Motif ID: REST.p3

Z-value: 5.632


Transcription factors associated with REST.p3:

Gene SymbolEntrez IDGene Name
REST 5978 RE1-silencing transcription factor

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
RESThg19_v1_chr4_+_57774035_57774076-0.183.3e-01Click!


Activity profile for motif REST.p3.

activity profile for motif REST.p3


Sorted Z-values histogram for motif REST.p3

Sorted Z-values for motif REST.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of REST.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_+_71014989 67.768 NM_004291
CARTPT
CART prepropeptide
chr14_+_93389491 42.791 CHGA
chromogranin A (parathyroid secretory protein 1)
chr1_+_33352071 42.432 NM_002143
HPCA
hippocalcin
chr17_+_42385780 37.778 NM_001144825
NM_001144826
NM_006695
RUNDC3A


RUN domain containing 3A


chr20_+_5891973 37.715 NM_001819
CHGB
chromogranin B (secretogranin 1)
chr9_+_140033588 36.522 NM_000832
NM_001185090
NM_001185091
NM_007327
NM_021569
GRIN1




glutamate receptor, ionotropic, N-methyl D-aspartate 1




chr20_+_44657858 34.995 SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5
chr19_-_55691468 34.604 NM_003180
SYT5
synaptotagmin V
chrX_-_49056638 33.178 NM_003179
SYP
synaptophysin
chr5_+_175298492 32.642 NM_001008220
CPLX2
complexin 2
chr4_+_158141735 32.082 NM_000826
NM_001083619
NM_001083620
GRIA2


glutamate receptor, ionotropic, AMPA 2


chr3_-_187388105 31.425 NM_001048
SST
somatostatin
chr1_-_241520467 30.894 NM_002924
RGS7
regulator of G-protein signaling 7
chr12_+_113229548 30.285 NM_001143854
NM_014954
RPH3A

rabphilin 3A homolog (mouse)

chr10_+_26505593 30.080 GAD2
glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
chr1_-_102462371 29.655 OLFM3
olfactomedin 3
chr1_+_154540250 28.858 NM_000748
CHRNB2
cholinergic receptor, nicotinic, beta 2 (neuronal)
chr12_+_113229713 28.473 RPH3A
rabphilin 3A homolog (mouse)
chr16_+_24267672 28.341 CACNG3
calcium channel, voltage-dependent, gamma subunit 3
chrX_-_153141284 28.099 L1CAM
L1 cell adhesion molecule
chr15_-_83378488 27.982 NM_004644
AP3B2
adaptor-related protein complex 3, beta 2 subunit
chr5_+_175298538 27.926 CPLX2
complexin 2
chr14_+_93389444 27.609 NM_001275
CHGA
chromogranin A (parathyroid secretory protein 1)
chr14_-_51561657 25.984 TRIM9
tripartite motif containing 9
chr19_+_4769144 25.778 MIR7-3HG
MIR7-3 host gene (non-protein coding)
chr7_-_100808832 25.650 NM_003378
VGF
VGF nerve growth factor inducible
chr20_+_44657812 25.505 NM_020708
SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5
chr5_+_175298604 25.087 CPLX2
complexin 2
chr7_+_8474016 25.083 NXPH1
neurexophilin 1
chrX_-_153141398 24.425 NM_000425
NM_001143963
NM_024003
L1CAM


L1 cell adhesion molecule


chr8_-_91094924 24.224 NM_004929
CALB1
calbindin 1, 28kDa
chr20_-_10200137 23.887 LOC100131208
uncharacterized LOC100131208
chr3_+_120627026 23.868 NM_014980
STXBP5L
syntaxin binding protein 5-like
chr3_-_131753757 23.695 NM_130808
CPNE4
copine IV
chr16_+_24267474 23.418 CACNG3
calcium channel, voltage-dependent, gamma subunit 3
chr12_+_119419299 23.191 NM_194286
SRRM4
serine/arginine repetitive matrix 4
chr19_-_40724272 22.654 NM_152479
TTC9B
tetratricopeptide repeat domain 9B
chr8_-_145559831 22.610 NM_031309
SCRT1
scratch homolog 1, zinc finger protein (Drosophila)
chr10_+_60937226 22.585 NM_001143774
PHYHIPL
phytanoyl-CoA 2-hydroxylase interacting protein-like
chr20_-_60795270 22.228 NM_007232
HRH3
histamine receptor H3
chr10_+_26505235 22.088 NM_000818
NM_001134366
GAD2

glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)

chr10_-_50970321 21.815 NM_001143996
NM_001143997
NM_018245
OGDHL


oxoglutarate dehydrogenase-like


chr2_-_51259536 21.278 NM_001135659
NM_004801
NRXN1

neurexin 1

chr11_+_22359666 20.882 NM_020346
SLC17A6
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
chr5_-_176037091 20.737 NM_052899
GPRIN1
G protein regulated inducer of neurite outgrowth 1
chr1_+_210111537 20.675 NM_001146261
NM_001146262
NM_001146264
NM_153262
SYT14



synaptotagmin XIV



chr11_+_45907198 20.631 MAPK8IP1
mitogen-activated protein kinase 8 interacting protein 1
chr3_+_62304667 20.602 C3orf14
chromosome 3 open reading frame 14
chrX_-_47479095 20.340


chr2_+_115199898 20.031 NM_020868
DPP10
dipeptidyl-peptidase 10 (non-functional)
chr1_+_154540300 19.988 CHRNB2
cholinergic receptor, nicotinic, beta 2 (neuronal)
chr7_-_19812403 19.853 NM_152774
TMEM196
transmembrane protein 196
chr7_+_8473584 19.655 NM_152745
NXPH1
neurexophilin 1
chr8_-_57358511 19.582 NM_006211
PENK
proenkephalin
chr3_+_62305395 19.430 NM_020685
C3orf14
chromosome 3 open reading frame 14
chrX_-_47479229 19.329 NM_006950
NM_133499
SYN1

synapsin I

chr14_-_51562044 19.290 TRIM9
tripartite motif containing 9
chr1_-_175712669 19.176 NM_003285
TNR
tenascin R (restrictin, janusin)
chr1_+_210111575 19.165 SYT14
synaptotagmin XIV
chr17_+_30813928 19.126 NM_003885
CDK5R1
cyclin-dependent kinase 5, regulatory subunit 1 (p35)
chr11_-_123524881 19.025 SCN3B
sodium channel, voltage-gated, type III, beta
chr11_+_45907046 18.628 NM_005456
MAPK8IP1
mitogen-activated protein kinase 8 interacting protein 1
chr6_+_110300197 18.571 NM_005284
GPR6
G protein-coupled receptor 6
chr14_-_105071080 18.171 NM_207379
TMEM179
transmembrane protein 179
chr10_+_99609994 17.749 NM_001010917
GOLGA7B
golgin A7 family, member B
chr18_-_40857245 17.631 NM_020783
SYT4
synaptotagmin IV
chr3_+_9745509 17.601 NM_153635
CPNE9
copine family member IX
chr15_-_27018917 17.193 NM_021912
GABRB3
gamma-aminobutyric acid (GABA) A receptor, beta 3
chr17_-_27332888 17.105 NM_001098635
NM_178860
SEZ6

seizure related 6 homolog (mouse)

chr1_-_102462789 16.885 NM_058170
OLFM3
olfactomedin 3
chr19_+_41036430 16.653 SPTBN4
spectrin, beta, non-erythrocytic 4
chr14_-_74892804 16.553 NM_001105579
SYNDIG1L
synapse differentiation inducing 1-like
chr16_+_5008317 15.687 NM_014692
SEC14L5
SEC14-like 5 (S. cerevisiae)
chr15_+_75287829 15.462 NM_001178111
NM_001178112
NM_138967
SCAMP5


secretory carrier membrane protein 5


chr7_+_8473237 15.204 NXPH1
neurexophilin 1
chr1_-_151689246 15.024 NM_007185
CELF3
CUGBP, Elav-like family member 3
chr19_+_41036367 14.373 NM_025213
SPTBN4
spectrin, beta, non-erythrocytic 4
chr1_-_241520384 13.368 RGS7
regulator of G-protein signaling 7
chr18_-_5197240 13.248 NM_001145194
C18orf42
chromosome 18 open reading frame 42
chr7_+_145813452 13.155 NM_014141
CNTNAP2
contactin associated protein-like 2
chr12_+_175872 13.056 NM_001170738
IQSEC3
IQ motif and Sec7 domain 3
chr6_+_35773070 13.036 NM_182548
LHFPL5
lipoma HMGIC fusion partner-like 5
chr4_-_175750377 12.803 NM_001042543
NM_006529
GLRA3

glycine receptor, alpha 3

chr11_-_75141015 11.082 KLHL35
kelch-like 35 (Drosophila)
chr10_-_102790850 10.511 PDZD7
PDZ domain containing 7
chr2_-_51259239 10.332 NRXN1
neurexin 1
chr16_+_67686813 10.311 RLTPR
RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing
chr20_-_62284701 9.671 NM_015894
STMN3
stathmin-like 3
chr12_-_3601984 9.490 LOC100129223
uncharacterized LOC100129223
chr6_+_44238479 9.375 NM_001137560
TMEM151B
transmembrane protein 151B
chr11_-_66115016 9.096 NM_006876
B3GNT1
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
chr2_+_207507141 8.287 NM_001102659
LOC200726
hCG1657980
chr6_+_153071931 8.282 NM_003381
NM_194435
VIP

vasoactive intestinal peptide

chr16_+_3019341 8.181 NM_152341
PAQR4
progestin and adipoQ receptor family member IV
chr11_+_62380212 8.064 NM_000327
ROM1
retinal outer segment membrane protein 1
chr11_-_75141210 7.901 KLHL35
kelch-like 35 (Drosophila)
chr15_-_32162778 7.265 OTUD7A
OTU domain containing 7A
chr2_+_131513782 6.614 NM_001105194
NM_001105195
FAM123C

family with sequence similarity 123C

chr19_-_39402797 6.589 NM_001243212
LOC643669
uncharacterized LOC643669
chr3_-_48700317 6.479 NM_001407
CELSR3
cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila)
chr12_+_52695648 5.224 NM_002284
KRT86
keratin 86
chr20_+_30555804 4.889 NM_001011718
XKR7
XK, Kell blood group complex subunit-related family, member 7
chr15_-_72612127 4.693 CELF6
CUGBP, Elav-like family member 6
chr11_-_75141517 4.391 NM_001039548
KLHL35
kelch-like 35 (Drosophila)
chr6_+_154360442 4.330 NM_000914
NM_001008503
NM_001008504
NM_001008505
NM_001145282
NM_001145283
NM_001145284
NM_001145285
NM_001145286
OPRM1








opioid receptor, mu 1








chr9_-_74061819 4.257 TRPM3
transient receptor potential cation channel, subfamily M, member 3
chr6_+_25652373 4.158 NM_006998
SCGN
secretagogin, EF-hand calcium binding protein
chr15_-_32162896 3.694 OTUD7A
OTU domain containing 7A
chr12_-_99288502 2.792 NM_001204065
NM_001204079
NM_001204080
NM_001204081
ANKS1B



ankyrin repeat and sterile alpha motif domain containing 1B



chr10_-_102790877 2.695 NM_001195263
NM_024895
PDZD7

PDZ domain containing 7

chr8_+_57358361 2.608


chr20_+_62328002 2.406 NM_003823
TNFRSF6B
tumor necrosis factor receptor superfamily, member 6b, decoy
chr20_+_62328068 2.183 TNFRSF6B
tumor necrosis factor receptor superfamily, member 6b, decoy
chr8_+_6565870 2.158 NM_018361
AGPAT5
1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic acid acyltransferase, epsilon)
chr8_+_6566153 2.003 AGPAT5
1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic acid acyltransferase, epsilon)
chr15_+_69222838 1.956 NM_145658
NM_001184780
SPESP1
NOX5
sperm equatorial segment protein 1
NADPH oxidase, EF-hand calcium binding domain 5
chr16_+_2510080 1.842 NM_025108
C16orf59
chromosome 16 open reading frame 59
chr8_+_6565914 1.678 AGPAT5
1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic acid acyltransferase, epsilon)
chr11_-_27721179 1.348 NM_170734
BDNF
brain-derived neurotrophic factor
chr14_-_58332591 1.298 NM_001206920
SLC35F4
solute carrier family 35, member F4
chr11_-_27742224 1.222 NM_001143805
NM_001143806
NM_170732
BDNF


brain-derived neurotrophic factor


chr11_-_128807712 0.955 NM_001195194
TP53AIP1
tumor protein p53 regulated apoptosis inducing protein 1
chr12_+_71833518 0.907 LGR5
leucine-rich repeat containing G protein-coupled receptor 5
chr6_-_71666740 0.901 NM_080742
B3GAT2
beta-1,3-glucuronyltransferase 2 (glucuronosyltransferase S)
chr17_+_73723729 0.889 ITGB4
integrin, beta 4
chr2_-_42720476 0.746 KCNG3
potassium voltage-gated channel, subfamily G, member 3
chr17_+_80332152 0.626 NM_018949
UTS2R
urotensin 2 receptor
chr17_-_65362667 0.596 NM_002816
NM_174871
PSMD12

proteasome (prosome, macropain) 26S subunit, non-ATPase, 12

chr17_+_1173857 0.539 NM_001164405
BHLHA9
basic helix-loop-helix family, member a9
chr8_+_68864723 0.471 PREX2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr8_+_68864589 0.419 NM_024870
NM_025170
PREX2

phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2

chr9_-_104357202 0.315 NM_147180
PPP3R2
protein phosphatase 3, regulatory subunit B, beta
chr17_-_65362635 0.306 PSMD12
proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
chr5_+_69696805 0.302 SMA4
glucuronidase, beta pseudogene
chr5_-_69881965 0.265 SMA4
glucuronidase, beta pseudogene
chr8_-_93977715 0.237 NM_001191036
C8orf83
chromosome 8 open reading frame 83
chr11_-_134123138 0.202 NM_001037304
NM_001037305
NM_014174
NM_199297
NM_199298
THYN1




thymocyte nuclear protein 1




chr11_+_32112607 0.177 RCN1
reticulocalbin 1, EF-hand calcium binding domain
chr12_+_6561176 0.158 NM_018009
TAPBPL
TAP binding protein-like
chr9_-_123812535 0.074 NM_001735
C5
complement component 5
chr22_-_18256748 0.074 NM_001244572
NM_197966
BID

BH3 interacting domain death agonist

chr12_+_51347781 0.058 NM_001109619
HIGD1C
HIG1 hypoxia inducible domain family, member 1C
chr1_-_33336289 0.033 NM_001171940
NM_153756
FNDC5

fibronectin type III domain containing 5

chr1_+_101004456 0.004 GPR88
G protein-coupled receptor 88

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
9.44 2.22e-11 GO:0019226 transmission of nerve impulse
9.44 2.22e-11 GO:0035637 multicellular organismal signaling
10.04 3.94e-11 GO:0007268 synaptic transmission
6.17 3.83e-08 GO:0007267 cell-cell signaling
4.32 1.30e-07 GO:0050877 neurological system process
4.90 6.51e-07 GO:0007154 cell communication
3.60 2.17e-06 GO:0003008 system process
6.63 7.33e-05 GO:0046903 secretion
14.69 1.61e-04 GO:0003001 generation of a signal involved in cell-cell signaling
14.69 1.61e-04 GO:0023061 signal release
7.65 2.27e-04 GO:0032940 secretion by cell
15.16 9.24e-04 GO:0001505 regulation of neurotransmitter levels
13.08 2.18e-03 GO:0006836 neurotransmitter transport
17.65 3.13e-03 GO:0007269 neurotransmitter secretion
1.80 1.16e-02 GO:0032501 multicellular organismal process
9.74 1.18e-02 GO:0031644 regulation of neurological system process
6.19 1.49e-02 GO:0007610 behavior
2.18 1.79e-02 GO:0006810 transport
2.00 1.93e-02 GO:0023052 signaling
2.15 2.32e-02 GO:0051234 establishment of localization
30.31 4.34e-02 GO:0008038 neuron recognition
1.98 4.52e-02 GO:0051179 localization

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
9.75 9.99e-11 GO:0045202 synapse
11.59 2.18e-10 GO:0044456 synapse part
25.55 5.43e-10 GO:0008021 synaptic vesicle
39.51 2.14e-09 GO:0030672 synaptic vesicle membrane
11.21 1.13e-08 GO:0030659 cytoplasmic vesicle membrane
15.19 1.36e-08 GO:0030136 clathrin-coated vesicle
23.54 1.42e-08 GO:0030665 clathrin coated vesicle membrane
10.83 1.73e-08 GO:0012506 vesicle membrane
5.86 8.79e-08 GO:0016023 cytoplasmic membrane-bounded vesicle
9.30 1.12e-07 GO:0044433 cytoplasmic vesicle part
12.42 1.18e-07 GO:0030135 coated vesicle
5.75 1.19e-07 GO:0031988 membrane-bounded vesicle
8.14 1.37e-07 GO:0043005 neuron projection
17.40 2.18e-07 GO:0030662 coated vesicle membrane
5.51 2.31e-07 GO:0031410 cytoplasmic vesicle
6.28 3.31e-07 GO:0030054 cell junction
5.34 3.86e-07 GO:0031982 vesicle
4.09 2.83e-04 GO:0042995 cell projection
9.16 1.12e-03 GO:0043025 neuronal cell body
8.90 1.36e-03 GO:0044297 cell body
2.52 1.76e-03 GO:0044459 plasma membrane part
1.58 1.87e-03 GO:0016020 membrane
8.29 2.16e-03 GO:0030425 dendrite
9.02 5.42e-03 GO:0045211 postsynaptic membrane
39.22 5.81e-03 GO:0032589 neuron projection membrane
1.64 6.38e-03 GO:0044425 membrane part
11.24 8.38e-03 GO:0019717 synaptosome
111.11 1.22e-02 GO:0032590 dendrite membrane

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
3.53 1.64e-04 GO:0005215 transporter activity
15.44 1.52e-03 GO:0005230 extracellular ligand-gated ion channel activity
5.26 4.32e-03 GO:0005216 ion channel activity
5.18 4.87e-03 GO:0022838 substrate-specific channel activity
18.92 5.01e-03 GO:0005231 excitatory extracellular ligand-gated ion channel activity
5.03 6.16e-03 GO:0015267 channel activity
5.01 6.28e-03 GO:0022803 passive transmembrane transporter activity
11.24 7.09e-03 GO:0005179 hormone activity
31.76 9.49e-03 GO:0005184 neuropeptide hormone activity
8.90 2.13e-02 GO:0015276 ligand-gated ion channel activity
8.90 2.13e-02 GO:0022834 ligand-gated channel activity
5.18 3.44e-02 GO:0022836 gated channel activity
3.55 4.10e-02 GO:0005509 calcium ion binding