Motif ID: NR6A1.p2

Z-value: 1.753


Transcription factors associated with NR6A1.p2:

Gene SymbolEntrez IDGene Name
NR6A1 2649 nuclear receptor subfamily 6, group A, member 1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NR6A1hg19_v1_chr9_-_127533397_127533624-0.551.1e-03Click!


Activity profile for motif NR6A1.p2.

activity profile for motif NR6A1.p2


Sorted Z-values histogram for motif NR6A1.p2

Sorted Z-values for motif NR6A1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NR6A1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 161 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_-_48264039 15.219 COL1A1
collagen, type I, alpha 1
chr14_-_106453162 14.061 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr12_+_7169192 13.785


chr19_-_6720585 12.306 NM_000064
 C3
complement component 3
chr22_+_23229959 11.441 NM_001178126
 IGLL5
IGLC1
immunoglobulin lambda-like polypeptide 5
immunoglobulin lambda constant 1 (Mcg marker)
chr7_-_150038689 11.120 NM_002889
 RARRES2
retinoic acid receptor responder (tazarotene induced) 2
chr6_+_31973358 11.014 NM_000500
NM_001128590
 CYP21A2

cytochrome P450, family 21, subfamily A, polypeptide 2

chr14_-_106967528 10.507 IGHA1
IGHA2
IGHG1
IGHM
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant alpha 2 (A2m marker)
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant mu
chr9_-_14313509 9.928 NFIB
nuclear factor I/B
chr9_-_14314036 9.681 NM_001190737
NM_005596
 NFIB

nuclear factor I/B

chr7_+_100199881 7.388 NM_002593
 PCOLCE
procollagen C-endopeptidase enhancer
chr19_-_7796977 6.944 NM_001244856
NM_198492
 CLEC4G

C-type lectin domain family 4, member G

chr9_-_14313899 6.306 NFIB
nuclear factor I/B
chr14_-_106539099 6.168 IGHA1
IGHG1
IGHG3
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
chr15_+_101420004 5.309 NM_000693
 ALDH1A3
aldehyde dehydrogenase 1 family, member A3
chr9_-_38069082 5.306 SHB
Src homology 2 domain containing adaptor protein B
chr15_+_101420032 5.144 ALDH1A3
aldehyde dehydrogenase 1 family, member A3
chr14_-_106471439 4.836 IGHA1
IGHG1
IGHM
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant mu
chr10_-_71892514 4.809 AIFM2
apoptosis-inducing factor, mitochondrion-associated, 2
chr9_-_14313943 4.626 NFIB
nuclear factor I/B

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 19 of 19 entries
Enrichment   P-value GO Accession GO Term
281.47 5.62e-03 GO:0001969 regulation of activation of membrane attack complex
281.47 5.62e-03 GO:0001970 positive regulation of activation of membrane attack complex
281.47 5.62e-03 GO:0045917 positive regulation of complement activation
281.47 5.62e-03 GO:2000259 positive regulation of protein activation cascade
40.22 6.27e-05 GO:0002455 humoral immune response mediated by circulating immunoglobulin
36.33 1.87e-03 GO:0006958 complement activation, classical pathway
26.82 6.47e-03 GO:0006956 complement activation
25.60 6.37e-04 GO:0016064 immunoglobulin mediated immune response
25.15 6.97e-04 GO:0019724 B cell mediated immunity
20.41 1.98e-03 GO:0002449 lymphocyte mediated immunity
19.03 2.80e-03 GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
18.53 3.20e-03 GO:0002250 adaptive immune response
18.47 2.87e-02 GO:0072376 protein activation cascade
17.61 4.12e-03 GO:0006959 humoral immune response
16.19 6.21e-03 GO:0002443 leukocyte mediated immunity
6.72 3.42e-02 GO:0032787 monocarboxylic acid metabolic process
5.54 3.96e-02 GO:0002684 positive regulation of immune system process
4.98 1.63e-03 GO:0006955 immune response
4.06 4.31e-04 GO:0002376 immune system process

Gene overrepresentation in compartment category:

Showing 1 to 5 of 5 entries
Enrichment   P-value GO Accession GO Term
4.55 8.84e-04 GO:0005615 extracellular space
4.09 4.81e-04 GO:0044421 extracellular region part
3.70 3.04e-02 GO:0005624 membrane fraction
3.58 3.92e-02 GO:0005626 insoluble fraction
3.56 7.80e-07 GO:0005576 extracellular region

Gene overrepresentation in function category:

Showing 1 to 1 of 1 entries
Enrichment   P-value GO Accession GO Term
49.27 8.57e-09 GO:0003823 antigen binding