Motif ID: REST.p3

Z-value: 5.632


Transcription factors associated with REST.p3:

Gene SymbolEntrez IDGene Name
REST 5978 RE1-silencing transcription factor

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
RESThg19_v1_chr4_+_57774035_57774076-0.183.3e-01Click!


Activity profile for motif REST.p3.

activity profile for motif REST.p3


Sorted Z-values histogram for motif REST.p3

Sorted Z-values for motif REST.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of REST.p3

PNG image of the network

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Top targets:


Showing 1 to 20 of 144 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_71014989 67.768 NM_004291
 CARTPT
CART prepropeptide
chr14_+_93389491 42.791 CHGA
chromogranin A (parathyroid secretory protein 1)
chr1_+_33352071 42.432 NM_002143
 HPCA
hippocalcin
chr17_+_42385780 37.778 NM_001144825
NM_001144826
NM_006695
 RUNDC3A


RUN domain containing 3A


chr20_+_5891973 37.715 NM_001819
 CHGB
chromogranin B (secretogranin 1)
chr9_+_140033588 36.522 NM_000832
NM_001185090
NM_001185091
NM_007327
NM_021569
 GRIN1




glutamate receptor, ionotropic, N-methyl D-aspartate 1




chr20_+_44657858 34.995 SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5
chr19_-_55691468 34.604 NM_003180
 SYT5
synaptotagmin V
chrX_-_49056638 33.178 NM_003179
 SYP
synaptophysin
chr5_+_175298492 32.642 NM_001008220
 CPLX2
complexin 2
chr4_+_158141735 32.082 NM_000826
NM_001083619
NM_001083620
 GRIA2


glutamate receptor, ionotropic, AMPA 2


chr3_-_187388105 31.425 NM_001048
 SST
somatostatin
chr1_-_241520467 30.894 NM_002924
 RGS7
regulator of G-protein signaling 7
chr12_+_113229548 30.285 NM_001143854
NM_014954
 RPH3A

rabphilin 3A homolog (mouse)

chr10_+_26505593 30.080 GAD2
glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
chr1_-_102462371 29.655 OLFM3
olfactomedin 3
chr1_+_154540250 28.858 NM_000748
 CHRNB2
cholinergic receptor, nicotinic, beta 2 (neuronal)
chr12_+_113229713 28.473 RPH3A
rabphilin 3A homolog (mouse)
chr16_+_24267672 28.341 CACNG3
calcium channel, voltage-dependent, gamma subunit 3
chrX_-_153141284 28.099 L1CAM
L1 cell adhesion molecule

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 22 entries
Enrichment   P-value GO Accession GO Term
30.31 4.34e-02 GO:0008038 neuron recognition
17.65 3.13e-03 GO:0007269 neurotransmitter secretion
15.16 9.24e-04 GO:0001505 regulation of neurotransmitter levels
14.69 1.61e-04 GO:0003001 generation of a signal involved in cell-cell signaling
14.69 1.61e-04 GO:0023061 signal release
13.08 2.18e-03 GO:0006836 neurotransmitter transport
10.04 3.94e-11 GO:0007268 synaptic transmission
9.74 1.18e-02 GO:0031644 regulation of neurological system process
9.44 2.22e-11 GO:0019226 transmission of nerve impulse
9.44 2.22e-11 GO:0035637 multicellular organismal signaling
7.65 2.27e-04 GO:0032940 secretion by cell
6.63 7.33e-05 GO:0046903 secretion
6.19 1.49e-02 GO:0007610 behavior
6.17 3.83e-08 GO:0007267 cell-cell signaling
4.90 6.51e-07 GO:0007154 cell communication
4.32 1.30e-07 GO:0050877 neurological system process
3.60 2.17e-06 GO:0003008 system process
2.18 1.79e-02 GO:0006810 transport
2.15 2.32e-02 GO:0051234 establishment of localization
2.00 1.93e-02 GO:0023052 signaling

Gene overrepresentation in compartment category:

Showing 1 to 20 of 28 entries
Enrichment   P-value GO Accession GO Term
111.11 1.22e-02 GO:0032590 dendrite membrane
39.51 2.14e-09 GO:0030672 synaptic vesicle membrane
39.22 5.81e-03 GO:0032589 neuron projection membrane
25.55 5.43e-10 GO:0008021 synaptic vesicle
23.54 1.42e-08 GO:0030665 clathrin coated vesicle membrane
17.40 2.18e-07 GO:0030662 coated vesicle membrane
15.19 1.36e-08 GO:0030136 clathrin-coated vesicle
12.42 1.18e-07 GO:0030135 coated vesicle
11.59 2.18e-10 GO:0044456 synapse part
11.24 8.38e-03 GO:0019717 synaptosome
11.21 1.13e-08 GO:0030659 cytoplasmic vesicle membrane
10.83 1.73e-08 GO:0012506 vesicle membrane
9.75 9.99e-11 GO:0045202 synapse
9.30 1.12e-07 GO:0044433 cytoplasmic vesicle part
9.16 1.12e-03 GO:0043025 neuronal cell body
9.02 5.42e-03 GO:0045211 postsynaptic membrane
8.90 1.36e-03 GO:0044297 cell body
8.29 2.16e-03 GO:0030425 dendrite
8.14 1.37e-07 GO:0043005 neuron projection
6.28 3.31e-07 GO:0030054 cell junction

Gene overrepresentation in function category:

Showing 1 to 13 of 13 entries
Enrichment   P-value GO Accession GO Term
31.76 9.49e-03 GO:0005184 neuropeptide hormone activity
18.92 5.01e-03 GO:0005231 excitatory extracellular ligand-gated ion channel activity
15.44 1.52e-03 GO:0005230 extracellular ligand-gated ion channel activity
11.24 7.09e-03 GO:0005179 hormone activity
8.90 2.13e-02 GO:0015276 ligand-gated ion channel activity
8.90 2.13e-02 GO:0022834 ligand-gated channel activity
5.26 4.32e-03 GO:0005216 ion channel activity
5.18 4.87e-03 GO:0022838 substrate-specific channel activity
5.18 3.44e-02 GO:0022836 gated channel activity
5.03 6.16e-03 GO:0015267 channel activity
5.01 6.28e-03 GO:0022803 passive transmembrane transporter activity
3.55 4.10e-02 GO:0005509 calcium ion binding
3.53 1.64e-04 GO:0005215 transporter activity