Motif ID: NKX2-3_NKX2-5.p2

Z-value: 1.400


Transcription factors associated with NKX2-3_NKX2-5.p2:

Gene SymbolEntrez IDGene Name
NKX2-3 159296 NK2 transcription factor related, locus 3 (Drosophila)
NKX2-5 1482 NK2 transcription factor related, locus 5 (Drosophila)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NKX2-3hg19_v1_chr10_+_101292689_1012927370.336.7e-02Click!
NKX2-5hg19_v1_chr5_-_172662085_172662314-0.291.1e-01Click!


Activity profile for motif NKX2-3_NKX2-5.p2.

activity profile for motif NKX2-3_NKX2-5.p2


Sorted Z-values histogram for motif NKX2-3_NKX2-5.p2

Sorted Z-values for motif NKX2-3_NKX2-5.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-3_NKX2-5.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_+_41831484 7.234 NM_013377
 PDZRN4
PDZ domain containing ring finger 4
chr7_+_94297448 6.140 PEG10
paternally expressed 10
chr5_+_71502700 3.795 MAP1B
microtubule-associated protein 1B
chr17_+_68071386 3.496 NM_018658
NM_170741
 KCNJ16

potassium inwardly-rectifying channel, subfamily J, member 16

chr12_-_16760935 3.453 NM_001001395
NM_001243609
 LMO3

LIM domain only 3 (rhombotin-like 2)

chr5_-_13944588 3.310 NM_001369
 DNAH5
dynein, axonemal, heavy chain 5
chr13_-_86373328 3.221 NM_032229
 SLITRK6
SLIT and NTRK-like family, member 6
chr8_+_104831415 3.197 NM_014677
 RIMS2
regulating synaptic membrane exocytosis 2
chrX_+_105937067 3.167 NM_024539
 RNF128
ring finger protein 128
chr2_+_102953716 3.115 NM_003856
 IL1RL1
interleukin 1 receptor-like 1
chr19_+_45409003 3.109 NM_000041
 APOE
apolipoprotein E
chr9_+_130026755 3.071 NM_032293
 GARNL3
GTPase activating Rap/RanGAP domain-like 3
chr12_+_41086189 3.050 NM_001843
NM_175038
 CNTN1

contactin 1

chr2_+_234826042 2.893 NM_024080
 TRPM8
transient receptor potential cation channel, subfamily M, member 8
chr3_-_151034514 2.862 NM_023915
 GPR87
G protein-coupled receptor 87
chr7_-_27205123 2.829 HOXA9
homeobox A9
chr7_-_27205075 2.821 HOXA9
homeobox A9
chr12_-_6484389 2.802 NM_001159576
 SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr8_+_24298442 2.768 NM_003817
 ADAM7
ADAM metallopeptidase domain 7
chr2_-_216245573 2.720 FN1
fibronectin 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 9 of 9 entries
Enrichment   P-value GO Accession GO Term
3.26 4.26e-02 GO:0032989 cellular component morphogenesis
3.22 4.98e-02 GO:0030030 cell projection organization
2.98 8.43e-03 GO:0048468 cell development
2.52 4.99e-03 GO:0007399 nervous system development
2.14 2.79e-04 GO:0048731 system development
2.05 3.16e-04 GO:0048856 anatomical structure development
1.92 1.68e-03 GO:0007275 multicellular organismal development
1.86 1.85e-03 GO:0032502 developmental process
1.57 3.88e-02 GO:0032501 multicellular organismal process

Gene overrepresentation in compartment category:

Showing 1 to 4 of 4 entries
Enrichment   P-value GO Accession GO Term
2.99 4.41e-03 GO:0005615 extracellular space
2.55 1.40e-02 GO:0044421 extracellular region part
1.95 3.49e-02 GO:0005576 extracellular region
1.88 4.88e-02 GO:0044459 plasma membrane part

Gene overrepresentation in function category:

Showing 1 to 3 of 3 entries
Enrichment   P-value GO Accession GO Term
17.62 1.18e-02 GO:0015020 glucuronosyltransferase activity
7.32 7.99e-03 GO:0008194 UDP-glycosyltransferase activity
6.67 4.65e-02 GO:0008201 heparin binding