Motif ID: RFX1..5_RFXANK_RFXAP.p2

Z-value: 8.189


Transcription factors associated with RFX1..5_RFXANK_RFXAP.p2:

Gene SymbolEntrez IDGene Name
RFX1 5989 regulatory factor X, 1 (influences HLA class II expression)
RFX2 5990 regulatory factor X, 2 (influences HLA class II expression)
RFX3 5991 regulatory factor X, 3 (influences HLA class II expression)
RFX4 5992 regulatory factor X, 4 (influences HLA class II expression)
RFX5 5993 regulatory factor X, 5 (influences HLA class II expression)
RFXANK 8625 regulatory factor X-associated ankyrin-containing protein
RFXAP 5994 regulatory factor X-associated protein

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
RFX4hg19_v1_chr12_+_106976684_1069766990.796.6e-08Click!
RFX2hg19_v1_chr19_-_6110491_61105550.708.6e-06Click!
RFXAPhg19_v1_chr13_+_37393306_373934930.663.5e-05Click!
RFX3hg19_v1_chr9_-_3525721_35259570.621.4e-04Click!
RFX5hg19_v1_chr1_-_151319674_1513197020.364.6e-02Click!
RFX1hg19_v1_chr19_-_14116875_141169530.193.0e-01Click!
RFXANKhg19_v1_chr19_+_19303732_19303772-0.029.1e-01Click!


Activity profile for motif RFX1..5_RFXANK_RFXAP.p2.

activity profile for motif RFX1..5_RFXANK_RFXAP.p2


Sorted Z-values histogram for motif RFX1..5_RFXANK_RFXAP.p2

Sorted Z-values for motif RFX1..5_RFXANK_RFXAP.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of RFX1..5_RFXANK_RFXAP.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr21_-_43916298 37.556 NM_080860
 RSPH1
radial spoke head 1 homolog (Chlamydomonas)
chr17_-_74137370 37.025 NM_001454
 FOXJ1
forkhead box J1
chr1_-_169396654 34.443 NM_021179
 C1orf114
chromosome 1 open reading frame 114
chr5_+_34839268 34.219 NM_144725
 TTC23L
tetratricopeptide repeat domain 23-like
chr1_-_109656478 33.594 NM_001122961
 C1orf194
chromosome 1 open reading frame 194
chr15_+_71184781 29.935 NM_001199017
NM_017691
NM_001199018
 LRRC49


leucine rich repeat containing 49


chr17_-_60885650 24.381 NM_152598
 MARCH10
membrane-associated ring finger (C3HC4) 10
chr1_-_159869897 23.677 NM_012337
 CCDC19
coiled-coil domain containing 19
chr1_+_161068150 23.133 NM_001007255
NM_152366
 KLHDC9

kelch domain containing 9

chr11_-_75379113 22.828 MAP6
microtubule-associated protein 6
chr5_-_157098444 22.700 SOX30
SRY (sex determining region Y)-box 30
chrX_-_48693934 22.067 NM_013271
 PCSK1N
proprotein convertase subtilisin/kexin type 1 inhibitor
chr11_+_8060179 20.918 NM_003320
 TUB
tubby homolog (mouse)
chr2_+_120302024 20.538 NM_001029996
 PCDP1
primary ciliary dyskinesia protein 1
chr1_-_118727780 20.311 NM_206996
 SPAG17
sperm associated antigen 17
chr11_-_75379414 19.977 NM_033063
NM_207577
 MAP6

microtubule-associated protein 6

chr8_-_49647717 19.784 NM_001142857
NM_024593
 EFCAB1

EF-hand calcium binding domain 1

chr4_-_177116713 19.564 NM_144644
 SPATA4
spermatogenesis associated 4
chr4_-_153700892 19.283 NM_145720
 TIGD4
tigger transposable element derived 4
chr10_+_22634373 19.262 NM_001253854
NM_001253855
NM_012443
NM_172242
 SPAG6



sperm associated antigen 6




Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 10 of 10 entries
Enrichment   P-value GO Accession GO Term
11.39 1.53e-06 GO:0042384 cilium assembly
8.95 5.89e-06 GO:0060271 cilium morphogenesis
6.49 2.69e-04 GO:0010927 cellular component assembly involved in morphogenesis
5.20 3.09e-03 GO:0030031 cell projection assembly
4.70 1.63e-03 GO:0007018 microtubule-based movement
3.74 1.62e-05 GO:0007017 microtubule-based process
3.14 1.76e-04 GO:0007283 spermatogenesis
3.14 1.76e-04 GO:0048232 male gamete generation
2.74 1.22e-04 GO:0019953 sexual reproduction
2.70 1.44e-03 GO:0007276 gamete generation

Gene overrepresentation in compartment category:

Showing 1 to 20 of 20 entries
Enrichment   P-value GO Accession GO Term
18.64 7.00e-03 GO:0035086 flagellar axoneme
18.64 7.00e-03 GO:0097014 microtubule-based flagellar cytoplasm
14.34 3.13e-03 GO:0060170 cilium membrane
12.73 3.25e-10 GO:0035085 cilium axoneme
11.57 1.37e-12 GO:0005930 axoneme
10.49 9.42e-12 GO:0044441 cilium part
9.54 2.63e-06 GO:0005932 microtubule basal body
8.92 5.68e-06 GO:0019861 flagellum
8.19 1.53e-20 GO:0005929 cilium
7.68 5.88e-03 GO:0009434 microtubule-based flagellum
7.25 8.70e-03 GO:0030286 dynein complex
4.76 1.69e-03 GO:0005875 microtubule associated complex
4.68 6.31e-12 GO:0005874 microtubule
3.17 1.24e-11 GO:0015630 microtubule cytoskeleton
2.97 1.65e-05 GO:0044463 cell projection part
2.88 5.22e-04 GO:0005815 microtubule organizing center
2.42 5.53e-07 GO:0042995 cell projection
2.21 1.96e-06 GO:0044430 cytoskeletal part
2.06 1.27e-05 GO:XXXXXXX unannotated
2.00 6.98e-07 GO:0005856 cytoskeleton

Gene overrepresentation in function category:

Showing 1 to 3 of 3 entries
Enrichment   P-value GO Accession GO Term
13.56 3.55e-02 GO:0051018 protein kinase A binding
6.64 1.56e-05 GO:0003777 microtubule motor activity
4.53 5.39e-05 GO:0003774 motor activity