Motif ID: NKX6-1,2.p2

Z-value: 1.356


Transcription factors associated with NKX6-1,2.p2:

Gene SymbolEntrez IDGene Name
NKX6-1 4825 NK6 homeobox 1
NKX6-2 84504 NK6 homeobox 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NKX6-2hg19_v1_chr10_-_134599477_1345995360.202.8e-01Click!
NKX6-1hg19_v1_chr4_-_85419386_854193860.125.2e-01Click!


Activity profile for motif NKX6-1,2.p2.

activity profile for motif NKX6-1,2.p2


Sorted Z-values histogram for motif NKX6-1,2.p2

Sorted Z-values for motif NKX6-1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX6-1,2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_+_101988746 6.287 NM_002465
NM_206819
NM_206820
NM_206821
 MYBPC1



myosin binding protein C, slow type



chr6_+_118869441 4.278 NM_002667
 PLN
phospholamban
chr4_-_177190258 3.989 NM_080874
 ASB5
ankyrin repeat and SOCS box containing 5
chr8_+_79428335 3.892 NM_006823
NM_181839
 PKIA

protein kinase (cAMP-dependent, catalytic) inhibitor alpha

chr6_+_41020939 3.574 NM_006789
 APOBEC2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2
chr1_+_110993748 3.466 NM_032414
 PROK1
prokineticin 1
chr19_-_49220213 3.261 NM_182574
 MAMSTR
MEF2 activating motif and SAP domain containing transcriptional regulator
chrX_-_33229428 3.229 NM_004006
 DMD
dystrophin
chr4_+_169418167 3.177 NM_001166108
NM_016081
 PALLD

palladin, cytoskeletal associated protein

chr5_+_145316120 3.140 NM_152550
 SH3RF2
SH3 domain containing ring finger 2
chr5_+_149997205 2.885 NM_001166209
 SYNPO
synaptopodin
chr3_-_47957475 2.833


chr18_+_32290195 2.633 NM_001198941
NM_032978
 DTNA

dystrobrevin, alpha

chr15_+_36932805 2.574 NM_032499
 C15orf41
chromosome 15 open reading frame 41
chr11_-_7727940 2.550 NM_198185
 OVCH2
ovochymase 2 (gene/pseudogene)
chr2_-_161056762 2.543 ITGB6
integrin, beta 6
chr4_+_75174189 2.536 NM_001013442
 EPGN
epithelial mitogen homolog (mouse)
chrX_-_103087106 2.448 NM_016370
 RAB9B
RAB9B, member RAS oncogene family
chr13_+_23755059 2.389 NM_000231
 SGCG
sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
chr19_+_51376688 2.382 NM_001002231
NM_005551
 KLK2

kallikrein-related peptidase 2


Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 5 of 5 entries
Enrichment   P-value GO Accession GO Term
7.80 1.22e-03 GO:0007517 muscle organ development
7.39 4.15e-05 GO:0061061 muscle structure development
2.14 4.03e-03 GO:0048731 system development
1.98 1.58e-02 GO:0048856 anatomical structure development
1.86 4.31e-02 GO:0007275 multicellular organismal development

Gene overrepresentation in compartment category:

Showing 1 to 6 of 6 entries
Enrichment   P-value GO Accession GO Term
79.67 5.98e-04 GO:0016012 sarcoglycan complex
68.29 1.04e-03 GO:0016011 dystroglycan complex
37.49 4.12e-04 GO:0016010 dystrophin-associated glycoprotein complex
9.62 1.04e-03 GO:0030016 myofibril
9.08 1.53e-03 GO:0043292 contractile fiber
2.64 4.20e-02 GO:0044421 extracellular region part

Gene overrepresentation in function category:

Showing 1 to 2 of 2 entries
Enrichment   P-value GO Accession GO Term
106.22 1.43e-02 GO:0051371 muscle alpha-actinin binding
18.53 8.57e-04 GO:0008307 structural constituent of muscle