Motif ID: POU5F1.p2

Z-value: 3.256


Transcription factors associated with POU5F1.p2:

Gene SymbolEntrez IDGene Name
POU5F1 5460 POU class 5 homeobox 1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
POU5F1hg19_v1_chr6_-_31138180_311384500.096.1e-01Click!


Activity profile for motif POU5F1.p2.

activity profile for motif POU5F1.p2


Sorted Z-values histogram for motif POU5F1.p2

Sorted Z-values for motif POU5F1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of POU5F1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr22_+_23063107 15.703 IGLJ3
immunoglobulin lambda joining 3
chr14_-_106733392 14.541 IGHG1
IGHG3
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
chr2_+_89185055 12.999


chr2_+_90077732 12.803


chr2_-_89442551 12.604 IGKC
IGK@
immunoglobulin kappa constant
immunoglobulin kappa locus
chr14_-_106641585 11.322 IGHV4-31
IGHA1
IGHA2
IGHG1
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant alpha 2 (A2m marker)
immunoglobulin heavy constant gamma 1 (G1m marker)
chr14_-_107048697 11.035 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr14_-_106552313 10.262 IGHA1
IGHD
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant delta
immunoglobulin heavy constant gamma 1 (G1m marker)
chr14_-_106791054 10.228 IGHV4-31
IGHV3-30
IGHA1
IGHD
IGHG1
IGHG2
IGHG3
IGHM
SCFV
immunoglobulin heavy variable 4-31
immunoglobulin heavy variable 3-30
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant delta
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 2 (G2m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
immunoglobulin heavy constant mu
single-chain Fv fragment
chr14_-_107066061 9.828 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr14_-_106691698 9.582


chr6_-_108145507 9.410 NM_198081
 SCML4
sex comb on midleg-like 4 (Drosophila)
chr14_-_106405633 9.131 IGHM
immunoglobulin heavy constant mu
chr14_-_107083398 8.909 IGH@
IGHA1
IGHG1
immunoglobulin heavy locus
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr14_-_107179043 8.660 IGHA1
immunoglobulin heavy constant alpha 1
chr22_+_22697538 8.619


chr14_-_106877689 8.537 IGHV4-31
IGH@
IGHA1
IGHA2
IGHG1
IGHG4
IGHM
immunoglobulin heavy variable 4-31
immunoglobulin heavy locus
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant alpha 2 (A2m marker)
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 4 (G4m marker)
immunoglobulin heavy constant mu
chr14_-_107170076 8.479 IGHV1-69
IGHG1
immunoglobulin heavy variable 1-69
immunoglobulin heavy constant gamma 1 (G1m marker)
chr15_-_80263460 8.422 NM_001114735
NM_004049
 BCL2A1

BCL2-related protein A1

chr2_-_89513056 8.365 IGKC
immunoglobulin kappa constant

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 84 entries
Enrichment   P-value GO Accession GO Term
28.07 4.23e-04 GO:0043368 positive T cell selection
22.46 2.36e-02 GO:0045576 mast cell activation
16.55 1.54e-04 GO:0050853 B cell receptor signaling pathway
15.85 1.76e-03 GO:0045058 T cell selection
9.63 4.36e-02 GO:0030890 positive regulation of B cell proliferation
9.46 2.30e-03 GO:0030888 regulation of B cell proliferation
8.70 2.92e-09 GO:0050851 antigen receptor-mediated signaling pathway
8.13 2.50e-09 GO:0002768 immune response-regulating cell surface receptor signaling pathway
8.01 1.27e-08 GO:0002429 immune response-activating cell surface receptor signaling pathway
7.67 4.50e-02 GO:0050871 positive regulation of B cell activation
7.49 1.46e-02 GO:0002263 cell activation involved in immune response
7.49 1.46e-02 GO:0002366 leukocyte activation involved in immune response
7.25 1.54e-03 GO:0030217 T cell differentiation
7.19 1.39e-04 GO:0050852 T cell receptor signaling pathway
7.09 4.12e-06 GO:0030098 lymphocyte differentiation
6.74 9.97e-03 GO:0050864 regulation of B cell activation
6.16 7.14e-03 GO:0050671 positive regulation of lymphocyte proliferation
6.07 8.09e-03 GO:0032946 positive regulation of mononuclear cell proliferation
5.99 9.15e-03 GO:0070665 positive regulation of leukocyte proliferation
5.91 1.17e-08 GO:0002764 immune response-regulating signaling pathway

Gene overrepresentation in compartment category:

Showing 1 to 9 of 9 entries
Enrichment   P-value GO Accession GO Term
12.83 4.08e-02 GO:0042613 MHC class II protein complex
6.74 1.34e-03 GO:0000786 nucleosome
3.69 4.16e-02 GO:0043235 receptor complex
2.55 1.27e-02 GO:0045202 synapse
2.14 1.55e-05 GO:0005887 integral to plasma membrane
2.10 2.89e-05 GO:0031226 intrinsic to plasma membrane
2.03 3.11e-09 GO:0044459 plasma membrane part
1.64 2.66e-08 GO:0005886 plasma membrane
1.62 3.73e-08 GO:0071944 cell periphery

Gene overrepresentation in function category:

Showing 1 to 16 of 16 entries
Enrichment   P-value GO Accession GO Term
15.62 5.42e-06 GO:0001608 nucleotide receptor activity, G-protein coupled
15.62 5.42e-06 GO:0045028 purinergic nucleotide receptor activity, G-protein coupled
13.48 1.06e-08 GO:0003823 antigen binding
11.98 5.65e-05 GO:0001614 purinergic nucleotide receptor activity
11.98 5.65e-05 GO:0016502 nucleotide receptor activity
11.23 1.65e-02 GO:0001637 G-protein chemoattractant receptor activity
11.23 1.65e-02 GO:0004950 chemokine receptor activity
10.57 1.62e-04 GO:0035586 purinergic receptor activity
10.21 2.70e-02 GO:0019956 chemokine binding
7.34 3.01e-03 GO:0005070 SH3/SH2 adaptor activity
5.99 1.38e-02 GO:0035591 signaling adaptor activity
1.98 6.20e-03 GO:0001071 nucleic acid binding transcription factor activity
1.98 6.20e-03 GO:0003700 sequence-specific DNA binding transcription factor activity
1.80 9.31e-04 GO:0004872 receptor activity
1.72 5.07e-04 GO:0004871 signal transducer activity
1.72 5.07e-04 GO:0060089 molecular transducer activity