Motif ID: NKX2-2,8.p2

Z-value: 1.233


Transcription factors associated with NKX2-2,8.p2:

Gene SymbolEntrez IDGene Name
NKX2-2 4821 NK2 homeobox 2
NKX2-8 26257 NK2 homeobox 8

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NKX2-8hg19_v1_chr14_-_37051785_37051811-0.593.6e-04Click!
NKX2-2hg19_v1_chr20_-_21494663_21494663-0.163.9e-01Click!


Activity profile for motif NKX2-2,8.p2.

activity profile for motif NKX2-2,8.p2


Sorted Z-values histogram for motif NKX2-2,8.p2

Sorted Z-values for motif NKX2-2,8.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-2,8.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_-_150920946 3.250 NM_013308
 GPR171
G protein-coupled receptor 171
chr19_-_14889347 3.121 NM_013447
NM_152916
NM_152917
NM_152918
NM_152919
NM_152920
NM_152921
 EMR2






egf-like module containing, mucin-like, hormone receptor-like 2






chr6_+_87964925 3.001 ZNF292
zinc finger protein 292
chr3_-_121379757 2.972 NM_005335
 HCLS1
hematopoietic cell-specific Lyn substrate 1
chr7_+_37723378 2.812


chr3_-_121379701 2.753 HCLS1
hematopoietic cell-specific Lyn substrate 1
chr3_+_158991090 2.638 SCHIP1
schwannomin interacting protein 1
chr3_-_152058778 2.587 NM_001123228
 TMEM14E
transmembrane protein 14E
chr4_+_95376396 2.533 PDLIM5
PDZ and LIM domain 5
chr3_-_150966901 2.514 NM_001081455
 P2RY14
purinergic receptor P2Y, G-protein coupled, 14
chr12_+_8666135 2.511 NM_080387
 CLEC4D
C-type lectin domain family 4, member D
chr12_-_54689536 2.510 NM_006163
 NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr13_-_41556188 2.486 ELF1
E74-like factor 1 (ets domain transcription factor)
chr9_+_96233420 2.474 FAM120A
family with sequence similarity 120A
chr3_-_44489718 2.305


chr11_+_65271145 2.241


chr17_-_29641068 2.173 EVI2B
ecotropic viral integration site 2B
chr19_-_44174497 2.124 NM_001005376
NM_001005377
NM_002659
 PLAUR


plasminogen activator, urokinase receptor


chr1_+_244214576 2.105 ZNF238
zinc finger protein 238
chr1_-_153363544 2.092 NM_002964
 S100A8
S100 calcium binding protein A8

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 16 of 16 entries
Enrichment   P-value GO Accession GO Term
13.25 4.23e-03 GO:0050852 T cell receptor signaling pathway
10.69 1.47e-02 GO:0050851 antigen receptor-mediated signaling pathway
9.84 2.35e-02 GO:0002429 immune response-activating cell surface receptor signaling pathway
9.47 2.93e-02 GO:0002768 immune response-regulating cell surface receptor signaling pathway
7.76 6.41e-03 GO:0002757 immune response-activating signal transduction
7.58 7.59e-03 GO:0002764 immune response-regulating signaling pathway
6.23 3.12e-02 GO:0002253 activation of immune response
5.51 2.69e-02 GO:0050778 positive regulation of immune response
4.53 2.21e-02 GO:0023057 negative regulation of signaling
4.43 2.70e-02 GO:0050776 regulation of immune response
2.47 1.11e-02 GO:0048583 regulation of response to stimulus
2.24 3.95e-02 GO:0048523 negative regulation of cellular process
2.20 2.57e-02 GO:0048519 negative regulation of biological process
1.97 1.54e-02 GO:0007165 signal transduction
1.93 8.73e-03 GO:0023052 signaling
1.79 4.21e-02 GO:0051716 cellular response to stimulus

Nothing significant found in compartment category.

Gene overrepresentation in function category:

Showing 1 to 6 of 6 entries
Enrichment   P-value GO Accession GO Term
28.80 1.31e-03 GO:0001608 nucleotide receptor activity, G-protein coupled
28.80 1.31e-03 GO:0045028 purinergic nucleotide receptor activity, G-protein coupled
22.08 3.91e-03 GO:0001614 purinergic nucleotide receptor activity
22.08 3.91e-03 GO:0016502 nucleotide receptor activity
19.49 6.50e-03 GO:0035586 purinergic receptor activity
3.28 1.12e-02 GO:0019899 enzyme binding