Motif ID: POU5F1.p2

Z-value: 3.256


Transcription factors associated with POU5F1.p2:

Gene SymbolEntrez IDGene Name
POU5F1 5460 POU class 5 homeobox 1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
POU5F1hg19_v1_chr6_-_31138180_311384500.096.1e-01Click!


Activity profile for motif POU5F1.p2.

activity profile for motif POU5F1.p2


Sorted Z-values histogram for motif POU5F1.p2

Sorted Z-values for motif POU5F1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of POU5F1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr22_+_23063107 15.703 IGLJ3
immunoglobulin lambda joining 3
chr14_-_106733392 14.541 IGHG1
IGHG3
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
chr2_+_89185055 12.999


chr2_+_90077732 12.803


chr2_-_89442551 12.604 IGKC
IGK@
immunoglobulin kappa constant
immunoglobulin kappa locus
chr14_-_106641585 11.322 IGHV4-31
IGHA1
IGHA2
IGHG1
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant alpha 2 (A2m marker)
immunoglobulin heavy constant gamma 1 (G1m marker)
chr14_-_107048697 11.035 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr14_-_106552313 10.262 IGHA1
IGHD
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant delta
immunoglobulin heavy constant gamma 1 (G1m marker)
chr14_-_106791054 10.228 IGHV4-31
IGHV3-30
IGHA1
IGHD
IGHG1
IGHG2
IGHG3
IGHM
SCFV
immunoglobulin heavy variable 4-31
immunoglobulin heavy variable 3-30
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant delta
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 2 (G2m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
immunoglobulin heavy constant mu
single-chain Fv fragment
chr14_-_107066061 9.828 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr14_-_106691698 9.582


chr6_-_108145507 9.410 NM_198081
SCML4
sex comb on midleg-like 4 (Drosophila)
chr14_-_106405633 9.131 IGHM
immunoglobulin heavy constant mu
chr14_-_107083398 8.909 IGH@
IGHA1
IGHG1
immunoglobulin heavy locus
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr14_-_107179043 8.660 IGHA1
immunoglobulin heavy constant alpha 1
chr22_+_22697538 8.619


chr14_-_106877689 8.537 IGHV4-31
IGH@
IGHA1
IGHA2
IGHG1
IGHG4
IGHM
immunoglobulin heavy variable 4-31
immunoglobulin heavy locus
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant alpha 2 (A2m marker)
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 4 (G4m marker)
immunoglobulin heavy constant mu
chr14_-_107170076 8.479 IGHV1-69
IGHG1
immunoglobulin heavy variable 1-69
immunoglobulin heavy constant gamma 1 (G1m marker)
chr15_-_80263460 8.422 NM_001114735
NM_004049
BCL2A1

BCL2-related protein A1

chr2_-_89513056 8.365 IGKC
immunoglobulin kappa constant
chr22_+_22735134 8.331 CYAT1
immunoglobulin lambda light chain-like
chr1_+_27668499 8.314 SYTL1
synaptotagmin-like 1
chr22_+_22735207 8.276 IGLJ3
immunoglobulin lambda joining 3
chr14_-_106692107 8.230 IGHV4-31
IGHA1
IGHD
IGHG1
IGHG3
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant delta
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
chr22_+_23134980 8.226


chr4_-_71532206 8.195 IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr22_+_22385340 8.168


chr14_-_106478129 7.935 IGHV4-31
IGHD
IGHG3
IGHM
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant delta
immunoglobulin heavy constant gamma 3 (G3m marker)
immunoglobulin heavy constant mu
chr22_+_22764094 7.933


chr14_-_107131217 7.892 IGHA1
immunoglobulin heavy constant alpha 1
chr22_+_23213671 7.868 IGLV4-3
immunoglobulin lambda variable 4-3
chr14_-_107170400 7.702 IGHV4-31
IGHV1-69
IGHA1
IGHG1
IGHG3
IGHM
immunoglobulin heavy variable 4-31
immunoglobulin heavy variable 1-69
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
immunoglobulin heavy constant mu
chr22_+_23154240 7.697


chr22_+_23165273 7.613


chr14_-_106494166 7.556 IGHV4-31
IGHA1
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant alpha 1
chr14_-_106967528 7.528 IGHA1
IGHA2
IGHG1
IGHM
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant alpha 2 (A2m marker)
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant mu
chr14_-_106453162 7.480 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr9_-_34691135 7.473 NM_006274
CCL19
chemokine (C-C motif) ligand 19
chr22_+_22550112 7.420


chr19_-_39108534 7.409 NM_001042600
NM_007181
MAP4K1

mitogen-activated protein kinase kinase kinase kinase 1

chr4_-_71532341 7.376 NM_144646
IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr22_+_22676814 7.376


chr22_+_22550159 7.326 IGLV6-57
immunoglobulin lambda variable 6-57
chr14_-_106610338 7.324 IGHV4-31
IGHG1
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant gamma 1 (G1m marker)
chr22_+_23040394 7.283 IGL@
immunoglobulin lambda locus
chr22_+_23029175 7.240 IGLV3-25
immunoglobulin lambda variable 3-25
chr14_-_107013474 7.104 IGHA1
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr2_+_68961912 7.053 NM_001007231
NM_001166277
ARHGAP25

Rho GTPase activating protein 25

chr22_+_22735202 7.048


chr2_+_90211704 7.042


chr22_+_22712091 7.035 IGLV1-44
IGL@
immunoglobulin lambda variable 1-44
immunoglobulin lambda locus
chr14_-_106994001 7.015 IGHV3-48
IGH@
IGHA1
IGHM
immunoglobulin heavy variable 3-48
immunoglobulin heavy locus
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant mu
chr15_-_22473092 6.815


chr14_-_106967080 6.803 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr22_+_22758538 6.784


chr14_-_106586333 6.743 IGHV4-31
immunoglobulin heavy variable 4-31
chr1_+_27668462 6.702 NM_001193308
NM_032872
SYTL1

synaptotagmin-like 1

chr14_-_106714594 6.679


chr6_-_128222175 6.663 NM_001010923
NM_001164685
THEMIS

thymocyte selection associated

chr14_-_106573348 6.620 IGHV4-31
IGHA1
IGHA2
IGHG1
IGHG3
IGHM
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant alpha 2 (A2m marker)
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
immunoglobulin heavy constant mu
chr14_-_107113943 6.522 IGHA1
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr14_-_107218786 6.477 IGHA1
IGHG1
IGHM
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant mu
chr22_+_23010757 6.393


chr14_-_106725620 6.291 IGHV4-31
IGHV3-23
IGHA1
IGHG1
IGHM
immunoglobulin heavy variable 4-31
immunoglobulin heavy variable 3-23
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant mu
chr7_-_83824216 6.270 NM_006080
SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr14_-_106746056 6.212


chr14_-_107013122 6.048 IGHV4-31
IGHG1
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant gamma 1 (G1m marker)
chr17_-_8815799 6.028 NM_014308
PIK3R5
phosphoinositide-3-kinase, regulatory subunit 5
chrX_-_48776282 6.023 NM_006875
PIM2
pim-2 oncogene
chr14_-_107199126 5.913 IGHG3
immunoglobulin heavy constant gamma 3 (G3m marker)
chr14_-_107099379 5.885 IGHG1
IGHG3
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
chr1_+_24840800 5.499 NM_001251980
NM_001251982
NM_001251985
RCAN3


RCAN family member 3


chr2_-_113594325 5.462 NM_000576
IL1B
interleukin 1, beta
chr22_+_22786283 5.451


chr2_-_175712276 5.436 NM_001206602
CHN1
chimerin (chimaerin) 1
chr1_-_108231122 5.396 NM_001079874
VAV3
vav 3 guanine nucleotide exchange factor
chr14_-_107211131 5.368 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr16_+_23847271 5.329 NM_002738
NM_212535
PRKCB

protein kinase C, beta

chr12_-_123201319 5.269 NM_006018
HCAR3
hydroxycarboxylic acid receptor 3
chr14_-_107122358 5.249


chr6_-_154651214 5.235 NM_001130699
IPCEF1
interaction protein for cytohesin exchange factors 1
chr1_-_42965948 5.226 TMSB4XP1
thymosin beta 4, X-linked pseudogene 1
chr2_-_89619820 5.197 IGKC
immunoglobulin kappa constant
chr3_+_46395224 5.104 NM_001123041
NM_001123396
CCR2

chemokine (C-C motif) receptor 2

chr14_-_107034760 5.070 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr4_+_71091787 5.045 NM_152997
C4orf7
chromosome 4 open reading frame 7
chr16_+_23847496 5.035 PRKCB
protein kinase C, beta
chr19_+_35820069 4.985 NM_001185099
NM_001185100
NM_001185101
NM_001771
CD22



CD22 molecule



chr9_+_125796845 4.974 NM_005294
GPR21
G protein-coupled receptor 21
chr14_-_106725232 4.898 ZCWPW2
IGHV3-23
IGKV3-20
IGK@
zinc finger, CW type with PWWP domain 2
immunoglobulin heavy variable 3-23
immunoglobulin kappa variable 3-20
immunoglobulin kappa locus
chrX_-_13835012 4.876 GPM6B
glycoprotein M6B
chr10_+_11206928 4.793 NM_001025076
NM_001083591
CELF2

CUGBP, Elav-like family member 2

chr5_-_111091947 4.768 NM_001142483
C5orf13
chromosome 5 open reading frame 13
chr14_-_107078578 4.743


chr16_+_23847359 4.702 PRKCB
protein kinase C, beta
chr3_+_181429711 4.686 NM_003106
SOX2
SRY (sex determining region Y)-box 2
chr3_+_181430075 4.668 SOX2
SRY (sex determining region Y)-box 2
chr1_-_228645517 4.601 NM_033445
HIST3H2A
histone cluster 3, H2a
chr14_-_106518424 4.503 IGH@
IGHA1
IGHG1
IGHG2
IGHM
immunoglobulin heavy locus
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 2 (G2m marker)
immunoglobulin heavy constant mu
chr1_-_157789832 4.497 NM_001159397
NM_001159398
NM_052938
FCRL1


Fc receptor-like 1


chr14_-_107259620 4.467 IGHV5-78
immunoglobulin heavy variable 5-78 (pseudogene)
chr14_-_106539099 4.440 IGHA1
IGHG1
IGHG3
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
chr3_+_46395574 4.419 CCR2
chemokine (C-C motif) receptor 2
chrX_-_77582979 4.339 NM_006639
CYSLTR1
cysteinyl leukotriene receptor 1
chr4_-_139163222 4.308 NM_014331
SLC7A11
solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
chr1_+_192778168 4.249 NM_002923
RGS2
regulator of G-protein signaling 2, 24kDa
chr7_-_3083346 4.214 NM_032415
CARD11
caspase recruitment domain family, member 11
chr2_-_161130151 4.208 RBMS1
RNA binding motif, single stranded interacting protein 1
chr16_+_23847321 4.115 PRKCB
protein kinase C, beta
chr1_+_66458389 4.112 NM_001037340
PDE4B
phosphodiesterase 4B, cAMP-specific
chr21_+_43823970 4.051 NM_001001895
NM_001243467
NM_018961
UBASH3A


ubiquitin associated and SH3 domain containing A


chr14_-_99737821 4.032 NM_022898
NM_138576
BCL11B

B-cell CLL/lymphoma 11B (zinc finger protein)

chr10_+_11207053 4.013 CELF2
CUGBP, Elav-like family member 2
chr3_+_98250742 3.997 NM_005290
GPR15
G protein-coupled receptor 15
chr1_+_84609987 3.977 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr1_-_153363544 3.962 NM_002964
S100A8
S100 calcium binding protein A8
chr11_+_131240370 3.942 NM_001048209
NTM
neurotrimin
chr18_-_60795878 3.912 BCL2
B-cell CLL/lymphoma 2
chr5_-_39203061 3.790 FYB
FYN binding protein
chr1_+_228645807 3.775 NM_175055
HIST3H2BB
histone cluster 3, H2bb
chr12_-_123187842 3.769 NM_177551
HCAR2
hydroxycarboxylic acid receptor 2
chr6_+_26251826 3.709 NM_003524
HIST1H2BH
histone cluster 1, H2bh
chr4_-_176734181 3.690 NM_201591
GPM6A
glycoprotein M6A
chr14_-_106926393 3.678 IGHA1
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr17_-_62009620 3.668 NM_000626
NM_001039933
NM_021602
CD79B


CD79b molecule, immunoglobulin-associated beta


chr14_-_106452693 3.668 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr16_+_31366468 3.642 NM_000887
ITGAX
integrin, alpha X (complement component 3 receptor 4 subunit)
chr6_-_31560497 3.636 NM_001145466
NM_001145467
NM_147130
NCR3


natural cytotoxicity triggering receptor 3


chr6_-_26216871 3.624 NM_003518
HIST1H2BG
NCALD
histone cluster 1, H2bg
neurocalcin delta
chr2_+_152214105 3.619 NM_007115
TNFAIP6
tumor necrosis factor, alpha-induced protein 6
chr4_-_176733901 3.602 GPM6A
glycoprotein M6A
chr11_-_47399986 3.562 SPI1
spleen focus forming virus (SFFV) proviral integration oncogene spi1
chr6_-_32784727 3.551 NM_002120
HLA-DOB
major histocompatibility complex, class II, DO beta
chr1_+_209941894 3.539 TRAF3IP3
TRAF3 interacting protein 3
chr6_+_87964925 3.502 ZNF292
zinc finger protein 292
chr12_-_45269340 3.495 NM_001145109
NELL2
NEL-like 2 (chicken)
chr5_+_156607847 3.493 NM_005546
ITK
IL2-inducible T-cell kinase
chr4_+_68424444 3.484 NM_012108
STAP1
signal transducing adaptor family member 1
chr12_+_132312917 3.469 NM_016155
MMP17
matrix metallopeptidase 17 (membrane-inserted)
chr11_-_47400096 3.446 NM_001080547
NM_003120
SPI1

spleen focus forming virus (SFFV) proviral integration oncogene spi1

chr1_+_198608244 3.428 PTPRC
protein tyrosine phosphatase, receptor type, C
chr4_-_164534656 3.374 NM_017923
MARCH1
membrane-associated ring finger (C3HC4) 1
chr12_-_16760935 3.347 NM_001001395
NM_001243609
LMO3

LIM domain only 3 (rhombotin-like 2)

chr4_-_176733413 3.334 GPM6A
glycoprotein M6A
chr2_-_167005641 3.325 NM_001202435
SCN1A
sodium channel, voltage-gated, type I, alpha subunit
chr5_-_39270708 3.308 NM_001243093
FYB
FYN binding protein
chr1_-_157746863 3.305 NM_030764
FCRL2
Fc receptor-like 2
chr12_-_122240827 3.302


chr4_-_176733378 3.265 GPM6A
glycoprotein M6A
chr7_-_76829109 3.258 NM_006682
FGL2
fibrinogen-like 2
chrX_-_13835313 3.242 NM_001001995
NM_001001996
NM_005278
GPM6B


glycoprotein M6B


chr11_-_47399903 3.239


chrX_-_13835213 3.220 GPM6B
glycoprotein M6B
chr6_+_35265594 3.204 NM_022047
DEF6
differentially expressed in FDCP 6 homolog (mouse)
chr1_-_31230673 3.199 NM_006762
LAPTM5
lysosomal protein transmembrane 5
chr5_-_66492574 3.167 NM_005582
CD180
CD180 molecule
chr8_-_108510094 3.165 NM_001146
NM_001199859
ANGPT1

angiopoietin 1

chr6_-_149806116 3.158 NM_207360
ZC3H12D
zinc finger CCCH-type containing 12D
chr6_+_167536240 3.132 NM_031409
CCR6
chemokine (C-C motif) receptor 6
chr1_+_192544856 3.095 NM_002922
RGS1
regulator of G-protein signaling 1
chr1_+_50574601 3.082 ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr16_+_31366519 3.073 ITGAX
integrin, alpha X (complement component 3 receptor 4 subunit)
chr16_+_10971038 3.061 NM_000246
CIITA
class II, major histocompatibility complex, transactivator
chr16_+_30483959 3.056 NM_001114380
NM_002209
ITGAL

integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)

chrX_+_99839789 3.053 NM_022144
TNMD
tenomodulin
chr1_-_160681552 3.031 NM_001778
CD48
CD48 molecule
chr17_-_73840495 3.025 UNC13D
unc-13 homolog D (C. elegans)
chr3_-_71294229 2.977 NM_001244814
FOXP1
forkhead box P1
chrX_+_107288199 2.948 NM_001170553
NM_182607
VSIG1

V-set and immunoglobulin domain containing 1

chr19_+_14693895 2.928 NM_001204118
NM_207390
CLEC17A

C-type lectin domain family 17, member A

chr7_+_50348255 2.916 IKZF1
IKAROS family zinc finger 1 (Ikaros)
chr12_-_9760481 2.913 NM_002258
KLRB1
killer cell lectin-like receptor subfamily B, member 1
chr19_+_17858504 2.886 NM_001161357
NM_001161358
FCHO1

FCH domain only 1

chr22_-_24096551 2.885 NM_013378
VPREB3
pre-B lymphocyte 3
chr17_-_16875388 2.879 NM_012452
TNFRSF13B
tumor necrosis factor receptor superfamily, member 13B
chrX_+_80457302 2.877 NM_003022
SH3BGRL
SH3 domain binding glutamic acid-rich protein like
chr2_+_215276460 2.871 NM_001080500
VWC2L
von Willebrand factor C domain containing protein 2-like
chr12_-_16758312 2.868 NM_001243611
LMO3
LIM domain only 3 (rhombotin-like 2)
chr5_+_175108463 2.866 NM_022304
HRH2
histamine receptor H2
chr9_-_117160748 2.860 AKNA
AT-hook transcription factor
chr8_+_11351509 2.859 NM_001715
BLK
B lymphoid tyrosine kinase
chr12_+_86268072 2.844 NM_006183
NTS
neurotensin
chr9_-_35618300 2.837 NM_001782
CD72
CD72 molecule
chr8_-_27115897 2.822 NM_030795
STMN4
stathmin-like 4
chr12_-_16759939 2.821 NM_001243613
LMO3
LIM domain only 3 (rhombotin-like 2)
chr17_-_73840422 2.810 UNC13D
unc-13 homolog D (C. elegans)
chr20_-_52687014 2.807 BCAS1
breast carcinoma amplified sequence 1
chr7_+_74188308 2.798 NM_000265
NCF1
NCF1B
neutrophil cytosolic factor 1
neutrophil cytosolic factor 1B pseudogene
chr12_+_105153258 2.789 CHST11
carbohydrate (chondroitin 4) sulfotransferase 11
chr5_+_49962771 2.781 NM_001178056
NM_024615
PARP8

poly (ADP-ribose) polymerase family, member 8

chr16_+_30484049 2.772 ITGAL
integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
chr6_-_42419782 2.763 NM_033502
TRERF1
transcriptional regulating factor 1
chr6_+_12717036 2.743 NM_001242648
NM_030948
PHACTR1

phosphatase and actin regulator 1

chr18_-_30352841 2.708 NM_020805
KLHL14
kelch-like 14 (Drosophila)
chr19_+_55385548 2.694 NM_002000
NM_133269
NM_133271
NM_133272
NM_133273
NM_133274
NM_133277
NM_133278
NM_133279
FCAR








Fc fragment of IgA, receptor for








chr16_+_31366529 2.689 ITGAX
integrin, alpha X (complement component 3 receptor 4 subunit)
chr12_-_16759430 2.666 LMO3
LIM domain only 3 (rhombotin-like 2)
chr12_-_16759733 2.653 NM_001243610
LMO3
LIM domain only 3 (rhombotin-like 2)
chr2_+_196521470 2.636 NM_001127257
SLC39A10
solute carrier family 39 (zinc transporter), member 10
chr1_+_65730423 2.633 NM_014787
DNAJC6
DnaJ (Hsp40) homolog, subfamily C, member 6

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
3.63 1.63e-24 GO:0002376 immune system process
3.76 5.81e-15 GO:0006955 immune response
3.49 3.13e-11 GO:0002682 regulation of immune system process
1.84 5.44e-11 GO:0023052 signaling
1.56 1.03e-10 GO:0050896 response to stimulus
1.88 1.58e-10 GO:0007165 signal transduction
2.98 8.20e-10 GO:0009611 response to wounding
8.13 2.50e-09 GO:0002768 immune response-regulating cell surface receptor signaling pathway
5.27 2.65e-09 GO:0045321 leukocyte activation
8.70 2.92e-09 GO:0050851 antigen receptor-mediated signaling pathway
5.91 1.17e-08 GO:0002764 immune response-regulating signaling pathway
8.01 1.27e-08 GO:0002429 immune response-activating cell surface receptor signaling pathway
3.65 1.60e-08 GO:0001775 cell activation
3.82 1.76e-08 GO:0050776 regulation of immune response
1.40 5.12e-08 GO:0065007 biological regulation
5.78 5.18e-08 GO:0002757 immune response-activating signal transduction
2.17 5.34e-08 GO:0007166 cell surface receptor linked signaling pathway
3.75 5.95e-08 GO:0002684 positive regulation of immune system process
2.86 1.31e-07 GO:0006952 defense response
1.40 6.36e-07 GO:0050789 regulation of biological process
4.31 6.40e-07 GO:0050778 positive regulation of immune response
4.85 6.58e-07 GO:0002253 activation of immune response
5.10 1.53e-06 GO:0046649 lymphocyte activation
1.61 2.68e-06 GO:0051716 cellular response to stimulus
7.09 4.12e-06 GO:0030098 lymphocyte differentiation
1.40 4.99e-06 GO:0050794 regulation of cellular process
5.02 5.09e-06 GO:0050867 positive regulation of cell activation
5.21 6.89e-06 GO:0051251 positive regulation of lymphocyte activation
2.65 8.70e-06 GO:0048584 positive regulation of response to stimulus
4.36 1.21e-05 GO:0030097 hemopoiesis
4.07 2.01e-05 GO:0048534 hemopoietic or lymphoid organ development
4.85 2.23e-05 GO:0002696 positive regulation of leukocyte activation
5.80 2.46e-05 GO:0002521 leukocyte differentiation
4.17 2.67e-05 GO:0050865 regulation of cell activation
1.95 2.70e-05 GO:0048583 regulation of response to stimulus
3.89 4.78e-05 GO:0006954 inflammatory response
4.34 6.14e-05 GO:0051249 regulation of lymphocyte activation
4.14 6.47e-05 GO:0002694 regulation of leukocyte activation
5.37 7.51e-05 GO:0050870 positive regulation of T cell activation
1.78 8.19e-05 GO:0006950 response to stress
3.77 8.27e-05 GO:0002520 immune system development
7.19 1.39e-04 GO:0050852 T cell receptor signaling pathway
16.55 1.54e-04 GO:0050853 B cell receptor signaling pathway
1.71 1.75e-04 GO:0048518 positive regulation of biological process
2.10 2.64e-04 GO:0051239 regulation of multicellular organismal process
28.07 4.23e-04 GO:0043368 positive T cell selection
4.33 1.45e-03 GO:0050863 regulation of T cell activation
1.63 1.53e-03 GO:0048731 system development
7.25 1.54e-03 GO:0030217 T cell differentiation
15.85 1.76e-03 GO:0045058 T cell selection
2.61 1.91e-03 GO:0042060 wound healing
9.46 2.30e-03 GO:0030888 regulation of B cell proliferation
5.12 2.31e-03 GO:0042110 T cell activation
2.26 2.81e-03 GO:0040011 locomotion
5.39 3.39e-03 GO:0050670 regulation of lymphocyte proliferation
5.34 3.77e-03 GO:0032944 regulation of mononuclear cell proliferation
1.56 4.43e-03 GO:0048856 anatomical structure development
5.18 5.15e-03 GO:0070663 regulation of leukocyte proliferation
4.43 5.31e-03 GO:0002252 immune effector process
2.32 5.42e-03 GO:2000026 regulation of multicellular organismal development
1.75 6.64e-03 GO:0048513 organ development
6.16 7.14e-03 GO:0050671 positive regulation of lymphocyte proliferation
6.07 8.09e-03 GO:0032946 positive regulation of mononuclear cell proliferation
4.25 8.64e-03 GO:0050900 leukocyte migration
5.99 9.15e-03 GO:0070665 positive regulation of leukocyte proliferation
6.74 9.97e-03 GO:0050864 regulation of B cell activation
2.52 1.16e-02 GO:0007186 G-protein coupled receptor protein signaling pathway
7.49 1.46e-02 GO:0002263 cell activation involved in immune response
7.49 1.46e-02 GO:0002366 leukocyte activation involved in immune response
1.17 1.46e-02 GO:0009987 cellular process
2.59 1.59e-02 GO:0007599 hemostasis
2.03 2.18e-02 GO:0007154 cell communication
1.67 2.35e-02 GO:0030154 cell differentiation
22.46 2.36e-02 GO:0045576 mast cell activation
1.65 3.07e-02 GO:0048869 cellular developmental process
2.42 3.57e-02 GO:0006928 cellular component movement
1.35 3.75e-02 GO:0032501 multicellular organismal process
1.58 3.88e-02 GO:0048522 positive regulation of cellular process
2.50 4.07e-02 GO:0007596 blood coagulation
2.50 4.07e-02 GO:0050817 coagulation
9.63 4.36e-02 GO:0030890 positive regulation of B cell proliferation
2.16 4.37e-02 GO:0007267 cell-cell signaling
7.67 4.50e-02 GO:0050871 positive regulation of B cell activation
5.62 4.54e-02 GO:0042113 B cell activation

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
2.03 3.11e-09 GO:0044459 plasma membrane part
1.64 2.66e-08 GO:0005886 plasma membrane
1.62 3.73e-08 GO:0071944 cell periphery
2.14 1.55e-05 GO:0005887 integral to plasma membrane
2.10 2.89e-05 GO:0031226 intrinsic to plasma membrane
6.74 1.34e-03 GO:0000786 nucleosome
2.55 1.27e-02 GO:0045202 synapse
12.83 4.08e-02 GO:0042613 MHC class II protein complex
3.69 4.16e-02 GO:0043235 receptor complex

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
13.48 1.06e-08 GO:0003823 antigen binding
15.62 5.42e-06 GO:0001608 nucleotide receptor activity, G-protein coupled
15.62 5.42e-06 GO:0045028 purinergic nucleotide receptor activity, G-protein coupled
11.98 5.65e-05 GO:0001614 purinergic nucleotide receptor activity
11.98 5.65e-05 GO:0016502 nucleotide receptor activity
10.57 1.62e-04 GO:0035586 purinergic receptor activity
1.72 5.07e-04 GO:0004871 signal transducer activity
1.72 5.07e-04 GO:0060089 molecular transducer activity
1.80 9.31e-04 GO:0004872 receptor activity
7.34 3.01e-03 GO:0005070 SH3/SH2 adaptor activity
1.98 6.20e-03 GO:0001071 nucleic acid binding transcription factor activity
1.98 6.20e-03 GO:0003700 sequence-specific DNA binding transcription factor activity
5.99 1.38e-02 GO:0035591 signaling adaptor activity
11.23 1.65e-02 GO:0001637 G-protein chemoattractant receptor activity
11.23 1.65e-02 GO:0004950 chemokine receptor activity
10.21 2.70e-02 GO:0019956 chemokine binding