Motif ID: NKX2-3_NKX2-5.p2

Z-value: 1.400


Transcription factors associated with NKX2-3_NKX2-5.p2:

Gene SymbolEntrez IDGene Name
NKX2-3 159296 NK2 transcription factor related, locus 3 (Drosophila)
NKX2-5 1482 NK2 transcription factor related, locus 5 (Drosophila)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NKX2-3hg19_v1_chr10_+_101292689_1012927370.336.7e-02Click!
NKX2-5hg19_v1_chr5_-_172662085_172662314-0.291.1e-01Click!


Activity profile for motif NKX2-3_NKX2-5.p2.

activity profile for motif NKX2-3_NKX2-5.p2


Sorted Z-values histogram for motif NKX2-3_NKX2-5.p2

Sorted Z-values for motif NKX2-3_NKX2-5.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-3_NKX2-5.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_+_41831484 7.234 NM_013377
PDZRN4
PDZ domain containing ring finger 4
chr7_+_94297448 6.140 PEG10
paternally expressed 10
chr5_+_71502700 3.795 MAP1B
microtubule-associated protein 1B
chr17_+_68071386 3.496 NM_018658
NM_170741
KCNJ16

potassium inwardly-rectifying channel, subfamily J, member 16

chr12_-_16760935 3.453 NM_001001395
NM_001243609
LMO3

LIM domain only 3 (rhombotin-like 2)

chr5_-_13944588 3.310 NM_001369
DNAH5
dynein, axonemal, heavy chain 5
chr13_-_86373328 3.221 NM_032229
SLITRK6
SLIT and NTRK-like family, member 6
chr8_+_104831415 3.197 NM_014677
RIMS2
regulating synaptic membrane exocytosis 2
chrX_+_105937067 3.167 NM_024539
RNF128
ring finger protein 128
chr2_+_102953716 3.115 NM_003856
IL1RL1
interleukin 1 receptor-like 1
chr19_+_45409003 3.109 NM_000041
APOE
apolipoprotein E
chr9_+_130026755 3.071 NM_032293
GARNL3
GTPase activating Rap/RanGAP domain-like 3
chr12_+_41086189 3.050 NM_001843
NM_175038
CNTN1

contactin 1

chr2_+_234826042 2.893 NM_024080
TRPM8
transient receptor potential cation channel, subfamily M, member 8
chr3_-_151034514 2.862 NM_023915
GPR87
G protein-coupled receptor 87
chr7_-_27205123 2.829 HOXA9
homeobox A9
chr7_-_27205075 2.821 HOXA9
homeobox A9
chr12_-_6484389 2.802 NM_001159576
SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr8_+_24298442 2.768 NM_003817
ADAM7
ADAM metallopeptidase domain 7
chr2_-_216245573 2.720 FN1
fibronectin 1
chr10_-_123356158 2.690 NM_001144915
FGFR2
fibroblast growth factor receptor 2
chr7_-_27205148 2.684 NM_152739
HOXA9
homeobox A9
chr13_+_99058147 2.663


chr10_-_105845619 2.629 NM_000494
COL17A1
collagen, type XVII, alpha 1
chr12_-_6484904 2.607 NM_001038
SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr1_+_156030965 2.606 NM_020387
RAB25
RAB25, member RAS oncogene family
chr1_+_50574601 2.605 ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr12_-_6484557 2.543 SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr2_+_103089761 2.531 NM_001011552
SLC9A4
solute carrier family 9 (sodium/hydrogen exchanger), member 4
chr3_-_100712248 2.472 NM_015429
ABI3BP
ABI family, member 3 (NESH) binding protein
chr8_-_30706532 2.443 NM_031271
TEX15
testis expressed 15
chr17_-_78450247 2.409 NM_002522
NPTX1
neuronal pentraxin I
chr6_-_136847078 2.382 NM_001198608
NM_001198609
NM_001198611
MAP7


microtubule-associated protein 7


chr7_-_137028533 2.346 NM_002825
PTN
pleiotrophin
chr13_+_53602829 2.301 NM_006418
OLFM4
olfactomedin 4
chr3_-_120401401 2.295 NM_000187
HGD
homogentisate 1,2-dioxygenase
chr11_+_34642651 2.264 EHF
ets homologous factor
chr3_-_120400957 2.257 HGD
homogentisate 1,2-dioxygenase
chr14_+_62462540 2.181 NM_031914
SYT16
synaptotagmin XVI
chrX_+_102965836 2.141 NM_182541
TMEM31
transmembrane protein 31
chr17_+_27370155 2.081 PIPOX
pipecolic acid oxidase
chr14_+_39703119 2.079 NM_054024
MIA2
melanoma inhibitory activity 2
chr7_+_114055048 2.075 NM_001172766
NM_014491
NM_148898
NM_148900
FOXP2



forkhead box P2



chr3_-_79817058 2.067 NM_002941
ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr10_-_105845556 2.059 COL17A1
collagen, type XVII, alpha 1
chr2_+_234601511 2.058 NM_001072
UGT1A6
UDP glucuronosyltransferase 1 family, polypeptide A6
chr4_-_69817478 2.043 NM_024743
UGT2A3
UDP glucuronosyltransferase 2 family, polypeptide A3
chr4_-_176733901 2.039 GPM6A
glycoprotein M6A
chr3_-_119963141 2.038 NM_001168271
NM_153002
GPR156

G protein-coupled receptor 156

chr10_-_96829074 1.986 NM_000770
NM_001198853
NM_001198854
NM_001198855
CYP2C8



cytochrome P450, family 2, subfamily C, polypeptide 8



chr5_+_169780880 1.975 NM_001034838
KCNIP1
Kv channel interacting protein 1
chr2_+_171571800 1.967 NM_001003845
SP5
Sp5 transcription factor
chr4_+_69313166 1.963 NM_014058
TMPRSS11E
transmembrane protease, serine 11E
chr5_+_59784004 1.941 PART1
prostate androgen-regulated transcript 1 (non-protein coding)
chr1_+_209878135 1.919 NM_005525
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr18_+_61370193 1.913 NM_080475
SERPINB11
serpin peptidase inhibitor, clade B (ovalbumin), member 11 (gene/pseudogene)
chr5_+_176811431 1.892 NM_001167579
NM_003052
SLC34A1

solute carrier family 34 (sodium phosphate), member 1

chrX_-_10544852 1.860 NM_001193277
MID1
midline 1 (Opitz/BBB syndrome)
chr2_-_31352489 1.859 NM_001253827
GALNT14
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)
chr2_+_210444364 1.838 NM_002374
NM_031845
NM_031847
MAP2


microtubule-associated protein 2


chr3_+_46919235 1.837 NM_000316
PTH1R
parathyroid hormone 1 receptor
chr7_+_129847699 1.782 NM_145268
C7orf45
chromosome 7 open reading frame 45
chr10_+_95517565 1.777 NM_005097
LGI1
leucine-rich, glioma inactivated 1
chr14_+_78870092 1.774 NM_004796
NRXN3
neurexin 3
chr16_+_86612114 1.750 NM_005250
FOXL1
forkhead box L1
chr12_-_16759430 1.749 LMO3
LIM domain only 3 (rhombotin-like 2)
chr17_-_56494889 1.748 RNF43
ring finger protein 43
chr3_+_16216155 1.724 NM_054110
GALNTL2
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 2
chr14_-_65409445 1.711 NM_002083
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr20_+_32250089 1.709 NM_080825
C20orf144
chromosome 20 open reading frame 144
chr11_+_92085261 1.704 NM_001008781
FAT3
FAT tumor suppressor homolog 3 (Drosophila)
chrX_-_114252132 1.687 NM_000640
IL13RA2
interleukin 13 receptor, alpha 2
chr11_+_34642587 1.673 NM_001206615
NM_012153
EHF

ets homologous factor

chr17_-_64225496 1.673 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr7_-_92855780 1.621 NM_001039372
HEPACAM2
HEPACAM family member 2
chr17_+_68100994 1.619 NM_170742
KCNJ16
potassium inwardly-rectifying channel, subfamily J, member 16
chr6_-_114384008 1.592 NM_153612
HS3ST5
heparan sulfate (glucosamine) 3-O-sulfotransferase 5
chr18_-_3845295 1.585 NM_001003809
NM_001242765
NM_001242766
DLGAP1


discs, large (Drosophila) homolog-associated protein 1


chr22_-_37215516 1.582 NM_002854
PVALB
parvalbumin
chr11_+_89392464 1.578 NM_153696
FOLH1B
folate hydrolase 1B
chr2_+_158851690 1.559 NM_001135098
UPP2
uridine phosphorylase 2
chr12_-_16757944 1.524 LMO3
LIM domain only 3 (rhombotin-like 2)
chr11_+_117947785 1.520 TMPRSS4
transmembrane protease, serine 4
chr6_-_52774460 1.519 NM_000847
GSTA3
glutathione S-transferase alpha 3
chr3_+_159943252 1.507 NM_001168214
C3orf80
chromosome 3 open reading frame 80
chr1_-_183622447 1.493 NM_203454
APOBEC4
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative)
chr11_-_7727940 1.489 NM_198185
OVCH2
ovochymase 2 (gene/pseudogene)
chr1_+_209757044 1.482 NM_020439
CAMK1G
calcium/calmodulin-dependent protein kinase IG
chr2_+_234627423 1.480 NM_007120
UGT1A4
UDP glucuronosyltransferase 1 family, polypeptide A4
chr6_+_50786438 1.468 NM_003221
TFAP2B
transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
chr4_+_77356252 1.464 NM_020859
SHROOM3
shroom family member 3
chrX_+_111119278 1.464 NM_001195576
NM_001195578
LOC100329135

uncharacterized LOC100329135

chr8_-_86290333 1.457 NM_001128829
NM_001128830
NM_001128831
NM_001738
CA1



carbonic anhydrase I



chr1_+_50574589 1.444 NM_001144774
NM_021952
ELAVL4

ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)

chr22_-_38506532 1.442 BAIAP2L2
BAI1-associated protein 2-like 2
chr12_-_24103842 1.441 SOX5
SRY (sex determining region Y)-box 5
chr7_-_14029641 1.433 NM_001163147
NM_004956
ETV1

ets variant 1

chr4_-_110723127 1.431 CFI
complement factor I
chr4_-_111563278 1.429 NM_001204397
NM_001204398
NM_001204399
NM_153426
NM_153427
PITX2




paired-like homeodomain 2




chr13_+_46276445 1.429 NM_152719
SPERT
spermatid associated
chr9_-_27297106 1.426 NM_001161585
NM_020641
C9orf11

chromosome 9 open reading frame 11

chr14_-_38064440 1.421 NM_004496
FOXA1
forkhead box A1
chr13_-_61989654 1.416 NM_022843
PCDH20
protocadherin 20
chr4_-_87281374 1.409 NM_138980
NM_138982
MAPK10

mitogen-activated protein kinase 10

chr16_-_11375094 1.400 NM_002761
PRM1
protamine 1
chr4_-_138453628 1.394 NM_019035
PCDH18
protocadherin 18
chr2_-_79386878 1.394 NM_138938
NM_002580
NM_138937
REG3A


regenerating islet-derived 3 alpha


chr2_-_183387063 1.371 NM_005019
NM_001003683
PDE1A

phosphodiesterase 1A, calmodulin-dependent

chr5_+_34687663 1.361 NM_001145523
RAI14
retinoic acid induced 14
chr3_-_170303774 1.361 NM_020949
SLC7A14
solute carrier family 7 (orphan transporter), member 14
chr12_-_49488570 1.359 NM_021044
DHH
desert hedgehog
chr12_-_16759420 1.355 LMO3
LIM domain only 3 (rhombotin-like 2)
chr19_-_48389571 1.344 NM_003167
SULT2A1
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
chr4_-_176734181 1.339 NM_201591
GPM6A
glycoprotein M6A
chr20_-_29978285 1.333 NM_153289
NM_153323
NM_173460
DEFB119


defensin, beta 119


chr5_+_40909558 1.326 NM_000587
C7
complement component 7
chr12_-_24103953 1.311 SOX5
SRY (sex determining region Y)-box 5
chr21_-_33957746 1.310 NM_144659
TCP10L
t-complex 10 (mouse)-like
chr1_-_57045235 1.298 NM_003713
PPAP2B
phosphatidic acid phosphatase type 2B
chr6_-_87804773 1.292 NM_000735
NM_001252383
CGA

glycoprotein hormones, alpha polypeptide

chr5_+_40909617 1.290 C7
complement component 7
chr1_+_50575465 1.284 ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr12_-_16759939 1.279 NM_001243613
LMO3
LIM domain only 3 (rhombotin-like 2)
chr16_-_15835382 1.258 MYH11
myosin, heavy chain 11, smooth muscle
chr13_+_78109808 1.253 NM_001160706
NM_003843
NM_144777
SCEL


sciellin


chr5_+_68710938 1.251 NM_001038603
NM_001244734
MARVELD2

MARVEL domain containing 2

chr5_+_152870083 1.248 NM_000827
NM_001114183
GRIA1

glutamate receptor, ionotropic, AMPA 1

chr1_+_35246789 1.238 NM_024009
GJB3
gap junction protein, beta 3, 31kDa
chr19_-_48389514 1.232 SULT2A1
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
chr3_-_187009469 1.231 NM_001031849
NM_001879
NM_139125
MASP1


mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)


chr9_-_117265452 1.226 NM_001083885
DFNB31
deafness, autosomal recessive 31
chr4_+_69681709 1.221 NM_001075
NM_001144767
UGT2B10

UDP glucuronosyltransferase 2 family, polypeptide B10

chr6_-_49931817 1.220 NM_001037499
DEFB114
defensin, beta 114
chr2_+_211458078 1.217 NM_001122634
CPS1
carbamoyl-phosphate synthase 1, mitochondrial
chr12_-_88423145 1.210 NM_152589
C12orf50
chromosome 12 open reading frame 50
chr1_+_50569581 1.203 NM_001144776
ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chrX_+_22050920 1.182 NM_000444
PHEX
phosphate regulating endopeptidase homolog, X-linked
chrX_-_15288172 1.181 NM_001031739
NM_001168530
NM_024087
ASB9


ankyrin repeat and SOCS box containing 9


chr20_+_44350987 1.180 NM_178455
SPINT4
serine peptidase inhibitor, Kunitz type 4
chr7_-_121944485 1.179 NM_001024613
NM_001160264
FEZF1

FEZ family zinc finger 1

chr9_-_23826062 1.177 NM_004432
ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr6_+_134758840 1.171 LOC154092
uncharacterized LOC154092
chr8_-_82373757 1.170 NM_001080526
FABP9
fatty acid binding protein 9, testis
chr12_+_49741040 1.168 NM_024902
DNAJC22
DnaJ (Hsp40) homolog, subfamily C, member 22
chr1_-_57045129 1.160 PPAP2B
phosphatidic acid phosphatase type 2B
chr10_-_52645430 1.158 NM_001198818
NM_001198819
NM_001198820
NM_014576
NM_138932
NM_138933
A1CF





APOBEC1 complementation factor





chr13_+_96085852 1.154 NM_001160100
NM_182848
CLDN10

claudin 10

chr7_-_107880492 1.152 NM_001037132
NRCAM
neuronal cell adhesion molecule
chr1_+_63063186 1.149 NM_014495
ANGPTL3
angiopoietin-like 3
chr13_-_36429798 1.143 NM_001195415
NM_001195416
NM_001195430
DCLK1


doublecortin-like kinase 1


chr4_-_87374282 1.140 NM_002753
MAPK10
mitogen-activated protein kinase 10
chr11_+_101983170 1.139 NM_001195045
YAP1
Yes-associated protein 1
chr3_-_149095413 1.132 TM4SF1
transmembrane 4 L six family member 1
chr2_+_158114109 1.127 NM_014568
GALNT5
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)
chr3_+_85775631 1.125 NM_153184
CADM2
cell adhesion molecule 2
chr9_+_118916069 1.120 NM_002581
PAPPA
pregnancy-associated plasma protein A, pappalysin 1
chr17_-_42908178 1.115 NM_001080383
GJC1
gap junction protein, gamma 1, 45kDa
chr17_+_56833231 1.111 NM_014906
PPM1E
protein phosphatase, Mg2+/Mn2+ dependent, 1E
chr12_-_91505215 1.110 LUM
lumican
chrX_-_10851808 1.088 NM_033290
MID1
midline 1 (Opitz/BBB syndrome)
chr5_-_35938736 1.083 NM_001042625
NM_144647
CAPSL

calcyphosine-like

chr9_-_95166827 1.081 NM_014057
NM_033014
OGN

osteoglycin

chr4_-_152149042 1.079 NM_001243349
SH3D19
SH3 domain containing 19
chr1_-_57045214 1.059 PPAP2B
phosphatidic acid phosphatase type 2B
chr2_+_189839078 1.052 NM_000090
COL3A1
collagen, type III, alpha 1
chrX_+_30248552 1.049 NM_002365
MAGEB3
melanoma antigen family B, 3
chr12_+_52056547 1.043 NM_001177984
SCN8A
sodium channel, voltage gated, type VIII, alpha subunit
chr12_-_16759733 1.033 NM_001243610
LMO3
LIM domain only 3 (rhombotin-like 2)
chr3_-_74570262 1.032 NM_020872
CNTN3
contactin 3 (plasmacytoma associated)
chr1_+_147374945 1.028 NM_005267
GJA8
gap junction protein, alpha 8, 50kDa
chr4_+_75174189 1.025 NM_001013442
EPGN
epithelial mitogen homolog (mouse)
chr1_-_116383692 1.021 NM_005599
NHLH2
nescient helix loop helix 2
chr12_-_16759531 1.020 NM_018640
LMO3
LIM domain only 3 (rhombotin-like 2)
chr11_-_85437457 1.020 NM_206927
NM_206928
SYTL2

synaptotagmin-like 2

chr7_-_41742666 1.016 NM_002192
INHBA
inhibin, beta A
chr19_-_36304200 1.015 NM_021232
PRODH2
proline dehydrogenase (oxidase) 2
chr2_+_48796158 1.013 NM_172311
STON1-GTF2A1L
STON1-GTF2A1L readthrough
chrX_+_50027539 0.995 NM_033031
NM_033670
CCNB3

cyclin B3

chr5_-_137475076 0.990 NM_003551
NME5
non-metastatic cells 5, protein expressed in (nucleoside-diphosphate kinase)
chr10_+_101542460 0.985 NM_000392
ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr16_-_20416032 0.984 NM_174924
PDILT
protein disulfide isomerase-like, testis expressed
chr4_+_30721865 0.982 NM_032456
NM_001173523
NM_002589
NM_032457
PCDH7



protocadherin 7



chr1_+_68150858 0.973 NM_001199741
NM_001199742
NM_001924
GADD45A


growth arrest and DNA-damage-inducible, alpha


chr15_-_69707358 0.972 LOC145694
uncharacterized LOC145694
chr5_-_148758787 0.969 NM_014443
IL17B
interleukin 17B
chr3_+_2933898 0.964 NM_001206956
NM_175613
CNTN4

contactin 4

chr5_+_31193852 0.964 CDH6
cadherin 6, type 2, K-cadherin (fetal kidney)
chr16_-_20338808 0.960 NM_001007240
NM_001007241
NM_001007242
NM_001502
GP2



glycoprotein 2 (zymogen granule membrane)



chr21_+_19617145 0.959 NM_024944
CHODL
chondrolectin
chr9_-_104357202 0.958 NM_147180
PPP3R2
protein phosphatase 3, regulatory subunit B, beta
chr10_+_124670216 0.956 NM_001029888
FAM24A
family with sequence similarity 24, member A
chr4_+_155484131 0.947 NM_001184741
NM_005141
FGB

fibrinogen beta chain

chrX_-_55057408 0.946 NM_000032
NM_001037967
NM_001037968
ALAS2


aminolevulinate, delta-, synthase 2


chr4_+_78432905 0.944 NM_006419
CXCL13
chemokine (C-X-C motif) ligand 13
chr2_+_171571936 0.944


chr18_-_40857245 0.940 NM_020783
SYT4
synaptotagmin IV
chr17_-_38956146 0.937 NM_181535
KRT28
keratin 28
chr1_-_54199876 0.936 NM_147193
GLIS1
GLIS family zinc finger 1
chr20_+_62795826 0.935 NM_004535
MYT1
myelin transcription factor 1
chr12_-_52914080 0.935 NM_000424
KRT5
keratin 5

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
2.14 2.79e-04 GO:0048731 system development
2.05 3.16e-04 GO:0048856 anatomical structure development
1.92 1.68e-03 GO:0007275 multicellular organismal development
1.86 1.85e-03 GO:0032502 developmental process
2.52 4.99e-03 GO:0007399 nervous system development
2.98 8.43e-03 GO:0048468 cell development
1.57 3.88e-02 GO:0032501 multicellular organismal process
3.26 4.26e-02 GO:0032989 cellular component morphogenesis
3.22 4.98e-02 GO:0030030 cell projection organization

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
2.99 4.41e-03 GO:0005615 extracellular space
2.55 1.40e-02 GO:0044421 extracellular region part
1.95 3.49e-02 GO:0005576 extracellular region
1.88 4.88e-02 GO:0044459 plasma membrane part

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
7.32 7.99e-03 GO:0008194 UDP-glycosyltransferase activity
17.62 1.18e-02 GO:0015020 glucuronosyltransferase activity
6.67 4.65e-02 GO:0008201 heparin binding