Motif ID: NKX3-2.p2

Z-value: 1.416


Transcription factors associated with NKX3-2.p2:

Gene SymbolEntrez IDGene Name
NKX3-2 579 NK3 homeobox 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NKX3-2hg19_v1_chr4_-_13546037_13546113-0.019.7e-01Click!


Activity profile for motif NKX3-2.p2.

activity profile for motif NKX3-2.p2


Sorted Z-values histogram for motif NKX3-2.p2

Sorted Z-values for motif NKX3-2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX3-2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr14_-_106452693 4.867 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr14_-_106877689 4.685 IGHV4-31
IGH@
IGHA1
IGHA2
IGHG1
IGHG4
IGHM
immunoglobulin heavy variable 4-31
immunoglobulin heavy locus
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant alpha 2 (A2m marker)
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 4 (G4m marker)
immunoglobulin heavy constant mu
chr14_-_107179043 4.642 IGHA1
immunoglobulin heavy constant alpha 1
chr14_-_106471439 4.385 IGHA1
IGHG1
IGHM
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant mu
chr17_-_72619794 4.270 NM_181449
CD300E
CD300e molecule
chr6_-_32497925 4.035 NM_002125
HLA-DRB5
major histocompatibility complex, class II, DR beta 5
chr5_+_118604417 3.895 NM_001077654
TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr14_-_106829736 3.877 IGHA1
IGHD
IGHG3
IGHM
SKAP2
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant delta
immunoglobulin heavy constant gamma 3 (G3m marker)
immunoglobulin heavy constant mu
src kinase associated phosphoprotein 2
chr5_+_118604504 3.868 TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr1_-_157670280 3.425 NM_052939
FCRL3
Fc receptor-like 3
chr11_+_60223281 3.329 NM_021950
NM_152866
MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr14_-_106453162 3.218 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr10_-_7451198 3.176 NM_001018039
SFMBT2
Scm-like with four mbt domains 2
chr17_-_38721701 3.139 NM_001838
CCR7
chemokine (C-C motif) receptor 7
chr3_+_121774208 2.901 NM_001206924
NM_001206925
NM_175862
CD86


CD86 molecule


chr14_-_106494166 2.587 IGHV4-31
IGHA1
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant alpha 1
chr16_-_88717395 2.503 NM_000101
CYBA
cytochrome b-245, alpha polypeptide
chr6_-_32731266 2.438 NM_001198858
HLA-DQB2
major histocompatibility complex, class II, DQ beta 2
chrX_+_117629871 2.396 NM_144658
DOCK11
dedicator of cytokinesis 11
chr6_-_31550065 2.367 NM_002341
NM_009588
LTB

lymphotoxin beta (TNF superfamily, member 3)

chr1_-_24239758 2.261 NM_001841
CNR2
cannabinoid receptor 2 (macrophage)
chr11_-_111249902 2.148 POU2AF1
POU class 2 associating factor 1
chr1_-_111743261 2.146 NM_024901
DENND2D
DENN/MADD domain containing 2D
chr14_-_25078818 2.118 NM_033423
GZMH
granzyme H (cathepsin G-like 2, protein h-CCPX)
chr14_-_106539099 2.115 IGHA1
IGHG1
IGHG3
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
chr2_+_218990735 2.094 NM_001557
CXCR2
chemokine (C-X-C motif) receptor 2
chr14_-_106733392 2.084 IGHG1
IGHG3
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
chr17_+_45810609 2.079 NM_013351
TBX21
T-box 21
chr2_+_204801453 2.058 NM_012092
ICOS
inducible T-cell co-stimulator
chr12_-_123201319 2.051 NM_006018
HCAR3
hydroxycarboxylic acid receptor 3
chr9_-_137809710 2.050 NM_002003
FCN1
ficolin (collagen/fibrinogen domain containing) 1
chr3_+_108541544 2.037 NM_016388
TRAT1
T cell receptor associated transmembrane adaptor 1
chr4_-_164534656 1.967 NM_017923
MARCH1
membrane-associated ring finger (C3HC4) 1
chr19_-_51920841 1.929 NM_001171156
NM_001171157
NM_001171158
NM_001171159
NM_001171160
NM_001171161
NM_033130
SIGLEC10






sialic acid binding Ig-like lectin 10






chr11_-_59633942 1.904 NM_001062
TCN1
transcobalamin I (vitamin B12 binding protein, R binder family)
chr11_-_118084073 1.878 NM_153206
AMICA1
adhesion molecule, interacts with CXADR antigen 1
chr21_+_39628869 1.870 NM_170736
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr1_-_111743080 1.834


chr2_-_113594325 1.831 NM_000576
IL1B
interleukin 1, beta
chr12_-_123187842 1.815 NM_177551
HCAR2
hydroxycarboxylic acid receptor 2
chr14_-_107083398 1.808 IGH@
IGHA1
IGHG1
immunoglobulin heavy locus
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr3_-_182880463 1.791 NM_014398
LAMP3
lysosomal-associated membrane protein 3
chr14_-_106967080 1.778 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr1_-_153363544 1.773 NM_002964
S100A8
S100 calcium binding protein A8
chrX_+_128913897 1.763 SASH3
SAM and SH3 domain containing 3
chrX_+_128913881 1.761 NM_018990
SASH3
SAM and SH3 domain containing 3
chr19_+_50922194 1.738 NM_001243998
NM_001243999
NM_001244000
NM_003121
SPIB



Spi-B transcription factor (Spi-1/PU.1 related)



chr6_-_32557431 1.705 NM_001243965
NM_002124
HLA-DRB1

HLA-DRB4
HLA-DRB5
major histocompatibility complex, class II, DR beta 1

major histocompatibility complex, class II, DR beta 4
major histocompatibility complex, class II, DR beta 5
chr1_+_26644458 1.663 CD52
CD52 molecule
chr14_-_106321626 1.660


chr19_+_42381189 1.640 NM_001783
NM_021601
CD79A

CD79a molecule, immunoglobulin-associated alpha

chr22_+_37257004 1.639 NM_000631
NM_013416
NCF4

neutrophil cytosolic factor 4, 40kDa

chr6_-_41715078 1.625 NM_001166424
NM_002630
PGC

progastricsin (pepsinogen C)

chr9_+_95736717 1.624 NM_033086
FGD3
FYVE, RhoGEF and PH domain containing 3
chr11_+_117857062 1.618 NM_001558
IL10RA
interleukin 10 receptor, alpha
chr15_+_77287738 1.618 PSTPIP1
proline-serine-threonine phosphatase interacting protein 1
chr5_-_149792335 1.612


chr19_+_1026627 1.605 CNN2
calponin 2
chr3_+_186714335 1.604


chr11_+_117857123 1.595 IL10RA
interleukin 10 receptor, alpha
chr18_-_30352841 1.590 NM_020805
KLHL14
kelch-like 14 (Drosophila)
chr21_+_39628663 1.587 NM_002243
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr19_+_1026608 1.585 CNN2
calponin 2
chr1_-_36948423 1.583 CSF3R
colony stimulating factor 3 receptor (granulocyte)
chrX_-_100641143 1.580 NM_000061
BTK
Bruton agammaglobulinemia tyrosine kinase
chr1_-_111743297 1.561 DENND2D
DENN/MADD domain containing 2D
chr1_-_160492982 1.527 NM_001184714
NM_001184715
NM_001184716
NM_052931
SLAMF6



SLAM family member 6



chr1_+_17634689 1.523 NM_012387
PADI4
peptidyl arginine deiminase, type IV
chr1_+_26856252 1.523 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr17_-_72527592 1.510 NM_174892
CD300LB
CD300 molecule-like family member b
chr19_+_1026582 1.500 CNN2
calponin 2
chr19_-_7766978 1.491 NM_001220500
NM_002002
FCER2

Fc fragment of IgE, low affinity II, receptor for (CD23)

chr5_-_149792370 1.480 NM_001025158
NM_001025159
NM_004355
CD74


CD74 molecule, major histocompatibility complex, class II invariant chain


chr1_+_26856240 1.479 NM_002953
RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr17_-_43319100 1.478


chr2_+_68592432 1.459 PLEK
pleckstrin
chr9_-_215892 1.448 NM_152569
C9orf66
chromosome 9 open reading frame 66
chr13_+_31287614 1.444 NM_001204406
ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr2_-_145277879 1.440 NM_001171653
NM_014795
ZEB2

zinc finger E-box binding homeobox 2

chr17_+_76126835 1.435 NM_152468
TMC8
transmembrane channel-like 8
chr1_+_153330329 1.428 NM_002965
S100A9
S100 calcium binding protein A9
chr14_-_107099379 1.427 IGHG1
IGHG3
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
chr11_-_111250156 1.417 NM_006235
POU2AF1
POU class 2 associating factor 1
chr1_+_158259558 1.412 NM_001765
CD1C
CD1c molecule
chr12_+_4382882 1.410 NM_001759
CCND2
cyclin D2
chr13_+_108921976 1.408 NM_001145645
NM_006573
TNFSF13B

tumor necrosis factor (ligand) superfamily, member 13b

chr5_-_39424930 1.405 DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr9_-_117692874 1.386 NM_001244
NM_001252290
TNFSF8

tumor necrosis factor (ligand) superfamily, member 8

chr13_+_108922205 1.385 TNFSF13B
tumor necrosis factor (ligand) superfamily, member 13b
chr11_+_65407591 1.382 NM_153253
SIPA1
signal-induced proliferation-associated 1
chr17_-_79623561 1.364 NM_002602
PDE6G
phosphodiesterase 6G, cGMP-specific, rod, gamma
chr12_-_57006864 1.355 BAZ2A
bromodomain adjacent to zinc finger domain, 2A
chr1_-_161601752 1.354 NM_000570
FCGR3B
Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
chr6_+_29974352 1.340 HLA-J
major histocompatibility complex, class I, J (pseudogene)
chr14_+_105953531 1.340 CRIP1
cysteine-rich protein 1 (intestinal)
chr1_-_31230594 1.337 LAPTM5
lysosomal protein transmembrane 5
chr17_-_46655544 1.336 NM_024015
HOXB4
homeobox B4
chr6_+_32407618 1.329 NM_019111
HLA-DRA
major histocompatibility complex, class II, DR alpha
chr1_-_157522151 1.324 NM_001195388
NM_031281
FCRL5

Fc receptor-like 5

chr7_+_139528951 1.322 NM_001061
NM_001166253
NM_030984
TBXAS1


thromboxane A synthase 1 (platelet)


chr14_-_106641585 1.316 IGHV4-31
IGHA1
IGHA2
IGHG1
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant alpha 2 (A2m marker)
immunoglobulin heavy constant gamma 1 (G1m marker)
chr13_-_103719195 1.310 NM_000452
SLC10A2
solute carrier family 10 (sodium/bile acid cotransporter family), member 2
chr1_-_25256718 1.309 RUNX3
runt-related transcription factor 3
chr14_-_24809031 1.308 NM_006871
RIPK3
receptor-interacting serine-threonine kinase 3
chr17_-_56409868 1.306


chr12_-_54694647 1.296 NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr19_+_1026624 1.296 CNN2
calponin 2
chr22_+_44577256 1.285 NM_001137606
PARVG
parvin, gamma
chr15_-_74726258 1.284 NM_001146029
NM_003612
SEMA7A

semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)

chr1_+_117544371 1.281 NM_004258
CD101
CD101 molecule
chr20_+_54987167 1.269 NM_001164116
NM_001164114
NM_001164115
NM_020356
CASS4



Cas scaffolding protein family member 4



chr17_-_76128487 1.267 NM_007267
TMC6
transmembrane channel-like 6
chr10_+_49893514 1.267 NM_020945
WDFY4
WDFY family member 4
chr14_-_105531739 1.263 NM_013345
GPR132
G protein-coupled receptor 132
chr5_-_39425030 1.262 DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr19_-_8642309 1.258 NM_012335
MYO1F
myosin IF
chr7_+_26403944 1.257 NM_001199838
SNX10
sorting nexin 10
chr15_+_77287688 1.249 PSTPIP1
proline-serine-threonine phosphatase interacting protein 1
chr2_-_192015733 1.242 STAT4
signal transducer and activator of transcription 4
chr20_-_1472168 1.239 NM_001122962
NM_001134836
SIRPB2

signal-regulatory protein beta 2

chr1_-_25256767 1.232 NM_004350
RUNX3
runt-related transcription factor 3
chr2_+_102979096 1.229 NM_003855
IL18R1
interleukin 18 receptor 1
chr1_+_172628157 1.228 NM_000639
FASLG
Fas ligand (TNF superfamily, member 6)
chr16_+_28996369 1.224 NM_001014987
NM_001014988
NM_014387
LAT


linker for activation of T cells


chr1_+_26644380 1.213 NM_001803
CD52
CD52 molecule
chrX_-_19905449 1.207 SH3KBP1
SH3-domain kinase binding protein 1
chr2_+_228678556 1.207 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr20_-_1472004 1.202 SIRPB2
signal-regulatory protein beta 2
chr10_+_11047253 1.201 NM_001025077
CELF2
CUGBP, Elav-like family member 2
chr12_+_69742130 1.198 NM_000239
LYZ
lysozyme
chr1_+_111742946 1.198


chr8_+_22019167 1.192 NM_001172357
NM_001172410
NM_003018
SFTPC


surfactant protein C


chr5_+_133451297 1.184 NM_001134851
NM_201632
NM_201634
NM_213648
TCF7



transcription factor 7 (T-cell specific, HMG-box)



chr12_-_54694717 1.178 NM_001136023
NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr12_+_54891539 1.171 NCKAP1L
NCK-associated protein 1-like
chr17_-_16875388 1.170 NM_012452
TNFRSF13B
tumor necrosis factor receptor superfamily, member 13B
chr16_+_29674282 1.168 NM_001030288
SPN
sialophorin
chr7_+_139478033 1.161 NM_001130966
NM_001166254
TBXAS1

thromboxane A synthase 1 (platelet)

chr1_-_23857284 1.158 E2F2
E2F transcription factor 2
chr15_-_40600025 1.157 PLCB2
phospholipase C, beta 2
chr22_+_23165273 1.157


chr22_+_22569155 1.154


chr19_+_7702020 1.152 STXBP2
syntaxin binding protein 2
chr4_-_25032306 1.148 NM_018176
LGI2
leucine-rich repeat LGI family, member 2
chr16_-_28222700 1.145 XPO6
exportin 6
chr11_-_128457452 1.145 NM_001143820
ETS1
v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)
chr9_+_78505514 1.141 NM_001190482
NM_006200
PCSK5

proprotein convertase subtilisin/kexin type 5

chrX_-_47489703 1.140 NM_002621
CFP
complement factor properdin
chr15_-_40599872 1.138 PLCB2
phospholipase C, beta 2
chr6_+_20404033 1.136 NM_001243076
E2F3
E2F transcription factor 3
chr17_+_4835591 1.135 NM_000173
GP1BA
glycoprotein Ib (platelet), alpha polypeptide
chr14_-_107113943 1.134 IGHA1
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr9_-_33447527 1.128 NM_004925
AQP3
aquaporin 3 (Gill blood group)
chr1_+_211519705 1.126 NM_145759
TRAF5
TNF receptor-associated factor 5
chr16_-_30394133 1.125 NM_052838
SEPT1
septin 1
chr6_-_31324955 1.118 HLA-B
major histocompatibility complex, class I, B
chr1_+_32674694 1.113 NM_001099434
DCDC2B
doublecortin domain containing 2B
chr1_-_160990971 1.108 NM_016946
F11R
F11 receptor
chr8_+_32785485 1.101


chr2_-_192015751 1.098 STAT4
signal transducer and activator of transcription 4
chr19_+_7733971 1.098 NM_001193374
NM_020415
RETN

resistin

chr9_-_139927291 1.090 NM_004479
FUT7
fucosyltransferase 7 (alpha (1,3) fucosyltransferase)
chr22_-_37545944 1.088 NM_000878
IL2RB
interleukin 2 receptor, beta
chr1_-_160990862 1.085 F11R
F11 receptor
chr1_-_159895279 1.079 NM_003564
TAGLN2
transgelin 2
chr6_+_26251826 1.077 NM_003524
HIST1H2BH
histone cluster 1, H2bh
chr1_+_154975041 1.074 NM_001252405
NM_015872
ZBTB7B

zinc finger and BTB domain containing 7B

chr1_-_92949500 1.072 GFI1
growth factor independent 1 transcription repressor
chr6_-_31324898 1.070 HLA-B
major histocompatibility complex, class I, B
chr19_+_544026 1.069 NM_005317
GZMM
granzyme M (lymphocyte met-ase 1)
chr2_+_219125737 1.069 NM_001077191
NM_001077194
NM_170699
GPBAR1


G protein-coupled bile acid receptor 1


chr2_-_145277568 1.064 ZEB2
zinc finger E-box binding homeobox 2
chr3_+_122044010 1.063 NM_005213
CSTA
cystatin A (stefin A)
chr13_+_31309644 1.061 NM_001629
ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr15_-_40600118 1.061 NM_004573
PLCB2
phospholipase C, beta 2
chr1_+_168250277 1.060 NM_005149
TBX19
T-box 19
chr5_-_55529185 1.058 NM_024669
ANKRD55
ankyrin repeat domain 55
chr6_-_30712294 1.057 NM_003897
IER3
immediate early response 3
chr5_-_176936542 1.054


chr6_-_32634287 1.054 NM_001243961
NM_002123
HLA-DQB1

major histocompatibility complex, class II, DQ beta 1

chr8_-_134072404 1.052 NM_006748
SLA
Src-like-adaptor
chr1_+_107682628 1.049 NM_001113226
NM_001113228
NM_014917
NTNG1


netrin G1


chr12_+_69742140 1.039 LYZ
lysozyme
chr17_-_29648631 1.037 NM_001003927
NM_014210
EVI2A

ecotropic viral integration site 2A

chr19_+_16435734 1.031 KLF2
Kruppel-like factor 2 (lung)
chr8_-_99057594 1.027 RPL30
ribosomal protein L30
chr2_-_70781146 1.025 NM_001099691
NM_003236
TGFA

transforming growth factor, alpha

chr19_-_52150007 1.023 NM_001098612
SIGLEC14
sialic acid binding Ig-like lectin 14
chr19_+_35940616 1.020 NM_005306
FFAR2
free fatty acid receptor 2
chr13_-_46756326 1.019 NM_002298
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr19_+_49838673 1.018 NM_001040031
NM_001774
CD37

CD37 molecule

chr4_+_36283243 1.016 NM_001136536
DTHD1
death domain containing 1
chr15_+_58430394 1.004 NM_020980
AQP9
aquaporin 9
chr19_+_52264452 1.002 NM_001005738
FPR2
formyl peptide receptor 2
chr8_-_66701175 1.001 NM_002603
PDE7A
phosphodiesterase 7A
chr2_+_70142303 1.000 MXD1
MAX dimerization protein 1
chrX_-_153979796 0.999 GAB3
GRB2-associated binding protein 3
chr1_-_25291474 0.996 NM_001031680
RUNX3
runt-related transcription factor 3
chr11_+_118215058 0.995 NM_000073
CD3G
CD3g molecule, gamma (CD3-TCR complex)
chr14_+_21423627 0.990 NM_002934
RNASE2
ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
5.56 6.60e-23 GO:0002376 immune system process
6.82 2.83e-19 GO:0006955 immune response
6.42 2.91e-09 GO:0002684 positive regulation of immune system process
8.54 1.16e-08 GO:0050865 regulation of cell activation
4.91 1.17e-08 GO:0002682 regulation of immune system process
6.07 2.71e-08 GO:0050776 regulation of immune response
1.81 3.52e-08 GO:0050896 response to stimulus
8.35 6.61e-08 GO:0002694 regulation of leukocyte activation
8.05 1.72e-06 GO:0051249 regulation of lymphocyte activation
8.64 2.79e-06 GO:0050867 positive regulation of cell activation
41.98 2.79e-06 GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
14.28 9.77e-06 GO:0002699 positive regulation of immune effector process
8.71 1.05e-05 GO:0051251 positive regulation of lymphocyte activation
17.30 1.37e-05 GO:0019882 antigen processing and presentation
8.12 2.32e-05 GO:0002696 positive regulation of leukocyte activation
2.26 2.84e-05 GO:0048518 positive regulation of biological process
6.15 5.26e-05 GO:0050778 positive regulation of immune response
11.52 6.58e-05 GO:0050851 antigen receptor-mediated signaling pathway
7.89 1.19e-04 GO:0050863 regulation of T cell activation
10.60 1.35e-04 GO:0002429 immune response-activating cell surface receptor signaling pathway
3.60 1.41e-04 GO:0048584 positive regulation of response to stimulus
8.88 1.48e-04 GO:0050870 positive regulation of T cell activation
3.55 1.78e-04 GO:0006952 defense response
10.20 1.89e-04 GO:0002768 immune response-regulating cell surface receptor signaling pathway
1.96 5.44e-04 GO:0007165 signal transduction
1.83 6.25e-04 GO:0051716 cellular response to stimulus
6.96 1.40e-03 GO:0002757 immune response-activating signal transduction
6.15 1.43e-03 GO:0002253 activation of immune response
6.80 1.73e-03 GO:0002764 immune response-regulating signaling pathway
1.85 1.84e-03 GO:0023052 signaling
2.34 2.13e-03 GO:0048583 regulation of response to stimulus
1.48 3.05e-03 GO:0050789 regulation of biological process
7.29 3.21e-03 GO:0002697 regulation of immune effector process
1.44 6.07e-03 GO:0065007 biological regulation
5.84 6.76e-03 GO:0071345 cellular response to cytokine stimulus
11.90 8.39e-03 GO:0050864 regulation of B cell activation
11.52 1.02e-02 GO:0031294 lymphocyte costimulation
11.52 1.02e-02 GO:0031295 T cell costimulation
26.43 1.03e-02 GO:0002702 positive regulation of production of molecular mediator of immune response
4.92 1.19e-02 GO:0006954 inflammatory response
15.65 1.21e-02 GO:0030888 regulation of B cell proliferation
14.51 1.76e-02 GO:0050871 positive regulation of B cell activation
5.18 1.91e-02 GO:0045321 leukocyte activation
6.71 2.04e-02 GO:0002252 immune effector process
4.63 2.11e-02 GO:0034097 response to cytokine stimulus
2.75 2.88e-02 GO:0042127 regulation of cell proliferation
9.52 3.05e-02 GO:0050852 T cell receptor signaling pathway
12.93 3.12e-02 GO:0002700 regulation of production of molecular mediator of immune response
3.53 3.43e-02 GO:0008284 positive regulation of cell proliferation
2.78 3.98e-02 GO:0009611 response to wounding

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
2.17 2.62e-10 GO:0071944 cell periphery
2.14 1.44e-09 GO:0005886 plasma membrane
50.97 1.12e-07 GO:0042613 MHC class II protein complex
2.57 2.01e-07 GO:0044459 plasma membrane part
22.31 2.98e-05 GO:0042611 MHC protein complex
8.62 3.14e-05 GO:0009897 external side of plasma membrane
1.57 1.66e-04 GO:0044425 membrane part
8.35 6.60e-04 GO:0005765 lysosomal membrane
1.59 1.14e-03 GO:0031224 intrinsic to membrane
5.02 1.61e-03 GO:0000323 lytic vacuole
5.02 1.61e-03 GO:0005764 lysosome
2.53 1.94e-03 GO:0031226 intrinsic to plasma membrane
1.41 3.31e-03 GO:0016020 membrane
2.47 4.21e-03 GO:0005887 integral to plasma membrane
6.39 4.66e-03 GO:0005774 vacuolar membrane
1.55 5.39e-03 GO:0016021 integral to membrane
6.11 6.46e-03 GO:0044437 vacuolar part
7.12 7.28e-03 GO:0005770 late endosome
4.25 7.36e-03 GO:0005773 vacuole
3.92 7.51e-03 GO:0009986 cell surface
79.29 2.60e-02 GO:0019814 immunoglobulin complex
79.29 2.60e-02 GO:0019815 B cell receptor complex
3.33 3.47e-02 GO:0005768 endosome

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
26.76 5.05e-09 GO:0003823 antigen binding
2.22 3.97e-04 GO:0004871 signal transducer activity
2.22 3.97e-04 GO:0060089 molecular transducer activity
12.75 1.04e-03 GO:0004896 cytokine receptor activity
25.04 2.39e-03 GO:0005164 tumor necrosis factor receptor binding
44.60 4.49e-03 GO:0032395 MHC class II receptor activity
7.71 4.99e-03 GO:0019955 cytokine binding
2.19 6.10e-03 GO:0004872 receptor activity
15.35 1.79e-02 GO:0032813 tumor necrosis factor receptor superfamily binding