Motif ID: NKX2-2,8.p2

Z-value: 1.233


Transcription factors associated with NKX2-2,8.p2:

Gene SymbolEntrez IDGene Name
NKX2-2 4821 NK2 homeobox 2
NKX2-8 26257 NK2 homeobox 8

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NKX2-8hg19_v1_chr14_-_37051785_37051811-0.593.6e-04Click!
NKX2-2hg19_v1_chr20_-_21494663_21494663-0.163.9e-01Click!


Activity profile for motif NKX2-2,8.p2.

activity profile for motif NKX2-2,8.p2


Sorted Z-values histogram for motif NKX2-2,8.p2

Sorted Z-values for motif NKX2-2,8.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-2,8.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_-_150920946 3.250 NM_013308
GPR171
G protein-coupled receptor 171
chr19_-_14889347 3.121 NM_013447
NM_152916
NM_152917
NM_152918
NM_152919
NM_152920
NM_152921
EMR2






egf-like module containing, mucin-like, hormone receptor-like 2






chr6_+_87964925 3.001 ZNF292
zinc finger protein 292
chr3_-_121379757 2.972 NM_005335
HCLS1
hematopoietic cell-specific Lyn substrate 1
chr7_+_37723378 2.812


chr3_-_121379701 2.753 HCLS1
hematopoietic cell-specific Lyn substrate 1
chr3_+_158991090 2.638 SCHIP1
schwannomin interacting protein 1
chr3_-_152058778 2.587 NM_001123228
TMEM14E
transmembrane protein 14E
chr4_+_95376396 2.533 PDLIM5
PDZ and LIM domain 5
chr3_-_150966901 2.514 NM_001081455
P2RY14
purinergic receptor P2Y, G-protein coupled, 14
chr12_+_8666135 2.511 NM_080387
CLEC4D
C-type lectin domain family 4, member D
chr12_-_54689536 2.510 NM_006163
NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr13_-_41556188 2.486 ELF1
E74-like factor 1 (ets domain transcription factor)
chr9_+_96233420 2.474 FAM120A
family with sequence similarity 120A
chr3_-_44489718 2.305


chr11_+_65271145 2.241


chr17_-_29641068 2.173 EVI2B
ecotropic viral integration site 2B
chr19_-_44174497 2.124 NM_001005376
NM_001005377
NM_002659
PLAUR


plasminogen activator, urokinase receptor


chr1_+_244214576 2.105 ZNF238
zinc finger protein 238
chr1_-_153363544 2.092 NM_002964
S100A8
S100 calcium binding protein A8
chr17_-_29641094 2.076 NM_006495
EVI2B
ecotropic viral integration site 2B
chr1_+_244214552 1.979 NM_205768
ZNF238
zinc finger protein 238
chr21_-_31864274 1.977 NM_181609
KRTAP19-3
keratin associated protein 19-3
chr8_-_133772808 1.954 NM_001145153
NM_144649
TMEM71

transmembrane protein 71

chr10_+_123754141 1.881 TACC2
transforming, acidic coiled-coil containing protein 2
chrX_-_15333726 1.852 NM_001201583
NM_080873
ASB11

ankyrin repeat and SOCS box containing 11

chr5_+_156820161 1.843 CYFIP2
cytoplasmic FMR1 interacting protein 2
chr1_-_144997110 1.806 NM_001195260
PDE4DIP
phosphodiesterase 4D interacting protein
chr3_+_158991035 1.779 NM_001197107
NM_001197108
NM_014575
SCHIP1


schwannomin interacting protein 1


chr11_-_47510518 1.740 NM_001025596
NM_001172640
CELF1

CUGBP, Elav-like family member 1

chr1_+_15990300 1.738


chr9_-_3223007 1.719


chr9_-_85882093 1.691 NM_001244962
FRMD3
FERM domain containing 3
chr6_+_142510627 1.687 VTA1
Vps20-associated 1 homolog (S. cerevisiae)
chr7_+_112092112 1.680 NM_001197079
IFRD1
interferon-related developmental regulator 1
chr3_-_57326709 1.668 NM_001142733
ASB14
ankyrin repeat and SOCS box containing 14
chr1_+_198608244 1.624 PTPRC
protein tyrosine phosphatase, receptor type, C
chr22_+_40322609 1.619 GRAP2
GRB2-related adaptor protein 2
chr7_+_44078677 1.606 FLJ35390
uncharacterized LOC255031
chr17_-_29641087 1.548 EVI2B
ecotropic viral integration site 2B
chr11_+_65266642 1.547


chr1_-_207095198 1.543 NM_001193338
NM_001142473
NM_005449
FAIM3


Fas apoptotic inhibitory molecule 3


chr1_+_198608216 1.526 PTPRC
protein tyrosine phosphatase, receptor type, C
chr2_+_228356287 1.525 AGFG1
ArfGAP with FG repeats 1
chr6_-_41254392 1.518 NM_001242589
NM_001242590
NM_018643
TREM1


triggering receptor expressed on myeloid cells 1


chr17_-_29624249 1.515 NM_002544
OMG
oligodendrocyte myelin glycoprotein
chr18_+_19353635 1.514 MIB1
mindbomb homolog 1 (Drosophila)
chr3_+_152017193 1.491 NM_207293
NM_207294
NM_207295
NM_207296
NM_207297
MBNL1




muscleblind-like (Drosophila)




chr15_+_25227140 1.450 SNRPN
small nuclear ribonucleoprotein polypeptide N
chr7_+_139528951 1.447 NM_001061
NM_001166253
NM_030984
TBXAS1


thromboxane A synthase 1 (platelet)


chr7_-_76829109 1.433 NM_006682
FGL2
fibrinogen-like 2
chr2_-_225378320 1.420 CUL3
cullin 3
chr10_+_90521162 1.413 NM_001102469
LIPN
lipase, family member N
chr12_-_46633551 1.408 SLC38A1
solute carrier family 38, member 1
chr6_-_119252887 1.393 NM_017696
MCM9
minichromosome maintenance complex component 9
chr19_+_49838673 1.390 NM_001040031
NM_001774
CD37

CD37 molecule

chr3_-_15839674 1.380 NM_001195098
ANKRD28
ankyrin repeat domain 28
chr14_-_89878733 1.375 FOXN3
forkhead box N3
chrX_+_129139163 1.373 NM_021946
BCORL1
BCL6 corepressor-like 1
chr7_+_104681378 1.358 MLL5
myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila)
chr4_-_153273683 1.358 NM_018315
FBXW7
F-box and WD repeat domain containing 7
chr5_-_78281135 1.356 ARSB
arylsulfatase B
chr3_+_63953419 1.350 NM_001128149
ATXN7
ataxin 7
chr12_-_58240493 1.332 CTDSP2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
chr15_-_56209305 1.330 NM_198400
NEDD4
neural precursor cell expressed, developmentally down-regulated 4
chr18_+_32558207 1.327 NM_001143827
MAPRE2
microtubule-associated protein, RP/EB family, member 2
chrX_+_14903412 1.316 NM_001177475
MOSPD2
motile sperm domain containing 2
chr20_-_36152952 1.315 NM_001167823
BLCAP
bladder cancer associated protein
chr19_-_40228611 1.312 NM_001828
CLC
Charcot-Leyden crystal protein
chrX_-_19817854 1.307 SH3KBP1
SH3-domain kinase binding protein 1
chr1_+_192127591 1.297 NM_130782
RGS18
regulator of G-protein signaling 18
chr2_-_191872322 1.293 STAT1
signal transducer and activator of transcription 1, 91kDa
chr1_+_145487301 1.287 LIX1L
Lix1 homolog (mouse)-like
chr5_-_78281688 1.286 NM_198709
ARSB
arylsulfatase B
chr11_+_118175294 1.284 NM_000733
CD3E
CD3e molecule, epsilon (CD3-TCR complex)
chr5_-_78281076 1.273 ARSB
arylsulfatase B
chr22_-_50523670 1.265 MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr5_-_78281556 1.238 ARSB
arylsulfatase B
chr1_+_104159953 1.233 NM_000699
AMY2A
amylase, alpha 2A (pancreatic)
chr1_+_198608136 1.233 NM_002838
NM_080921
NM_080923
PTPRC


protein tyrosine phosphatase, receptor type, C


chr13_-_48987017 1.230 LPAR6
lysophosphatidic acid receptor 6
chr18_-_67615088 1.220 CD226
CD226 molecule
chr6_-_139613114 1.217 NM_153235
TXLNB
taxilin beta
chr11_+_65266980 1.200


chr8_-_66701175 1.198 NM_002603
PDE7A
phosphodiesterase 7A
chr3_+_127641901 1.192 NM_207335
KBTBD12
kelch repeat and BTB (POZ) domain containing 12
chr2_-_40739570 1.180 NM_001112802
SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr1_+_84630014 1.180 NM_001242857
NM_001242858
NM_001242859
PRKACB


protein kinase, cAMP-dependent, catalytic, beta


chr1_+_212475147 1.177 NM_001199756
PPP2R5A
protein phosphatase 2, regulatory subunit B', alpha
chrX_-_55208943 1.174 NM_001190708
MTRNR2L10
MT-RNR2-like 10
chrX_+_91090459 1.173 NM_001168360
NM_001168361
NM_001168362
NM_001168363
PCDH11X



protocadherin 11 X-linked



chr9_+_103340335 1.168 NM_001018116
MURC
muscle-related coiled-coil protein
chr17_+_67498391 1.166 MAP2K6
mitogen-activated protein kinase kinase 6
chr19_+_49838700 1.164 CD37
CD37 molecule
chr3_-_196911001 1.164 NM_001204387
NM_001204388
DLG1

discs, large homolog 1 (Drosophila)

chr12_-_90049818 1.158 NM_001001323
NM_001682
ATP2B1

ATPase, Ca++ transporting, plasma membrane 1

chrX_-_49121171 1.154 NM_001114377
NM_014009
FOXP3

forkhead box P3

chr1_+_145663156 1.153 RNF115
ring finger protein 115
chr8_-_38205652 1.148 WHSC1L1
Wolf-Hirschhorn syndrome candidate 1-like 1
chr20_+_30697291 1.130 NM_014742
TM9SF4
transmembrane 9 superfamily protein member 4
chr2_-_145275086 1.113 ZEB2
zinc finger E-box binding homeobox 2
chr14_-_25078818 1.112 NM_033423
GZMH
granzyme H (cathepsin G-like 2, protein h-CCPX)
chr15_+_52201590 1.111 TMOD3
tropomodulin 3 (ubiquitous)
chr14_-_100841656 1.103 WARS
tryptophanyl-tRNA synthetase
chr12_-_58240746 1.102 NM_005730
CTDSP2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
chr3_+_108541544 1.094 NM_016388
TRAT1
T cell receptor associated transmembrane adaptor 1
chr5_-_39270708 1.092 NM_001243093
FYB
FYN binding protein
chr3_-_151058439 1.086 NM_176876
P2RY12
purinergic receptor P2Y, G-protein coupled, 12
chr22_-_50523853 1.084 MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr19_+_49838646 1.078 CD37
CD37 molecule
chr2_+_102953716 1.073 NM_003856
IL1RL1
interleukin 1 receptor-like 1
chr7_+_28475233 1.071 NM_004904
CREB5
cAMP responsive element binding protein 5
chr17_+_57743498 1.069 CLTC
clathrin, heavy chain (Hc)
chrX_-_70474402 1.066 NM_001171163
NM_005096
ZMYM3

zinc finger, MYM-type 3

chr16_-_53405040 1.062 NM_001207030
LOC643802
u3 small nucleolar ribonucleoprotein protein MPP10-like
chrX_+_123095598 1.054 STAG2
stromal antigen 2
chr3_-_119582422 1.038 GSK3B
glycogen synthase kinase 3 beta
chr5_-_137848517 1.033 ETF1
eukaryotic translation termination factor 1
chr19_+_49838734 1.032 CD37
CD37 molecule
chr16_-_46782104 1.031 NM_182493
MYLK3
myosin light chain kinase 3
chr14_-_73360792 1.022 NM_012074
DPF3
D4, zinc and double PHD fingers, family 3
chr1_+_171481164 1.021 PRRC2C
proline-rich coiled-coil 2C
chr5_+_148206155 1.016 NM_000024
ADRB2
adrenergic, beta-2-, receptor, surface
chr5_-_88119604 1.015 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr5_+_147774274 1.014 FBXO38
F-box protein 38
chr6_+_158733691 1.008 NM_001007466
NM_020245
TULP4

tubby like protein 4

chr4_-_83347222 1.006 HNRPDL
heterogeneous nuclear ribonucleoprotein D-like
chr4_+_106067031 1.001 NM_017628
TET2
tet methylcytosine dioxygenase 2
chr12_-_10021932 0.997 CLEC2B
C-type lectin domain family 2, member B
chr3_-_167191808 0.996 NM_006217
SERPINI2
serpin peptidase inhibitor, clade I (pancpin), member 2
chr1_+_84630374 0.994 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr2_+_233709104 0.990 GIGYF2
GRB10 interacting GYF protein 2
chr2_-_142889269 0.983 NM_018557
LRP1B
low density lipoprotein receptor-related protein 1B
chr1_+_110560111 0.972 AHCYL1
adenosylhomocysteinase-like 1
chr1_-_226926875 0.971 NM_002221
ITPKB
inositol-trisphosphate 3-kinase B
chrX_+_75648045 0.969 NM_020932
MAGEE1
melanoma antigen family E, 1
chrX_-_19817907 0.964 NM_001024666
SH3KBP1
SH3-domain kinase binding protein 1
chr19_-_44174271 0.963 PLAUR
plasminogen activator, urokinase receptor
chr5_+_162930230 0.949 NM_182796
MAT2B
methionine adenosyltransferase II, beta
chr14_-_100841793 0.948 WARS
tryptophanyl-tRNA synthetase
chr7_-_108142934 0.945 PNPLA8
patatin-like phospholipase domain containing 8
chr5_+_43609261 0.944 NNT
nicotinamide nucleotide transhydrogenase
chr1_-_198906536 0.938 LOC100131234
familial acute myelogenous leukemia related factor
chrX_-_30595883 0.938 NM_025159
CXorf21
chromosome X open reading frame 21
chr6_-_152702450 0.936 SYNE1
spectrin repeat containing, nuclear envelope 1
chr1_+_167298280 0.931 NM_001198783
POU2F1
POU class 2 homeobox 1
chr2_-_20512016 0.923 PUM2
pumilio homolog 2 (Drosophila)
chr9_+_131447364 0.921 NM_001248000
SET
SET nuclear oncogene
chr6_+_26365397 0.921 NM_001197247
NM_001197249
NM_007047
NM_001197248
BTN3A2



butyrophilin, subfamily 3, member A2



chr10_-_94003002 0.918 NM_001178137
CPEB3
cytoplasmic polyadenylation element binding protein 3
chr4_-_140060601 0.914 NM_201999
ELF2
E74-like factor 2 (ets domain transcription factor)
chr8_-_134087171 0.910 SLA
Src-like-adaptor
chr5_-_78281132 0.909 ARSB
arylsulfatase B
chr21_-_36421195 0.908 RUNX1
runt-related transcription factor 1
chr4_+_155484131 0.897 NM_001184741
NM_005141
FGB

fibrinogen beta chain

chr12_-_56563964 0.896 SMARCC2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
chr7_+_91924291 0.892


chr10_+_98740987 0.887 NM_015652
C10orf12
chromosome 10 open reading frame 12
chr4_+_87928083 0.884 NM_005935
AFF1
AF4/FMR2 family, member 1
chr3_+_151591428 0.884 NM_033050
SUCNR1
succinate receptor 1
chr5_-_58571916 0.879 NM_001197220
PDE4D
phosphodiesterase 4D, cAMP-specific
chr17_-_1248346 0.877 PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr3_-_71592707 0.874 NM_001244816
FOXP1
forkhead box P1
chr1_+_167298382 0.873 POU2F1
POU class 2 homeobox 1
chr1_+_16259046 0.872


chr15_-_60690115 0.872 NM_001002857
NM_001002858
NM_001136015
NM_004039
ANXA2



annexin A2



chr7_+_114066554 0.867 NM_001172767
NM_148899
FOXP2

forkhead box P2

chr11_-_1619481 0.867 NM_001004325
KRTAP5-2
keratin associated protein 5-2
chr14_-_81864726 0.863 NM_033104
STON2
stonin 2
chrX_-_118726852 0.851 NM_001173488
NKRF
NFKB repressing factor
chr10_-_98336445 0.847 TM9SF3
transmembrane 9 superfamily member 3
chr8_-_124544376 0.847 NM_148177
FBXO32
F-box protein 32
chr16_+_24567628 0.847 RBBP6
retinoblastoma binding protein 6
chr17_-_72357957 0.835 NM_001080466
BTBD17
BTB (POZ) domain containing 17
chr1_+_84609987 0.834 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr9_+_100263461 0.832 NM_001166116
TMOD1
tropomodulin 1
chr1_-_51887740 0.823 NM_001159969
EPS15
epidermal growth factor receptor pathway substrate 15
chr3_-_33700480 0.821 CLASP2
cytoplasmic linker associated protein 2
chr9_+_116263706 0.820 NM_130795
RGS3
regulator of G-protein signaling 3
chr3_+_186714335 0.818


chr5_-_150521200 0.818 NM_001193544
ANXA6
annexin A6
chr2_+_33661392 0.817 NM_170672
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr22_+_35695267 0.809 NM_001135729
TOM1
target of myb1 (chicken)
chr9_+_125132823 0.806 PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr5_-_139937677 0.806 NM_001035235
SRA1
steroid receptor RNA activator 1
chr3_+_38207247 0.805 OXSR1
oxidative-stress responsive 1
chr1_-_31538762 0.803 PUM1
pumilio homolog 1 (Drosophila)
chr4_+_114214102 0.799 ANK2
ankyrin 2, neuronal
chr3_-_51996855 0.798 NM_033010
PCBP4
poly(rC) binding protein 4
chr12_+_64803741 0.796 XPOT
exportin, tRNA (nuclear export receptor for tRNAs)
chr13_+_111855406 0.795 ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7
chr7_+_80267782 0.793 NM_000072
NM_001001548
CD36

CD36 molecule (thrombospondin receptor)

chr9_+_125132785 0.791 PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr14_-_31957150 0.791 NM_001197184
GPR33
G protein-coupled receptor 33 (gene/pseudogene)
chr15_+_42696957 0.789 NM_173089
NM_173090
CAPN3

calpain 3, (p94)

chr10_+_63808968 0.786 NM_001244638
ARID5B
AT rich interactive domain 5B (MRF1-like)
chr8_-_125580745 0.780 MTSS1
metastasis suppressor 1
chr5_-_58295758 0.777 NM_001197223
PDE4D
phosphodiesterase 4D, cAMP-specific
chrX_+_49091926 0.772 NM_014008
CCDC22
coiled-coil domain containing 22
chr1_-_217113007 0.768 NM_001243512
NM_001243513
NM_001243510
NM_001243511
ESRRG



estrogen-related receptor gamma




Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
13.25 4.23e-03 GO:0050852 T cell receptor signaling pathway
7.76 6.41e-03 GO:0002757 immune response-activating signal transduction
7.58 7.59e-03 GO:0002764 immune response-regulating signaling pathway
1.93 8.73e-03 GO:0023052 signaling
2.47 1.11e-02 GO:0048583 regulation of response to stimulus
10.69 1.47e-02 GO:0050851 antigen receptor-mediated signaling pathway
1.97 1.54e-02 GO:0007165 signal transduction
4.53 2.21e-02 GO:0023057 negative regulation of signaling
9.84 2.35e-02 GO:0002429 immune response-activating cell surface receptor signaling pathway
2.20 2.57e-02 GO:0048519 negative regulation of biological process
5.51 2.69e-02 GO:0050778 positive regulation of immune response
4.43 2.70e-02 GO:0050776 regulation of immune response
9.47 2.93e-02 GO:0002768 immune response-regulating cell surface receptor signaling pathway
6.23 3.12e-02 GO:0002253 activation of immune response
2.24 3.95e-02 GO:0048523 negative regulation of cellular process
1.79 4.21e-02 GO:0051716 cellular response to stimulus

Nothing significant found in compartment category.

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
28.80 1.31e-03 GO:0001608 nucleotide receptor activity, G-protein coupled
28.80 1.31e-03 GO:0045028 purinergic nucleotide receptor activity, G-protein coupled
22.08 3.91e-03 GO:0001614 purinergic nucleotide receptor activity
22.08 3.91e-03 GO:0016502 nucleotide receptor activity
19.49 6.50e-03 GO:0035586 purinergic receptor activity
3.28 1.12e-02 GO:0019899 enzyme binding