Motif ID: NR4A2.p2

Z-value: 2.693


Transcription factors associated with NR4A2.p2:

monomer

Gene SymbolEntrez IDGene Name
NR4A2 4929 nuclear receptor subfamily 4, group A, member 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NR4A2hg19_v1_chr2_-_157186681_157186700-0.183.2e-01Click!


Activity profile for motif NR4A2.p2.

activity profile for motif NR4A2.p2


Sorted Z-values histogram for motif NR4A2.p2

Sorted Z-values for motif NR4A2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NR4A2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_236849753 20.476 NM_001103
 ACTN2
actinin, alpha 2
chr20_-_62130390 13.017 NM_001958
 EEF1A2
eukaryotic translation elongation factor 1 alpha 2
chr5_+_80529138 10.506 NM_001099735
NM_001099736
NM_001825
 CKMT2


creatine kinase, mitochondrial 2 (sarcomeric)


chrX_-_21776158 9.245 NM_014332
 SMPX
small muscle protein, X-linked
chr3_-_42744318 9.195 NM_020707
 HHATL
hedgehog acyltransferase-like
chr16_-_4292052 8.263 NM_001098814
 SRL
sarcalumenin
chr2_+_88367298 8.255 NM_198274
 SMYD1
SET and MYND domain containing 1
chr22_-_36019363 8.137 NM_203377
 MB
myoglobin
chr8_+_67039130 7.889 NM_033058
NM_184085
NM_184086
NM_184087
 TRIM55



tripartite motif containing 55



chr17_+_4854383 7.423 NM_001193503
NM_001976
NM_053013
 ENO3


enolase 3 (beta, muscle)


chr3_-_194072004 7.194 NM_001080513
 CPN2
carboxypeptidase N, polypeptide 2
chr11_-_64528186 6.993 NM_001164716
NM_005609
 PYGM

phosphorylase, glycogen, muscle

chr6_-_53530505 6.727 NM_001003760
 KLHL31
kelch-like 31 (Drosophila)
chr1_-_229569839 6.238 NM_001100
 ACTA1
actin, alpha 1, skeletal muscle
chr1_-_154164551 6.086 NM_152263
 TPM3
tropomyosin 3
chr4_+_41614725 6.000 LIMCH1
LIM and calponin homology domains 1
chr4_-_65275000 5.876 NM_001010874
 TECRL
trans-2,3-enoyl-CoA reductase-like
chr3_-_47957475 5.831


chr5_+_145316120 5.793 NM_152550
 SH3RF2
SH3 domain containing ring finger 2
chr2_+_170366211 5.787 NM_006063
 KBTBD10
kelch repeat and BTB (POZ) domain containing 10

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 39 entries
Enrichment   P-value GO Accession GO Term
14.07 2.03e-07 GO:0030049 muscle filament sliding
14.07 2.03e-07 GO:0033275 actin-myosin filament sliding
13.70 2.80e-07 GO:0070252 actin-mediated cell contraction
12.90 5.73e-03 GO:0006942 regulation of striated muscle contraction
12.90 5.73e-03 GO:0034367 macromolecular complex remodeling
12.90 5.73e-03 GO:0034368 protein-lipid complex remodeling
12.90 5.73e-03 GO:0034369 plasma lipoprotein particle remodeling
11.83 1.59e-06 GO:0042773 ATP synthesis coupled electron transport
11.83 1.59e-06 GO:0042775 mitochondrial ATP synthesis coupled electron transport
11.51 6.74e-05 GO:0006941 striated muscle contraction
11.31 2.18e-14 GO:0022904 respiratory electron transport chain
11.13 6.03e-07 GO:0030048 actin filament-based movement
10.92 1.64e-02 GO:0071825 protein-lipid complex subunit organization
10.92 1.64e-02 GO:0071827 plasma lipoprotein particle organization
10.62 5.51e-06 GO:0006119 oxidative phosphorylation
10.51 7.96e-04 GO:0006120 mitochondrial electron transport, NADH to ubiquinone
10.04 5.66e-03 GO:0009060 aerobic respiration
9.70 7.28e-15 GO:0045333 cellular respiration
9.28 2.65e-18 GO:0006936 muscle contraction
9.08 2.72e-19 GO:0003012 muscle system process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 44 entries
Enrichment   P-value GO Accession GO Term
28.38 2.16e-02 GO:0033018 sarcoplasmic reticulum lumen
23.65 4.25e-02 GO:0031430 M band
21.83 3.10e-05 GO:0031672 A band
19.71 6.87e-04 GO:0042627 chylomicron
18.20 1.10e-03 GO:0005865 striated muscle thin filament
14.07 4.06e-08 GO:0016529 sarcoplasmic reticulum
13.70 5.61e-08 GO:0016528 sarcoplasm
11.83 1.17e-02 GO:0034361 very-low-density lipoprotein particle
11.83 1.17e-02 GO:0034385 triglyceride-rich lipoprotein particle
11.59 7.93e-17 GO:0030017 sarcomere
11.42 1.20e-19 GO:0030016 myofibril
11.31 8.93e-19 GO:0044449 contractile fiber part
11.27 1.51e-02 GO:0033017 sarcoplasmic reticulum membrane
11.16 4.41e-20 GO:0043292 contractile fiber
10.04 1.91e-08 GO:0070469 respiratory chain
9.96 2.48e-04 GO:0030018 Z disc
9.86 1.21e-05 GO:0031674 I band
9.71 3.06e-04 GO:0005747 mitochondrial respiratory chain complex I
9.71 3.06e-04 GO:0030964 NADH dehydrogenase complex
9.71 3.06e-04 GO:0045271 respiratory chain complex I

Gene overrepresentation in function category:

Showing 1 to 20 of 23 entries
Enrichment   P-value GO Accession GO Term
12.10 3.49e-07 GO:0008307 structural constituent of muscle
10.23 2.85e-04 GO:0003954 NADH dehydrogenase activity
10.23 2.85e-04 GO:0008137 NADH dehydrogenase (ubiquinone) activity
10.23 2.85e-04 GO:0050136 NADH dehydrogenase (quinone) activity
9.86 4.27e-02 GO:0004129 cytochrome-c oxidase activity
9.86 4.27e-02 GO:0015002 heme-copper terminal oxidase activity
9.86 4.27e-02 GO:0016675 oxidoreductase activity, acting on a heme group of donors
9.86 4.27e-02 GO:0016676 oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
8.80 9.59e-04 GO:0016655 oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor
5.37 2.17e-03 GO:0015078 hydrogen ion transmembrane transporter activity
4.16 5.72e-04 GO:0015077 monovalent inorganic cation transmembrane transporter activity
4.07 2.43e-07 GO:0003779 actin binding
3.72 3.46e-04 GO:0048037 cofactor binding
3.66 8.40e-04 GO:0022890 inorganic cation transmembrane transporter activity
3.13 1.55e-06 GO:0008092 cytoskeletal protein binding
2.83 1.09e-06 GO:0016491 oxidoreductase activity
2.30 2.68e-02 GO:0008324 cation transmembrane transporter activity
2.22 1.49e-04 GO:0022892 substrate-specific transporter activity
2.21 6.17e-03 GO:0015075 ion transmembrane transporter activity
2.13 4.58e-03 GO:0022891 substrate-specific transmembrane transporter activity