Motif ID: SPI1.p2

Z-value: 3.914


Transcription factors associated with SPI1.p2:

Gene SymbolEntrez IDGene Name
SPI1 6688 spleen focus forming virus (SFFV) proviral integration oncogene spi1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
SPI1hg19_v1_chr11_-_47400096_474001260.914.7e-13Click!


Activity profile for motif SPI1.p2.

activity profile for motif SPI1.p2


Sorted Z-values histogram for motif SPI1.p2

Sorted Z-values for motif SPI1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SPI1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_-_47489243 14.375 NM_001145252
 CFP
complement factor properdin
chr1_+_26644458 12.397 CD52
CD52 molecule
chr6_-_32160289 12.032 GPSM3
G-protein signaling modulator 3
chr22_+_37257004 11.263 NM_000631
NM_013416
 NCF4

neutrophil cytosolic factor 4, 40kDa

chr16_-_29757264 9.980 NM_175900
 C16orf54
chromosome 16 open reading frame 54
chrX_-_47489703 9.829 NM_002621
 CFP
complement factor properdin
chr6_-_32160637 9.625 GPSM3
G-protein signaling modulator 3
chr1_-_153518265 9.111 NM_002961
NM_019554
 S100A4

S100 calcium binding protein A4

chr14_-_99737554 8.805 BCL11B
B-cell CLL/lymphoma 11B (zinc finger protein)
chr12_-_53600999 8.627 NM_000889
 ITGB7
integrin, beta 7
chr14_-_99737821 8.622 NM_022898
NM_138576
 BCL11B

B-cell CLL/lymphoma 11B (zinc finger protein)

chrX_+_48542193 8.532 WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr17_+_43299277 8.337 NM_005892
 FMNL1
formin-like 1
chr10_-_135090325 8.268 NM_001109
NM_001164489
NM_001164490
 ADAM8


ADAM metallopeptidase domain 8


chr11_+_67171400 8.140 NM_198517
 TBC1D10C
TBC1 domain family, member 10C
chr6_-_32157511 8.082 NM_002586
 PBX2
pre-B-cell leukemia homeobox 2
chr6_-_31550065 8.056 NM_002341
NM_009588
 LTB

lymphotoxin beta (TNF superfamily, member 3)

chr16_+_29674568 7.994 NM_003123
 SPN
sialophorin
chr1_+_111742946 7.847


chr1_-_157789832 7.826 NM_001159397
NM_001159398
NM_052938
 FCRL1


Fc receptor-like 1



Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 260 entries
Enrichment   P-value GO Accession GO Term
13.73 2.90e-04 GO:0001782 B cell homeostasis
10.22 1.33e-04 GO:0050853 B cell receptor signaling pathway
10.07 4.80e-03 GO:0033003 regulation of mast cell activation
9.59 1.38e-03 GO:0022409 positive regulation of cell-cell adhesion
8.99 1.09e-04 GO:0002260 lymphocyte homeostasis
8.88 1.34e-02 GO:0045124 regulation of bone resorption
8.63 1.74e-04 GO:0001776 leukocyte homeostasis
8.39 2.10e-02 GO:0002675 positive regulation of acute inflammatory response
8.39 2.10e-02 GO:0046850 regulation of bone remodeling
7.99 4.12e-04 GO:0034103 regulation of tissue remodeling
7.55 4.72e-02 GO:0046631 alpha-beta T cell activation
7.50 1.25e-02 GO:0002712 regulation of B cell mediated immunity
7.50 1.25e-02 GO:0002889 regulation of immunoglobulin mediated immune response
7.06 5.36e-08 GO:0060326 cell chemotaxis
6.93 6.81e-03 GO:0030890 positive regulation of B cell proliferation
6.84 5.06e-05 GO:0050871 positive regulation of B cell activation
6.78 6.89e-04 GO:0002824 positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
6.61 5.54e-08 GO:0031294 lymphocyte costimulation
6.61 5.54e-08 GO:0031295 T cell costimulation
6.59 9.51e-04 GO:0002821 positive regulation of adaptive immune response

Gene overrepresentation in compartment category:

Showing 1 to 20 of 24 entries
Enrichment   P-value GO Accession GO Term
21.57 2.83e-02 GO:0019814 immunoglobulin complex
21.57 2.83e-02 GO:0019815 B cell receptor complex
11.98 6.50e-03 GO:0043020 NADPH oxidase complex
5.83 1.38e-03 GO:0032587 ruffle membrane
3.77 3.83e-02 GO:0019897 extrinsic to plasma membrane
3.75 5.71e-06 GO:0009897 external side of plasma membrane
3.71 4.44e-02 GO:0031256 leading edge membrane
3.64 3.81e-03 GO:0001726 ruffle
3.51 2.10e-02 GO:0009898 internal side of plasma membrane
3.22 1.04e-03 GO:0043235 receptor complex
3.13 6.48e-05 GO:0031252 cell leading edge
2.92 4.75e-03 GO:0045121 membrane raft
2.01 2.60e-02 GO:0009986 cell surface
1.83 1.04e-06 GO:0005887 integral to plasma membrane
1.81 1.35e-06 GO:0031226 intrinsic to plasma membrane
1.77 1.30e-11 GO:0044459 plasma membrane part
1.67 3.37e-08 GO:0005829 cytosol
1.56 1.44e-14 GO:0071944 cell periphery
1.55 1.05e-13 GO:0005886 plasma membrane
1.24 7.86e-07 GO:0016020 membrane

Gene overrepresentation in function category:

Showing 1 to 20 of 40 entries
Enrichment   P-value GO Accession GO Term
17.97 5.68e-04 GO:0016494 C-X-C chemokine receptor activity
15.41 1.91e-03 GO:0019958 C-X-C chemokine binding
13.48 4.90e-03 GO:0016175 superoxide-generating NADPH oxidase activity
9.96 5.88e-03 GO:0050664 oxidoreductase activity, acting on NADH or NADPH, oxygen as acceptor
7.55 9.52e-03 GO:0001637 G-protein chemoattractant receptor activity
7.55 9.52e-03 GO:0004950 chemokine receptor activity
7.01 7.28e-06 GO:0003823 antigen binding
6.86 1.93e-02 GO:0019956 chemokine binding
6.16 1.30e-02 GO:0005100 Rho GTPase activator activity
6.10 4.76e-05 GO:0008009 chemokine activity
5.57 2.92e-02 GO:0032813 tumor necrosis factor receptor superfamily binding
5.50 1.80e-04 GO:0042379 chemokine receptor binding
5.28 8.01e-04 GO:0005070 SH3/SH2 adaptor activity
4.98 2.66e-02 GO:0004715 non-membrane spanning protein tyrosine kinase activity
4.31 7.60e-03 GO:0035591 signaling adaptor activity
3.80 2.30e-04 GO:0019955 cytokine binding
3.78 9.62e-04 GO:0004725 protein tyrosine phosphatase activity
3.48 1.98e-06 GO:0005126 cytokine receptor binding
3.38 2.60e-03 GO:0051020 GTPase binding
3.26 1.49e-04 GO:0005085 guanyl-nucleotide exchange factor activity