Motif ID: NKX3-2.p2

Z-value: 1.416


Transcription factors associated with NKX3-2.p2:

Gene SymbolEntrez IDGene Name
NKX3-2 579 NK3 homeobox 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NKX3-2hg19_v1_chr4_-_13546037_13546113-0.019.7e-01Click!


Activity profile for motif NKX3-2.p2.

activity profile for motif NKX3-2.p2


Sorted Z-values histogram for motif NKX3-2.p2

Sorted Z-values for motif NKX3-2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX3-2.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_-_106452693 4.867 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr14_-_106877689 4.685 IGHV4-31
IGH@
IGHA1
IGHA2
IGHG1
IGHG4
IGHM
immunoglobulin heavy variable 4-31
immunoglobulin heavy locus
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant alpha 2 (A2m marker)
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 4 (G4m marker)
immunoglobulin heavy constant mu
chr14_-_107179043 4.642 IGHA1
immunoglobulin heavy constant alpha 1
chr14_-_106471439 4.385 IGHA1
IGHG1
IGHM
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant mu
chr17_-_72619794 4.270 NM_181449
 CD300E
CD300e molecule
chr6_-_32497925 4.035 NM_002125
 HLA-DRB5
major histocompatibility complex, class II, DR beta 5
chr5_+_118604417 3.895 NM_001077654
 TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr14_-_106829736 3.877 IGHA1
IGHD
IGHG3
IGHM
SKAP2
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant delta
immunoglobulin heavy constant gamma 3 (G3m marker)
immunoglobulin heavy constant mu
src kinase associated phosphoprotein 2
chr5_+_118604504 3.868 TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr1_-_157670280 3.425 NM_052939
 FCRL3
Fc receptor-like 3
chr11_+_60223281 3.329 NM_021950
NM_152866
 MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr14_-_106453162 3.218 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr10_-_7451198 3.176 NM_001018039
 SFMBT2
Scm-like with four mbt domains 2
chr17_-_38721701 3.139 NM_001838
 CCR7
chemokine (C-C motif) receptor 7
chr3_+_121774208 2.901 NM_001206924
NM_001206925
NM_175862
 CD86


CD86 molecule


chr14_-_106494166 2.587 IGHV4-31
IGHA1
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant alpha 1
chr16_-_88717395 2.503 NM_000101
 CYBA
cytochrome b-245, alpha polypeptide
chr6_-_32731266 2.438 NM_001198858
 HLA-DQB2
major histocompatibility complex, class II, DQ beta 2
chrX_+_117629871 2.396 NM_144658
 DOCK11
dedicator of cytokinesis 11
chr6_-_31550065 2.367 NM_002341
NM_009588
 LTB

lymphotoxin beta (TNF superfamily, member 3)


Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 50 entries
Enrichment   P-value GO Accession GO Term
41.98 2.79e-06 GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
26.43 1.03e-02 GO:0002702 positive regulation of production of molecular mediator of immune response
17.30 1.37e-05 GO:0019882 antigen processing and presentation
15.65 1.21e-02 GO:0030888 regulation of B cell proliferation
14.51 1.76e-02 GO:0050871 positive regulation of B cell activation
14.28 9.77e-06 GO:0002699 positive regulation of immune effector process
12.93 3.12e-02 GO:0002700 regulation of production of molecular mediator of immune response
11.90 8.39e-03 GO:0050864 regulation of B cell activation
11.52 6.58e-05 GO:0050851 antigen receptor-mediated signaling pathway
11.52 1.02e-02 GO:0031294 lymphocyte costimulation
11.52 1.02e-02 GO:0031295 T cell costimulation
10.60 1.35e-04 GO:0002429 immune response-activating cell surface receptor signaling pathway
10.20 1.89e-04 GO:0002768 immune response-regulating cell surface receptor signaling pathway
9.52 3.05e-02 GO:0050852 T cell receptor signaling pathway
8.88 1.48e-04 GO:0050870 positive regulation of T cell activation
8.71 1.05e-05 GO:0051251 positive regulation of lymphocyte activation
8.64 2.79e-06 GO:0050867 positive regulation of cell activation
8.54 1.16e-08 GO:0050865 regulation of cell activation
8.35 6.61e-08 GO:0002694 regulation of leukocyte activation
8.12 2.32e-05 GO:0002696 positive regulation of leukocyte activation

Gene overrepresentation in compartment category:

Showing 1 to 20 of 23 entries
Enrichment   P-value GO Accession GO Term
79.29 2.60e-02 GO:0019814 immunoglobulin complex
79.29 2.60e-02 GO:0019815 B cell receptor complex
50.97 1.12e-07 GO:0042613 MHC class II protein complex
22.31 2.98e-05 GO:0042611 MHC protein complex
8.62 3.14e-05 GO:0009897 external side of plasma membrane
8.35 6.60e-04 GO:0005765 lysosomal membrane
7.12 7.28e-03 GO:0005770 late endosome
6.39 4.66e-03 GO:0005774 vacuolar membrane
6.11 6.46e-03 GO:0044437 vacuolar part
5.02 1.61e-03 GO:0000323 lytic vacuole
5.02 1.61e-03 GO:0005764 lysosome
4.25 7.36e-03 GO:0005773 vacuole
3.92 7.51e-03 GO:0009986 cell surface
3.33 3.47e-02 GO:0005768 endosome
2.57 2.01e-07 GO:0044459 plasma membrane part
2.53 1.94e-03 GO:0031226 intrinsic to plasma membrane
2.47 4.21e-03 GO:0005887 integral to plasma membrane
2.17 2.62e-10 GO:0071944 cell periphery
2.14 1.44e-09 GO:0005886 plasma membrane
1.59 1.14e-03 GO:0031224 intrinsic to membrane

Gene overrepresentation in function category:

Showing 1 to 9 of 9 entries
Enrichment   P-value GO Accession GO Term
44.60 4.49e-03 GO:0032395 MHC class II receptor activity
26.76 5.05e-09 GO:0003823 antigen binding
25.04 2.39e-03 GO:0005164 tumor necrosis factor receptor binding
15.35 1.79e-02 GO:0032813 tumor necrosis factor receptor superfamily binding
12.75 1.04e-03 GO:0004896 cytokine receptor activity
7.71 4.99e-03 GO:0019955 cytokine binding
2.22 3.97e-04 GO:0004871 signal transducer activity
2.22 3.97e-04 GO:0060089 molecular transducer activity
2.19 6.10e-03 GO:0004872 receptor activity