Motif ID: POU5F1_SOX2{dimer}.p2

Z-value: 1.631


Transcription factors associated with POU5F1_SOX2{dimer}.p2:

Gene SymbolEntrez IDGene Name
POU5F1 5460 POU class 5 homeobox 1
SOX2 6657 SRY (sex determining region Y)-box 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
SOX2hg19_v1_chr3_+_181429711_1814297150.431.4e-02Click!
POU5F1hg19_v1_chr6_-_31134614_311346140.154.0e-01Click!


Activity profile for motif POU5F1_SOX2{dimer}.p2.

activity profile for motif POU5F1_SOX2{dimer}.p2


Sorted Z-values histogram for motif POU5F1_SOX2{dimer}.p2

Sorted Z-values for motif POU5F1_SOX2{dimer}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of POU5F1_SOX2{dimer}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_216241321 12.718 FN1
fibronectin 1
chr3_+_133494275 5.563 TF
transferrin
chr4_+_100495972 4.978 MTTP
microsomal triglyceride transfer protein
chr10_+_7745325 4.528 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr8_+_120079423 4.348 NM_006438
 COLEC10
collectin sub-family member 10 (C-type lectin)
chr11_+_69455938 4.342 CCND1
cyclin D1
chr8_-_17752847 4.306 NM_147203
NM_201553
NM_004467
NM_201552
 FGL1



fibrinogen-like 1



chr12_-_91573264 4.298 NM_133503
 DCN
decorin
chr17_+_27370155 4.291 PIPOX
pipecolic acid oxidase
chr16_-_55867016 4.287 NM_001025194
NM_001025195
NM_001266
 CES1


carboxylesterase 1


chr11_-_35441501 4.283 NM_001195728
NM_001252652
 SLC1A2

solute carrier family 1 (glial high affinity glutamate transporter), member 2

chr9_+_6215785 4.178 NM_001199640
NM_001199641
NM_033439
 IL33


interleukin 33


chr10_+_7745229 4.064 NM_002216
 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr10_+_7745284 3.959 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr11_-_49229994 3.918 NM_001014986
NM_001193471
NM_001193472
NM_001193473
NM_004476
 FOLH1




folate hydrolase (prostate-specific membrane antigen) 1




chr11_+_69455884 3.914 CCND1
cyclin D1
chr17_+_27369917 3.813 NM_016518
 PIPOX
pipecolic acid oxidase
chr4_+_77610610 3.766 SHROOM3
shroom family member 3
chr5_-_39364562 3.740 NM_001737
 C9
complement component 9
chr11_+_69455837 3.728 NM_053056
 CCND1
cyclin D1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 38 entries
Enrichment   P-value GO Accession GO Term
125.10 4.65e-02 GO:0001897 cytolysis by symbiont of host cells
125.10 4.65e-02 GO:0001907 killing by symbiont of host cells
125.10 4.65e-02 GO:0019836 hemolysis by symbiont of host erythrocytes
125.10 4.65e-02 GO:0044004 disruption by symbiont of host cells
125.10 4.65e-02 GO:0044179 hemolysis in other organism
125.10 4.65e-02 GO:0051715 cytolysis in other organism
125.10 4.65e-02 GO:0051801 cytolysis in other organism involved in symbiotic interaction
125.10 4.65e-02 GO:0052025 modification by symbiont of host cell membrane
125.10 4.65e-02 GO:0052043 modification by symbiont of host cellular component
125.10 4.65e-02 GO:0052111 modification by symbiont of host structure
125.10 4.65e-02 GO:0052185 modification of structure of other organism involved in symbiotic interaction
125.10 4.65e-02 GO:0052188 modification of cellular component in other organism involved in symbiotic interaction
125.10 4.65e-02 GO:0052331 hemolysis in other organism involved in symbiotic interaction
125.10 4.65e-02 GO:0052332 modification by organism of cell membrane in other organism involved in symbiotic interaction
46.92 1.28e-06 GO:0015721 bile acid and bile salt transport
41.70 1.35e-03 GO:0043252 sodium-independent organic anion transport
41.70 2.97e-02 GO:0031638 zymogen activation
29.44 6.28e-03 GO:0007597 blood coagulation, intrinsic pathway
27.05 3.14e-07 GO:0008206 bile acid metabolic process
25.03 1.26e-02 GO:0072378 blood coagulation, fibrin clot formation

Gene overrepresentation in compartment category:

Showing 1 to 13 of 13 entries
Enrichment   P-value GO Accession GO Term
53.62 2.39e-03 GO:0005577 fibrinogen complex
14.44 4.90e-04 GO:0031983 vesicle lumen
13.31 4.96e-03 GO:0031093 platelet alpha granule lumen
13.04 5.50e-03 GO:0034774 secretory granule lumen
12.52 6.72e-03 GO:0060205 cytoplasmic membrane-bounded vesicle lumen
10.98 1.27e-02 GO:0031091 platelet alpha granule
4.37 2.47e-08 GO:0005615 extracellular space
3.50 1.38e-06 GO:0044421 extracellular region part
3.28 3.96e-04 GO:0005624 membrane fraction
3.17 6.42e-04 GO:0005626 insoluble fraction
3.02 2.49e-10 GO:0005576 extracellular region
2.42 2.98e-02 GO:0000267 cell fraction
1.91 3.87e-02 GO:0044459 plasma membrane part

Gene overrepresentation in function category:

Showing 1 to 8 of 8 entries
Enrichment   P-value GO Accession GO Term
125.10 1.12e-02 GO:0047026 androsterone dehydrogenase (A-specific) activity
125.10 1.12e-02 GO:0047718 indanol dehydrogenase activity
93.82 3.49e-04 GO:0047023 androsterone dehydrogenase activity
93.82 3.49e-04 GO:0047115 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
25.03 3.72e-02 GO:0008514 organic anion transmembrane transporter activity
23.46 4.56e-02 GO:0015125 bile acid transmembrane transporter activity
18.77 1.26e-04 GO:0003823 antigen binding
3.78 2.97e-02 GO:0030246 carbohydrate binding