Motif ID: RXRG_dimer.p3

Z-value: 1.718


Transcription factors associated with RXRG_dimer.p3:

Gene SymbolEntrez IDGene Name
NR1H2 7376 nuclear receptor subfamily 1, group H, member 2
PPARA 5465 peroxisome proliferator-activated receptor alpha
PPARG 5468 peroxisome proliferator-activated receptor gamma
RXRA 6256 retinoid X receptor, alpha
RXRB 6257 retinoid X receptor, beta
RXRG 6258 retinoid X receptor, gamma

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
RXRAhg19_v1_chr9_+_137218313_1372183180.732.4e-06Click!
PPARAhg19_v1_chr22_+_46546498_465465620.663.4e-05Click!
RXRBhg19_v1_chr6_-_33168369_33168437-0.503.8e-03Click!
NR1H2hg19_v1_chr19_+_50879681_50879773-0.485.1e-03Click!
RXRGhg19_v1_chr1_-_165414499_165414591-0.441.2e-02Click!
PPARGhg19_v1_chr3_+_12392993_12393131-0.212.6e-01Click!


Activity profile for motif RXRG_dimer.p3.

activity profile for motif RXRG_dimer.p3


Sorted Z-values histogram for motif RXRG_dimer.p3

Sorted Z-values for motif RXRG_dimer.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of RXRG_dimer.p3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_116700620 14.878 NM_000040
 APOC3
apolipoprotein C-III
chr20_+_56136136 9.758 NM_002591
 PCK1
phosphoenolpyruvate carboxykinase 1 (soluble)
chr11_-_116708334 8.788 NM_000039
 APOA1
apolipoprotein A-I
chr3_+_46539484 7.767 NM_031440
 RTP3
receptor (chemosensory) transporter protein 3
chr4_-_72671236 7.186 NM_001204306
 GC
group-specific component (vitamin D binding protein)
chr1_-_173886464 6.734 NM_000488
 SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr6_+_31623688 6.290 APOM
apolipoprotein M
chr19_+_45116921 6.080 NM_001205280
 IGSF23
immunoglobulin superfamily, member 23
chr1_-_120311466 5.921 NM_001166107
NM_005518
 HMGCS2

3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)

chr2_+_219283809 5.638 NM_007127
 VIL1
villin 1
chr6_+_31623668 5.633 NM_019101
 APOM
apolipoprotein M
chr1_+_145727712 5.449 PDZK1
PDZ domain containing 1
chr10_-_96829074 5.314 NM_000770
NM_001198853
NM_001198854
NM_001198855
 CYP2C8



cytochrome P450, family 2, subfamily C, polypeptide 8



chr9_+_74764266 5.292 NM_001242505
NM_001242506
NM_004293
 GDA


guanine deaminase


chr1_+_145727665 5.249 NM_001201325
NM_001201326
NM_002614
 PDZK1


PDZ domain containing 1


chr9_+_74764394 4.537 GDA
guanine deaminase
chr10_-_52645430 4.502 NM_001198818
NM_001198819
NM_001198820
NM_014576
NM_138932
NM_138933
 A1CF





APOBEC1 complementation factor





chr10_+_102732285 4.414 NM_001203244
NM_017893
 SEMA4G

sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G

chr12_+_56624500 4.398 NM_001135195
 SLC39A5
solute carrier family 39 (metal ion transporter), member 5
chr3_-_48936227 4.263 NM_000387
 SLC25A20
solute carrier family 25 (carnitine/acylcarnitine translocase), member 20

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 31 entries
Enrichment   P-value GO Accession GO Term
175.92 1.82e-02 GO:0010903 negative regulation of very-low-density lipoprotein particle remodeling
131.95 3.64e-02 GO:0032488 Cdc42 protein signal transduction
65.98 4.76e-03 GO:0034377 plasma lipoprotein particle assembly
65.98 4.76e-03 GO:0065005 protein-lipid complex assembly
62.10 1.82e-04 GO:0043691 reverse cholesterol transport
56.56 7.84e-03 GO:0034375 high-density lipoprotein particle remodeling
41.68 2.06e-02 GO:0034381 plasma lipoprotein particle clearance
39.59 2.42e-02 GO:0006699 bile acid biosynthetic process
37.71 2.81e-02 GO:0033344 cholesterol efflux
36.00 3.25e-02 GO:0034367 macromolecular complex remodeling
36.00 3.25e-02 GO:0034368 protein-lipid complex remodeling
36.00 3.25e-02 GO:0034369 plasma lipoprotein particle remodeling
26.40 6.56e-03 GO:0030301 cholesterol transport
25.76 7.24e-03 GO:0015918 sterol transport
17.04 5.71e-04 GO:0008203 cholesterol metabolic process
16.17 7.78e-04 GO:0006694 steroid biosynthetic process
15.85 8.76e-04 GO:0016125 sterol metabolic process
10.86 7.79e-03 GO:0006869 lipid transport
9.97 1.26e-02 GO:0010876 lipid localization
8.99 5.81e-05 GO:0032787 monocarboxylic acid metabolic process

Gene overrepresentation in compartment category:

Showing 1 to 12 of 12 entries
Enrichment   P-value GO Accession GO Term
98.96 2.32e-04 GO:0034366 spherical high-density lipoprotein particle
39.59 4.57e-03 GO:0034361 very-low-density lipoprotein particle
39.59 4.57e-03 GO:0034385 triglyceride-rich lipoprotein particle
33.00 8.02e-03 GO:0034364 high-density lipoprotein particle
22.63 2.52e-02 GO:0032994 protein-lipid complex
22.63 2.52e-02 GO:0034358 plasma lipoprotein particle
7.40 3.39e-03 GO:0005759 mitochondrial matrix
6.21 1.02e-02 GO:0005743 mitochondrial inner membrane
5.70 1.74e-02 GO:0019866 organelle inner membrane
4.81 1.91e-02 GO:0005740 mitochondrial envelope
4.58 1.82e-03 GO:0044429 mitochondrial part
3.41 8.11e-04 GO:0005739 mitochondrion

Gene overrepresentation in function category:

Showing 1 to 4 of 4 entries
Enrichment   P-value GO Accession GO Term
175.92 4.28e-03 GO:0070653 high-density lipoprotein particle receptor binding
30.46 1.27e-02 GO:0032934 sterol binding
20.31 4.55e-04 GO:0005496 steroid binding
5.71 2.48e-03 GO:0008289 lipid binding