Motif ID: NKX6-1,2.p2

Z-value: 1.356


Transcription factors associated with NKX6-1,2.p2:

Gene SymbolEntrez IDGene Name
NKX6-1 4825 NK6 homeobox 1
NKX6-2 84504 NK6 homeobox 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NKX6-2hg19_v1_chr10_-_134599477_1345995360.202.8e-01Click!
NKX6-1hg19_v1_chr4_-_85419386_854193860.125.2e-01Click!


Activity profile for motif NKX6-1,2.p2.

activity profile for motif NKX6-1,2.p2


Sorted Z-values histogram for motif NKX6-1,2.p2

Sorted Z-values for motif NKX6-1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX6-1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_+_101988746 6.287 NM_002465
NM_206819
NM_206820
NM_206821
MYBPC1



myosin binding protein C, slow type



chr6_+_118869441 4.278 NM_002667
PLN
phospholamban
chr4_-_177190258 3.989 NM_080874
ASB5
ankyrin repeat and SOCS box containing 5
chr8_+_79428335 3.892 NM_006823
NM_181839
PKIA

protein kinase (cAMP-dependent, catalytic) inhibitor alpha

chr6_+_41020939 3.574 NM_006789
APOBEC2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2
chr1_+_110993748 3.466 NM_032414
PROK1
prokineticin 1
chr19_-_49220213 3.261 NM_182574
MAMSTR
MEF2 activating motif and SAP domain containing transcriptional regulator
chrX_-_33229428 3.229 NM_004006
DMD
dystrophin
chr4_+_169418167 3.177 NM_001166108
NM_016081
PALLD

palladin, cytoskeletal associated protein

chr5_+_145316120 3.140 NM_152550
SH3RF2
SH3 domain containing ring finger 2
chr5_+_149997205 2.885 NM_001166209
SYNPO
synaptopodin
chr3_-_47957475 2.833


chr18_+_32290195 2.633 NM_001198941
NM_032978
DTNA

dystrobrevin, alpha

chr15_+_36932805 2.574 NM_032499
C15orf41
chromosome 15 open reading frame 41
chr11_-_7727940 2.550 NM_198185
OVCH2
ovochymase 2 (gene/pseudogene)
chr2_-_161056762 2.543 ITGB6
integrin, beta 6
chr4_+_75174189 2.536 NM_001013442
EPGN
epithelial mitogen homolog (mouse)
chrX_-_103087106 2.448 NM_016370
RAB9B
RAB9B, member RAS oncogene family
chr13_+_23755059 2.389 NM_000231
SGCG
sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
chr19_+_51376688 2.382 NM_001002231
NM_005551
KLK2

kallikrein-related peptidase 2

chr2_-_161056573 2.326 NM_000888
ITGB6
integrin, beta 6
chr20_+_20037289 2.312 NM_001167816
C20orf26
chromosome 20 open reading frame 26
chr16_-_46782104 2.201 NM_182493
MYLK3
myosin light chain kinase 3
chr5_-_150727088 2.198 NM_181776
SLC36A2
solute carrier family 36 (proton/amino acid symporter), member 2
chr11_-_118047145 2.194 SCN2B
sodium channel, voltage-gated, type II, beta
chr3_-_39234071 2.163 NM_194293
NM_001198621
XIRP1

xin actin-binding repeat containing 1

chr5_+_155753755 2.138 NM_000337
NM_001128209
NM_172244
SGCD


sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)


chr10_-_115423640 2.116 NM_006175
NM_198060
NRAP

nebulin-related anchoring protein

chr8_-_82395401 2.107 NM_001442
FABP4
fatty acid binding protein 4, adipocyte
chr2_-_157186681 2.097 NR4A2
nuclear receptor subfamily 4, group A, member 2
chr17_-_67057046 2.080 NM_080283
ABCA9
ATP-binding cassette, sub-family A (ABC1), member 9
chr12_-_6233684 2.050 NM_000552
VWF
von Willebrand factor
chr3_-_196242190 1.999 NM_001077657
C3orf43
chromosome 3 open reading frame 43
chr11_-_118047336 1.958 NM_004588
SCN2B
sodium channel, voltage-gated, type II, beta
chr14_+_101295409 1.934 MEG3
maternally expressed 3 (non-protein coding)
chr22_-_36013303 1.925 NM_005368
NM_203378
MB

myoglobin

chr8_-_52721903 1.868 NM_144651
PXDNL
peroxidasin homolog (Drosophila)-like
chr18_-_3219986 1.846 NM_003803
NM_019856
MYOM1

myomesin 1, 185kDa

chr2_-_211168315 1.821 NM_079422
MYL1
myosin, light chain 1, alkali; skeletal, fast
chr1_+_209602164 1.784 NM_001104548
MIR205HG
MIR205 host gene (non-protein coding)
chrX_+_135230736 1.780 NM_001159700
FHL1
four and a half LIM domains 1
chr4_+_41258895 1.739 NM_004181
UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr12_+_119616594 1.736 NM_014365
HSPB8
heat shock 22kDa protein 8
chr12_-_122839015 1.735 CLIP1
CAP-GLY domain containing linker protein 1
chr4_+_41700736 1.697 LIMCH1
LIM and calponin homology domains 1
chr2_-_217559497 1.640 IGFBP5
insulin-like growth factor binding protein 5
chr13_+_53602829 1.637 NM_006418
OLFM4
olfactomedin 4
chr4_+_41258909 1.605 UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr7_-_137028533 1.601 NM_002825
PTN
pleiotrophin
chr20_+_43835637 1.592 NM_003007
SEMG1
semenogelin I
chr18_-_3219846 1.580 MYOM1
myomesin 1, 185kDa
chr4_-_186733372 1.579 NM_003603
NM_001145670
SORBS2

sorbin and SH3 domain containing 2

chr5_+_79330990 1.558 NM_003248
THBS4
thrombospondin 4
chr1_+_172389827 1.553 NM_139240
C1orf105
chromosome 1 open reading frame 105
chr3_+_16216155 1.506 NM_054110
GALNTL2
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 2
chr4_-_186732047 1.499 NM_001145672
SORBS2
sorbin and SH3 domain containing 2
chr1_+_74701070 1.498 NM_015978
TNNI3K
TNNI3 interacting kinase
chr9_+_130026755 1.491 NM_032293
GARNL3
GTPase activating Rap/RanGAP domain-like 3
chr14_-_61115906 1.458 NM_005982
SIX1
SIX homeobox 1
chr13_-_44203608 1.456 NM_001127615
ENOX1
ecto-NOX disulfide-thiol exchanger 1
chr12_+_107078476 1.455 NM_032491
RFX4
regulatory factor X, 4 (influences HLA class II expression)
chr6_-_146056896 1.446 NM_001018041
NM_005670
EPM2A

epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)

chr6_+_53883713 1.426 NM_138569
MLIP
muscular LMNA-interacting protein
chr2_-_217560247 1.414 NM_000599
IGFBP5
insulin-like growth factor binding protein 5
chr3_-_15839674 1.380 NM_001195098
ANKRD28
ankyrin repeat domain 28
chr18_+_55816546 1.370 NM_001144965
NM_001144968
NM_001144969
NM_001144971
NEDD4L



neural precursor cell expressed, developmentally down-regulated 4-like



chr8_-_15095791 1.368 NM_139167
SGCZ
sarcoglycan, zeta
chr8_+_39771327 1.349 NM_002164
IDO1
indoleamine 2,3-dioxygenase 1
chr12_+_112890999 1.341 PTPN11
protein tyrosine phosphatase, non-receptor type 11
chr8_+_24298442 1.340 NM_003817
ADAM7
ADAM metallopeptidase domain 7
chr12_+_48513012 1.332 NM_000289
PFKM
phosphofructokinase, muscle
chr3_-_58563070 1.317 FAM107A
family with sequence similarity 107, member A
chr3_+_189507448 1.317 NM_001114980
NM_001114981
NM_001114982
TP63


tumor protein p63


chr5_-_58295758 1.313 NM_001197223
PDE4D
phosphodiesterase 4D, cAMP-specific
chr4_-_65275000 1.303 NM_001010874
TECRL
trans-2,3-enoyl-CoA reductase-like
chr1_-_109935869 1.291 NM_001205228
SORT1
sortilin 1
chr8_-_72274466 1.288 NM_000503
EYA1
eyes absent homolog 1 (Drosophila)
chr19_+_12175513 1.278 NM_001136501
ZNF844
zinc finger protein 844
chr16_+_78062985 1.262 NM_001244755
CLEC3A
C-type lectin domain family 3, member A
chr2_-_238322814 1.261 COL6A3
collagen, type VI, alpha 3
chrX_-_138286434 1.260 FGF13
fibroblast growth factor 13
chr3_-_69171536 1.247 NM_198271
LMOD3
leiomodin 3 (fetal)
chr2_+_220309373 1.236 SPEG
SPEG complex locus
chr4_+_76995862 1.233 NM_001130016
NM_001179
ART3

ADP-ribosyltransferase 3

chr18_+_43306917 1.232 NM_001146037
SLC14A1
solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
chr13_-_33760215 1.229 NM_001243466
NM_178007
STARD13

StAR-related lipid transfer (START) domain containing 13

chr6_+_47666288 1.226 NM_153838
GPR115
G protein-coupled receptor 115
chr6_-_46293628 1.219 NM_005822
RCAN2
regulator of calcineurin 2
chr17_+_11465073 1.202 SHISA6
shisa homolog 6 (Xenopus laevis)
chr4_-_47840058 1.198 NM_006587
CORIN
corin, serine peptidase
chr11_+_111126706 1.193 NM_198498
C11orf53
chromosome 11 open reading frame 53
chr2_-_100939194 1.175 NM_198461
LONRF2
LON peptidase N-terminal domain and ring finger 2
chr2_-_238322806 1.167 COL6A3
collagen, type VI, alpha 3
chr7_+_123249076 1.155 NM_080928
ASB15
ankyrin repeat and SOCS box containing 15
chr3_-_58563490 1.154 NM_001076778
NM_007177
FAM107A

family with sequence similarity 107, member A

chr13_-_36429798 1.143 NM_001195415
NM_001195416
NM_001195430
DCLK1


doublecortin-like kinase 1


chr5_+_38445577 1.139 NM_182801
EGFLAM
EGF-like, fibronectin type III and laminin G domains
chr13_-_45048436 1.129 NM_001243798
TSC22D1
TSC22 domain family, member 1
chr2_-_238322840 1.129 NM_004369
NM_057164
NM_057165
NM_057166
NM_057167
COL6A3




collagen, type VI, alpha 3




chr13_-_38172862 1.116 NM_001135934
NM_001135935
NM_001135936
NM_006475
POSTN



periostin, osteoblast specific factor



chrX_-_15402469 1.111 NM_004469
FIGF
c-fos induced growth factor (vascular endothelial growth factor D)
chr11_-_102401430 1.103 NM_002423
MMP7
matrix metallopeptidase 7 (matrilysin, uterine)
chr2_-_238322815 1.098 COL6A3
collagen, type VI, alpha 3
chr12_+_75784849 1.093 GLIPR1L2
GLI pathogenesis-related 1 like 2
chr1_+_12403045 1.077 VPS13D
vacuolar protein sorting 13 homolog D (S. cerevisiae)
chr1_+_155853546 1.072 SYT11
synaptotagmin XI
chr3_+_85775631 1.069 NM_153184
CADM2
cell adhesion molecule 2
chr21_-_31864274 1.067 NM_181609
KRTAP19-3
keratin associated protein 19-3
chr19_-_42931500 1.065 NM_005357
LIPE
lipase, hormone-sensitive
chr4_-_138453628 1.053 NM_019035
PCDH18
protocadherin 18
chr14_+_32798478 1.051 NM_004274
AKAP6
A kinase (PRKA) anchor protein 6
chr17_-_42992852 1.049 NM_001131019
NM_001242376
NM_002055
GFAP


glial fibrillary acidic protein


chr9_+_82186846 1.046 NM_007005
TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr3_+_174158646 1.042 NAALADL2
N-acetylated alpha-linked acidic dipeptidase-like 2
chr8_-_7212868 1.039 FAM66B
family with sequence similarity 66, member B
chr9_-_21385258 1.037 NM_000605
IFNA2
interferon, alpha 2
chr4_-_152149042 1.029 NM_001243349
SH3D19
SH3 domain containing 19
chr4_-_44653657 1.028 NM_182592
YIPF7
Yip1 domain family, member 7
chr2_-_178787522 1.018 NM_001077358
PDE11A
phosphodiesterase 11A
chr15_+_80733579 1.013 ARNT2
aryl-hydrocarbon receptor nuclear translocator 2
chr8_-_23712297 1.007 NM_003155
STC1
stanniocalcin 1
chr3_-_150966901 1.007 NM_001081455
P2RY14
purinergic receptor P2Y, G-protein coupled, 14
chr10_+_50887683 1.006 NM_001042427
NM_182554
C10orf53

chromosome 10 open reading frame 53

chr1_-_217250230 0.996 NM_001243507
NM_001243509
ESRRG

estrogen-related receptor gamma

chr2_-_178973065 0.988 NM_001077197
PDE11A
phosphodiesterase 11A
chr1_-_54199876 0.974 NM_147193
GLIS1
GLIS family zinc finger 1
chr4_+_119948322 0.974 SYNPO2
synaptopodin 2
chr6_+_158733691 0.973 NM_001007466
NM_020245
TULP4

tubby like protein 4

chr4_-_87374282 0.969 NM_002753
MAPK10
mitogen-activated protein kinase 10
chr7_+_23286384 0.969 GPNMB
glycoprotein (transmembrane) nmb
chr6_-_56716412 0.964 DST
dystonin
chr5_+_140566655 0.962 NM_019119
PCDHB9
protocadherin beta 9
chr9_+_71944240 0.958 NM_004816
FAM189A2
family with sequence similarity 189, member A2
chr8_-_72268720 0.953 NM_172058
NM_172059
NM_172060
EYA1


eyes absent homolog 1 (Drosophila)


chr12_-_111358353 0.949 NM_000432
MYL2
myosin, light chain 2, regulatory, cardiac, slow
chr5_+_166711842 0.945 NM_001122679
ODZ2
odz, odd Oz/ten-m homolog 2 (Drosophila)
chr8_-_109799769 0.941 NM_153015
TMEM74
transmembrane protein 74
chr8_-_82359620 0.938 NM_002677
PMP2
peripheral myelin protein 2
chr13_+_24883715 0.938 NM_178540
C1QTNF9
C1q and tumor necrosis factor related protein 9
chr15_-_93277303 0.933 FAM174B
family with sequence similarity 174, member B
chr4_+_41258941 0.932 UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr20_-_50313990 0.927 ATP9A
ATPase, class II, type 9A
chr7_+_23286420 0.926 GPNMB
glycoprotein (transmembrane) nmb
chr21_-_31588242 0.901 NM_199328
CLDN8
claudin 8
chr7_+_77469446 0.899 NM_001127357
NM_001127359
NM_020432
PHTF2


putative homeodomain transcription factor 2


chr18_-_40857245 0.889 NM_020783
SYT4
synaptotagmin IV
chr3_-_112013073 0.880 NM_183061
SLC9A10
solute carrier family 9, member 10
chr1_-_42776760 0.874


chr4_+_119948273 0.872 SYNPO2
synaptopodin 2
chr12_-_46633551 0.871 SLC38A1
solute carrier family 38, member 1
chr4_-_170077807 0.869 SH3RF1
SH3 domain containing ring finger 1
chr3_-_52294427 0.867 WDR82
WD repeat domain 82
chr1_-_115269672 0.861 CSDE1
cold shock domain containing E1, RNA-binding
chr15_-_77154284 0.855 NM_001145923
SCAPER
S-phase cyclin A-associated protein in the ER
chr2_-_228244005 0.849 NM_024795
TM4SF20
transmembrane 4 L six family member 20
chr18_+_61370193 0.839 NM_080475
SERPINB11
serpin peptidase inhibitor, clade B (ovalbumin), member 11 (gene/pseudogene)
chr12_+_58003962 0.837 NM_001111270
ARHGEF25
Rho guanine nucleotide exchange factor (GEF) 25
chr7_+_64601439 0.831 INTS4L1
integrator complex subunit 4-like 1
chr19_+_41281281 0.830 NM_006533
MIA
melanoma inhibitory activity
chr12_+_111284763 0.817 NM_152591
CCDC63
coiled-coil domain containing 63
chr1_+_84864214 0.814 NM_021233
DNASE2B
deoxyribonuclease II beta
chr4_-_140201339 0.799 NM_032623
C4orf49
chromosome 4 open reading frame 49
chr6_+_72922513 0.798 NM_001168407
NM_001168408
RIMS1

regulating synaptic membrane exocytosis 1

chr5_+_140739589 0.797 NM_018923
NM_032096
PCDHGB2

protocadherin gamma subfamily B, 2

chr3_-_93747453 0.784 NM_001001850
STX19
syntaxin 19
chr8_-_124749573 0.781 NM_001003954
NM_004306
ANXA13

annexin A13

chr4_-_185139018 0.779 NM_153343
ENPP6
ectonucleotide pyrophosphatase/phosphodiesterase 6
chr12_+_32654976 0.778 NM_139241
FGD4
FYVE, RhoGEF and PH domain containing 4
chr1_-_110933635 0.774 SLC16A4
solute carrier family 16, member 4 (monocarboxylic acid transporter 5)
chrX_-_78623006 0.773 NM_001171581
NM_004867
ITM2A

integral membrane protein 2A

chr3_+_132036210 0.771 NM_001099
NM_001134194
ACPP

acid phosphatase, prostate

chr10_+_31610063 0.770 NM_001128128
NM_001174094
ZEB1

zinc finger E-box binding homeobox 1

chr7_+_23286386 0.770 GPNMB
glycoprotein (transmembrane) nmb
chr15_-_89456549 0.770 MFGE8
milk fat globule-EGF factor 8 protein
chr4_+_77227178 0.757 NM_003943
STBD1
starch binding domain 1
chr14_+_72399785 0.752 NM_001204416
NM_001204417
NM_001204418
NM_001204419
NM_001204420
NM_001204421
NM_001204422
NM_004296
RGS6







regulator of G-protein signaling 6







chr13_-_47470967 0.752 NM_000621
NM_001165947
HTR2A

5-hydroxytryptamine (serotonin) receptor 2A

chr22_-_19435727 0.742 NM_001166242
NM_173793
C22orf39

chromosome 22 open reading frame 39

chr1_-_21377452 0.740 EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr3_-_21792815 0.734 NM_024697
ZNF385D
zinc finger protein 385D
chr18_+_11851388 0.733 NM_020412
CHMP1B
charged multivesicular body protein 1B
chrX_+_110366304 0.732 NM_001128168
NM_001128172
NM_001128173
PAK3


p21 protein (Cdc42/Rac)-activated kinase 3


chr18_+_55862577 0.731 NM_001144970
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr12_+_57943843 0.728 NM_004984
KIF5A
kinesin family member 5A
chr1_+_151611331 0.727 SNX27
sorting nexin family member 27
chr5_+_95066628 0.725 NM_014899
RHOBTB3
Rho-related BTB domain containing 3
chr1_-_21377387 0.723 EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr3_-_138478184 0.720 NM_006219
PIK3CB
phosphoinositide-3-kinase, catalytic, beta polypeptide
chr8_+_26150731 0.719 NM_001177591
PPP2R2A
protein phosphatase 2, regulatory subunit B, alpha
chr4_-_76957139 0.718 NM_005409
CXCL11
chemokine (C-X-C motif) ligand 11
chr3_+_135741576 0.716 NM_181897
PPP2R3A
protein phosphatase 2, regulatory subunit B'', alpha
chr6_-_56716713 0.713 DST
dystonin
chr7_+_23286390 0.713 GPNMB
glycoprotein (transmembrane) nmb
chr1_-_67594219 0.712 NM_001013674
C1orf141
chromosome 1 open reading frame 141
chr11_-_107582733 0.710 NM_003063
SLN
sarcolipin
chr11_+_103907307 0.709 NM_001001711
DDI1
DNA-damage inducible 1 homolog 1 (S. cerevisiae)
chr4_-_138453564 0.704 PCDH18
protocadherin 18
chr12_-_46357949 0.703


chr7_+_132937819 0.703 NM_001037126
NM_021807
EXOC4

exocyst complex component 4

chr12_+_54393876 0.703 NM_006897
HOXC9
homeobox C9

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
7.39 4.15e-05 GO:0061061 muscle structure development
7.80 1.22e-03 GO:0007517 muscle organ development
2.14 4.03e-03 GO:0048731 system development
1.98 1.58e-02 GO:0048856 anatomical structure development
1.86 4.31e-02 GO:0007275 multicellular organismal development

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
37.49 4.12e-04 GO:0016010 dystrophin-associated glycoprotein complex
79.67 5.98e-04 GO:0016012 sarcoglycan complex
68.29 1.04e-03 GO:0016011 dystroglycan complex
9.62 1.04e-03 GO:0030016 myofibril
9.08 1.53e-03 GO:0043292 contractile fiber
2.64 4.20e-02 GO:0044421 extracellular region part

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
18.53 8.57e-04 GO:0008307 structural constituent of muscle
106.22 1.43e-02 GO:0051371 muscle alpha-actinin binding