Motif ID: PRDM1.p3

Z-value: 2.009


Transcription factors associated with PRDM1.p3:

Gene SymbolEntrez IDGene Name
PRDM1 639 PR domain containing 1, with ZNF domain

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
PRDM1hg19_v1_chr6_+_106546736_1065468730.251.7e-01Click!


Activity profile for motif PRDM1.p3.

activity profile for motif PRDM1.p3


Sorted Z-values histogram for motif PRDM1.p3

Sorted Z-values for motif PRDM1.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of PRDM1.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_-_34710062 13.854 NM_002989
CCL21
chemokine (C-C motif) ligand 21
chr10_-_44880452 11.685 NM_000609
NM_001033886
NM_001178134
NM_199168
CXCL12



chemokine (C-X-C motif) ligand 12



chr6_-_112575766 10.893 NM_001105206
NM_001105207
NM_001105208
NM_001105209
NM_002290
LAMA4




laminin, alpha 4




chr6_-_112575708 9.410 LAMA4
laminin, alpha 4
chr4_-_100242487 9.065 NM_000668
ADH1A
ADH1B
alcohol dehydrogenase 1A (class I), alpha polypeptide
alcohol dehydrogenase 1B (class I), beta polypeptide
chr2_+_239756672 8.604 NM_057179
TWIST2
twist homolog 2 (Drosophila)
chr6_-_112575345 7.451 LAMA4
laminin, alpha 4
chr10_-_131762017 6.843 NM_001005463
EBF3
early B-cell factor 3
chr6_-_112575880 6.754 LAMA4
laminin, alpha 4
chr6_-_29527477 6.467 UBD
ubiquitin D
chr1_+_19971865 6.280 NM_001204085
NBL1
neuroblastoma, suppression of tumorigenicity 1
chr2_-_190044330 6.066 NM_000393
COL5A2
collagen, type V, alpha 2
chr8_+_134203281 6.036 NM_001204869
NM_001204870
NM_003882
NM_080838
WISP1



WNT1 inducible signaling pathway protein 1



chr15_+_96876568 5.964 NM_001145157
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr22_-_30642683 5.481 NM_002309
LIF
leukemia inhibitory factor (cholinergic differentiation factor)
chr1_+_19972259 5.201 NM_001204086
NBL1
neuroblastoma, suppression of tumorigenicity 1
chr1_+_212781969 5.059 NM_001040619
NM_001206484
NM_001206488
NM_001674
ATF3



activating transcription factor 3



chr6_-_29527701 4.972 NM_006398
UBD
ubiquitin D
chr9_-_16727887 4.823 BNC2
basonuclin 2
chr1_+_212782103 4.790 ATF3
activating transcription factor 3
chr6_+_127440047 4.600 NM_032784
RSPO3
R-spondin 3
chr3_+_8543508 4.373 NM_014583
LMCD1
LIM and cysteine-rich domains 1
chr12_-_71003622 4.363 NM_001206971
NM_001206972
NM_002837
PTPRB


protein tyrosine phosphatase, receptor type, B


chr6_+_127439803 4.318 RSPO3
R-spondin 3
chr4_+_186990308 4.297 NM_003265
TLR3
toll-like receptor 3
chr15_-_37393364 4.263 NM_001220482
NM_002399
MEIS2

Meis homeobox 2

chr1_+_110453456 4.235 CSF1
colony stimulating factor 1 (macrophage)
chr3_+_8543539 4.156 LMCD1
LIM and cysteine-rich domains 1
chr1_-_44497132 4.118 NM_001024845
SLC6A9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr1_+_110453232 4.105 NM_000757
NM_172210
NM_172212
CSF1


colony stimulating factor 1 (macrophage)


chr22_+_22550159 4.033 IGLV6-57
immunoglobulin lambda variable 6-57
chr8_+_39771327 3.920 NM_002164
IDO1
indoleamine 2,3-dioxygenase 1
chr1_+_162602308 3.596 DDR2
discoidin domain receptor tyrosine kinase 2
chr13_-_110802708 3.556 COL4A1
collagen, type IV, alpha 1
chr2_-_19558371 3.374 NM_145260
OSR1
odd-skipped related 1 (Drosophila)
chr8_+_144640476 3.165 NM_024736
GSDMD
gasdermin D
chr9_+_137533643 2.973 NM_000093
COL5A1
collagen, type V, alpha 1
chr14_-_69262959 2.826 NM_001244701
ZFP36L1
zinc finger protein 36, C3H type-like 1
chr22_-_36556781 2.822 NM_145640
APOL3
apolipoprotein L, 3
chr1_-_44497028 2.811 SLC6A9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr1_+_162602198 2.782 NM_001014796
NM_006182
DDR2

discoidin domain receptor tyrosine kinase 2

chr4_-_186578122 2.678 NM_001145674
NM_001145675
SORBS2

sorbin and SH3 domain containing 2

chr8_+_97506020 2.647 SDC2
syndecan 2
chr12_-_57505176 2.629 NM_001178078
NM_001178080
NM_001178081
NM_003153
STAT6



signal transducer and activator of transcription 6, interleukin-4 induced



chr10_-_97321094 2.613 NM_015385
NM_024991
SORBS1

sorbin and SH3 domain containing 1

chr17_+_17398334 2.599


chr1_-_161168816 2.555 NM_005099
ADAMTS4
ADAM metallopeptidase with thrombospondin type 1 motif, 4
chr8_+_97505876 2.505 NM_002998
SDC2
syndecan 2
chr8_-_79717540 2.494 NM_000880
NM_001199886
NM_001199887
NM_001199888
IL7



interleukin 7



chr22_+_22550112 2.486


chr1_-_8075678 2.354 ERRFI1
ERBB receptor feedback inhibitor 1
chr11_+_46402333 2.328 NM_001012334
MDK
midkine (neurite growth-promoting factor 2)
chr2_+_205410716 2.268 PARD3B
par-3 partitioning defective 3 homolog B (C. elegans)
chr2_+_205410465 2.123 NM_057177
NM_152526
NM_205863
PARD3B


par-3 partitioning defective 3 homolog B (C. elegans)


chr3_-_49851217 2.103 UBA7
ubiquitin-like modifier activating enzyme 7
chr9_+_97766414 2.066 C9orf3
chromosome 9 open reading frame 3
chr10_+_114135965 2.027 ACSL5
acyl-CoA synthetase long-chain family member 5
chr14_-_69259654 2.003 ZFP36L1
zinc finger protein 36, C3H type-like 1
chr2_+_231191877 2.001 NM_138402
SP140L
SP140 nuclear body protein-like
chr8_+_97505895 1.994 SDC2
syndecan 2
chr12_-_57505121 1.920 STAT6
signal transducer and activator of transcription 6, interleukin-4 induced
chr2_+_234526290 1.874 NM_019076
UGT1A8
UDP glucuronosyltransferase 1 family, polypeptide A8
chr8_+_97506071 1.858 SDC2
syndecan 2
chr10_+_114135937 1.828 NM_016234
ACSL5
acyl-CoA synthetase long-chain family member 5
chr22_+_39417117 1.824 NM_152426
APOBEC3D
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D
chr3_-_49851356 1.758 NM_003335
UBA7
ubiquitin-like modifier activating enzyme 7
chr5_+_96212167 1.687 ERAP2
endoplasmic reticulum aminopeptidase 2
chr17_-_38520941 1.682 NM_152219
GJD3
gap junction protein, delta 3, 31.9kDa
chr11_+_32112607 1.676 RCN1
reticulocalbin 1, EF-hand calcium binding domain
chr21_-_43346780 1.667 NM_199050
C2CD2
C2 calcium-dependent domain containing 2
chr4_+_15376174 1.660 NM_001135171
C1QTNF7
C1q and tumor necrosis factor related protein 7
chr6_-_10412606 1.637 NM_001032280
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr7_-_83270746 1.582 NM_001178129
SEMA3E
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
chr8_-_23712297 1.574 NM_003155
STC1
stanniocalcin 1
chr1_-_111746917 1.567 DENND2D
DENN/MADD domain containing 2D
chr7_+_134464161 1.506 NM_004342
NM_033138
NM_033157
CALD1


caldesmon 1


chr12_-_57504935 1.503 STAT6
signal transducer and activator of transcription 6, interleukin-4 induced
chr21_-_40033617 1.501 NM_001243432
NM_001136154
NM_004449
ERG


v-ets erythroblastosis virus E26 oncogene homolog (avian)


chr6_-_105584542 1.473 NM_007073
BVES
blood vessel epicardial substance
chr4_-_186577858 1.449 SORBS2
sorbin and SH3 domain containing 2
chr10_-_13749622 1.408 FRMD4A
FERM domain containing 4A
chr2_+_231280933 1.402 SP100
SP100 nuclear antigen
chr1_-_150780705 1.373 NM_000396
CTSK
cathepsin K
chr4_+_152020732 1.360 NM_001006
RPS3A
ribosomal protein S3A
chr2_+_231280906 1.360 SP100
SP100 nuclear antigen
chr2_+_231280870 1.358 NM_001080391
NM_001206701
NM_001206702
NM_001206703
NM_003113
SP100




SP100 nuclear antigen




chr10_+_114136014 1.352 ACSL5
acyl-CoA synthetase long-chain family member 5
chr11_+_65190272 1.333


chr7_+_42971938 1.330 NM_031903
MRPL32
mitochondrial ribosomal protein L32
chr7_+_89843133 1.321 NM_001040666
STEAP2
STEAP family member 2, metalloreductase
chr11_+_71709951 1.313 NM_001039659
NM_001039660
NM_173044
NM_005699
NM_173042
IL18BP




interleukin 18 binding protein




chr2_+_205410556 1.280 PARD3B
par-3 partitioning defective 3 homolog B (C. elegans)
chr2_+_234545099 1.279 NM_019075
UGT1A10
UDP glucuronosyltransferase 1 family, polypeptide A10
chr11_+_71710971 1.278 NM_001145055
IL18BP
interleukin 18 binding protein
chr11_+_65190267 1.277 NEAT1
nuclear paraspeckle assembly transcript 1 (non-protein coding)
chr5_+_73109342 1.257 NM_001244364
RGNEF
190 kDa guanine nucleotide exchange factor
chr3_+_46448678 1.242 NM_003965
NM_001130910
CCRL2

chemokine (C-C motif) receptor-like 2

chr6_-_32811773 1.232 NM_148919
PSMB8
proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
chr10_+_18429605 1.226 NM_201593
NM_201596
NM_201597
NM_001167945
NM_201571
NM_201572
CACNB2





calcium channel, voltage-dependent, beta 2 subunit





chr4_+_142557722 1.203 NM_000585
NM_172175
IL15

interleukin 15

chr14_-_69260630 1.203 NM_001244698
NM_004926
ZFP36L1

zinc finger protein 36, C3H type-like 1

chr3_+_174577069 1.186 NM_207015
NAALADL2
N-acetylated alpha-linked acidic dipeptidase-like 2
chr3_+_187871473 1.173 NM_001167672
LPP
LIM domain containing preferred translocation partner in lipoma
chr4_+_146403955 1.136 NM_001003688
SMAD1
SMAD family member 1
chr17_-_48271365 1.104


chr22_+_39436608 1.103 NM_001006666
NM_145298
APOBEC3F

apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F

chr4_-_100140330 1.078 NM_000672
NM_001102470
ADH6

alcohol dehydrogenase 6 (class V)

chr10_+_102123420 1.053


chr19_+_49977465 1.039 NM_001204502
NM_001459
FLT3LG

fms-related tyrosine kinase 3 ligand

chr9_-_117568292 1.025 NM_005118
TNFSF15
tumor necrosis factor (ligand) superfamily, member 15
chr19_+_13105970 1.004 NM_002501
NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr6_-_105584982 0.985 NM_001199563
BVES
blood vessel epicardial substance
chr18_-_53071225 0.985 NM_001243232
TCF4
transcription factor 4
chr6_+_36973409 0.966 NM_173558
FGD2
FYVE, RhoGEF and PH domain containing 2
chr16_+_57023411 0.958 NLRC5
NLR family, CARD domain containing 5
chr12_+_102271349 0.944 DRAM1
DNA-damage regulated autophagy modulator 1
chrX_+_102883647 0.919 NM_001006640
TCEAL1
transcription elongation factor A (SII)-like 1
chr11_+_71710662 0.910 NM_001145057
IL18BP
interleukin 18 binding protein
chr9_+_109625347 0.882 NM_021224
ZNF462
zinc finger protein 462
chr13_+_108921976 0.871 NM_001145645
NM_006573
TNFSF13B

tumor necrosis factor (ligand) superfamily, member 13b

chr12_+_102271082 0.863 NM_018370
DRAM1
DNA-damage regulated autophagy modulator 1
chr10_+_123754141 0.862 TACC2
transforming, acidic coiled-coil containing protein 2
chr2_+_132480063 0.817 NM_013310
C2orf27A
chromosome 2 open reading frame 27A
chr16_-_85145995 0.817 NM_198491
FAM92B
family with sequence similarity 92, member B
chr10_+_63808968 0.797 NM_001244638
ARID5B
AT rich interactive domain 5B (MRF1-like)
chr6_-_32806545 0.787 NM_000544
NM_018833
TAP2

transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)

chr9_+_112542496 0.759 NM_053016
NM_007203
NM_147150
PALM2
PALM2-AKAP2

paralemmin 2
PALM2-AKAP2 readthrough

chr6_-_99797530 0.754 NM_032511
C6orf168
chromosome 6 open reading frame 168
chr19_+_49977817 0.745 NM_001204503
FLT3LG
fms-related tyrosine kinase 3 ligand
chr17_+_41158741 0.737 NM_005533
IFI35
interferon-induced protein 35
chr1_-_57045235 0.716 NM_003713
PPAP2B
phosphatidic acid phosphatase type 2B
chr17_+_6659155 0.697 NM_017523
NM_199139
XAF1

XIAP associated factor 1

chr21_+_34144410 0.690 C21orf49
chromosome 21 open reading frame 49
chr1_+_159796478 0.689 NM_020125
SLAMF8
SLAM family member 8
chr5_-_56778553 0.686 NM_001017992
ACTBL2
actin, beta-like 2
chr13_+_108922205 0.667 TNFSF13B
tumor necrosis factor (ligand) superfamily, member 13b
chr9_+_18474078 0.659 NM_001040272
NM_052866
ADAMTSL1

ADAMTS-like 1

chr15_-_82641705 0.639 NM_001164465
GOLGA6L10
golgin A6 family-like 10
chr9_+_18474138 0.633 ADAMTSL1
ADAMTS-like 1
chr7_+_134464372 0.621 CALD1
caldesmon 1
chr6_-_31704272 0.617 CLIC1
chloride intracellular channel 1
chr4_-_120243257 0.615 NM_000134
FABP2
fatty acid binding protein 2, intestinal
chr2_-_231084600 0.609 NM_004509
NM_004510
NM_080424
SP110


SP110 nuclear body protein


chr9_-_14868974 0.598 FREM1
FRAS1 related extracellular matrix 1
chr1_+_221052845 0.596 HLX
H2.0-like homeobox
chr8_-_42065037 0.589 PLAT
plasminogen activator, tissue
chr22_+_39473009 0.588 NM_021822
APOBEC3G
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
chrX_+_102883891 0.581 NM_001006639
NM_004780
TCEAL1

transcription elongation factor A (SII)-like 1

chr2_+_3627725 0.580 RPS7
ribosomal protein S7
chr16_-_73092533 0.565 NM_001164766
ZFHX3
zinc finger homeobox 3
chr6_+_32821924 0.562 NM_002800
PSMB9
proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)
chr6_-_33281847 0.555 TAPBP
TAP binding protein (tapasin)
chr8_-_93075190 0.552 NM_004349
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr3_+_69915374 0.551 NM_198177
MITF
microphthalmia-associated transcription factor
chr15_+_83098709 0.546 NM_198181
GOLGA6L9
golgin A6 family-like 9
chr1_+_2985730 0.545 NM_022114
NM_199454
PRDM16

PR domain containing 16

chr8_-_23540401 0.542 NM_006167
NKX3-1
NK3 homeobox 1
chr14_+_24701624 0.535 NM_001002000
NM_001002001
GMPR2

guanosine monophosphate reductase 2

chr5_+_32710742 0.531 NM_001204376
NPR3
natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
chr2_+_121554866 0.525 NM_005270
GLI2
GLI family zinc finger 2
chr19_+_49838700 0.525 CD37
CD37 molecule
chr3_-_71353910 0.503 NM_001244812
FOXP1
forkhead box P1
chr11_-_104839263 0.498 NM_001225
CASP4
caspase 4, apoptosis-related cysteine peptidase
chrX_-_154563735 0.496 NM_001289
CLIC2
chloride intracellular channel 2
chr6_-_33281790 0.493 TAPBP
TAP binding protein (tapasin)
chr2_-_202508223 0.488 NM_001044385
TMEM237
transmembrane protein 237
chr5_+_6746100 0.482 NM_001171806
PAPD7
PAP associated domain containing 7
chr12_-_31479084 0.465 FAM60A
family with sequence similarity 60, member A
chr1_+_111889194 0.462 NM_181643
C1orf88
chromosome 1 open reading frame 88
chr11_-_5706186 0.461 NM_033034
NM_033092
NM_033093
TRIM5


tripartite motif containing 5


chr1_+_200863948 0.450 NM_001142569
C1orf106
chromosome 1 open reading frame 106
chr6_-_32812189 0.448 PSMB8
proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
chr12_-_56709831 0.441 NM_001190991
NM_014255
CNPY2

canopy 2 homolog (zebrafish)

chr3_-_11623829 0.440 NM_001128220
VGLL4
vestigial like 4 (Drosophila)
chr2_+_169643048 0.436 NM_001171631
NOSTRIN
nitric oxide synthase trafficker
chr6_-_130031278 0.429 NM_033515
ARHGAP18
Rho GTPase activating protein 18
chr19_+_49838734 0.426 CD37
CD37 molecule
chr15_+_71184781 0.423 NM_001199017
NM_017691
NM_001199018
LRRC49


leucine rich repeat containing 49


chr19_-_11639929 0.420 NM_001142464
NM_001142465
NM_016581
ECSIT


ECSIT homolog (Drosophila)


chr11_-_104905849 0.417 CASP1
caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
chr12_-_9913415 0.405 NM_001781
CD69
CD69 molecule
chr14_-_24701559 0.399 NEDD8
neural precursor cell expressed, developmentally down-regulated 8
chr6_+_25962978 0.398 NM_006355
TRIM38
tripartite motif containing 38
chr11_+_64008530 0.398 NM_001135208
FKBP2
FK506 binding protein 2, 13kDa
chr3_+_51976274 0.394 NM_001003931
NM_005485
PARP3

poly (ADP-ribose) polymerase family, member 3

chr7_+_120702818 0.392 C7orf58
chromosome 7 open reading frame 58
chr6_+_3259185 0.386 PSMG4
proteasome (prosome, macropain) assembly chaperone 4
chr11_+_77532159 0.378 NM_024684
C11orf67
chromosome 11 open reading frame 67
chr10_+_5238756 0.377 NM_001818
AKR1C4
aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
chr22_-_36562224 0.372 NM_145641
NM_145642
APOL3

apolipoprotein L, 3

chr1_-_20445991 0.372 NM_012400
PLA2G2D
phospholipase A2, group IID
chr11_-_128392061 0.372 NM_001162422
NM_005238
ETS1

v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)

chr19_-_42192095 0.367 NM_006890
CEACAM7
carcinoembryonic antigen-related cell adhesion molecule 7
chr1_+_226012974 0.363 NM_000120
EPHX1
epoxide hydrolase 1, microsomal (xenobiotic)
chr12_-_31479038 0.363 FAM60A
family with sequence similarity 60, member A
chr17_-_80407601 0.359 NM_001193655
C17orf62
chromosome 17 open reading frame 62
chr1_-_144520918 0.358 LOC728855
uncharacterized LOC728855
chr9_+_33624214 0.342 ANXA2P2
annexin A2 pseudogene 2
chr12_-_31479120 0.338 NM_001135811
NM_021238
NM_001135812
FAM60A


family with sequence similarity 60, member A


chr19_-_18197632 0.318 NM_005535
NM_153701
IL12RB1

interleukin 12 receptor, beta 1


Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
2.48 6.71e-03 GO:0048522 positive regulation of cellular process
2.56 6.81e-03 GO:0042221 response to chemical stimulus
61.42 6.94e-03 GO:0006067 ethanol metabolic process
61.42 6.94e-03 GO:0006069 ethanol oxidation
61.42 6.94e-03 GO:0034308 primary alcohol metabolic process
6.73 1.21e-02 GO:0001944 vasculature development
2.33 1.23e-02 GO:0048518 positive regulation of biological process
3.98 2.08e-02 GO:0006955 immune response
150.12 3.01e-02 GO:0060426 lung vasculature development
2.47 4.80e-02 GO:0030154 cell differentiation

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
3.97 7.09e-05 GO:0044421 extracellular region part
2.85 1.06e-04 GO:0005576 extracellular region
3.94 1.85e-03 GO:0005615 extracellular space
150.12 5.29e-03 GO:0005588 collagen type V
18.78 4.88e-02 GO:0005581 collagen

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
9.30 2.31e-04 GO:0005125 cytokine activity
75.07 7.21e-04 GO:0004022 alcohol dehydrogenase (NAD) activity
8.77 1.52e-03 GO:0005126 cytokine receptor binding
3.32 6.66e-03 GO:0005102 receptor binding
1.29 7.91e-03 GO:0005488 binding
112.59 1.21e-02 GO:0004024 alcohol dehydrogenase activity, zinc-dependent