Motif ID: POU2F1..3.p2

Z-value: 5.787


Transcription factors associated with POU2F1..3.p2:

Gene SymbolEntrez IDGene Name
POU2F1 5451 POU class 2 homeobox 1
POU2F2 5452 POU class 2 homeobox 2
POU2F3 25833 POU class 2 homeobox 3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
POU2F2hg19_v1_chr19_-_42636559_426366240.691.2e-05Click!
POU2F1hg19_v1_chr1_+_167298280_167298317-0.241.9e-01Click!
POU2F3hg19_v1_chr11_+_120107348_1201073480.038.5e-01Click!


Activity profile for motif POU2F1..3.p2.

activity profile for motif POU2F1..3.p2


Sorted Z-values histogram for motif POU2F1..3.p2

Sorted Z-values for motif POU2F1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of POU2F1..3.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_-_106552313 63.782 IGHA1
IGHD
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant delta
immunoglobulin heavy constant gamma 1 (G1m marker)
chr14_-_106791054 61.977 IGHV4-31
IGHV3-30
IGHA1
IGHD
IGHG1
IGHG2
IGHG3
IGHM
SCFV
immunoglobulin heavy variable 4-31
immunoglobulin heavy variable 3-30
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant delta
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 2 (G2m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
immunoglobulin heavy constant mu
single-chain Fv fragment
chr14_-_107099379 59.535 IGHG1
IGHG3
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
chr14_-_107013474 58.580 IGHA1
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr14_-_106610338 57.703 IGHV4-31
IGHG1
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant gamma 1 (G1m marker)
chr14_-_106994001 56.512 IGHV3-48
IGH@
IGHA1
IGHM
immunoglobulin heavy variable 3-48
immunoglobulin heavy locus
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant mu
chr14_-_106725620 54.965 IGHV4-31
IGHV3-23
IGHA1
IGHG1
IGHM
immunoglobulin heavy variable 4-31
immunoglobulin heavy variable 3-23
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant mu
chr14_-_106714594 54.873


chr14_-_106573348 51.746 IGHV4-31
IGHA1
IGHA2
IGHG1
IGHG3
IGHM
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant alpha 2 (A2m marker)
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
immunoglobulin heavy constant mu
chr14_-_107218786 50.341 IGHA1
IGHG1
IGHM
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant mu
chr14_-_106926393 50.064 IGHA1
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr14_-_107211131 49.538 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr14_-_106692107 49.513 IGHV4-31
IGHA1
IGHD
IGHG1
IGHG3
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant delta
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
chr14_-_107113943 47.586 IGHA1
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr14_-_106518424 45.810 IGH@
IGHA1
IGHG1
IGHG2
IGHM
immunoglobulin heavy locus
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 2 (G2m marker)
immunoglobulin heavy constant mu
chr14_-_106725232 44.858 ZCWPW2
IGHV3-23
IGKV3-20
IGK@
zinc finger, CW type with PWWP domain 2
immunoglobulin heavy variable 3-23
immunoglobulin kappa variable 3-20
immunoglobulin kappa locus
chr14_-_107048697 44.771 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr14_-_107013122 38.707 IGHV4-31
IGHG1
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant gamma 1 (G1m marker)
chr14_-_106586333 38.381 IGHV4-31
immunoglobulin heavy variable 4-31
chr14_-_107170076 32.751 IGHV1-69
IGHG1
immunoglobulin heavy variable 1-69
immunoglobulin heavy constant gamma 1 (G1m marker)

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 54 entries
Enrichment   P-value GO Accession GO Term
14.54 9.18e-12 GO:0006334 nucleosome assembly
13.94 2.76e-12 GO:0034728 nucleosome organization
13.79 2.19e-11 GO:0031497 chromatin assembly
12.69 1.39e-11 GO:0071824 protein-DNA complex subunit organization
12.62 9.30e-11 GO:0065004 protein-DNA complex assembly
10.54 1.66e-09 GO:0006323 DNA packaging
10.53 3.31e-10 GO:0006333 chromatin assembly or disassembly
9.61 1.52e-09 GO:0071103 DNA conformation change
9.44 7.06e-03 GO:0060333 interferon-gamma-mediated signaling pathway
9.11 2.51e-05 GO:0002429 immune response-activating cell surface receptor signaling pathway
8.99 1.23e-04 GO:0050851 antigen receptor-mediated signaling pathway
8.76 3.78e-05 GO:0002768 immune response-regulating cell surface receptor signaling pathway
8.61 1.31e-02 GO:0071346 cellular response to interferon-gamma
8.36 3.95e-03 GO:0006959 humoral immune response
8.13 1.92e-02 GO:0042113 B cell activation
7.32 3.82e-02 GO:0034341 response to interferon-gamma
7.04 1.43e-02 GO:0030098 lymphocyte differentiation
6.07 1.41e-02 GO:0002521 leukocyte differentiation
5.87 7.61e-04 GO:0002757 immune response-activating signal transduction
5.74 9.73e-04 GO:0002764 immune response-regulating signaling pathway

Gene overrepresentation in compartment category:

Showing 1 to 7 of 7 entries
Enrichment   P-value GO Accession GO Term
22.30 8.18e-16 GO:0000786 nucleosome
14.08 2.11e-12 GO:0032993 protein-DNA complex
7.27 4.04e-10 GO:0000785 chromatin
3.81 2.97e-05 GO:0044427 chromosomal part
3.36 1.20e-04 GO:0005694 chromosome
2.17 4.26e-03 GO:0005887 integral to plasma membrane
2.13 6.03e-03 GO:0031226 intrinsic to plasma membrane

Gene overrepresentation in function category:

Showing 1 to 8 of 8 entries
Enrichment   P-value GO Accession GO Term
20.90 4.30e-09 GO:0003823 antigen binding
14.54 2.38e-02 GO:0001608 nucleotide receptor activity, G-protein coupled
14.54 2.38e-02 GO:0045028 purinergic nucleotide receptor activity, G-protein coupled
2.16 4.14e-02 GO:0001071 nucleic acid binding transcription factor activity
2.16 4.14e-02 GO:0003700 sequence-specific DNA binding transcription factor activity
1.78 1.98e-02 GO:0004871 signal transducer activity
1.78 1.98e-02 GO:0060089 molecular transducer activity
1.77 7.72e-03 GO:0003677 DNA binding