Motif ID: SMAD1..7,9.p2

Z-value: 1.165


Transcription factors associated with SMAD1..7,9.p2:

Gene SymbolEntrez IDGene Name
SMAD1 4086 SMAD family member 1
SMAD2 4087 SMAD family member 2
SMAD3 4088 SMAD family member 3
SMAD4 4089 SMAD family member 4
SMAD5 4090 SMAD family member 5
SMAD6 4091 SMAD family member 6
SMAD7 4092 SMAD family member 7
SMAD9 4093 SMAD family member 9

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
SMAD9hg19_v1_chr13_-_37494370_374944080.476.5e-03Click!
SMAD6hg19_v1_chr15_+_67000929_670009290.421.5e-02Click!
SMAD1hg19_v1_chr4_+_146403955_1464039620.402.3e-02Click!
SMAD4hg19_v1_chr18_+_48556483_485565860.355.0e-02Click!
SMAD7hg19_v1_chr18_-_46475702_46475702-0.115.6e-01Click!
SMAD5hg19_v1_chr5_+_135468522_1354685370.086.7e-01Click!
SMAD2hg19_v1_chr18_-_45457454_45457524-0.077.0e-01Click!
SMAD3hg19_v1_chr15_+_67458492_674585000.048.2e-01Click!


Activity profile for motif SMAD1..7,9.p2.

activity profile for motif SMAD1..7,9.p2


Sorted Z-values histogram for motif SMAD1..7,9.p2

Sorted Z-values for motif SMAD1..7,9.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SMAD1..7,9.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_-_45826131 4.487 CKM
creatine kinase, muscle
chr19_-_45826232 3.535 NM_001824
CKM
creatine kinase, muscle
chr5_-_146833150 2.562 NM_001387
DPYSL3
dihydropyrimidinase-like 3
chr1_-_16345284 2.506 NM_014424
HSPB7
heat shock 27kDa protein family, member 7 (cardiovascular)
chr2_-_97509733 2.375 NM_144994
ANKRD23
ankyrin repeat domain 23
chr3_+_35681008 2.288 ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr22_-_24640850 2.107 NM_001099781
NM_001099782
NM_004121
GGT5


gamma-glutamyltransferase 5


chr2_+_220283098 2.006 NM_001927
DES
desmin
chr11_-_2018885 2.001 H19
RPS12
H19, imprinted maternally expressed transcript (non-protein coding)
ribosomal protein S12
chr12_+_53443834 1.998 NM_170754
TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr11_+_66824308 1.981 RHOD
ras homolog gene family, member D
chr10_+_88428263 1.853 NM_001080116
NM_001080114
NM_001080115
NM_001171611
NM_007078
LDB3




LIM domain binding 3




chr15_-_42448769 1.762 NM_213600
PLA2G4F
phospholipase A2, group IVF
chr3_-_195306274 1.742 APOD
apolipoprotein D
chr11_-_2019007 1.740 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr11_+_47608229 1.691 NM_001164379
FAM180B
family with sequence similarity 180, member B
chr17_-_37353731 1.670 NM_000723
NM_199247
NM_199248
CACNB1


calcium channel, voltage-dependent, beta 1 subunit


chr1_+_110009099 1.654 NM_001040709
SYPL2
synaptophysin-like 2
chr2_+_233404436 1.606 NM_005199
CHRNG
cholinergic receptor, nicotinic, gamma
chr20_+_30598244 1.575 NM_080625
C20orf160
chromosome 20 open reading frame 160
chr1_+_159141376 1.557 NM_021189
NM_001127173
CADM3

cell adhesion molecule 3

chr1_+_201159952 1.523 NM_001164586
IGFN1
immunoglobulin-like and fibronectin type III domain containing 1
chr2_+_18059923 1.510 NM_002252
KCNS3
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3
chr1_-_203055088 1.499 MYOG
myogenin (myogenic factor 4)
chr10_-_97200895 1.450 NM_001034954
NM_001034955
NM_001034956
NM_001034957
NM_006434
SORBS1




sorbin and SH3 domain containing 1




chr21_+_41239346 1.401 NM_006198
PCP4
Purkinje cell protein 4
chr1_+_159173802 1.376 NM_002036
DARC
Duffy blood group, chemokine receptor
chr9_+_134165075 1.358 NM_032728
PPAPDC3
phosphatidic acid phosphatase type 2 domain containing 3
chr12_-_111358353 1.348 NM_000432
MYL2
myosin, light chain 2, regulatory, cardiac, slow
chr2_-_110874142 1.322 NM_005434
MALL
mal, T-cell differentiation protein-like
chr22_+_31518923 1.300 NM_001002837
INPP5J
inositol polyphosphate-5-phosphatase J
chr4_-_8160435 1.256 NM_001130083
NM_001130084
NM_001130085
NM_001130086
NM_001130087
NM_001130088
NM_032432
ABLIM2






actin binding LIM protein family, member 2






chr8_-_107782417 1.243 NM_139166
ABRA
actin-binding Rho activating protein
chr9_+_124329398 1.236 NM_032552
DAB2IP
DAB2 interacting protein
chr6_+_133562488 1.228 NM_004100
NM_172103
NM_172105
EYA4


eyes absent homolog 4 (Drosophila)


chr10_+_50507186 1.224 NM_001135196
NM_199459
C10orf71

chromosome 10 open reading frame 71

chr16_+_28889808 1.223 NM_004320
NM_173201
ATP2A1

ATPase, Ca++ transporting, cardiac muscle, fast twitch 1

chr7_-_100493481 1.210 NM_000665
NM_015831
ACHE

acetylcholinesterase

chr1_-_203055376 1.209 NM_002479
MYOG
myogenin (myogenic factor 4)
chr3_-_52488030 1.203 NM_003280
TNNC1
troponin C type 1 (slow)
chr11_-_2018568 1.178 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr3_+_42727010 1.167 NM_152393
KBTBD5
kelch repeat and BTB (POZ) domain containing 5
chr11_-_107582733 1.167 NM_003063
SLN
sarcolipin
chr2_-_218867677 1.166 TNS1
tensin 1
chr11_-_2017822 1.152 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr8_+_106331146 1.151 NM_012082
ZFPM2
zinc finger protein, multitype 2
chr14_-_94423766 1.113 NM_016150
ASB2
ankyrin repeat and SOCS box containing 2
chr1_+_110009220 1.110 SYPL2
synaptophysin-like 2
chr15_+_33603162 1.101 NM_001036
NM_001243996
RYR3

ryanodine receptor 3

chr5_-_138842291 1.098 NM_001077693
ECSCR
endothelial cell-specific chemotaxis regulator
chr8_+_49984902 1.082 NM_001007176
C8orf22
chromosome 8 open reading frame 22
chr15_+_42694587 1.059 NM_173088
CAPN3
calpain 3, (p94)
chr16_+_66400524 1.059 NM_001795
CDH5
cadherin 5, type 2 (vascular endothelium)
chr5_+_40909617 1.058 C7
complement component 7
chr3_+_112931374 1.024 NM_033254
BOC
Boc homolog (mouse)
chr11_-_2019070 1.015 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr16_-_46782104 1.012 NM_182493
MYLK3
myosin light chain kinase 3
chr5_+_40909558 1.000 NM_000587
C7
complement component 7
chr11_+_3666357 0.996 NM_004314
ART1
ADP-ribosyltransferase 1
chr19_-_42569921 0.993 NM_002088
GRIK5
glutamate receptor, ionotropic, kainate 5
chr1_-_1850704 0.990 NM_178545
TMEM52
transmembrane protein 52
chr11_-_64527369 0.985 PYGM
phosphorylase, glycogen, muscle
chr9_-_104249333 0.971 NM_032342
C9orf125
chromosome 9 open reading frame 125
chr17_+_70117154 0.965 NM_000346
SOX9
SRY (sex determining region Y)-box 9
chr12_-_58209840 0.964 NM_006576
AVIL
advillin
chr2_+_56411123 0.962 NM_001080433
CCDC85A
coiled-coil domain containing 85A
chr1_+_26348265 0.945 NM_004455
EXTL1
exostoses (multiple)-like 1
chr8_-_70747200 0.943 NM_030958
SLCO5A1
solute carrier organic anion transporter family, member 5A1
chr5_+_40909487 0.942 C7
complement component 7
chr6_+_118228688 0.921 NM_001029858
SLC35F1
solute carrier family 35, member F1
chr1_-_145039631 0.919 NM_001198832
PDE4DIP
phosphodiesterase 4D interacting protein
chr1_+_201857789 0.917 NM_198149
SHISA4
shisa homolog 4 (Xenopus laevis)
chr3_+_89156673 0.914 NM_005233
NM_182644
EPHA3

EPH receptor A3

chr16_+_66400585 0.914 CDH5
cadherin 5, type 2 (vascular endothelium)
chr10_-_76868853 0.911 NM_001007271
NM_001007272
NM_001007273
DUSP13


dual specificity phosphatase 13


chr5_+_87564729 0.910 LOC100505894
uncharacterized LOC100505894
chr2_+_219472618 0.907 PLCD4
phospholipase C, delta 4
chr16_+_4430878 0.900 VASN
vasorin
chr11_-_2018703 0.898 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr17_-_70116928 0.895 FLJ37644
uncharacterized LOC400618
chr1_+_16062808 0.895 NM_207348
SLC25A34
solute carrier family 25, member 34
chr1_-_201081693 0.890 NM_000069
CACNA1S
calcium channel, voltage-dependent, L type, alpha 1S subunit
chr12_+_50497790 0.884 NM_005276
GPD1
glycerol-3-phosphate dehydrogenase 1 (soluble)
chr14_+_100203998 0.883 EML1
echinoderm microtubule associated protein like 1
chr8_+_86351055 0.872 NM_005181
CA3
carbonic anhydrase III, muscle specific
chr1_-_31845818 0.871 NM_004102
FABP3
fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)
chrX_-_8700170 0.865 NM_000216
KAL1
Kallmann syndrome 1 sequence
chr11_-_34535302 0.864 NM_001243080
NM_001422
ELF5

E74-like factor 5 (ets domain transcription factor)

chr5_+_126626455 0.863 NM_032446
MEGF10
multiple EGF-like-domains 10
chrX_+_153170528 0.863 NM_000054
NM_001146151
AVPR2

arginine vasopressin receptor 2

chr8_-_119964059 0.861 NM_002546
TNFRSF11B
tumor necrosis factor receptor superfamily, member 11b
chr19_+_2249112 0.857 NM_000479
AMH
anti-Mullerian hormone
chr5_+_113698304 0.854 KCNN2
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
chr11_+_113931228 0.842 NM_001018011
ZBTB16
zinc finger and BTB domain containing 16
chrX_+_70521627 0.838 NM_012278
ITGB1BP2
integrin beta 1 binding protein (melusin) 2
chr4_+_24797084 0.837 NM_003102
SOD3
superoxide dismutase 3, extracellular
chr2_+_103236147 0.835 NM_003048
SLC9A2
solute carrier family 9 (sodium/hydrogen exchanger), member 2
chr17_-_27949814 0.829 CORO6
coronin 6
chr15_-_93632161 0.827 NM_020211
RGMA
RGM domain family, member A
chr16_-_75272524 0.816 BCAR1
breast cancer anti-estrogen resistance 1
chr20_+_34700257 0.808 NM_177996
EPB41L1
erythrocyte membrane protein band 4.1-like 1
chr17_+_180995 0.805 NM_001242780
LOC100506388
uncharacterized LOC100506388
chr4_-_174320616 0.803 NM_007281
SCRG1
stimulator of chondrogenesis 1
chr10_-_71176567 0.801 NM_001057
TACR2
tachykinin receptor 2
chr19_-_45822841 0.798 CKM
creatine kinase, muscle
chr1_+_205782430 0.790


chr11_+_66824285 0.784 NM_014578
RHOD
ras homolog gene family, member D
chr8_-_143867931 0.783 NM_003695
LY6D
lymphocyte antigen 6 complex, locus D
chr16_-_325867 0.783 NM_003834
NM_183337
RGS11

regulator of G-protein signaling 11

chr9_+_124048869 0.775 GSN
gelsolin
chr20_+_10199455 0.774 NM_003081
NM_130811
SNAP25

synaptosomal-associated protein, 25kDa

chr1_+_16091458 0.772 NM_001024216
FBLIM1
filamin binding LIM protein 1
chr6_-_6007097 0.771 NRN1
neuritin 1
chr5_+_42423811 0.768 NM_000163
GHR
growth hormone receptor
chr5_-_10307873 0.767 CMBL
carboxymethylenebutenolidase homolog (Pseudomonas)
chr1_+_26348308 0.767 EXTL1
exostoses (multiple)-like 1
chr6_-_94129059 0.766 NM_004440
EPHA7
EPH receptor A7
chr6_-_46922533 0.760 NM_015234
GPR116
G protein-coupled receptor 116
chr16_+_67022487 0.747 NM_173815
CES4A
carboxylesterase 4A
chr19_-_47975244 0.746 NM_015063
SLC8A2
solute carrier family 8 (sodium/calcium exchanger), member 2
chr16_-_75300678 0.746 NM_001170716
BCAR1
breast cancer anti-estrogen resistance 1
chr7_+_134464417 0.746 CALD1
caldesmon 1
chr15_-_30114336 0.741 TJP1
tight junction protein 1 (zona occludens 1)
chr11_-_2018446 0.739 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr15_-_99551023 0.739 NM_001167902
PGPEP1L
pyroglutamyl-peptidase I-like
chr19_-_46285746 0.736 DMPK
dystrophia myotonica-protein kinase
chr22_+_33197678 0.736 TIMP3
TIMP metallopeptidase inhibitor 3
chr13_-_33924759 0.734 STARD13
StAR-related lipid transfer (START) domain containing 13
chrX_-_8700132 0.731 KAL1
Kallmann syndrome 1 sequence
chr11_-_111782447 0.729 NM_001885
CRYAB
crystallin, alpha B
chr3_+_50304989 0.728 NM_001005914
NM_004636
SEMA3B

sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B

chr4_+_48485276 0.724 NM_152679
SLC10A4
solute carrier family 10 (sodium/bile acid cotransporter family), member 4
chr19_+_41281281 0.722 NM_006533
MIA
melanoma inhibitory activity
chr9_+_124043719 0.721 GSN
gelsolin
chr1_-_166135978 0.715


chr17_+_77020229 0.712 NM_030968
NM_198594
C1QTNF1

C1q and tumor necrosis factor related protein 1

chrX_-_13062720 0.700 NM_174901
FAM9C
family with sequence similarity 9, member C
chr20_+_36531498 0.698 NM_080607
VSTM2L
V-set and transmembrane domain containing 2 like
chr5_-_58334936 0.697 NM_001197221
NM_001197222
PDE4D

phosphodiesterase 4D, cAMP-specific

chrX_-_43741500 0.696 MAOB
monoamine oxidase B
chr2_+_171673071 0.689 NM_000817
NM_013445
GAD1

glutamate decarboxylase 1 (brain, 67kDa)

chr9_+_124086842 0.687 GSN
gelsolin
chr19_-_49567123 0.687 NM_006179
NTF4
neurotrophin 4
chr12_+_54402795 0.685 NM_022658
HOXC8
homeobox C8
chr16_-_4292052 0.683 NM_001098814
SRL
sarcalumenin
chr7_+_54610018 0.679 NM_182546
VSTM2A
V-set and transmembrane domain containing 2A
chr2_+_177053306 0.673 NM_024501
HOXD1
homeobox D1
chr18_+_43304091 0.670 NM_001128588
NM_001146036
NM_015865
SLC14A1


solute carrier family 14 (urea transporter), member 1 (Kidd blood group)


chr1_-_27339326 0.665 NM_052943
FAM46B
family with sequence similarity 46, member B
chr19_+_13056656 0.664 RAD23A
RAD23 homolog A (S. cerevisiae)
chr11_+_1861431 0.663 NM_001145841
TNNI2
troponin I type 2 (skeletal, fast)
chr3_-_125899403 0.663 NM_012190
ALDH1L1
aldehyde dehydrogenase 1 family, member L1
chr1_+_205012427 0.662 CNTN2
contactin 2 (axonal)
chr8_+_142432006 0.662 NM_007079
NM_032611
PTP4A3

protein tyrosine phosphatase type IVA, member 3

chr7_+_154002194 0.662 NM_001936
DPP6
dipeptidyl-peptidase 6
chr3_-_119379269 0.660 NM_022135
POPDC2
popeye domain containing 2
chr22_+_31477231 0.660 NM_006932
NM_134269
NM_134270
SMTN


smoothelin


chr2_-_110873638 0.659 MALL
mal, T-cell differentiation protein-like
chr1_+_228395740 0.656 NM_001098623
NM_052843
OBSCN

obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF

chr2_+_168675181 0.656 NM_020981
B3GALT1
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1
chr4_+_148402244 0.653 EDNRA
endothelin receptor type A
chr12_+_53440809 0.652 NM_198316
TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr4_+_24797203 0.651 SOD3
superoxide dismutase 3, extracellular
chr2_+_219472631 0.651 PLCD4
phospholipase C, delta 4
chr1_+_156589085 0.651 NM_021817
HAPLN2
hyaluronan and proteoglycan link protein 2
chr9_-_37576248 0.651 NM_012166
FBXO10
F-box protein 10
chrX_-_43741593 0.649 NM_000898
MAOB
monoamine oxidase B
chr16_+_66400559 0.648 CDH5
cadherin 5, type 2 (vascular endothelium)
chr1_+_26485510 0.648 NM_024869
FAM110D
family with sequence similarity 110, member D
chr17_+_77020278 0.648 C1QTNF1
C1q and tumor necrosis factor related protein 1
chr16_+_30034654 0.647 NM_001109659
NM_001109660
C16orf92

chromosome 16 open reading frame 92

chr19_-_49220213 0.647 NM_182574
MAMSTR
MEF2 activating motif and SAP domain containing transcriptional regulator
chr1_+_63788729 0.646 NM_012183
FOXD3
forkhead box D3
chr19_+_46801632 0.643 NM_022462
NM_152796
HIF3A

hypoxia inducible factor 3, alpha subunit

chr22_+_31489343 0.641 SMTN
smoothelin
chr7_+_134464161 0.640 NM_004342
NM_033138
NM_033157
CALD1


caldesmon 1


chr10_-_44880452 0.639 NM_000609
NM_001033886
NM_001178134
NM_199168
CXCL12



chemokine (C-X-C motif) ligand 12



chr3_-_47957475 0.637


chr1_-_10856704 0.634 NM_001079843
NM_017766
CASZ1

castor zinc finger 1

chr9_+_123963728 0.631 GSN
gelsolin
chr4_+_30721865 0.630 NM_032456
NM_001173523
NM_002589
NM_032457
PCDH7



protocadherin 7



chr1_+_20396652 0.624 NM_000929
PLA2G5
phospholipase A2, group V
chr13_+_39261172 0.623 NM_207361
FREM2
FRAS1 related extracellular matrix protein 2
chr17_+_8214139 0.621 NM_025014
ARHGEF15
Rho guanine nucleotide exchange factor (GEF) 15
chr3_-_47933997 0.618 MAP4
microtubule-associated protein 4
chr20_+_36974823 0.617 NM_004139
LBP
lipopolysaccharide binding protein
chrX_-_106960028 0.609 TSC22D3
TSC22 domain family, member 3
chr14_+_76837689 0.604 NM_004452
ESRRB
estrogen-related receptor beta
chr17_-_74533623 0.604 NM_134268
CYGB
cytoglobin
chr3_-_149375584 0.604 NM_001168280
NM_015472
WWTR1

WW domain containing transcription regulator 1

chr6_-_31514393 0.603 ATP6V1G2
ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
chr16_+_2198607 0.602 NM_014353
RAB26
RAB26, member RAS oncogene family
chr4_-_16900028 0.602 LDB2
LIM domain binding 2
chr15_-_65503786 0.600 NM_003613
CILP
cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
chr19_+_44764032 0.599 NM_001207005
NM_181756
ZNF233

zinc finger protein 233

chr12_-_7848324 0.599 NM_020634
GDF3
growth differentiation factor 3
chr7_-_44365019 0.598 NM_001220
NM_172078
NM_172079
NM_172080
NM_172081
NM_172082
NM_172083
NM_172084
CAMK2B







calcium/calmodulin-dependent protein kinase II beta







chr5_-_156390206 0.594 NM_001146726
NM_138379
TIMD4

T-cell immunoglobulin and mucin domain containing 4

chr3_+_134514044 0.589 NM_004441
EPHB1
EPH receptor B1
chr9_+_132934685 0.586 NM_014286
NCS1
neuronal calcium sensor 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
29.99 3.05e-03 GO:0055002 striated muscle cell development
26.72 4.86e-03 GO:0055001 muscle cell development
14.59 7.39e-03 GO:0042692 muscle cell differentiation
52.47 8.08e-03 GO:0030239 myofibril assembly
40.81 1.76e-02 GO:0031032 actomyosin structure organization
18.85 1.94e-02 GO:0051146 striated muscle cell differentiation
8.53 2.19e-02 GO:0061061 muscle structure development
10.69 3.27e-02 GO:0003012 muscle system process

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
26.24 6.38e-07 GO:0030017 sarcomere
22.76 1.73e-06 GO:0044449 contractile fiber part
22.17 2.07e-06 GO:0030016 myofibril
20.91 3.12e-06 GO:0043292 contractile fiber
30.61 7.27e-04 GO:0031674 I band

Nothing significant found in function category.