Motif ID: PITX1..3.p2

Z-value: 3.570


Transcription factors associated with PITX1..3.p2:

Gene SymbolEntrez IDGene Name
PITX1 5307 paired-like homeodomain 1
PITX2 5308 paired-like homeodomain 2
PITX3 5309 paired-like homeodomain 3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
PITX3hg19_v1_chr10_-_104001229_104001230-0.261.5e-01Click!
PITX2hg19_v1_chr4_-_111563278_111563278-0.125.3e-01Click!
PITX1hg19_v1_chr5_-_134369841_134369978-0.115.5e-01Click!


Activity profile for motif PITX1..3.p2.

activity profile for motif PITX1..3.p2


Sorted Z-values histogram for motif PITX1..3.p2

Sorted Z-values for motif PITX1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PITX1..3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr22_-_24096551 11.320 NM_013378
VPREB3
pre-B lymphocyte 3
chr1_-_24239758 9.395 NM_001841
CNR2
cannabinoid receptor 2 (macrophage)
chr9_-_117156684 9.362 NM_030767
AKNA
AT-hook transcription factor
chr16_+_12058963 8.498 NM_001192
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr7_+_5920426 8.344 NM_001097622
OCM
oncomodulin
chr11_-_118213321 8.093 NM_000732
NM_001040651
CD3D

CD3d molecule, delta (CD3-TCR complex)

chr1_+_160765927 7.618 NM_001033667
NM_002348
LY9

lymphocyte antigen 9

chr19_-_17932312 7.587 NM_005543
INSL3
insulin-like 3 (Leydig cell)
chr19_-_54327428 7.525 NM_144687
NLRP12
NLR family, pyrin domain containing 12
chr1_-_150738292 7.439 NM_001199739
NM_004079
CTSS

cathepsin S

chr16_+_30484049 7.338 ITGAL
integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
chr19_-_2256415 7.328 NM_144616
JSRP1
junctional sarcoplasmic reticulum protein 1
chr16_+_30483959 7.280 NM_001114380
NM_002209
ITGAL

integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)

chr16_+_28943259 7.081 NM_001178098
NM_001770
CD19

CD19 molecule

chr16_-_30394133 6.963 NM_052838
SEPT1
septin 1
chr19_-_4302381 6.801 NM_001169126
NM_144615
TMIGD2

transmembrane and immunoglobulin domain containing 2

chr16_+_30484108 6.733


chr19_+_10959105 6.690 NM_001136482
C19orf38
chromosome 19 open reading frame 38
chr1_-_153348057 6.455 NM_005621
S100A12
S100 calcium binding protein A12
chr2_+_204571197 6.386 NM_001243077
NM_001243078
NM_006139
CD28


CD28 molecule


chr4_-_39033981 6.376 NM_024943
TMEM156
transmembrane protein 156
chr19_+_544026 6.285 NM_005317
GZMM
granzyme M (lymphocyte met-ase 1)
chr19_+_16254454 6.167 HSH2D
hematopoietic SH2 domain containing
chr22_+_35779103 6.102 HMOX1
heme oxygenase (decycling) 1
chr12_-_7902068 5.920 NM_130441
NM_203503
CLEC4C

C-type lectin domain family 4, member C

chr7_+_73624328 5.763 LAT2
linker for activation of T cells family, member 2
chr7_-_97619350 5.719 NM_006188
OCM2
oncomodulin 2
chr19_+_47840370 5.686 NM_018485
GPR77
G protein-coupled receptor 77
chr19_-_48547180 5.677 NM_019855
CABP5
calcium binding protein 5
chrX_-_70326637 5.532 NM_001025265
CXorf65
chromosome X open reading frame 65
chr7_+_73624347 5.409 LAT2
linker for activation of T cells family, member 2
chr11_+_65647283 5.296 NM_001335
CTSW
cathepsin W
chr3_+_48264836 5.252 NM_004345
CAMP
cathelicidin antimicrobial peptide
chr19_-_8567473 5.235 NM_032152
PRAM1
PML-RARA regulated adaptor molecule 1
chr9_-_117160748 5.205 AKNA
AT-hook transcription factor
chr1_+_40859016 5.187 NM_001198979
SMAP2
small ArfGAP2
chr7_+_141695678 5.184 NM_004668
MGAM
maltase-glucoamylase (alpha-glucosidase)
chr22_+_42095502 5.175 NM_152513
MEI1
meiosis inhibitor 1
chr1_+_247581350 5.171 NM_001127462
NM_001243133
NM_004895
NM_183395
NLRP3



NLR family, pyrin domain containing 3



chr16_-_18798077 5.073


chr4_-_1195144 5.013 LOC100130872
uncharacterized LOC100130872
chr7_+_73624086 4.993 NM_014146
NM_032463
NM_032464
LAT2


linker for activation of T cells family, member 2


chr14_-_106452693 4.980 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr17_-_74483806 4.978 NM_001005498
RHBDF2
rhomboid 5 homolog 2 (Drosophila)
chr3_+_39371196 4.965 NM_005201
CCR8
chemokine (C-C motif) receptor 8
chr20_-_42355566 4.906 NM_001008901
NM_176791
GTSF1L

gametocyte specific factor 1-like

chr19_+_14693895 4.881 NM_001204118
NM_207390
CLEC17A

C-type lectin domain family 17, member A

chr19_-_54850385 4.796 NM_012276
LILRA4
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4
chr3_-_195938256 4.783 NM_001039617
ZDHHC19
zinc finger, DHHC-type containing 19
chr17_-_33814757 4.775 NM_001195790
SLFN12L
schlafen family member 12-like
chr17_-_34625628 4.747 NM_001001437
NM_021006
CCL3L3
CCL3
CCL3L1
chemokine (C-C motif) ligand 3-like 3
chemokine (C-C motif) ligand 3
chemokine (C-C motif) ligand 3-like 1
chr5_-_42993423 4.656 FLJ32255
uncharacterized LOC643977
chr22_-_17680485 4.623 NM_177405
CECR1
cat eye syndrome chromosome region, candidate 1
chr22_-_17690778 4.620 NM_017424
CECR1
cat eye syndrome chromosome region, candidate 1
chr9_+_135894806 4.587 EEF1A1
eukaryotic translation elongation factor 1 alpha 1
chr12_-_56756526 4.570 NM_001638
APOF
apolipoprotein F
chr12_-_6756533 4.561 NM_032489
ACRBP
acrosin binding protein
chr16_+_50321822 4.492 NM_001114
ADCY7
adenylate cyclase 7
chr22_-_37975937 4.424 NM_006498
LGALS2
lectin, galactoside-binding, soluble, 2
chr17_-_34524054 4.397 NM_001001437
NM_021006
CCL3L3
CCL3
CCL3L1
chemokine (C-C motif) ligand 3-like 3
chemokine (C-C motif) ligand 3
chemokine (C-C motif) ligand 3-like 1
chr10_-_125853102 4.368 CHST15
carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
chr7_+_73624252 4.360 LAT2
linker for activation of T cells family, member 2
chr6_-_31560497 4.312 NM_001145466
NM_001145467
NM_147130
NCR3


natural cytotoxicity triggering receptor 3


chr1_-_150738255 4.311 CTSS
cathepsin S
chr1_-_150738232 4.278 CTSS
cathepsin S
chr19_+_55014012 4.218 NM_002288
NM_021270
LAIR2

leukocyte-associated immunoglobulin-like receptor 2

chr5_+_54320083 4.168 NM_002104
GZMK
granzyme K (granzyme 3; tryptase II)
chr19_+_14491920 4.161 NM_001025160
NM_001784
NM_078481
CD97


CD97 molecule


chr19_-_54311958 4.146 NM_033297
NLRP12
NLR family, pyrin domain containing 12
chr19_-_6670598 4.068 NM_003807
NM_172014
TNFSF14

tumor necrosis factor (ligand) superfamily, member 14

chr1_-_160832466 4.032 NM_001166663
NM_001166664
NM_016382
CD244


CD244 molecule, natural killer cell receptor 2B4


chr6_-_128239741 4.016 NM_001164687
THEMIS
thymocyte selection associated
chr1_+_207070787 3.990 NM_001185156
NM_001185157
NM_001185158
NM_006850
IL24



interleukin 24



chr13_+_50202434 3.971 NM_138450
ARL11
ADP-ribosylation factor-like 11
chr22_-_17700265 3.935 CECR1
cat eye syndrome chromosome region, candidate 1
chr16_-_29757264 3.934 NM_175900
C16orf54
chromosome 16 open reading frame 54
chr3_+_186739643 3.923 NM_003032
ST6GAL1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr14_-_31957150 3.840 NM_001197184
GPR33
G protein-coupled receptor 33 (gene/pseudogene)
chr3_+_32993065 3.781 NM_005508
CCR4
chemokine (C-C motif) receptor 4
chr6_-_74161978 3.754 MB21D1
Mab-21 domain containing 1
chr6_+_35704858 3.733 NM_145028
C6orf81
chromosome 6 open reading frame 81
chr1_-_100231348 3.705 NM_001013660
FRRS1
ferric-chelate reductase 1
chr6_-_32160637 3.671 GPSM3
G-protein signaling modulator 3
chr12_+_54892567 3.670 NM_001184976
NCKAP1L
NCK-associated protein 1-like
chr1_+_40713572 3.643 NM_001008740
TMCO2
transmembrane and coiled-coil domains 2
chr6_-_31763551 3.586 NM_006295
VARS
valyl-tRNA synthetase
chr19_-_2085227 3.579 MOB3A
MOB kinase activator 3A
chr14_-_23285011 3.550 NM_001126105
SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr20_+_361272 3.546 NM_021158
TRIB3
tribbles homolog 3 (Drosophila)
chr17_+_4835591 3.463 NM_000173
GP1BA
glycoprotein Ib (platelet), alpha polypeptide
chr19_+_16244837 3.430 NM_032855
HSH2D
hematopoietic SH2 domain containing
chr4_-_38784588 3.396 NM_001017388
NM_001195106
NM_001195107
NM_001195108
NM_030956
TLR10




toll-like receptor 10




chr3_-_182880463 3.394 NM_014398
LAMP3
lysosomal-associated membrane protein 3
chr11_-_67205151 3.378 NM_005608
PTPRCAP
protein tyrosine phosphatase, receptor type, C-associated protein
chr19_-_39826625 3.366 GMFG
glia maturation factor, gamma
chr19_+_44220213 3.318 NM_019612
IRGC
immunity-related GTPase family, cinema
chr14_+_21756135 3.300 NM_020366
RPGRIP1
retinitis pigmentosa GTPase regulator interacting protein 1
chr6_+_74104596 3.299 DDX43
DEAD (Asp-Glu-Ala-Asp) box polypeptide 43
chr19_-_2096280 3.291 MOB3A
MOB kinase activator 3A
chr19_-_55549612 3.272 NM_001083899
NM_016363
GP6

glycoprotein VI (platelet)

chr1_-_42965948 3.262 TMSB4XP1
thymosin beta 4, X-linked pseudogene 1
chr19_-_39826676 3.245 NM_004877
GMFG
glia maturation factor, gamma
chr5_-_140013285 3.235 NM_001040021
NM_001174104
NM_001174105
CD14


CD14 molecule


chr19_-_2096263 3.219 NM_130807
MOB3A
MOB kinase activator 3A
chr19_+_17634109 3.208 NM_001098524
NM_173544
FAM129C

family with sequence similarity 129, member C

chr5_+_54398473 3.198 NM_006144
GZMA
granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
chr19_-_47735858 3.183 NM_001127240
NM_001127241
NM_001127242
BBC3


BCL2 binding component 3


chr22_-_21984274 3.172 NM_001017964
YDJC
YdjC homolog (bacterial)
chr9_+_80850938 3.166 NM_001098802
NM_032171
CEP78

centrosomal protein 78kDa

chr19_-_51893791 3.154 NM_001193623
LOC147646
uncharacterized LOC147646
chr1_-_26699225 3.130 NM_001114759
NM_173574
ZNF683

zinc finger protein 683

chr19_-_48744276 3.127 NM_001184900
CARD8
caspase recruitment domain family, member 8
chr6_-_133078894 3.118 NM_001242350
NM_004665
VNN2

vanin 2

chr9_+_273025 3.116 NM_001190458
NM_001193536
DOCK8

dedicator of cytokinesis 8

chr19_-_54692132 3.104 MBOAT7
membrane bound O-acyltransferase domain containing 7
chr3_-_109056333 3.086 DPPA4
developmental pluripotency associated 4
chr6_-_44233499 3.081 NM_004556
NFKBIE
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
chr17_+_7239847 3.060 NM_014716
ACAP1
ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
chr12_+_47610051 3.054 NM_138371
FAM113B
family with sequence similarity 113, member B
chr2_+_219283809 3.048 NM_007127
VIL1
villin 1
chr6_-_74162036 3.034 NM_138441
MB21D1
Mab-21 domain containing 1
chr12_-_57644905 3.020 NM_145064
STAC3
SH3 and cysteine rich domain 3
chr16_+_29471206 3.018 NM_001017390
NM_177552
SULT1A4
SULT1A3
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
chr19_-_55458864 3.001 NM_001127255
NM_139176
NM_206828
NLRP7


NLR family, pyrin domain containing 7


chr12_-_6756597 2.990 ACRBP
acrosin binding protein
chr17_+_7982752 2.990


chr11_+_308106 2.990 NM_006435
IFITM2
interferon induced transmembrane protein 2 (1-8D)
chr15_+_81489218 2.978 NM_001172128
IL16
interleukin 16
chr12_+_10457044 2.977 NM_001114396
KLRD1
killer cell lectin-like receptor subfamily D, member 1
chr17_-_3599487 2.975 NM_001204519
NM_001204520
NM_002561
NM_175080
P2RX5-TAX1BP3
P2RX5



P2RX5-TAX1BP3 readthrough
purinergic receptor P2X, ligand-gated ion channel, 5



chr16_-_68033355 2.965 NM_022355
DPEP2
dipeptidase 2
chr8_-_27941387 2.941 NM_001010906
C8orf80
chromosome 8 open reading frame 80
chr1_+_24840800 2.934 NM_001251980
NM_001251982
NM_001251985
RCAN3


RCAN family member 3


chr12_-_109027565 2.927 SELPLG
selectin P ligand
chr2_+_204571379 2.921 CD28
CD28 molecule
chr12_-_109027615 2.893 SELPLG
selectin P ligand
chr20_-_56195446 2.886 NM_001160417
NM_001160418
NM_001160419
NM_030776
ZBP1



Z-DNA binding protein 1



chr19_+_52264452 2.882 NM_001005738
FPR2
formyl peptide receptor 2
chrX_-_70838298 2.882 NM_001142797
NM_001504
CXCR3

chemokine (C-X-C motif) receptor 3

chr1_-_15911461 2.877 NM_024758
AGMAT
agmatine ureohydrolase (agmatinase)
chr19_-_8642232 2.864 MYO1F
myosin IF
chrY_-_15592549 2.846 NM_007125
NM_182659
NM_182660
UTY


ubiquitously transcribed tetratricopeptide repeat gene, Y-linked


chr1_-_109203663 2.832 NM_001102592
HENMT1
HEN1 methyltransferase homolog 1 (Arabidopsis)
chr1_+_28832454 2.832 NM_001048199
RCC1
regulator of chromosome condensation 1
chr19_-_50847957 2.817 NAPSB
napsin B aspartic peptidase pseudogene
chr19_+_10222196 2.813 NM_002566
P2RY11
purinergic receptor P2Y, G-protein coupled, 11
chrX_+_9431314 2.804 NM_001139466
NM_001139467
NM_001139468
TBL1X


transducin (beta)-like 1X-linked


chr5_+_76145825 2.792 NM_130772
S100Z
S100 calcium binding protein Z
chr11_+_5641173 2.776 NM_001003827
TRIM34
tripartite motif containing 34
chr9_-_139927291 2.772 NM_004479
FUT7
fucosyltransferase 7 (alpha (1,3) fucosyltransferase)
chr16_-_18801624 2.769 NM_001019
NM_001030009
RPS15A

ribosomal protein S15a

chr19_-_14785626 2.752 NM_032571
EMR3
egf-like module containing, mucin-like, hormone receptor-like 3
chrX_-_30595883 2.744 NM_025159
CXorf21
chromosome X open reading frame 21
chr9_+_131217433 2.741 NM_153436
ODF2
outer dense fiber of sperm tails 2
chr19_-_8642309 2.734 NM_012335
MYO1F
myosin IF
chr1_-_150693321 2.725 NM_001199829
NM_032132
HORMAD1

HORMA domain containing 1

chr11_+_33037397 2.717 NM_001077242
DEPDC7
DEP domain containing 7
chr19_-_39805975 2.696 NM_020862
LRFN1
leucine rich repeat and fibronectin type III domain containing 1
chr22_-_21984366 2.696 YDJC
YdjC homolog (bacterial)
chr19_-_8642297 2.693 MYO1F
myosin IF
chr16_-_30393856 2.639 SEPT1
septin 1
chr17_-_38721701 2.601 NM_001838
CCR7
chemokine (C-C motif) receptor 7
chr16_+_30210548 2.593 NM_001017390
NM_177552
SULT1A4
SULT1A3
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
chr2_+_68961912 2.580 NM_001007231
NM_001166277
ARHGAP25

Rho GTPase activating protein 25

chr7_-_6474584 2.571 DAGLB
diacylglycerol lipase, beta
chr20_+_44518782 2.559 CTSA
cathepsin A
chr17_-_33885106 2.556 NM_001129820
SLFN14
schlafen family member 14
chr17_-_40346427 2.542 NM_001142622
NM_001142623
NM_032484
GHDC


GH3 domain containing


chr17_-_72709010 2.513 NM_139018
CD300LF
CD300 molecule-like family member f
chr17_-_3599359 2.512 P2RX5
purinergic receptor P2X, ligand-gated ion channel, 5
chr22_+_32753853 2.508 NM_001098535
RFPL3
ret finger protein-like 3
chr16_+_2016874 2.500 NM_174903
RNF151
ring finger protein 151
chr8_-_126963395 2.491 LOC100130231
uncharacterized LOC100130231
chr15_-_50405512 2.488 ATP8B4
ATPase, class I, type 8B, member 4
chr19_-_8642337 2.478 MYO1F
myosin IF
chr19_-_51872256 2.472 NM_152353
CLDND2
claudin domain containing 2
chr11_+_67171400 2.458 NM_198517
TBC1D10C
TBC1 domain family, member 10C
chr18_+_55297533 2.458 NM_001242804
LOC100505549
uncharacterized LOC100505549
chr12_-_57873628 2.458 NM_032496
ARHGAP9
Rho GTPase activating protein 9
chr19_-_14889347 2.457 NM_013447
NM_152916
NM_152917
NM_152918
NM_152919
NM_152920
NM_152921
EMR2






egf-like module containing, mucin-like, hormone receptor-like 2






chr1_-_156786500 2.456 NM_001161441
NM_001161442
NM_001161444
NM_003975
SH2D2A



SH2 domain containing 2A



chr19_-_10291056 2.447


chr22_+_39417117 2.444 NM_152426
APOBEC3D
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D
chr12_-_54689536 2.443 NM_006163
NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr20_+_62367945 2.440 NM_017806
LIME1
Lck interacting transmembrane adaptor 1
chr14_+_21249209 2.434 NM_005615
RNASE6
ribonuclease, RNase A family, k6
chr16_+_72042486 2.427 NM_001361
DHODH
dihydroorotate dehydrogenase (quinone)
chr6_-_42162693 2.384 NM_002098
GUCA1B
guanylate cyclase activator 1B (retina)
chr11_+_35198199 2.374 CD44
CD44 molecule (Indian blood group)
chr17_-_72527512 2.359 CD300LB
CD300 molecule-like family member b
chr11_+_67171379 2.358 TBC1D10C
TBC1 domain family, member 10C
chr12_-_57642922 2.349


chr19_-_17958773 2.338 JAK3
Janus kinase 3
chr19_-_17958814 2.298 NM_000215
JAK3
Janus kinase 3
chr17_+_76210329 2.289 BIRC5
baculoviral IAP repeat containing 5
chr1_-_173962050 2.286 NM_172071
RC3H1
ring finger and CCCH-type domains 1
chr19_+_11406823 2.286 NM_012466
TSPAN16
tetraspanin 16
chr6_+_74104575 2.284 DDX43
DEAD (Asp-Glu-Ala-Asp) box polypeptide 43
chr5_-_156390206 2.271 NM_001146726
NM_138379
TIMD4

T-cell immunoglobulin and mucin domain containing 4

chr3_+_169755733 2.271 NM_014373
GPR160
G protein-coupled receptor 160

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
2.64 6.78e-13 GO:0002376 immune system process
3.19 1.54e-12 GO:0006955 immune response
2.70 2.44e-08 GO:0006952 defense response
2.93 4.70e-05 GO:0002684 positive regulation of immune system process
3.41 1.32e-04 GO:0006954 inflammatory response
2.09 1.82e-03 GO:0009611 response to wounding
2.64 1.86e-03 GO:0050776 regulation of immune response
3.08 2.57e-03 GO:0050778 positive regulation of immune response
3.40 2.58e-03 GO:0002253 activation of immune response
2.75 4.58e-03 GO:0045087 innate immune response
2.18 7.56e-03 GO:0002682 regulation of immune system process
2.39 1.36e-02 GO:0001775 cell activation
3.39 2.86e-02 GO:0002757 immune response-activating signal transduction
1.52 3.39e-02 GO:0006950 response to stress
3.32 3.81e-02 GO:0002764 immune response-regulating signaling pathway

Nothing significant found in compartment category.

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
9.89 6.88e-03 GO:0019956 chemokine binding
1.54 1.28e-02 GO:0004871 signal transducer activity
1.54 1.28e-02 GO:0060089 molecular transducer activity
1.61 1.34e-02 GO:0004872 receptor activity
6.68 2.20e-02 GO:0043028 caspase regulator activity
10.66 2.32e-02 GO:0043027 caspase inhibitor activity
6.34 3.09e-02 GO:0003823 antigen binding