Motif ID: PRRX1,2.p2

Z-value: 1.824


Transcription factors associated with PRRX1,2.p2:

Gene SymbolEntrez IDGene Name
PRRX1 5396 paired related homeobox 1
PRRX2 51450 paired related homeobox 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
PRRX1hg19_v1_chr1_+_170633312_1706334130.346.0e-02Click!
PRRX2hg19_v1_chr9_+_132428016_132428116-0.038.5e-01Click!


Activity profile for motif PRRX1,2.p2.

activity profile for motif PRRX1,2.p2


Sorted Z-values histogram for motif PRRX1,2.p2

Sorted Z-values for motif PRRX1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PRRX1,2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_+_7382750 10.728 NM_145891
NM_145892
NM_145893
 RBFOX1


RNA binding protein, fox-1 homolog (C. elegans) 1


chr12_+_101988746 9.046 NM_002465
NM_206819
NM_206820
NM_206821
 MYBPC1



myosin binding protein C, slow type



chr17_-_10421858 8.951 NM_005963
 MYH1
myosin, heavy chain 1, skeletal muscle, adult
chr13_+_23755059 8.874 NM_000231
 SGCG
sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
chr15_+_25281105 7.154 SNRPN
small nuclear ribonucleoprotein polypeptide N
chr17_-_10452939 6.924 NM_001100112
NM_017534
 MYH2

myosin, heavy chain 2, skeletal muscle, adult

chrX_-_15332680 6.330 NM_001012428
 ASB11
ankyrin repeat and SOCS box containing 11
chr13_-_36050758 6.302 NM_005584
 MAB21L1
mab-21-like 1 (C. elegans)
chr3_+_35722428 6.256 NM_198399
 ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr3_-_167191808 5.960 NM_006217
 SERPINI2
serpin peptidase inhibitor, clade I (pancpin), member 2
chr10_+_69869249 5.841 NM_032578
 MYPN
myopalladin
chr6_-_123957941 5.817 NM_001251987
NM_006073
 TRDN

triadin

chr19_+_30863318 5.659 NM_014717
 ZNF536
zinc finger protein 536
chr3_-_195310770 5.431 APOD
apolipoprotein D
chr4_+_70796798 5.397 NM_001025104
NM_001890
 CSN1S1

casein alpha s1

chr5_+_71502700 5.379 MAP1B
microtubule-associated protein 1B
chr8_-_82395401 5.333 NM_001442
 FABP4
fatty acid binding protein 4, adipocyte
chr8_-_17555158 5.291 NM_020749
 MTUS1
microtubule associated tumor suppressor 1
chr3_+_35721115 5.140 NM_001025068
NM_001025069
 ARPP21

cAMP-regulated phosphoprotein, 21kDa

chr14_+_32798478 5.121 NM_004274
 AKAP6
A kinase (PRKA) anchor protein 6

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 23 entries
Enrichment   P-value GO Accession GO Term
15.12 1.49e-02 GO:0007026 negative regulation of microtubule depolymerization
14.23 2.07e-02 GO:0031114 regulation of microtubule depolymerization
9.16 1.03e-02 GO:0030049 muscle filament sliding
9.16 1.03e-02 GO:0033275 actin-myosin filament sliding
9.08 4.84e-02 GO:0007416 synapse assembly
8.92 1.25e-02 GO:0070252 actin-mediated cell contraction
5.00 1.07e-05 GO:0007517 muscle organ development
4.90 2.10e-04 GO:0006936 muscle contraction
4.50 6.72e-04 GO:0003012 muscle system process
3.74 5.54e-04 GO:0061061 muscle structure development
3.03 1.09e-03 GO:0007268 synaptic transmission
2.92 8.51e-04 GO:0019226 transmission of nerve impulse
2.92 8.51e-04 GO:0035637 multicellular organismal signaling
2.26 1.89e-02 GO:0007267 cell-cell signaling
2.20 4.44e-02 GO:0007155 cell adhesion
2.20 4.44e-02 GO:0022610 biological adhesion
2.08 1.10e-04 GO:0007399 nervous system development
1.85 3.56e-03 GO:0003008 system process
1.81 3.48e-06 GO:0048731 system development
1.64 3.50e-04 GO:0048856 anatomical structure development

Gene overrepresentation in compartment category:

Showing 1 to 19 of 19 entries
Enrichment   P-value GO Accession GO Term
13.44 5.82e-03 GO:0005859 muscle myosin complex
13.44 5.82e-03 GO:0032982 myosin filament
12.10 1.02e-02 GO:0016460 myosin II complex
9.18 5.23e-13 GO:0030016 myofibril
8.66 1.89e-12 GO:0043292 contractile fiber
8.57 3.97e-11 GO:0044449 contractile fiber part
8.40 3.75e-09 GO:0030017 sarcomere
7.85 2.34e-02 GO:0016529 sarcoplasmic reticulum
7.64 2.74e-02 GO:0016528 sarcoplasm
6.28 2.71e-02 GO:0034707 chloride channel complex
6.13 1.19e-03 GO:0014069 postsynaptic density
4.58 5.75e-04 GO:0045211 postsynaptic membrane
3.36 5.97e-04 GO:0044456 synapse part
3.12 1.35e-04 GO:0045202 synapse
2.99 2.04e-06 GO:0030054 cell junction
2.66 1.22e-02 GO:0043005 neuron projection
1.74 4.06e-04 GO:0044459 plasma membrane part
1.57 5.14e-06 GO:0005886 plasma membrane
1.56 6.46e-06 GO:0071944 cell periphery

Gene overrepresentation in function category:

Showing 1 to 5 of 5 entries
Enrichment   P-value GO Accession GO Term
12.38 2.49e-07 GO:0008307 structural constituent of muscle
5.45 3.22e-02 GO:0005254 chloride channel activity
3.70 1.29e-05 GO:0003779 actin binding
3.01 1.03e-05 GO:0008092 cytoskeletal protein binding
2.24 1.54e-02 GO:0005509 calcium ion binding