Motif ID: PITX1..3.p2

Z-value: 3.570


Transcription factors associated with PITX1..3.p2:

Gene SymbolEntrez IDGene Name
PITX1 5307 paired-like homeodomain 1
PITX2 5308 paired-like homeodomain 2
PITX3 5309 paired-like homeodomain 3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
PITX3hg19_v1_chr10_-_104001229_104001230-0.261.5e-01Click!
PITX2hg19_v1_chr4_-_111563278_111563278-0.125.3e-01Click!
PITX1hg19_v1_chr5_-_134369841_134369978-0.115.5e-01Click!


Activity profile for motif PITX1..3.p2.

activity profile for motif PITX1..3.p2


Sorted Z-values histogram for motif PITX1..3.p2

Sorted Z-values for motif PITX1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PITX1..3.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr22_-_24096551 11.320 NM_013378
 VPREB3
pre-B lymphocyte 3
chr1_-_24239758 9.395 NM_001841
 CNR2
cannabinoid receptor 2 (macrophage)
chr9_-_117156684 9.362 NM_030767
 AKNA
AT-hook transcription factor
chr16_+_12058963 8.498 NM_001192
 TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr7_+_5920426 8.344 NM_001097622
 OCM
oncomodulin
chr11_-_118213321 8.093 NM_000732
NM_001040651
 CD3D

CD3d molecule, delta (CD3-TCR complex)

chr1_+_160765927 7.618 NM_001033667
NM_002348
 LY9

lymphocyte antigen 9

chr19_-_17932312 7.587 NM_005543
 INSL3
insulin-like 3 (Leydig cell)
chr19_-_54327428 7.525 NM_144687
 NLRP12
NLR family, pyrin domain containing 12
chr1_-_150738292 7.439 NM_001199739
NM_004079
 CTSS

cathepsin S

chr16_+_30484049 7.338 ITGAL
integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
chr19_-_2256415 7.328 NM_144616
 JSRP1
junctional sarcoplasmic reticulum protein 1
chr16_+_30483959 7.280 NM_001114380
NM_002209
 ITGAL

integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)

chr16_+_28943259 7.081 NM_001178098
NM_001770
 CD19

CD19 molecule

chr16_-_30394133 6.963 NM_052838
 SEPT1
septin 1
chr19_-_4302381 6.801 NM_001169126
NM_144615
 TMIGD2

transmembrane and immunoglobulin domain containing 2

chr16_+_30484108 6.733


chr19_+_10959105 6.690 NM_001136482
 C19orf38
chromosome 19 open reading frame 38
chr1_-_153348057 6.455 NM_005621
 S100A12
S100 calcium binding protein A12
chr2_+_204571197 6.386 NM_001243077
NM_001243078
NM_006139
 CD28


CD28 molecule



Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 15 of 15 entries
Enrichment   P-value GO Accession GO Term
3.41 1.32e-04 GO:0006954 inflammatory response
3.40 2.58e-03 GO:0002253 activation of immune response
3.39 2.86e-02 GO:0002757 immune response-activating signal transduction
3.32 3.81e-02 GO:0002764 immune response-regulating signaling pathway
3.19 1.54e-12 GO:0006955 immune response
3.08 2.57e-03 GO:0050778 positive regulation of immune response
2.93 4.70e-05 GO:0002684 positive regulation of immune system process
2.75 4.58e-03 GO:0045087 innate immune response
2.70 2.44e-08 GO:0006952 defense response
2.64 6.78e-13 GO:0002376 immune system process
2.64 1.86e-03 GO:0050776 regulation of immune response
2.39 1.36e-02 GO:0001775 cell activation
2.18 7.56e-03 GO:0002682 regulation of immune system process
2.09 1.82e-03 GO:0009611 response to wounding
1.52 3.39e-02 GO:0006950 response to stress

Nothing significant found in compartment category.

Gene overrepresentation in function category:

Showing 1 to 7 of 7 entries
Enrichment   P-value GO Accession GO Term
10.66 2.32e-02 GO:0043027 caspase inhibitor activity
9.89 6.88e-03 GO:0019956 chemokine binding
6.68 2.20e-02 GO:0043028 caspase regulator activity
6.34 3.09e-02 GO:0003823 antigen binding
1.61 1.34e-02 GO:0004872 receptor activity
1.54 1.28e-02 GO:0004871 signal transducer activity
1.54 1.28e-02 GO:0060089 molecular transducer activity