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• Mean activities

• Activities table
• Activity deltas table
• Regulatory interactions
• Motifs sorted by significance (text)
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Motif ID: SPI1.p2

Z-value: 3.914

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chrX_-_47489243	14.375	NM_001145252	CFP	complement factor properdin
chr1_+_26644458	12.397		CD52	CD52 molecule
chr6_-_32160289	12.032		GPSM3	G-protein signaling modulator 3
chr22_+_37257004	11.263	NM_000631 NM_013416	NCF4	neutrophil cytosolic factor 4, 40kDa
chr16_-_29757264	9.980	NM_175900	C16orf54	chromosome 16 open reading frame 54
chrX_-_47489703	9.829	NM_002621	CFP	complement factor properdin
chr6_-_32160637	9.625		GPSM3	G-protein signaling modulator 3
chr1_-_153518265	9.111	NM_002961 NM_019554	S100A4	S100 calcium binding protein A4
chr14_-_99737554	8.805		BCL11B	B-cell CLL/lymphoma 11B (zinc finger protein)
chr12_-_53600999	8.627	NM_000889	ITGB7	integrin, beta 7
chr14_-_99737821	8.622	NM_022898 NM_138576	BCL11B	B-cell CLL/lymphoma 11B (zinc finger protein)
chrX_+_48542193	8.532		WAS	Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr17_+_43299277	8.337	NM_005892	FMNL1	formin-like 1
chr10_-_135090325	8.268	NM_001109 NM_001164489 NM_001164490	ADAM8	ADAM metallopeptidase domain 8
chr11_+_67171400	8.140	NM_198517	TBC1D10C	TBC1 domain family, member 10C
chr6_-_32157511	8.082	NM_002586	PBX2	pre-B-cell leukemia homeobox 2
chr6_-_31550065	8.056	NM_002341 NM_009588	LTB	lymphotoxin beta (TNF superfamily, member 3)
chr16_+_29674568	7.994	NM_003123	SPN	sialophorin
chr1_+_111742946	7.847
chr1_-_157789832	7.826	NM_001159397 NM_001159398 NM_052938	FCRL1	Fc receptor-like 1
chr11_+_64107687	7.772	NM_032251	CCDC88B	coiled-coil domain containing 88B
chr19_-_8642232	7.726		MYO1F	myosin IF
chr2_+_218990735	7.542	NM_001557	CXCR2	chemokine (C-X-C motif) receptor 2
chr22_+_44577256	7.507	NM_001137606	PARVG	parvin, gamma
chr15_+_81517639	7.444	NM_172217	IL16	interleukin 16
chr14_-_23288912	7.382	NM_001126106	SLC7A7	solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr5_+_118691692	7.150		TNFAIP8	tumor necrosis factor, alpha-induced protein 8
chr1_-_153363544	7.075	NM_002964	S100A8	S100 calcium binding protein A8
chr16_-_88717395	6.998	NM_000101	CYBA	cytochrome b-245, alpha polypeptide
chr16_+_29674564	6.971		SPN	sialophorin
chr11_+_128563772	6.951	NM_001167681 NM_002017	FLI1	Friend leukemia virus integration 1
chr17_-_72619794	6.945	NM_181449	CD300E	CD300e molecule
chr11_+_67171379	6.833		TBC1D10C	TBC1 domain family, member 10C
chr19_+_49838700	6.811		CD37	CD37 molecule
chr19_-_8642297	6.787		MYO1F	myosin IF
chr3_-_111851967	6.728	NM_001190259 NM_001190260 NM_152785	GCET2	germinal center expressed transcript 2
chr11_-_46142955	6.697	NM_001101802 NM_016621	PHF21A	PHD finger protein 21A
chr21_-_46340821	6.651		ITGB2	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr22_+_44577215	6.646		PARVG	parvin, gamma
chr6_+_31554475	6.641	NM_205837	LST1	leukocyte specific transcript 1
chr19_+_42381189	6.562	NM_001783 NM_021601	CD79A	CD79a molecule, immunoglobulin-associated alpha
chr6_-_30652434	6.396		PPP1R18	protein phosphatase 1, regulatory subunit 18
chr12_-_51717905	6.394	NM_016293	BIN2	bridging integrator 2
chr7_-_3083346	6.362	NM_032415	CARD11	caspase recruitment domain family, member 11
chr12_-_51717835	6.340		BIN2	bridging integrator 2
chr1_-_111743080	6.327
chr1_-_111743297	6.245		DENND2D	DENN/MADD domain containing 2D
chr19_-_7766978	6.235	NM_001220500 NM_002002	FCER2	Fc fragment of IgE, low affinity II, receptor for (CD23)
chr12_-_51717941	6.031		BIN2	bridging integrator 2
chr16_+_57576536	5.935		GPR114	G protein-coupled receptor 114
chr1_-_31230673	5.891	NM_006762	LAPTM5	lysosomal protein transmembrane 5
chrX_+_118892544	5.886	NM_001105576	ANKRD58	ankyrin repeat domain 58
chr14_-_23285011	5.877	NM_001126105	SLC7A7	solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr17_-_29641094	5.831	NM_006495	EVI2B	ecotropic viral integration site 2B
chr12_-_54785018	5.820	NM_001130967 NM_001130968	ZNF385A	zinc finger protein 385A
chr10_+_26727692	5.778		APBB1IP	amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
chrX_+_48542159	5.726	NM_000377	WAS	Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr1_+_26644380	5.680	NM_001803	CD52	CD52 molecule
chr5_-_39219578	5.626	NM_001465 NM_199335	FYB	FYN binding protein
chr6_+_42896859	5.609	NM_006586	CNPY3	canopy 3 homolog (zebrafish)
chr6_+_31553955	5.538	NM_205838 NM_205839	LST1	leukocyte specific transcript 1
chr1_-_111217275	5.517		KCNA3	potassium voltage-gated channel, shaker-related subfamily, member 3
chr1_-_167487701	5.495	NM_000734 NM_198053	CD247	CD247 molecule
chr17_-_29641068	5.487		EVI2B	ecotropic viral integration site 2B
chr6_+_31582978	5.384	NM_004847 NM_001623	AIF1	allograft inflammatory factor 1
chr5_-_176326314	5.370	NM_002115	HK3	hexokinase 3 (white cell)
chr4_-_84256012	5.337	NM_001098540	HPSE	heparanase
chr15_+_75074714	5.273		CSK	c-src tyrosine kinase
chr6_-_30654978	5.265		PPP1R18	protein phosphatase 1, regulatory subunit 18
chr2_-_182521732	5.264	NM_001030311 NM_001030312 NM_001030313 NM_001160277 NM_201548	CERKL	ceramide kinase-like
chr7_+_106505739	5.255		PIK3CG	phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr16_+_57576576	5.218	NM_153837	GPR114	G protein-coupled receptor 114
chr19_-_39108534	5.215	NM_001042600 NM_007181	MAP4K1	mitogen-activated protein kinase kinase kinase kinase 1
chr6_+_31543340	5.191	NM_000594	TNF	tumor necrosis factor
chr20_+_3776905	5.114		CDC25B	cell division cycle 25 homolog B (S. pombe)
chr6_+_31540092	5.100	NM_000595	LTA	lymphotoxin alpha (TNF superfamily, member 1)
chr16_+_29674979	4.965		SPN	sialophorin
chr22_+_22764094	4.946
chr22_-_37882214	4.937	NM_001166343 NM_002405	MFNG	MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr17_-_72709010	4.920	NM_139018	CD300LF	CD300 molecule-like family member f
chr12_-_53601051	4.914		ITGB7	integrin, beta 7
chr19_+_49838673	4.894	NM_001040031 NM_001774	CD37	CD37 molecule
chr6_-_30654406	4.887		PPP1R18	protein phosphatase 1, regulatory subunit 18
chr9_-_35650852	4.853	NM_014450	SIT1	signaling threshold regulating transmembrane adaptor 1
chr1_+_111415791	4.850		CD53	CD53 molecule
chr17_+_7482804	4.842	NM_001251 NM_001040059	CD68	CD68 molecule
chr17_-_29641087	4.826		EVI2B	ecotropic viral integration site 2B
chr2_+_143886969	4.810		ARHGAP15	Rho GTPase activating protein 15
chr9_+_273025	4.809	NM_001190458 NM_001193536	DOCK8	dedicator of cytokinesis 8
chr19_-_8642309	4.798	NM_012335	MYO1F	myosin IF
chr19_-_2282174	4.792	NM_198532	C19orf35	chromosome 19 open reading frame 35
chr22_+_37309618	4.792	NM_000395	CSF2RB	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
chr1_-_161039413	4.763		ARHGAP30	Rho GTPase activating protein 30
chr17_-_77813049	4.752	NM_003655	CBX4	chromobox homolog 4
chr14_+_21249209	4.721	NM_005615	RNASE6	ribonuclease, RNase A family, k6
chr2_+_241564661	4.719	NM_005301	GPR35	G protein-coupled receptor 35
chr1_+_40839368	4.716	NM_022733	SMAP2	small ArfGAP2
chr4_-_74847669	4.710	NM_002619	PF4	platelet factor 4
chr1_+_40839429	4.700		SMAP2	small ArfGAP2
chr1_+_111415721	4.691	NM_000560	CD53	CD53 molecule
chr7_+_150264457	4.691	NM_018326	GIMAP4	GTPase, IMAP family member 4
chr4_-_74853819	4.684	NM_002704	PPBP	pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
chr14_-_23284617	4.671		SLC7A7	solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr18_+_2846979	4.670	NM_032048	EMILIN2	elastin microfibril interfacer 2
chr4_-_109089444	4.666	NM_001130713 NM_001130714 NM_016269	LEF1	lymphoid enhancer-binding factor 1
chr11_+_65408191	4.616		SIPA1	signal-induced proliferation-associated 1
chr12_-_54689536	4.596	NM_006163	NFE2	nuclear factor (erythroid-derived 2), 45kDa
chr12_-_120687956	4.562	NM_025157	PXN	paxillin
chr1_+_32739711	4.545	NM_001042771	LCK	lymphocyte-specific protein tyrosine kinase
chr10_-_98480174	4.537	NM_152309	PIK3AP1	phosphoinositide-3-kinase adaptor protein 1
chr12_+_7060554	4.533		PTPN6	protein tyrosine phosphatase, non-receptor type 6
chr1_-_161039703	4.531		ARHGAP30	Rho GTPase activating protein 30
chr19_-_7764283	4.526	NM_001207019	FCER2	Fc fragment of IgE, low affinity II, receptor for (CD23)
chr10_+_49892860	4.525		WDFY4	WDFY family member 4
chr7_+_74188308	4.499	NM_000265	NCF1 NCF1B	neutrophil cytosolic factor 1 neutrophil cytosolic factor 1B pseudogene
chrX_-_118827060	4.496		SEPT6	septin 6
chr12_-_9760481	4.478	NM_002258	KLRB1	killer cell lectin-like receptor subfamily B, member 1
chr1_+_207070787	4.478	NM_001185156 NM_001185157 NM_001185158 NM_006850	IL24	interleukin 24
chr2_+_169923531	4.462	NM_199204	DHRS9	dehydrogenase/reductase (SDR family) member 9
chr21_-_46340776	4.456		ITGB2	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr19_+_49838646	4.440		CD37	CD37 molecule
chr17_+_7788094	4.434	NM_001005271	CHD3	chromodomain helicase DNA binding protein 3
chr22_-_30662787	4.434	NM_020530	OSM	oncostatin M
chr1_+_153330329	4.417	NM_002965	S100A9	S100 calcium binding protein A9
chr7_+_106505696	4.381		PIK3CG	phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr2_+_68592432	4.371		PLEK	pleckstrin
chr7_-_45018650	4.366		MYO1G	myosin IG
chr12_+_25205488	4.362		LRMP	lymphoid-restricted membrane protein
chr19_-_41934634	4.360	NM_198540	B3GNT8	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8
chr2_+_68592317	4.331	NM_002664	PLEK	pleckstrin
chr4_-_84255895	4.315	NM_001199830	HPSE	heparanase
chr19_-_38916801	4.292	NM_001146202 NM_001146203 NM_001146204 NM_001146205 NM_001146206 NM_001146207 NM_170604	RASGRP4	RAS guanyl releasing protein 4
chr17_+_34431219	4.254	NM_002984	CCL4	chemokine (C-C motif) ligand 4
chr21_-_46340874	4.248	NM_000211	ITGB2	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr1_-_92351476	4.232		TGFBR3	transforming growth factor, beta receptor III
chr12_+_7055753	4.226		PTPN6	protein tyrosine phosphatase, non-receptor type 6
chr10_+_26727651	4.216		APBB1IP	amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
chr17_+_34538464	4.204	NM_207007 NM_001001435	CCL4L2 CCL4L1	chemokine (C-C motif) ligand 4-like 2 chemokine (C-C motif) ligand 4-like 1
chr2_-_89442551	4.203		IGKC IGK@	immunoglobulin kappa constant immunoglobulin kappa locus
chr7_-_45018677	4.188	NM_033054	MYO1G	myosin IG
chr16_+_28505920	4.170	NM_018690	APOBR	apolipoprotein B receptor
chr1_-_161039649	4.168		ARHGAP30	Rho GTPase activating protein 30
chr17_-_34417386	4.167	NM_002983	CCL3	chemokine (C-C motif) ligand 3
chr20_+_24929862	4.165	NM_003650	CST7	cystatin F (leukocystatin)
chr5_+_49962771	4.158	NM_001178056 NM_024615	PARP8	poly (ADP-ribose) polymerase family, member 8
chr12_+_54891539	4.153		NCKAP1L	NCK-associated protein 1-like
chr7_+_114562908	4.131		MDFIC	MyoD family inhibitor domain containing
chrX_+_134654546	4.120	NM_182540	DDX26B	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B
chr20_+_24929904	4.119		CST7	cystatin F (leukocystatin)
chr15_+_94774763	4.109		MCTP2	multiple C2 domains, transmembrane 2
chr19_+_35645640	4.104	NM_144779 NM_001164605	FXYD5	FXYD domain containing ion transport regulator 5
chr19_+_49838734	4.091		CD37	CD37 molecule
chr5_-_88179278	4.077	NM_001193350 NM_002397	MEF2C	myocyte enhancer factor 2C
chr19_+_3178735	4.047	NM_003775	S1PR4	sphingosine-1-phosphate receptor 4
chr12_+_6930689	4.033	NM_014449 NM_019858	GPR162	G protein-coupled receptor 162
chr6_-_91006580	4.028	NM_001170794	BACH2	BTB and CNC homology 1, basic leucine zipper transcription factor 2
chr7_+_101928390	4.011	NM_020979	SH2B2	SH2B adaptor protein 2
chr19_-_10450262	4.011	NM_002162	ICAM3	intercellular adhesion molecule 3
chr1_+_161551128	4.006	NM_201563	FCGR2C	Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
chr4_-_76944585	4.002	NM_001565	CXCL10	chemokine (C-X-C motif) ligand 10
chr17_+_7482980	3.983		CD68	CD68 molecule
chr19_-_13213973	3.969	NM_005583	LYL1	lymphoblastic leukemia derived sequence 1
chr15_+_75074417	3.965	NM_001127190 NM_004383	CSK	c-src tyrosine kinase
chr12_+_25205180	3.956	NM_001204126 NM_001204127 NM_006152	LRMP	lymphoid-restricted membrane protein
chr16_+_30194730	3.955	NM_001193333 NM_007074	CORO1A	coronin, actin binding protein, 1A
chr7_+_21467572	3.919	NM_003112	SP4	Sp4 transcription factor
chr5_+_49962920	3.913		PARP8	poly (ADP-ribose) polymerase family, member 8
chr9_-_139927291	3.890	NM_004479	FUT7	fucosyltransferase 7 (alpha (1,3) fucosyltransferase)
chr16_+_31366529	3.872		ITGAX	integrin, alpha X (complement component 3 receptor 4 subunit)
chr16_+_27413482	3.860	NM_181078 NM_181079	IL21R	interleukin 21 receptor
chr7_+_101928417	3.848		SH2B2	SH2B adaptor protein 2
chr19_+_35645614	3.846	NM_014164	FXYD5	FXYD domain containing ion transport regulator 5
chr1_+_192127591	3.840	NM_130782	RGS18	regulator of G-protein signaling 18
chr17_-_38721701	3.838	NM_001838	CCR7	chemokine (C-C motif) receptor 7
chr11_-_60719116	3.836	NM_016582	SLC15A3	solute carrier family 15, member 3
chr17_-_73840587	3.830	NM_199242	UNC13D	unc-13 homolog D (C. elegans)
chr16_-_30394133	3.816	NM_052838	SEPT1	septin 1
chr19_-_15575333	3.810	NM_022904	RASAL3	RAS protein activator like 3
chr17_+_34640030	3.806	NM_207007 NM_001001435	CCL4L2 CCL4L1	chemokine (C-C motif) ligand 4-like 2 chemokine (C-C motif) ligand 4-like 1
chr1_-_183559669	3.801	NM_000433 NM_001190789 NM_001190794	NCF2	neutrophil cytosolic factor 2
chr5_+_57787260	3.796	NM_152687	GAPT	GRB2-binding adaptor protein, transmembrane
chr1_-_183559463	3.764		NCF2	neutrophil cytosolic factor 2
chr6_+_26368405	3.760	NM_001197246	BTN3A2	butyrophilin, subfamily 3, member A2
chr1_-_161039586	3.759		ARHGAP30	Rho GTPase activating protein 30
chr19_-_8642337	3.732		MYO1F	myosin IF
chr8_-_131028833	3.732		FAM49B	family with sequence similarity 49, member B
chr19_-_42636559	3.731	NM_001207025 NM_001207026 NM_001247994 NM_002698	POU2F2	POU class 2 homeobox 2
chr6_-_32908583	3.729	NM_002118	HLA-DMB	major histocompatibility complex, class II, DM beta
chr7_-_45018559	3.725		MYO1G	myosin IG
chr12_+_54891491	3.708	NM_005337	NCKAP1L	NCK-associated protein 1-like
chr19_+_36393381	3.704	NM_001007469 NM_014266	HCST	hematopoietic cell signal transducer
chr2_+_143886898	3.702	NM_018460	ARHGAP15	Rho GTPase activating protein 15
chr11_-_67771527	3.699	NM_030930	UNC93B1	unc-93 homolog B1 (C. elegans)
chr12_+_54891522	3.686		NCKAP1L	NCK-associated protein 1-like
chr2_-_136873740	3.680	NM_001008540	CXCR4	chemokine (C-X-C motif) receptor 4
chr5_+_133451297	3.678	NM_001134851 NM_201632 NM_201634 NM_213648	TCF7	transcription factor 7 (T-cell specific, HMG-box)
chr16_+_31366519	3.676		ITGAX	integrin, alpha X (complement component 3 receptor 4 subunit)
chr16_-_3306586	3.672	NM_000243 NM_001198536	MEFV	Mediterranean fever
chr1_+_11796211	3.665		AGTRAP	angiotensin II receptor-associated protein
chr1_-_155959860	3.662		ARHGEF2	Rho/Rac guanine nucleotide exchange factor (GEF) 2

Gene overrepresentation in process category:

Enrichment	P-value	GO Accession	GO Term
3.82	1.03e-61	GO:0002376	immune system process
4.02	4.76e-40	GO:0006955	immune response
4.10	1.69e-38	GO:0002682	regulation of immune system process
2.51	1.62e-32	GO:0048583	regulation of response to stimulus
4.45	6.21e-29	GO:0050776	regulation of immune response
1.96	7.67e-29	GO:0007165	signal transduction
1.51	4.39e-28	GO:0050789	regulation of biological process
4.39	1.01e-27	GO:0002684	positive regulation of immune system process
1.47	3.29e-27	GO:0065007	biological regulation
4.03	1.18e-25	GO:0001775	cell activation
1.51	1.26e-25	GO:0050794	regulation of cellular process
2.04	6.62e-25	GO:0048518	positive regulation of biological process
1.83	1.23e-24	GO:0023052	signaling
3.00	3.83e-23	GO:0009611	response to wounding
5.28	6.16e-23	GO:0050865	regulation of cell activation
1.73	1.75e-22	GO:0051716	cellular response to stimulus
1.54	1.93e-22	GO:0050896	response to stimulus
3.07	4.40e-22	GO:0006952	defense response
5.20	2.68e-21	GO:0002694	regulation of leukocyte activation
2.24	3.20e-21	GO:0007166	cell surface receptor linked signaling pathway
1.99	7.07e-20	GO:0006950	response to stress
4.62	9.36e-20	GO:0050778	positive regulation of immune response
5.54	1.14e-18	GO:0050867	positive regulation of cell activation
5.11	2.42e-18	GO:0051249	regulation of lymphocyte activation
1.94	4.91e-18	GO:0048522	positive regulation of cellular process
4.78	8.06e-18	GO:0045321	leukocyte activation
5.55	8.66e-18	GO:0002757	immune response-activating signal transduction
5.42	2.34e-17	GO:0002764	immune response-regulating signaling pathway
5.39	2.98e-17	GO:0002696	positive regulation of leukocyte activation
5.52	8.47e-17	GO:0051251	positive regulation of lymphocyte activation
2.78	1.93e-16	GO:0048584	positive regulation of response to stimulus
3.15	2.44e-16	GO:0042060	wound healing
4.66	2.27e-15	GO:0002253	activation of immune response
2.23	2.31e-15	GO:0009966	regulation of signal transduction
3.29	2.97e-15	GO:0007599	hemostasis
3.27	8.25e-15	GO:0007596	blood coagulation
3.27	8.25e-15	GO:0050817	coagulation
4.78	6.80e-14	GO:0046649	lymphocyte activation
2.97	2.84e-13	GO:0050878	regulation of body fluid levels
2.42	7.31e-13	GO:0042127	regulation of cell proliferation
6.49	1.71e-12	GO:0050851	antigen receptor-mediated signaling pathway
6.19	2.13e-12	GO:0002429	immune response-activating cell surface receptor signaling pathway
2.01	2.45e-12	GO:0023051	regulation of signaling
2.92	2.91e-12	GO:0006928	cellular component movement
3.91	3.03e-12	GO:0048534	hemopoietic or lymphoid organ development
5.31	3.29e-12	GO:0050870	positive regulation of T cell activation
5.96	6.64e-12	GO:0002768	immune response-regulating cell surface receptor signaling pathway
4.68	1.24e-11	GO:0050863	regulation of T cell activation
3.70	1.28e-11	GO:0002520	immune system development
2.27	2.10e-11	GO:0043067	regulation of programmed cell death
2.27	3.23e-11	GO:0042981	regulation of apoptosis
2.23	5.74e-11	GO:0010941	regulation of cell death
2.06	1.00e-10	GO:0035556	intracellular signal transduction
3.44	1.17e-10	GO:0031347	regulation of defense response
3.90	1.21e-10	GO:0030097	hemopoiesis
4.66	4.46e-10	GO:0050900	leukocyte migration
2.34	5.89e-10	GO:0040011	locomotion
2.76	3.18e-09	GO:0043065	positive regulation of apoptosis
2.74	4.20e-09	GO:0043068	positive regulation of programmed cell death
2.18	4.33e-09	GO:0009605	response to external stimulus
1.73	5.55e-09	GO:0048523	negative regulation of cellular process
3.41	6.45e-09	GO:0006954	inflammatory response
2.70	7.23e-09	GO:0080134	regulation of response to stress
2.69	8.64e-09	GO:0010942	positive regulation of cell death
1.68	1.03e-08	GO:0048519	negative regulation of biological process
4.40	1.23e-08	GO:0002697	regulation of immune effector process
3.02	1.62e-08	GO:0045087	innate immune response
4.92	2.27e-08	GO:0042110	T cell activation
7.06	5.36e-08	GO:0060326	cell chemotaxis
6.61	5.54e-08	GO:0031294	lymphocyte costimulation
6.61	5.54e-08	GO:0031295	T cell costimulation
2.61	7.51e-08	GO:0008284	positive regulation of cell proliferation
3.53	8.36e-08	GO:0030168	platelet activation
5.22	9.74e-08	GO:0030098	lymphocyte differentiation
3.29	1.20e-07	GO:0001817	regulation of cytokine production
4.52	1.70e-07	GO:0002521	leukocyte differentiation
1.67	1.92e-07	GO:0065008	regulation of biological quality
3.91	5.66e-07	GO:0031349	positive regulation of defense response
2.73	6.13e-07	GO:0016477	cell migration
4.10	7.70e-07	GO:0002252	immune effector process
2.50	1.27e-06	GO:0006935	chemotaxis
2.50	1.27e-06	GO:0042330	taxis
1.93	1.37e-06	GO:0010604	positive regulation of macromolecule metabolic process
5.88	1.57e-06	GO:0002703	regulation of leukocyte mediated immunity
2.50	1.66e-06	GO:0009967	positive regulation of signal transduction
1.87	1.76e-06	GO:0051239	regulation of multicellular organismal process
5.46	2.10e-06	GO:0002699	positive regulation of immune effector process
1.61	2.32e-06	GO:0042221	response to chemical stimulus
2.71	2.63e-06	GO:0010627	regulation of intracellular protein kinase cascade
2.43	3.20e-06	GO:0010647	positive regulation of cell communication
2.42	4.01e-06	GO:0023056	positive regulation of signaling
2.53	5.18e-06	GO:0048870	cell motility
2.53	5.18e-06	GO:0051674	localization of cell
2.62	5.35e-06	GO:0051707	response to other organism
1.85	5.62e-06	GO:0009893	positive regulation of metabolic process
6.16	6.63e-06	GO:0002822	regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
2.71	6.72e-06	GO:0051056	regulation of small GTPase mediated signal transduction
2.65	8.14e-06	GO:0007264	small GTPase mediated signal transduction
6.06	8.83e-06	GO:0002819	regulation of adaptive immune response
1.92	1.01e-05	GO:0010646	regulation of cell communication
4.53	1.11e-05	GO:0050670	regulation of lymphocyte proliferation
3.64	1.20e-05	GO:0030155	regulation of cell adhesion
4.49	1.34e-05	GO:0032944	regulation of mononuclear cell proliferation
5.18	1.48e-05	GO:0050852	T cell receptor signaling pathway
2.97	1.78e-05	GO:0010740	positive regulation of intracellular protein kinase cascade
5.75	2.00e-05	GO:0050864	regulation of B cell activation
4.36	2.32e-05	GO:0070663	regulation of leukocyte proliferation
1.74	2.33e-05	GO:0065009	regulation of molecular function
2.82	2.80e-05	GO:0034097	response to cytokine stimulus
1.15	3.22e-05	GO:0009987	cellular process
1.39	3.35e-05	GO:0019222	regulation of metabolic process
2.09	3.41e-05	GO:0010557	positive regulation of macromolecule biosynthetic process
2.66	4.06e-05	GO:0006917	induction of apoptosis
2.65	4.43e-05	GO:0012502	induction of programmed cell death
3.17	4.68e-05	GO:0071345	cellular response to cytokine stimulus
6.84	5.06e-05	GO:0050871	positive regulation of B cell activation
5.09	5.08e-05	GO:0045785	positive regulation of cell adhesion
2.72	5.10e-05	GO:0051098	regulation of binding
1.82	5.27e-05	GO:0031325	positive regulation of cellular metabolic process
1.91	5.55e-05	GO:0006357	regulation of transcription from RNA polymerase II promoter
5.02	6.34e-05	GO:0050671	positive regulation of lymphocyte proliferation
1.95	7.83e-05	GO:0051704	multi-organism process
4.96	7.88e-05	GO:0032946	positive regulation of mononuclear cell proliferation
3.65	8.21e-05	GO:0032844	regulation of homeostatic process
2.80	8.65e-05	GO:0030029	actin filament-based process
6.52	9.64e-05	GO:0030595	leukocyte chemotaxis
4.89	9.75e-05	GO:0070665	positive regulation of leukocyte proliferation
2.15	9.85e-05	GO:0001932	regulation of protein phosphorylation
1.96	1.08e-04	GO:0009891	positive regulation of biosynthetic process
8.99	1.09e-04	GO:0002260	lymphocyte homeostasis
1.97	1.22e-04	GO:0031328	positive regulation of cellular biosynthetic process
2.29	1.25e-04	GO:0009607	response to biotic stimulus
10.22	1.33e-04	GO:0050853	B cell receptor signaling pathway
1.42	1.33e-04	GO:0060255	regulation of macromolecule metabolic process
4.76	1.48e-04	GO:0042035	regulation of cytokine biosynthetic process
3.32	1.62e-04	GO:0045088	regulation of innate immune response
8.63	1.74e-04	GO:0001776	leukocyte homeostasis
4.64	2.21e-04	GO:0043900	regulation of multi-organism process
5.22	2.41e-04	GO:0030217	T cell differentiation
2.01	2.52e-04	GO:2000026	regulation of multicellular organismal development
2.39	2.56e-04	GO:0008285	negative regulation of cell proliferation
4.58	2.68e-04	GO:0048872	homeostasis of number of cells
2.87	2.87e-04	GO:0030036	actin cytoskeleton organization
13.73	2.90e-04	GO:0001782	B cell homeostasis
4.79	3.27e-04	GO:0042113	B cell activation
6.47	3.53e-04	GO:0071260	cellular response to mechanical stimulus
2.06	3.59e-04	GO:0042325	regulation of phosphorylation
4.47	3.93e-04	GO:0045637	regulation of myeloid cell differentiation
5.84	4.10e-04	GO:0050729	positive regulation of inflammatory response
7.99	4.12e-04	GO:0034103	regulation of tissue remodeling
5.39	4.13e-04	GO:0002706	regulation of lymphocyte mediated immunity
2.03	4.23e-04	GO:0019220	regulation of phosphate metabolic process
2.03	4.23e-04	GO:0051174	regulation of phosphorus metabolic process
1.95	4.31e-04	GO:0031399	regulation of protein modification process
2.37	4.82e-04	GO:0007243	intracellular protein kinase cascade
2.37	4.82e-04	GO:0023014	signal transduction via phosphorylation event
2.75	4.87e-04	GO:0051101	regulation of DNA binding
1.38	5.08e-04	GO:0031323	regulation of cellular metabolic process
1.92	5.67e-04	GO:0044093	positive regulation of molecular function
6.78	6.89e-04	GO:0002824	positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
1.38	6.95e-04	GO:0080090	regulation of primary metabolic process
3.87	8.42e-04	GO:0050727	regulation of inflammatory response
3.05	9.10e-04	GO:0019221	cytokine-mediated signaling pathway
6.59	9.51e-04	GO:0002821	positive regulation of adaptive immune response
1.81	1.10e-03	GO:0032879	regulation of localization
6.41	1.30e-03	GO:0022407	regulation of cell-cell adhesion
9.59	1.38e-03	GO:0022409	positive regulation of cell-cell adhesion
6.24	1.75e-03	GO:0030888	regulation of B cell proliferation
1.98	1.84e-03	GO:0010628	positive regulation of gene expression
1.78	1.89e-03	GO:0006793	phosphorus metabolic process
1.78	1.89e-03	GO:0006796	phosphate metabolic process
3.81	2.16e-03	GO:0051100	negative regulation of binding
1.45	2.27e-03	GO:0010556	regulation of macromolecule biosynthetic process
2.57	2.33e-03	GO:0051270	regulation of cellular component movement
1.70	2.45e-03	GO:0050790	regulation of catalytic activity
2.71	2.48e-03	GO:0051090	regulation of sequence-specific DNA binding transcription factor activity
1.37	2.54e-03	GO:0016043	cellular component organization
1.81	2.68e-03	GO:0050793	regulation of developmental process
2.70	2.71e-03	GO:0000165	MAPKKK cascade
2.70	2.71e-03	GO:0046578	regulation of Ras protein signal transduction
2.22	2.81e-03	GO:0051094	positive regulation of developmental process
2.21	2.99e-03	GO:0016044	cellular membrane organization
5.39	3.13e-03	GO:0002263	cell activation involved in immune response
5.39	3.13e-03	GO:0002366	leukocyte activation involved in immune response
2.13	3.30e-03	GO:0048585	negative regulation of response to stimulus
2.20	3.40e-03	GO:0008283	cell proliferation
2.20	3.40e-03	GO:0061024	membrane organization
2.66	3.53e-03	GO:0090046	regulation of transcription regulator activity
1.79	3.91e-03	GO:0070887	cellular response to chemical stimulus
4.26	4.02e-03	GO:0008063	Toll signaling pathway
3.82	4.11e-03	GO:0032103	positive regulation of response to external stimulus
2.21	4.20e-03	GO:0043069	negative regulation of programmed cell death
1.42	4.79e-03	GO:0009889	regulation of biosynthetic process
10.07	4.80e-03	GO:0033003	regulation of mast cell activation
1.94	4.92e-03	GO:0045595	regulation of cell differentiation
2.62	4.99e-03	GO:0009617	response to bacterium
3.32	5.19e-03	GO:0001819	positive regulation of cytokine production
5.65	5.25e-03	GO:0030183	B cell differentiation
3.19	5.60e-03	GO:0002237	response to molecule of bacterial origin
1.65	6.01e-03	GO:0010033	response to organic substance
3.39	6.77e-03	GO:0045089	positive regulation of innate immune response
6.93	6.81e-03	GO:0030890	positive regulation of B cell proliferation
4.98	7.81e-03	GO:0042108	positive regulation of cytokine biosynthetic process
2.17	8.05e-03	GO:0043066	negative regulation of apoptosis
1.96	8.40e-03	GO:0045893	positive regulation of transcription, DNA-dependent
2.14	8.82e-03	GO:0060548	negative regulation of cell death
1.41	9.70e-03	GO:0031326	regulation of cellular biosynthetic process
1.34	9.72e-03	GO:0071840	cellular component organization or biogenesis
3.75	1.05e-02	GO:0002758	innate immune response-activating signal transduction
5.27	1.10e-02	GO:0002274	myeloid leukocyte activation
3.25	1.25e-02	GO:0006470	protein dephosphorylation
7.50	1.25e-02	GO:0002712	regulation of B cell mediated immunity
7.50	1.25e-02	GO:0002889	regulation of immunoglobulin mediated immune response
3.90	1.27e-02	GO:0043392	negative regulation of DNA binding
8.88	1.34e-02	GO:0045124	regulation of bone resorption
1.91	1.35e-02	GO:0007167	enzyme linked receptor protein signaling pathway
5.16	1.38e-02	GO:0002700	regulation of production of molecular mediator of immune response
3.67	1.40e-02	GO:0002218	activation of innate immune response
1.83	1.50e-02	GO:0045935	positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.40	1.51e-02	GO:0019219	regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
2.03	1.53e-02	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
2.31	1.59e-02	GO:0045597	positive regulation of cell differentiation
3.81	1.73e-02	GO:0002224	toll-like receptor signaling pathway
3.18	1.78e-02	GO:0032496	response to lipopolysaccharide
2.96	1.87e-02	GO:0009615	response to virus
1.81	1.87e-02	GO:0051173	positive regulation of nitrogen compound metabolic process
4.25	2.01e-02	GO:0071214	cellular response to abiotic stimulus
3.97	2.07e-02	GO:0034142	toll-like receptor 4 signaling pathway
8.39	2.10e-02	GO:0002675	positive regulation of acute inflammatory response
8.39	2.10e-02	GO:0046850	regulation of bone remodeling
2.70	2.23e-02	GO:0043405	regulation of MAP kinase activity
2.57	2.26e-02	GO:0032101	regulation of response to external stimulus
1.89	2.35e-02	GO:0071310	cellular response to organic substance
3.36	2.45e-02	GO:0008624	induction of apoptosis by extracellular signals
2.05	2.50e-02	GO:0045944	positive regulation of transcription from RNA polymerase II promoter
2.03	2.64e-02	GO:0007010	cytoskeleton organization
4.84	2.65e-02	GO:0042102	positive regulation of T cell proliferation
2.25	2.73e-02	GO:0051240	positive regulation of multicellular organismal process
2.09	2.75e-02	GO:0023057	negative regulation of signaling
1.84	2.77e-02	GO:0043085	positive regulation of catalytic activity
3.49	2.78e-02	GO:0009612	response to mechanical stimulus
2.13	2.81e-02	GO:0009968	negative regulation of signal transduction
1.81	2.90e-02	GO:0006468	protein phosphorylation
2.08	2.92e-02	GO:0010648	negative regulation of cell communication
3.64	3.08e-02	GO:0002221	pattern recognition receptor signaling pathway
5.88	3.08e-02	GO:0046651	lymphocyte proliferation
4.06	3.33e-02	GO:0034130	toll-like receptor 1 signaling pathway
4.06	3.33e-02	GO:0034134	toll-like receptor 2 signaling pathway
4.06	3.33e-02	GO:0042129	regulation of T cell proliferation
1.37	3.39e-02	GO:0051171	regulation of nitrogen compound metabolic process
1.40	3.43e-02	GO:2000112	regulation of cellular macromolecule biosynthetic process
2.26	3.58e-02	GO:0032535	regulation of cellular component size
5.14	3.81e-02	GO:0045639	positive regulation of myeloid cell differentiation
1.42	4.24e-02	GO:0006355	regulation of transcription, DNA-dependent
3.22	4.49e-02	GO:0007265	Ras protein signal transduction
1.38	4.59e-02	GO:0010468	regulation of gene expression
2.34	4.70e-02	GO:0040012	regulation of locomotion
3.08	4.70e-02	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade
7.55	4.72e-02	GO:0046631	alpha-beta T cell activation
2.97	4.76e-02	GO:0051099	positive regulation of binding

Gene overrepresentation in compartment category:

Enrichment	P-value	GO Accession	GO Term
1.56	1.44e-14	GO:0071944	cell periphery
1.55	1.05e-13	GO:0005886	plasma membrane
1.77	1.30e-11	GO:0044459	plasma membrane part
1.67	3.37e-08	GO:0005829	cytosol
1.24	7.86e-07	GO:0016020	membrane
1.83	1.04e-06	GO:0005887	integral to plasma membrane
1.81	1.35e-06	GO:0031226	intrinsic to plasma membrane
3.75	5.71e-06	GO:0009897	external side of plasma membrane
3.13	6.48e-05	GO:0031252	cell leading edge
1.18	6.23e-04	GO:0005737	cytoplasm
1.06	7.79e-04	GO:0044464	cell part
1.06	7.97e-04	GO:0005623	cell
3.22	1.04e-03	GO:0043235	receptor complex
5.83	1.38e-03	GO:0032587	ruffle membrane
3.64	3.81e-03	GO:0001726	ruffle
2.92	4.75e-03	GO:0045121	membrane raft
11.98	6.50e-03	GO:0043020	NADPH oxidase complex
3.51	2.10e-02	GO:0009898	internal side of plasma membrane
2.01	2.60e-02	GO:0009986	cell surface
21.57	2.83e-02	GO:0019814	immunoglobulin complex
21.57	2.83e-02	GO:0019815	B cell receptor complex
3.77	3.83e-02	GO:0019897	extrinsic to plasma membrane
1.18	4.43e-02	GO:0044425	membrane part
3.71	4.44e-02	GO:0031256	leading edge membrane

Gene overrepresentation in function category:

Enrichment	P-value	GO Accession	GO Term
1.37	2.03e-15	GO:0005515	protein binding
2.89	3.29e-11	GO:0060589	nucleoside-triphosphatase regulator activity
2.92	3.38e-11	GO:0030695	GTPase regulator activity
1.67	6.64e-08	GO:0004871	signal transducer activity
1.67	6.64e-08	GO:0060089	molecular transducer activity
2.19	1.22e-07	GO:0019899	enzyme binding
1.99	1.79e-07	GO:0005102	receptor binding
1.98	8.85e-07	GO:0030234	enzyme regulator activity
3.48	1.98e-06	GO:0005126	cytokine receptor binding
2.88	2.07e-06	GO:0005083	small GTPase regulator activity
3.03	2.12e-06	GO:0005096	GTPase activator activity
7.01	7.28e-06	GO:0003823	antigen binding
6.10	4.76e-05	GO:0008009	chemokine activity
3.26	1.49e-04	GO:0005085	guanyl-nucleotide exchange factor activity
5.50	1.80e-04	GO:0042379	chemokine receptor binding
2.33	1.95e-04	GO:0008047	enzyme activator activity
3.80	2.30e-04	GO:0019955	cytokine binding
2.89	5.18e-04	GO:0005125	cytokine activity
17.97	5.68e-04	GO:0016494	C-X-C chemokine receptor activity
5.28	8.01e-04	GO:0005070	SH3/SH2 adaptor activity
3.78	9.62e-04	GO:0004725	protein tyrosine phosphatase activity
15.41	1.91e-03	GO:0019958	C-X-C chemokine binding
1.52	2.26e-03	GO:0004872	receptor activity
3.38	2.60e-03	GO:0051020	GTPase binding
13.48	4.90e-03	GO:0016175	superoxide-generating NADPH oxidase activity
2.40	5.73e-03	GO:0032403	protein complex binding
9.96	5.88e-03	GO:0050664	oxidoreductase activity, acting on NADH or NADPH, oxygen as acceptor
2.04	7.41e-03	GO:0019904	protein domain specific binding
4.31	7.60e-03	GO:0035591	signaling adaptor activity
7.55	9.52e-03	GO:0001637	G-protein chemoattractant receptor activity
7.55	9.52e-03	GO:0004950	chemokine receptor activity
6.16	1.30e-02	GO:0005100	Rho GTPase activator activity
6.86	1.93e-02	GO:0019956	chemokine binding
2.73	2.03e-02	GO:0004721	phosphoprotein phosphatase activity
4.98	2.66e-02	GO:0004715	non-membrane spanning protein tyrosine kinase activity
5.57	2.92e-02	GO:0032813	tumor necrosis factor receptor superfamily binding
2.16	3.05e-02	GO:0016564	transcription repressor activity
1.09	3.40e-02	GO:0005488	binding
2.33	3.71e-02	GO:0019900	kinase binding
1.70	3.75e-02	GO:0042802	identical protein binding