Motif ID: SOX2.p2

Z-value: 2.141


Transcription factors associated with SOX2.p2:

Gene SymbolEntrez IDGene Name
SOX2 6657 SRY (sex determining region Y)-box 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
SOX2hg19_v1_chr3_+_181430075_1814302020.664.0e-05Click!


Activity profile for motif SOX2.p2.

activity profile for motif SOX2.p2


Sorted Z-values histogram for motif SOX2.p2

Sorted Z-values for motif SOX2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SOX2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_+_39509069 26.915 NM_182935
MOBP
myelin-associated oligodendrocyte basic protein
chr3_+_181417387 14.838 SOX2-OT
SOX2 overlapping transcript (non-protein coding)
chr2_-_2334887 9.646 NM_015025
MYT1L
myelin transcription factor 1-like
chr16_-_11375094 9.545 NM_002761
PRM1
protamine 1
chr5_-_114515733 7.506 NM_001017397
NM_001017398
NM_018700
TRIM36


tripartite motif containing 36


chr5_+_140201221 7.323 NM_018908
NM_031501
PCDHA5

protocadherin alpha 5

chr2_+_149633173 6.556


chr5_-_160279045 6.447 NM_025153
ATP10B
ATPase, class V, type 10B
chr19_+_18062110 6.390 NM_002248
KCNN1
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1
chr8_+_104831415 6.230 NM_014677
RIMS2
regulating synaptic membrane exocytosis 2
chrX_+_84499037 6.170 ZNF711
zinc finger protein 711
chr7_+_20370724 6.099 NM_002214
ITGB8
integrin, beta 8
chr18_-_3874688 6.079 NM_001242762
NM_001242763
DLGAP1

discs, large (Drosophila) homolog-associated protein 1

chr5_+_140474198 5.820 NM_018936
PCDHB2
protocadherin beta 2
chrX_+_100333835 5.779 NM_021637
TMEM35
transmembrane protein 35
chr5_-_87969135 5.574 LINC00461
long intergenic non-protein coding RNA 461
chr1_+_166958497 5.533 NM_032858
MAEL
maelstrom homolog (Drosophila)
chr1_-_26233367 5.472 NM_203399
STMN1
stathmin 1
chrX_+_111119278 5.333 NM_001195576
NM_001195578
LOC100329135

uncharacterized LOC100329135

chr2_+_27070962 5.260 NM_020134
NM_001253723
NM_001253724
DPYSL5


dihydropyrimidinase-like 5


chrX_+_86772714 5.227 NM_019117
NM_057162
KLHL4

kelch-like 4 (Drosophila)

chrX_-_139866582 5.175 NM_004065
CDR1
cerebellar degeneration-related protein 1, 34kDa
chr15_+_84116172 5.171 SH3GL3
SH3-domain GRB2-like 3
chr5_-_110062365 5.097 NM_001039763
TMEM232
transmembrane protein 232
chr8_+_103563847 5.078 NM_024410
ODF1
outer dense fiber of sperm tails 1
chrX_-_24690740 4.919 NM_001163264
PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr20_+_17207596 4.888 NM_001201529
NM_002594
PCSK2

proprotein convertase subtilisin/kexin type 2

chr4_+_115543522 4.870 NM_003360
UGT8
UDP glycosyltransferase 8
chr11_-_85397215 4.865 NM_152723
CCDC89
coiled-coil domain containing 89
chr9_-_23826062 4.817 NM_004432
ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr7_+_154002194 4.708 NM_001936
DPP6
dipeptidyl-peptidase 6
chr7_+_94297448 4.695 PEG10
paternally expressed 10
chr9_-_19786886 4.690 NM_001193288
NM_020344
SLC24A2

solute carrier family 24 (sodium/potassium/calcium exchanger), member 2

chr5_+_140235594 4.689 NM_018901
NM_031859
NM_031860
PCDHA10


protocadherin alpha 10


chr13_-_53422773 4.682 NM_002590
NM_032949
PCDH8

protocadherin 8

chr15_+_84115979 4.584 NM_003027
SH3GL3
SH3-domain GRB2-like 3
chr4_-_87028805 4.420 NM_138981
MAPK10
mitogen-activated protein kinase 10
chr1_+_50571963 4.351 NM_001144775
ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr2_+_162272619 4.328 NM_006593
TBR1
T-box, brain, 1
chr12_+_57943843 4.308 NM_004984
KIF5A
kinesin family member 5A
chr5_-_146435589 4.269 NM_181674
NM_181676
PPP2R2B

protein phosphatase 2, regulatory subunit B, beta

chr9_-_73483933 4.109 NM_001007470
NM_020952
NM_024971
NM_206944
NM_206945
NM_206946
NM_206947
NM_206948
TRPM3







transient receptor potential cation channel, subfamily M, member 3







chr3_+_107096187 4.076 NM_032600
CCDC54
coiled-coil domain containing 54
chr13_-_39564857 4.017 NM_001144033
NM_145286
STOML3

stomatin (EPB72)-like 3

chr4_-_176733413 3.973 GPM6A
glycoprotein M6A
chr5_+_55062712 3.955 NM_001166534
DDX4
DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
chr1_+_87012758 3.931 NM_012128
CLCA4
chloride channel accessory 4
chr20_+_17206751 3.911 NM_001201528
PCSK2
proprotein convertase subtilisin/kexin type 2
chr1_+_228337414 3.904 NM_020435
GJC2
gap junction protein, gamma 2, 47kDa
chr1_+_50574601 3.811 ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr15_+_51973549 3.804 NM_001165257
NM_013243
SCG3

secretogranin III

chr4_-_87281374 3.765 NM_138980
NM_138982
MAPK10

mitogen-activated protein kinase 10

chr6_-_49989647 3.729 NM_001037497
NM_001037728
DEFB110

defensin, beta 110 locus

chr7_-_84751246 3.713 NM_152754
SEMA3D
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D
chr7_+_20370324 3.713 ITGB8
integrin, beta 8
chr12_+_48876285 3.691 NM_152319
C12orf54
chromosome 12 open reading frame 54
chr11_-_84634219 3.691 DLG2
discs, large homolog 2 (Drosophila)
chr4_+_110749149 3.629 NM_006583
RRH
retinal pigment epithelium-derived rhodopsin homolog
chr16_+_89989686 3.611 NM_006086
TUBB3
tubulin, beta 3 class III
chr18_-_3874252 3.606 NM_001242764
DLGAP1
discs, large (Drosophila) homolog-associated protein 1
chr13_-_25745620 3.590 FAM123A
family with sequence similarity 123A
chr12_+_122652265 3.551 NM_152759
LRRC43
leucine rich repeat containing 43
chr10_+_99349354 3.547 NM_001009997
C10orf62
chromosome 10 open reading frame 62
chr6_+_105404922 3.546 NM_001004317
LIN28B
lin-28 homolog B (C. elegans)
chr2_+_115219153 3.519 NM_001178036
DPP10
dipeptidyl-peptidase 10 (non-functional)
chr1_+_163038934 3.499 NM_001113381
RGS4
regulator of G-protein signaling 4
chr20_+_20348744 3.495 NM_002196
INSM1
insulinoma-associated 1
chr4_+_41258941 3.488 UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr22_-_50523853 3.475 MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr5_-_137475076 3.427 NM_003551
NME5
non-metastatic cells 5, protein expressed in (nucleoside-diphosphate kinase)
chr4_-_20985547 3.422 KCNIP4
Kv channel interacting protein 4
chr5_+_140207562 3.401 NM_018909
NM_031848
NM_031849
PCDHA6


protocadherin alpha 6


chr6_+_123100860 3.361 FABP7
fatty acid binding protein 7, brain
chr13_-_25745778 3.360 NM_152704
NM_199138
FAM123A

family with sequence similarity 123A

chr5_-_11903964 3.348 NM_001332
CTNND2
catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)
chr17_+_19990334 3.335 NM_001033553
NM_152904
SPECC1

sperm antigen with calponin homology and coiled-coil domains 1

chr12_-_16759531 3.324 NM_018640
LMO3
LIM domain only 3 (rhombotin-like 2)
chr19_-_6502224 3.300 NM_006087
TUBB4A
tubulin, beta 4A class IVa
chr4_-_176733378 3.299 GPM6A
glycoprotein M6A
chr6_+_12290528 3.270 NM_001168319
NM_001955
EDN1

endothelin 1

chr12_-_48963802 3.270 NM_002289
LALBA
lactalbumin, alpha-
chr6_+_123100645 3.247 NM_001446
FABP7
fatty acid binding protein 7, brain
chr5_+_161494647 3.247 NM_000816
NM_198903
NM_198904
GABRG2


gamma-aminobutyric acid (GABA) A receptor, gamma 2


chr3_-_58563490 3.245 NM_001076778
NM_007177
FAM107A

family with sequence similarity 107, member A

chr12_-_45307710 3.222 NM_001145110
NELL2
NEL-like 2 (chicken)
chr5_-_36301999 3.217 NM_001161429
NM_145000
RANBP3L

RAN binding protein 3-like

chrX_-_128788913 3.217 NM_017413
APLN
apelin
chrX_-_80457440 3.198 NM_030763
HMGN5
high mobility group nucleosome binding domain 5
chr17_+_54230835 3.186 NM_153228
ANKFN1
ankyrin-repeat and fibronectin type III domain containing 1
chr21_+_41239346 3.179 NM_006198
PCP4
Purkinje cell protein 4
chr1_-_23342342 3.152 NM_001242521
LOC729059
uncharacterized LOC729059
chr6_+_21666645 3.151 LINC00340
long intergenic non-protein coding RNA 340
chr9_-_77502635 3.145 NM_001177310
TRPM6
transient receptor potential cation channel, subfamily M, member 6
chr5_-_83680191 3.131 EDIL3
EGF-like repeats and discoidin I-like domains 3
chr18_+_29171729 3.127 NM_000371
TTR
transthyretin
chr1_-_205325915 3.116 NM_018203
KLHDC8A
kelch domain containing 8A
chr1_+_47137496 3.113 NM_001145474
ATPAF1-AS1
ATPAF1 antisense RNA 1 (non-protein coding)
chr12_+_49212253 3.095 NM_000725
NM_001206915
CACNB3

calcium channel, voltage-dependent, beta 3 subunit

chr3_-_123339178 3.084 MYLK
myosin light chain kinase
chr5_+_140480056 3.081 NM_018937
PCDHB3
protocadherin beta 3
chr17_-_37764165 3.040 NM_006160
NEUROD2
neurogenic differentiation 2
chr1_+_156589085 3.037 NM_021817
HAPLN2
hyaluronan and proteoglycan link protein 2
chrX_+_78003205 3.024 NM_005296
LPAR4
lysophosphatidic acid receptor 4
chr17_+_74864427 3.013 NM_001199172
NM_144677
MGAT5B

mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B

chr12_-_87232635 2.997 NM_013244
MGAT4C
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr9_+_103235634 2.987 TMEFF1
transmembrane protein with EGF-like and two follistatin-like domains 1
chr1_+_1361507 2.968 NM_001146685
TMEM88B
transmembrane protein 88B
chr20_-_44175995 2.967 NM_001198986
NM_020398
SPINLW1-WFDC6
SPINLW1
SPINLW1-WFDC6 readthrough
serine peptidase inhibitor-like, with Kunitz and WAP domains 1 (eppin)
chr3_-_149510609 2.951 NM_001144960
ANKUB1
ankyrin repeat and ubiquitin domain containing 1
chr7_-_112727799 2.945 GPR85
G protein-coupled receptor 85
chrX_+_51927918 2.942 NM_001098800
NM_001242362
NM_030801
NM_177535
NM_177537
MAGED4
MAGED4B



melanoma antigen family D, 4
melanoma antigen family D, 4B



chr1_+_163038564 2.940 NM_005613
RGS4
regulator of G-protein signaling 4
chr4_-_139163222 2.940 NM_014331
SLC7A11
solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
chr5_-_96478502 2.938 NM_153234
LIX1
Lix1 homolog (chicken)
chr16_+_27078218 2.919 NM_001145545
C16orf82
chromosome 16 open reading frame 82
chr5_+_140186658 2.918 NM_018907
NM_031500
PCDHA4

protocadherin alpha 4

chr2_-_198540583 2.914 NM_144629
RFTN2
raftlin family member 2
chr4_+_175839508 2.912 NM_001130703
NM_001130704
NM_001130705
NM_014269
ADAM29



ADAM metallopeptidase domain 29



chr3_-_123339423 2.894 NM_053031
NM_053032
MYLK

myosin light chain kinase

chr7_+_128349111 2.892 FAM71F1
family with sequence similarity 71, member F1
chr1_-_32801606 2.887 NM_023009
MARCKSL1
MARCKS-like 1
chr2_-_217724781 2.874 NM_003284
TNP1
transition protein 1 (during histone to protamine replacement)
chr9_-_95298251 2.873 NM_001197295
NM_001197296
NM_001393
ECM2


extracellular matrix protein 2, female organ and adipocyte specific


chr12_+_18891040 2.872 NM_033328
CAPZA3
capping protein (actin filament) muscle Z-line, alpha 3
chr20_+_32250089 2.871 NM_080825
C20orf144
chromosome 20 open reading frame 144
chr1_+_240255171 2.860 NM_020066
FMN2
formin 2
chr8_+_80523351 2.855 STMN2
stathmin-like 2
chr5_+_140213968 2.849 NM_018910
NM_031852
PCDHA7

protocadherin alpha 7

chr1_+_209757044 2.849 NM_020439
CAMK1G
calcium/calmodulin-dependent protein kinase IG
chr2_+_162272800 2.836 TBR1
T-box, brain, 1
chr8_+_80523376 2.833 STMN2
stathmin-like 2
chr12_+_85430098 2.829 NM_001079910
LRRIQ1
leucine-rich repeats and IQ motif containing 1
chr18_-_31802433 2.826 NM_001198547
NOL4
nucleolar protein 4
chr1_+_203096835 2.817 NM_000674
NM_001048230
ADORA1

adenosine A1 receptor

chr1_-_116383323 2.812 NM_001111061
NHLH2
nescient helix loop helix 2
chr20_+_17207680 2.806 PCSK2
proprotein convertase subtilisin/kexin type 2
chrX_-_138287180 2.798 NM_001139498
NM_001139500
NM_001139501
FGF13


fibroblast growth factor 13


chr2_+_14772839 2.792 FAM84A
family with sequence similarity 84, member A
chr9_-_127269689 2.790 NM_004959
NR5A1
nuclear receptor subfamily 5, group A, member 1
chrX_-_152160604 2.777 NM_001103150
NM_001103151
NM_052926
PNMA5


paraneoplastic antigen like 5


chr1_-_177133950 2.771 NM_004319
NM_207108
ASTN1

astrotactin 1

chr7_+_73245192 2.766 NM_001305
CLDN4
claudin 4
chr15_-_82338348 2.761 NM_032246
MEX3B
mex-3 homolog B (C. elegans)
chr6_+_121756744 2.743 NM_000165
GJA1
gap junction protein, alpha 1, 43kDa
chr16_+_89988416 2.725 NM_001197181
TUBB3
tubulin, beta 3 class III
chr3_-_116164363 2.719 NM_002338
LSAMP
limbic system-associated membrane protein
chrX_-_138724851 2.691 NM_001171877
NM_001171878
NM_001171879
NM_005369
MCF2



MCF.2 cell line derived transforming sequence



chr5_-_83680590 2.666 NM_005711
EDIL3
EGF-like repeats and discoidin I-like domains 3
chr8_-_87755880 2.659 NM_019098
CNGB3
cyclic nucleotide gated channel beta 3
chr18_+_31158540 2.657 NM_030632
ASXL3
additional sex combs like 3 (Drosophila)
chr2_-_241759627 2.650 NM_001244008
NM_004321
KIF1A

kinesin family member 1A

chr20_-_3762060 2.648 NM_015417
SPEF1
sperm flagellar 1
chr1_-_173638970 2.630 NM_198493
ANKRD45
ankyrin repeat domain 45
chr3_+_19189969 2.602 NM_144633
KCNH8
potassium voltage-gated channel, subfamily H (eag-related), member 8
chrX_+_84498993 2.598 NM_021998
ZNF711
zinc finger protein 711
chr19_+_12949258 2.598 NM_014975
MAST1
microtubule associated serine/threonine kinase 1
chr10_-_128209996 2.585 NM_001004298
C10orf90
chromosome 10 open reading frame 90
chr7_-_96633608 2.584 DLX6-AS1
DLX6 antisense RNA 1 (non-protein coding)
chrX_-_51812249 2.576 NM_001098800
NM_001242362
NM_030801
NM_177535
NM_177537
MAGED4
MAGED4B



melanoma antigen family D, 4
melanoma antigen family D, 4B



chr8_+_80523048 2.573 NM_001199214
NM_007029
STMN2

stathmin-like 2

chr2_+_166428845 2.573 NM_024969
CSRNP3
cysteine-serine-rich nuclear protein 3
chr12_+_64238511 2.569 NM_020762
SRGAP1
SLIT-ROBO Rho GTPase activating protein 1
chr15_-_83876769 2.549 HDGFRP3
hepatoma-derived growth factor, related protein 3
chr4_-_5889992 2.547 CRMP1
collapsin response mediator protein 1
chr7_-_137028533 2.537 NM_002825
PTN
pleiotrophin
chr1_+_218518675 2.533 NM_001135599
NM_003238
TGFB2

transforming growth factor, beta 2

chr1_-_177133818 2.529 ASTN1
astrotactin 1
chr2_-_26205327 2.522 KIF3C
kinesin family member 3C
chr4_-_101439071 2.517 NM_001159694
NM_016242
EMCN

endomucin

chr22_-_50523737 2.514 MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr17_-_39661803 2.509 NM_002274
NM_153490
KRT13

keratin 13

chr9_+_103235489 2.488 NM_003692
TMEFF1
transmembrane protein with EGF-like and two follistatin-like domains 1
chr11_-_83393436 2.486 NM_001142702
DLG2
discs, large homolog 2 (Drosophila)
chr18_+_66465316 2.484 NM_024781
CCDC102B
coiled-coil domain containing 102B
chr19_+_35782988 2.479 NM_001199216
NM_002361
NM_080600
MAG


myelin associated glycoprotein


chr14_+_29241989 2.479 C14orf23
chromosome 14 open reading frame 23
chr3_+_173116243 2.476 NM_014932
NLGN1
neuroligin 1
chr3_+_181429711 2.466 NM_003106
SOX2
SRY (sex determining region Y)-box 2
chrX_+_107288199 2.454 NM_001170553
NM_182607
VSIG1

V-set and immunoglobulin domain containing 1

chrX_-_13835187 2.453 GPM6B
glycoprotein M6B
chr14_-_60097223 2.442 RTN1
reticulon 1
chr8_-_30706532 2.435 NM_031271
TEX15
testis expressed 15
chr12_-_16759430 2.431 LMO3
LIM domain only 3 (rhombotin-like 2)
chr7_-_137028433 2.423 PTN
pleiotrophin
chr3_-_192635627 2.411 MB21D2
Mab-21 domain containing 2
chr18_+_72201669 2.403 NM_032649
CNDP1
carnosine dipeptidase 1 (metallopeptidase M20 family)
chrX_-_142605218 2.396 NM_001009609
SPANXN3
SPANX family, member N3
chr5_+_140254930 2.383 NM_018903
NM_031864
PCDHA12

protocadherin alpha 12

chr12_-_75603510 2.379 NM_139136
NM_139137
NM_153748
KCNC2


potassium voltage-gated channel, Shaw-related subfamily, member 2


chr2_+_210444364 2.376 NM_002374
NM_031845
NM_031847
MAP2


microtubule-associated protein 2


chr12_-_67072752 2.369 GRIP1
glutamate receptor interacting protein 1
chr17_-_29624249 2.364 NM_002544
OMG
oligodendrocyte myelin glycoprotein
chr2_-_1926501 2.364 MYT1L
myelin transcription factor 1-like
chr15_+_23810453 2.361 NM_005664
MKRN3
makorin ring finger protein 3
chr5_+_140739589 2.360 NM_018923
NM_032096
PCDHGB2

protocadherin gamma subfamily B, 2

chr1_+_87797301 2.348


chr4_+_158141735 2.347 NM_000826
NM_001083619
NM_001083620
GRIA2


glutamate receptor, ionotropic, AMPA 2


chr19_+_3880617 2.346 NM_033064
ATCAY
ataxia, cerebellar, Cayman type
chr20_+_36149606 2.329 NM_005386
NM_181689
NNAT

neuronatin

chr19_+_3880675 2.324 ATCAY
ataxia, cerebellar, Cayman type

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
3.11 2.29e-29 GO:0007399 nervous system development
1.96 1.57e-19 GO:0007275 multicellular organismal development
1.86 5.95e-18 GO:0032502 developmental process
1.97 1.27e-17 GO:0048856 anatomical structure development
2.03 4.64e-17 GO:0048731 system development
3.36 5.18e-15 GO:0030182 neuron differentiation
3.06 6.74e-15 GO:0048699 generation of neurons
1.60 2.00e-14 GO:0032501 multicellular organismal process
7.18 4.00e-14 GO:0007156 homophilic cell adhesion
2.88 1.69e-13 GO:0022008 neurogenesis
2.13 2.68e-13 GO:0030154 cell differentiation
2.09 8.29e-13 GO:0048869 cellular developmental process
4.53 2.28e-12 GO:0016337 cell-cell adhesion
3.37 3.59e-12 GO:0048666 neuron development
3.75 4.59e-12 GO:0048812 neuron projection morphogenesis
3.79 1.29e-11 GO:0007409 axonogenesis
3.47 4.59e-11 GO:0031175 neuron projection development
3.66 4.77e-11 GO:0048667 cell morphogenesis involved in neuron differentiation
3.34 3.62e-10 GO:0048858 cell projection morphogenesis
3.31 4.98e-10 GO:0032990 cell part morphogenesis
3.29 1.12e-09 GO:0000904 cell morphogenesis involved in differentiation
2.75 2.30e-09 GO:0007155 cell adhesion
2.75 2.30e-09 GO:0022610 biological adhesion
2.55 3.04e-09 GO:0048468 cell development
3.01 3.34e-09 GO:0000902 cell morphogenesis
2.91 6.79e-09 GO:0032989 cellular component morphogenesis
2.82 3.81e-08 GO:0030030 cell projection organization
3.49 4.89e-07 GO:0007411 axon guidance
2.22 4.80e-05 GO:0040011 locomotion
21.61 8.13e-05 GO:0007413 axonal fasciculation
1.84 1.26e-04 GO:0009653 anatomical structure morphogenesis
2.57 1.70e-04 GO:0006935 chemotaxis
2.57 1.70e-04 GO:0042330 taxis
2.53 3.61e-04 GO:0007417 central nervous system development
2.46 1.49e-03 GO:0019226 transmission of nerve impulse
2.46 1.49e-03 GO:0035637 multicellular organismal signaling
2.13 1.66e-03 GO:0007267 cell-cell signaling
3.41 2.07e-03 GO:0045664 regulation of neuron differentiation
2.52 2.74e-03 GO:0007268 synaptic transmission
1.93 3.06e-03 GO:0007154 cell communication
10.32 3.62e-03 GO:0008038 neuron recognition
6.24 4.31e-03 GO:0050808 synapse organization
4.05 5.09e-03 GO:0010975 regulation of neuron projection development
8.11 5.25e-03 GO:0007416 synapse assembly
1.89 7.90e-03 GO:0009605 response to external stimulus
2.96 1.10e-02 GO:0050767 regulation of neurogenesis
3.60 1.14e-02 GO:0031344 regulation of cell projection organization
12.47 3.63e-02 GO:0031102 neuron projection regeneration
3.76 4.97e-02 GO:0050804 regulation of synaptic transmission

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
2.93 2.62e-06 GO:0045202 synapse
2.40 2.67e-05 GO:0030054 cell junction
3.04 5.89e-05 GO:0044456 synapse part
1.62 6.11e-05 GO:0044459 plasma membrane part
2.71 6.54e-05 GO:0043005 neuron projection
3.43 9.94e-05 GO:0034702 ion channel complex
1.39 1.70e-04 GO:0071944 cell periphery
1.39 1.77e-04 GO:0005886 plasma membrane
4.08 1.81e-04 GO:0034703 cation channel complex
3.50 4.45e-04 GO:0030424 axon
1.94 1.24e-03 GO:0042995 cell projection
1.28 2.56e-03 GO:0031224 intrinsic to membrane
3.51 2.80e-03 GO:0045211 postsynaptic membrane
1.24 3.42e-03 GO:0044425 membrane part
3.15 6.19e-03 GO:0044297 cell body
1.27 8.00e-03 GO:0016021 integral to membrane
3.05 1.55e-02 GO:0043025 neuronal cell body
1.18 2.26e-02 GO:0016020 membrane
1.63 3.15e-02 GO:0005887 integral to plasma membrane
4.10 3.24e-02 GO:0014069 postsynaptic density
6.71 4.71e-02 GO:0034704 calcium channel complex

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
3.33 3.27e-09 GO:0015267 channel activity
3.32 3.54e-09 GO:0022803 passive transmembrane transporter activity
3.18 7.25e-08 GO:0022838 substrate-specific channel activity
3.15 1.72e-07 GO:0005216 ion channel activity
2.58 1.83e-07 GO:0005509 calcium ion binding
3.44 3.33e-06 GO:0005261 cation channel activity
3.12 1.55e-05 GO:0022836 gated channel activity
1.98 4.24e-03 GO:0015075 ion transmembrane transporter activity
3.12 5.45e-03 GO:0005244 voltage-gated ion channel activity
3.12 5.45e-03 GO:0022832 voltage-gated channel activity
4.63 6.41e-03 GO:0005262 calcium channel activity
1.82 7.19e-03 GO:0022857 transmembrane transporter activity
1.85 9.01e-03 GO:0022891 substrate-specific transmembrane transporter activity
3.43 9.13e-03 GO:0022843 voltage-gated cation channel activity
1.66 2.50e-02 GO:0005215 transporter activity
3.27 2.81e-02 GO:0005516 calmodulin binding