Motif ID: NR5A1,2.p2

Z-value: 2.120


Transcription factors associated with NR5A1,2.p2:

Gene SymbolEntrez IDGene Name
NR5A1 2516 nuclear receptor subfamily 5, group A, member 1
NR5A2 2494 nuclear receptor subfamily 5, group A, member 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NR5A2hg19_v1_chr1_+_199996729_1999970100.467.7e-03Click!
NR5A1hg19_v1_chr9_-_127269689_127269719-0.019.5e-01Click!


Activity profile for motif NR5A1,2.p2.

activity profile for motif NR5A1,2.p2


Sorted Z-values histogram for motif NR5A1,2.p2

Sorted Z-values for motif NR5A1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NR5A1,2.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_80529138 7.453 NM_001099735
NM_001099736
NM_001825
 CKMT2


creatine kinase, mitochondrial 2 (sarcomeric)


chr11_-_119234628 6.129 USP2
ubiquitin specific peptidase 2
chr10_-_101190201 5.916 NM_002079
 GOT1
glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)
chr1_-_27240430 5.830 NM_021969
 NR0B2
nuclear receptor subfamily 0, group B, member 2
chr1_+_236849753 5.559 NM_001103
 ACTN2
actinin, alpha 2
chr7_-_44105162 4.971 NM_000290
 PGAM2
phosphoglycerate mutase 2 (muscle)
chr6_+_118869441 4.739 NM_002667
 PLN
phospholamban
chr12_-_111358353 4.620 NM_000432
 MYL2
myosin, light chain 2, regulatory, cardiac, slow
chr10_+_115310589 4.577 NM_001177660
 HABP2
hyaluronan binding protein 2
chr4_+_41614911 4.518 NM_001112719
NM_001112720
 LIMCH1

LIM and calponin homology domains 1

chr4_-_70361578 4.385 NM_021139
 UGT2B4
UDP glucuronosyltransferase 2 family, polypeptide B4
chr7_+_116166346 4.328 NM_001172896
NM_001172897
 CAV1

caveolin 1, caveolae protein, 22kDa

chr19_-_45826131 4.306 CKM
creatine kinase, muscle
chr8_-_107782417 4.262 NM_139166
 ABRA
actin-binding Rho activating protein
chr19_-_4535202 4.089 NM_001013706
 PLIN5
perilipin 5
chr2_+_27505296 4.020 NM_032546
NM_187841
 TRIM54

tripartite motif containing 54

chr1_+_167064086 3.986 NM_001080426
 DUSP27
dual specificity phosphatase 27 (putative)
chr1_-_171621750 3.985 NM_000261
 MYOC
myocilin, trabecular meshwork inducible glucocorticoid response
chr5_+_42565963 3.983 NM_001242460
NM_001242461
NM_001242462
 GHR


growth hormone receptor


chr12_-_122296619 3.922 NM_002150
 HPD
4-hydroxyphenylpyruvate dioxygenase

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 42 entries
Enrichment   P-value GO Accession GO Term
48.11 1.27e-02 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan
48.11 1.27e-02 GO:0051451 myoblast migration
19.25 4.99e-02 GO:0006599 phosphagen metabolic process
19.25 4.99e-02 GO:0006600 creatine metabolic process
14.31 2.03e-07 GO:0006941 striated muscle contraction
11.71 7.00e-05 GO:0030049 muscle filament sliding
11.71 7.00e-05 GO:0033275 actin-myosin filament sliding
11.40 9.01e-05 GO:0070252 actin-mediated cell contraction
10.69 2.27e-02 GO:0031032 actomyosin structure organization
9.44 1.14e-04 GO:0030048 actin filament-based movement
9.31 6.61e-06 GO:0007519 skeletal muscle tissue development
8.75 1.40e-05 GO:0060538 skeletal muscle organ development
8.02 3.27e-02 GO:0006956 complement activation
7.86 9.91e-03 GO:0055002 striated muscle cell development
7.34 5.84e-08 GO:0014706 striated muscle tissue development
7.10 6.29e-03 GO:0072376 protein activation cascade
7.06 5.75e-04 GO:0002576 platelet degranulation
7.00 2.40e-02 GO:0055001 muscle cell development
6.72 2.32e-10 GO:0003012 muscle system process
6.72 2.67e-07 GO:0060537 muscle tissue development

Gene overrepresentation in compartment category:

Showing 1 to 20 of 37 entries
Enrichment   P-value GO Accession GO Term
36.09 8.27e-03 GO:0034363 intermediate-density lipoprotein particle
24.06 4.01e-02 GO:0031430 M band
18.51 1.00e-03 GO:0031672 A band
16.04 1.88e-02 GO:0034362 low-density lipoprotein particle
16.04 1.88e-02 GO:0042627 chylomicron
12.66 8.15e-03 GO:0005811 lipid particle
12.03 1.79e-03 GO:0034364 high-density lipoprotein particle
12.03 1.07e-02 GO:0034361 very-low-density lipoprotein particle
12.03 1.07e-02 GO:0034385 triglyceride-rich lipoprotein particle
11.40 1.49e-05 GO:0030018 Z disc
11.29 8.51e-16 GO:0030017 sarcomere
11.03 7.23e-07 GO:0031674 I band
10.79 1.82e-17 GO:0030016 myofibril
10.24 8.23e-06 GO:0031093 platelet alpha granule lumen
10.22 1.89e-15 GO:0044449 contractile fiber part
10.18 1.79e-06 GO:0031983 vesicle lumen
10.17 8.81e-17 GO:0043292 contractile fiber
10.03 1.02e-05 GO:0034774 secretory granule lumen
9.63 1.54e-05 GO:0060205 cytoplasmic membrane-bounded vesicle lumen
9.63 1.52e-03 GO:0032994 protein-lipid complex

Gene overrepresentation in function category:

Showing 1 to 17 of 17 entries
Enrichment   P-value GO Accession GO Term
8.95 8.65e-04 GO:0008307 structural constituent of muscle
6.02 2.10e-03 GO:0005201 extracellular matrix structural constituent
5.92 2.02e-02 GO:0005496 steroid binding
5.53 4.49e-03 GO:0004867 serine-type endopeptidase inhibitor activity
5.28 2.28e-05 GO:0004866 endopeptidase inhibitor activity
5.07 4.02e-05 GO:0061135 endopeptidase regulator activity
5.00 4.82e-05 GO:0030414 peptidase inhibitor activity
4.45 1.08e-04 GO:0061134 peptidase regulator activity
3.94 1.00e-02 GO:0001871 pattern binding
3.94 1.00e-02 GO:0030247 polysaccharide binding
3.93 2.05e-02 GO:0005539 glycosaminoglycan binding
3.72 9.48e-05 GO:0004857 enzyme inhibitor activity
3.68 1.59e-05 GO:0003779 actin binding
2.66 7.87e-03 GO:0008289 lipid binding
2.62 1.32e-03 GO:0008092 cytoskeletal protein binding
2.43 3.87e-03 GO:0005198 structural molecule activity
1.97 1.51e-02 GO:0005102 receptor binding