interleukin 16
chr6_+_31674639 0.438 NM_001003693
LY6G6F
lymphocyte antigen 6 complex, locus G6F
chr4_-_123542165 0.436 NM_001207006
NM_021803
IL21

interleukin 21

chr12_-_53600999 0.434 NM_000889
ITGB7
integrin, beta 7
chr1_+_145413190 0.434 NM_145277
NM_202004
NM_213652
NM_213653
HFE2



hemochromatosis type 2 (juvenile)



chr1_+_117297056 0.432 NM_001767
CD2
CD2 molecule
chr1_-_100643770 0.432 NM_144620
LRRC39
leucine rich repeat containing 39
chr7_-_115670811 0.427 TFEC
transcription factor EC
chr3_-_141747434 0.420 NM_001178141
NM_001178142
NM_006286
TFDP2


transcription factor Dp-2 (E2F dimerization partner 2)


chr13_-_75901897 0.413 TBC1D4
TBC1 domain family, member 4
chr6_+_158733691 0.413 NM_001007466
NM_020245
TULP4

tubby like protein 4

chr1_-_21377452 0.407 EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr3_-_157221362 0.406 NM_001167915
NM_001167916
VEPH1

ventricular zone expressed PH domain homolog 1 (zebrafish)

chr9_+_123884043 0.405 CNTRL
centriolin
chr3_-_49229290 0.400 NM_001080528
LOC646498
uncharacterized LOC646498
chr9_+_131446105 0.399 SET
SET nuclear oncogene
chr5_-_150683326 0.399 NM_001145017
NM_181774
SLC36A3

solute carrier family 36 (proton/amino acid symporter), member 3

chrX_-_153979796 0.398 GAB3
GRB2-associated binding protein 3
chrX_+_49197555 0.396 NM_012196
NM_001472
NM_001127200
NM_001098407
NM_001127212
GAGE8
GAGE2C
GAGE2E
GAGE12J
GAGE2D
GAGE2A
G antigen 8
G antigen 2C
G antigen 2E
G antigen 12J
G antigen 2D
G antigen 2A
chr20_+_2276612 0.396 NM_003245
TGM3
transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase)
chr12_-_121248679 0.392 SPPL3
signal peptide peptidase-like 3
chr4_-_102268483 0.391 PPP3CA
protein phosphatase 3, catalytic subunit, alpha isozyme
chr1_-_156460390 0.385 MEF2D
myocyte enhancer factor 2D
chr8_-_66701175 0.385 NM_002603
PDE7A
phosphodiesterase 7A
chrX_+_118714297 0.383 NM_181777
UBE2A
ubiquitin-conjugating enzyme E2A
chr9_+_137004913 0.383 NM_052821
WDR5
WD repeat domain 5
chr5_-_88199868 0.380 NM_001131005
NM_001193347
MEF2C

myocyte enhancer factor 2C

chr15_+_80364902 0.379 NM_001242915
NM_001242916
ZFAND6

zinc finger, AN1-type domain 6

chr18_-_46469118 0.377 NM_001190823
SMAD7
SMAD family member 7
chr5_-_145483877 0.377 NM_001029869
PLAC8L1
PLAC8-like 1
chrX_+_49226137 0.376 NM_001472
NM_001098407
GAGE2C
GAGE2E
GAGE2D
GAGE2A
G antigen 2C
G antigen 2E
G antigen 2D
G antigen 2A
chr12_+_120031263 0.372 NM_001136534
TMEM233
transmembrane protein 233
chr12_+_113416267 0.369 NM_001032731
NM_002535
NM_016817
OAS2


2'-5'-oligoadenylate synthetase 2, 69/71kDa


chr1_+_34326075 0.369 NM_145205
HMGB4
high mobility group box 4
chr17_-_8198124 0.368 NM_201520
SLC25A35
solute carrier family 25, member 35
chrX_+_144908927 0.366 NM_004709
CXorf1
chromosome X open reading frame 1
chr22_-_38881529 0.366 DDX17
DEAD (Asp-Glu-Ala-Asp) box polypeptide 17
chr1_+_84609941 0.364 NM_182948
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr6_-_2751153 0.362 NM_001012418
MYLK4
myosin light chain kinase family, member 4
chr3_-_172858959 0.359 NM_031955
SPATA16
spermatogenesis associated 16
chr2_-_192015706 0.359 STAT4
signal transducer and activator of transcription 4
chr16_-_68057769 0.357 NM_018380
DDX28
DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
chr9_+_113431050 0.354 NM_001166280
NM_001166281
NM_005592
MUSK


muscle, skeletal, receptor tyrosine kinase


chr20_-_23586512 0.353 NM_001008693
CST9
cystatin 9 (testatin)
chrX_+_49178508 0.352 NM_001098406
GAGE1
GAGE4
GAGE5
GAGE6
GAGE12J
G antigen 1
G antigen 4
G antigen 5
G antigen 6
G antigen 12J
chr6_+_155411422 0.351 NM_012454
TIAM2
T-cell lymphoma invasion and metastasis 2
chr15_-_25650647 0.347 NM_130838
UBE3A
ubiquitin protein ligase E3A
chr4_+_36283243 0.343 NM_001136536
DTHD1
death domain containing 1
chr4_+_37962055 0.341 NM_006607
PTTG2
pituitary tumor-transforming 2
chrX_+_49160124 0.339 NM_001098413
GAGE10
G antigen 10
chr15_-_93617091 0.339 NM_001166283
RGMA
RGM domain family, member A
chr1_-_160681552 0.339 NM_001778
CD48
CD48 molecule
chr9_+_6328348 0.338 NM_001001874
NM_001001875
NM_033516
TPD52L3


tumor protein D52-like 3


chr7_+_50348255 0.337 IKZF1
IKAROS family zinc finger 1 (Ikaros)
chr10_+_126630691 0.336 NM_017580
ZRANB1
zinc finger, RAN-binding domain containing 1
chr17_-_29641068 0.332 EVI2B
ecotropic viral integration site 2B
chr12_+_18891040 0.332 NM_033328
CAPZA3
capping protein (actin filament) muscle Z-line, alpha 3
chr10_-_49482912 0.331 NM_001018071
FRMPD2
FERM and PDZ domain containing 2
chr3_+_46411632 0.331 NM_000579
NM_001100168
CCR5

chemokine (C-C motif) receptor 5

chr6_+_159070994 0.329 NM_001009991
NM_001242384
NM_001242394
NM_001242395
SYTL3



synaptotagmin-like 3



chr6_+_42123143 0.329 NM_000409
GUCA1A
guanylate cyclase activator 1A (retina)
chr2_-_209054772 0.325 NM_001099334
C2orf80
chromosome 2 open reading frame 80

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
24.71 4.47e-03 GO:0042113 B cell activation

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
30.67 7.78e-09 GO:0030016 myofibril
28.93 1.25e-08 GO:0043292 contractile fiber
27.23 3.97e-06 GO:0030017 sarcomere
23.62 9.31e-06 GO:0044449 contractile fiber part
35.11 4.59e-03 GO:0030018 Z disc
27.80 9.26e-03 GO:0031674 I band

Nothing significant found in function category.