Motif ID: RUNX1..3.p2

Z-value: 5.717


Transcription factors associated with RUNX1..3.p2:

Gene SymbolEntrez IDGene Name
RUNX1 861 runt-related transcription factor 1
RUNX2 860 runt-related transcription factor 2
RUNX3 864 runt-related transcription factor 3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
RUNX3hg19_v1_chr1_-_25256767_252568060.917.0e-13Click!
RUNX1hg19_v1_chr21_-_36421558_364215770.714.6e-06Click!
RUNX2hg19_v1_chr6_+_45389818_453899130.639.6e-05Click!


Activity profile for motif RUNX1..3.p2.

activity profile for motif RUNX1..3.p2


Sorted Z-values histogram for motif RUNX1..3.p2

Sorted Z-values for motif RUNX1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of RUNX1..3.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_114414245 29.288 NM_001193431
NM_012411
NM_015967
 PTPN22


protein tyrosine phosphatase, non-receptor type 22 (lymphoid)


chr21_-_36421558 27.791 RUNX1
runt-related transcription factor 1
chr1_-_25291474 24.713 NM_001031680
 RUNX3
runt-related transcription factor 3
chr11_+_60739114 24.347 NM_006725
 CD6
CD6 molecule
chr16_+_29674568 23.229 NM_003123
 SPN
sialophorin
chr6_+_45296053 22.492 NM_001015051
NM_001024630
 RUNX2

runt-related transcription factor 2

chr17_-_29641094 21.175 NM_006495
 EVI2B
ecotropic viral integration site 2B
chr6_-_128222175 20.999 NM_001010923
NM_001164685
 THEMIS

thymocyte selection associated

chr1_-_168513201 20.429 NM_003175
 XCL1
XCL2
chemokine (C motif) ligand 1
chemokine (C motif) ligand 2
chr12_-_68553322 20.320 NM_000619
 IFNG
interferon, gamma
chr21_-_36421578 20.030 RUNX1
runt-related transcription factor 1
chr17_-_29641068 19.595 EVI2B
ecotropic viral integration site 2B
chr2_-_158300517 19.316 NM_004288
 CYTIP
cytohesin 1 interacting protein
chr4_+_71091787 19.183 NM_152997
 C4orf7
chromosome 4 open reading frame 7
chr6_-_32163299 18.855 NM_022107
 GPSM3
G-protein signaling modulator 3
chr21_-_36421461 18.320 RUNX1
runt-related transcription factor 1
chr17_-_29641087 17.918 EVI2B
ecotropic viral integration site 2B
chr12_-_10542616 17.656 NM_007360
 KLRK1
killer cell lectin-like receptor subfamily K, member 1
chr4_-_84035888 17.634 PLAC8
placenta-specific 8
chr4_-_84035908 17.431 NM_001130715
NM_016619
 PLAC8

placenta-specific 8


Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 132 entries
Enrichment   P-value GO Accession GO Term
23.70 1.19e-02 GO:0002710 negative regulation of T cell mediated immunity
19.75 3.49e-02 GO:0002820 negative regulation of adaptive immune response
19.75 3.49e-02 GO:0002823 negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
16.16 1.10e-03 GO:0050710 negative regulation of cytokine secretion
14.81 2.14e-03 GO:0032715 negative regulation of interleukin-6 production
12.20 1.33e-03 GO:0050709 negative regulation of protein secretion
10.46 2.48e-02 GO:0030101 natural killer cell activation
9.88 3.61e-02 GO:0032653 regulation of interleukin-10 production
8.78 3.86e-03 GO:0032655 regulation of interleukin-12 production
8.78 3.86e-03 GO:0032729 positive regulation of interferon-gamma production
8.64 1.93e-02 GO:0002637 regulation of immunoglobulin production
8.60 1.06e-03 GO:0031341 regulation of cell killing
8.47 5.24e-03 GO:0001910 regulation of leukocyte mediated cytotoxicity
8.30 2.60e-02 GO:0002763 positive regulation of myeloid leukocyte differentiation
8.08 1.91e-03 GO:0046651 lymphocyte proliferation
7.73 5.07e-05 GO:0032675 regulation of interleukin-6 production
7.62 3.28e-03 GO:0032943 mononuclear cell proliferation
7.41 6.38e-06 GO:0002695 negative regulation of leukocyte activation
7.41 4.25e-03 GO:0070661 leukocyte proliferation
7.41 1.57e-02 GO:0050777 negative regulation of immune response

Gene overrepresentation in compartment category:

Showing 1 to 15 of 15 entries
Enrichment   P-value GO Accession GO Term
22.22 3.65e-02 GO:0070382 exocytic vesicle
4.08 4.80e-05 GO:0009897 external side of plasma membrane
2.44 1.70e-03 GO:0009986 cell surface
2.35 2.28e-07 GO:0005615 extracellular space
2.07 5.91e-08 GO:0005887 integral to plasma membrane
2.06 6.19e-08 GO:0031226 intrinsic to plasma membrane
1.93 9.78e-05 GO:0044421 extracellular region part
1.85 5.95e-10 GO:0044459 plasma membrane part
1.69 4.42e-06 GO:0005576 extracellular region
1.61 4.30e-12 GO:0005886 plasma membrane
1.59 1.01e-11 GO:0071944 cell periphery
1.37 3.82e-06 GO:0016021 integral to membrane
1.35 8.46e-06 GO:0031224 intrinsic to membrane
1.34 6.02e-07 GO:0044425 membrane part
1.26 1.35e-05 GO:0016020 membrane

Gene overrepresentation in function category:

Showing 1 to 17 of 17 entries
Enrichment   P-value GO Accession GO Term
12.48 3.03e-05 GO:0005164 tumor necrosis factor receptor binding
10.37 7.61e-09 GO:0003823 antigen binding
7.65 2.21e-03 GO:0032813 tumor necrosis factor receptor superfamily binding
7.09 9.30e-05 GO:0008009 chemokine activity
6.97 3.22e-05 GO:0042379 chemokine receptor binding
6.05 1.54e-03 GO:0005070 SH3/SH2 adaptor activity
4.94 1.01e-02 GO:0035591 signaling adaptor activity
4.28 2.87e-08 GO:0005125 cytokine activity
4.12 6.74e-07 GO:0005126 cytokine receptor binding
3.74 9.44e-06 GO:0005529 sugar binding
3.62 1.25e-04 GO:0001664 G-protein-coupled receptor binding
2.68 9.97e-05 GO:0030246 carbohydrate binding
2.01 4.12e-10 GO:0004872 receptor activity
1.97 7.01e-12 GO:0004871 signal transducer activity
1.97 7.01e-12 GO:0060089 molecular transducer activity
1.93 1.81e-04 GO:0005102 receptor binding
1.85 6.28e-05 GO:0004888 transmembrane receptor activity