Motif ID: SOX2.p2

Z-value: 2.141


Transcription factors associated with SOX2.p2:

Gene SymbolEntrez IDGene Name
SOX2 6657 SRY (sex determining region Y)-box 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
SOX2hg19_v1_chr3_+_181430075_1814302020.664.0e-05Click!


Activity profile for motif SOX2.p2.

activity profile for motif SOX2.p2


Sorted Z-values histogram for motif SOX2.p2

Sorted Z-values for motif SOX2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SOX2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_39509069 26.915 NM_182935
 MOBP
myelin-associated oligodendrocyte basic protein
chr3_+_181417387 14.838 SOX2-OT
SOX2 overlapping transcript (non-protein coding)
chr2_-_2334887 9.646 NM_015025
 MYT1L
myelin transcription factor 1-like
chr16_-_11375094 9.545 NM_002761
 PRM1
protamine 1
chr5_-_114515733 7.506 NM_001017397
NM_001017398
NM_018700
 TRIM36


tripartite motif containing 36


chr5_+_140201221 7.323 NM_018908
NM_031501
 PCDHA5

protocadherin alpha 5

chr2_+_149633173 6.556


chr5_-_160279045 6.447 NM_025153
 ATP10B
ATPase, class V, type 10B
chr19_+_18062110 6.390 NM_002248
 KCNN1
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1
chr8_+_104831415 6.230 NM_014677
 RIMS2
regulating synaptic membrane exocytosis 2
chrX_+_84499037 6.170 ZNF711
zinc finger protein 711
chr7_+_20370724 6.099 NM_002214
 ITGB8
integrin, beta 8
chr18_-_3874688 6.079 NM_001242762
NM_001242763
 DLGAP1

discs, large (Drosophila) homolog-associated protein 1

chr5_+_140474198 5.820 NM_018936
 PCDHB2
protocadherin beta 2
chrX_+_100333835 5.779 NM_021637
 TMEM35
transmembrane protein 35
chr5_-_87969135 5.574 LINC00461
long intergenic non-protein coding RNA 461
chr1_+_166958497 5.533 NM_032858
 MAEL
maelstrom homolog (Drosophila)
chr1_-_26233367 5.472 NM_203399
 STMN1
stathmin 1
chrX_+_111119278 5.333 NM_001195576
NM_001195578
 LOC100329135

uncharacterized LOC100329135

chr2_+_27070962 5.260 NM_020134
NM_001253723
NM_001253724
 DPYSL5


dihydropyrimidinase-like 5



Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 49 entries
Enrichment   P-value GO Accession GO Term
21.61 8.13e-05 GO:0007413 axonal fasciculation
12.47 3.63e-02 GO:0031102 neuron projection regeneration
10.32 3.62e-03 GO:0008038 neuron recognition
8.11 5.25e-03 GO:0007416 synapse assembly
7.18 4.00e-14 GO:0007156 homophilic cell adhesion
6.24 4.31e-03 GO:0050808 synapse organization
4.53 2.28e-12 GO:0016337 cell-cell adhesion
4.05 5.09e-03 GO:0010975 regulation of neuron projection development
3.79 1.29e-11 GO:0007409 axonogenesis
3.76 4.97e-02 GO:0050804 regulation of synaptic transmission
3.75 4.59e-12 GO:0048812 neuron projection morphogenesis
3.66 4.77e-11 GO:0048667 cell morphogenesis involved in neuron differentiation
3.60 1.14e-02 GO:0031344 regulation of cell projection organization
3.49 4.89e-07 GO:0007411 axon guidance
3.47 4.59e-11 GO:0031175 neuron projection development
3.41 2.07e-03 GO:0045664 regulation of neuron differentiation
3.37 3.59e-12 GO:0048666 neuron development
3.36 5.18e-15 GO:0030182 neuron differentiation
3.34 3.62e-10 GO:0048858 cell projection morphogenesis
3.31 4.98e-10 GO:0032990 cell part morphogenesis

Gene overrepresentation in compartment category:

Showing 1 to 20 of 21 entries
Enrichment   P-value GO Accession GO Term
6.71 4.71e-02 GO:0034704 calcium channel complex
4.10 3.24e-02 GO:0014069 postsynaptic density
4.08 1.81e-04 GO:0034703 cation channel complex
3.51 2.80e-03 GO:0045211 postsynaptic membrane
3.50 4.45e-04 GO:0030424 axon
3.43 9.94e-05 GO:0034702 ion channel complex
3.15 6.19e-03 GO:0044297 cell body
3.05 1.55e-02 GO:0043025 neuronal cell body
3.04 5.89e-05 GO:0044456 synapse part
2.93 2.62e-06 GO:0045202 synapse
2.71 6.54e-05 GO:0043005 neuron projection
2.40 2.67e-05 GO:0030054 cell junction
1.94 1.24e-03 GO:0042995 cell projection
1.63 3.15e-02 GO:0005887 integral to plasma membrane
1.62 6.11e-05 GO:0044459 plasma membrane part
1.39 1.70e-04 GO:0071944 cell periphery
1.39 1.77e-04 GO:0005886 plasma membrane
1.28 2.56e-03 GO:0031224 intrinsic to membrane
1.27 8.00e-03 GO:0016021 integral to membrane
1.24 3.42e-03 GO:0044425 membrane part

Gene overrepresentation in function category:

Showing 1 to 16 of 16 entries
Enrichment   P-value GO Accession GO Term
4.63 6.41e-03 GO:0005262 calcium channel activity
3.44 3.33e-06 GO:0005261 cation channel activity
3.43 9.13e-03 GO:0022843 voltage-gated cation channel activity
3.33 3.27e-09 GO:0015267 channel activity
3.32 3.54e-09 GO:0022803 passive transmembrane transporter activity
3.27 2.81e-02 GO:0005516 calmodulin binding
3.18 7.25e-08 GO:0022838 substrate-specific channel activity
3.15 1.72e-07 GO:0005216 ion channel activity
3.12 1.55e-05 GO:0022836 gated channel activity
3.12 5.45e-03 GO:0005244 voltage-gated ion channel activity
3.12 5.45e-03 GO:0022832 voltage-gated channel activity
2.58 1.83e-07 GO:0005509 calcium ion binding
1.98 4.24e-03 GO:0015075 ion transmembrane transporter activity
1.85 9.01e-03 GO:0022891 substrate-specific transmembrane transporter activity
1.82 7.19e-03 GO:0022857 transmembrane transporter activity
1.66 2.50e-02 GO:0005215 transporter activity